KIT and RCC are useful in distinguishing chromophobe renal cell carcinoma from the granular variant of clear cell renal cell carcinoma

American Journal of Surgical Pathology

Volumn 29, Issue 5, 2005, Pages 640-646

  Wang, Huan You ^a,b   Mills, Stacey E ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

CD10; Chromophobe renal cell carcinoma; Colloidal iron; Granular cell variant of clear cell renal cell carcinoma; Immunohistochemistry; KIT (CD117); RCC; Renal cell carcinoma; Renal oncocytoma; RON

Indexed keywords

COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; FERRIC HYDROXIDE; STEM CELL FACTOR RECEPTOR; TUMOR MARKER;

ARTICLE; CLEAR CELL CARCINOMA; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; FLANK PAIN; GRANULAR CELL TUMOR; HEMATURIA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; KIDNEY EPITHELIUM; KIDNEY FAILURE; ONCOCYTOMA; ONCOGENE C KIT; ONCOGENE RON; PROTO ONCOGENE;

ADENOCARCINOMA, CLEAR CELL; ADENOMA, OXYPHILIC; ANTIGENS, NEOPLASM; CARCINOMA, RENAL CELL; CYTOPLASMIC GRANULES; DIAGNOSIS, DIFFERENTIAL; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY NEOPLASMS; MITOGEN-ACTIVATED PROTEIN KINASES; NEPRILYSIN; PROTO-ONCOGENE PROTEINS C-KIT; RECEPTOR PROTEIN-TYROSINE KINASES; TUMOR MARKERS, BIOLOGICAL;

EID: 17744391565     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pas.0000157943.33903.92     Document Type: Article

References (35)

1. Akin C, Fumo G, Yavuz AS, et al. A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib. Blood. 2004;103:3222-3225.
2. Avery AK, Beckstead J, Renshaw AA, et al. Use of antibodies to RCC and CD10 in the differential diagnosis of renal neoplasm. Am J Surg Pathol. 2002;24:203-210.
3. Chu P, Arber DA. Paraffin-section detection of CD10 in 505 non-hematopoietic neoplasms: frequent expression in renal cell carcinoma and endometrial stromal carcinoma, Am J Clin Pathol 2000;113:374-382.
4. Eble JN, Hull MT. Morphologic features of renal oncocyloma: a light and electron microscopic study. Hum Pathol. 1984;15:1054-1061.
5. Furitsu T, Tsujimura T, Tono T, et al. Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product. J Clin Invest 1993;92:1736-1744.
6. Gaudino G, Avantaggiato V, Follenzi A, et al. The proto-oncogene RON is involved in development of epithelial, bone, and neuroendocrine tissue. Oncogene. 1995;11:2627-2637.
7. Higgins JPT, Shinghal R, Gill H, et al. Gene expression patterns in renal cell carcinoma assessed by complementary DNA microarray. Am J Pathol. 2003;162:925-932.
8. Hirota S, Nishida T, Isozaki K, et al. Gain-of-function mutation at the extracellular domain of kit in gastrointestinal stromal tumors. J Pathol. 2001;93:505-510.
9. Holst VA, Marshall CE, Moskaluk CA, et al. KIT protein expression and analysis of c-kit gene mutation in adenoid cystic carcinoma. Mod Pathol. 1999;12:956-960.
10. Ikeda H, Kanakura Y, Tainaki T, et al. Expression and functional role of the protooncogene c-kit in acute mycloblastic leukemia cells. Blood. 1991;78:2962-2968.
11. Kluppel M, Huizinga JD, Malysz J, et al. Developmental origin and Kit-dependent development of the interstitial cells of cajal in the mammalian small intestine. Dev Dyn. 1998;211:60-71.
12. Kovacs G, Akhtar M, Beckwith BJ, et al. The Heidelberg classification of renal cell tumors. J Pathol. 1997;183:131-133.
13. Lammie A, Drobnjak M, Gerald W, et al. Expression of c-kit and kit ligand proteins in normal human tissues. J Histochem Cytochem. 1994;42: 1417-1425.
14. Langner C, Wegscheider BJ, Ratschek M, et al. Keratin immunohistochemistry in renal cell carcinoma subtypes and renal oncocytomas: a systemic analysis of 223 tumors. Virchows Arch. 2004;444:127-134.
15. Matthews W, Jordan CT, Wiegand GW, et al. A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched population. Cell 1991;65:1143-1152.
16. McCluggage WG, Sumathi VP, Maxwell P. CD10 is a sensitive and diagnostically useful immunohistochemical marker of normal endometrial stroma and of endometrial stromal neoplasms. Histopathology. 2001;39: 273-278.
17. Moskaluk CA, Tian Q, Marshall CR, et al. Mutations of c-kit JM domain are found in a minority of human gastrointestinal stromal tumors. Oncogene. 1999;18:1897-1902.
18. Mowry RW. Improved procedure for the staining of acidic polysaccharides by Muller's colloid (hydrous) ferric oxide and its combination with the Feulgen and the periodic acid Schiff reactions. Lab Invest. 1958;7:566-576.
19. Pan CC, Chen PC, Chiang H. Overexpression of KIT (CD117) in chromophobe renal cell carcinoma and renal oncocytoma. Am J Clin Pathol. 2004;121:878-883.
20. Patton KT, Tretiakova MS, Yao JL, et al. Expression of RON protooncogene in renal oncocytoma and chromophobe renal cell carcinoma. Am J Surg Pathol. 2004;28:1045-1050.
21. Peace BE, Hughes MJ, Degen SJF, et al. Point mutations and overexpression of Ron induce transformation, tumor formation, and metastasis. Oncogene. 2001;20:6142-6151.
22. Penner CR, Folpe AL, Budnick SD. C-kit expression distinguishes salivary gland adenoid carcinoma from polymorphous low-grade adenocarcinoma. Mod Pathol 2002;15:687-691.
23. Rampino T, Gregorini M, Soccio G, et al. The Ron proto-oncogene product is a phenotypic marker of renal oncytoma. Am J Surg Pathol. 2003:27:779-785.
24. Ritz J, Pesando JM. Notis-McConarty J, et al. A monoclonal antibody to human acute lymphoblastic leukemia antigen. Nature. 1980;283:583-585.
25. Sakuma Y, Sakurai S, Oguni S, et al. Alterations of c-kit gene in testicular germ cell tumors. Cancer Sci. 2003;94:486-491.
26. Storkel S, Eble JN, Adlakha K, et al. Classification of renal cell carcinoma. Cancer. 1997;80:987-989.
27. Thoenes W, Storkel S, Rumpelt HJ, et al. Chromophobe renal cell carcinoma and its variants: a report on 32 cases. J Pathol. 1988;155:277-287.
28. Tian Q, Frierson HF Jr, Krystal GW, et al. Activating c-kit mutation in human germ tell tumors. Am J Pathol. 1999;154:1643-1647.
29. Tickoo SK, Amin MB, Zarbo RJ. Colloidal iron staining in renal epithelial neoplasms, including chromophobe renal cell carcinoma: emphasis in technique and patterns of staining. Am J Surg Pathol. 1998;22:419-424.
30. Tickoo SK, Lee MW, Eble JN, et al. Discriminant value of ultrastructural (EM) features of mitochondria and microvesicles in the differential diagnosis of renal tumors with granular cytoplasm [Abstract]. Mod Pathol. 1997;10:91A.
31. Tomada C, Kushima R, Takeuti E, et al. CD10 expression is useful in the diagnosis of follicular carcinoma and follicular variant of papillary thyroid carcinoma. Thyroid. 2003;13:291-29S.
32. Wu SL, Kothari P, Wheeler TM, et al. Cytokeratin 7 and 20 immunoreactivity in chromophobe renal cell carcinoma and renal oncocytomas. Mod Pathol. 2002;15:712-07.
33. Xiao SY, Wang HL, Hart J, et al. cDNA arrays and immunohistochemistry identification of CD10/CALLA expression in hepatocellular carcinoma. Am J Pathol. 2001;159:1415-1421.
34. Yamazaki K, Sakamoto M, Ohta T, et al. Overexpression of KIT in chromophobe renal cell carcinoma. Oncogene. 2003;22:847-852.
35. Yoshida SO, Iman A. Monoclonal antibody to a proximal nephrogenic renal antigen: immunohistochemical analysis of formalin-fixed, paraffin-embedded human renal cell carcinomas. Cancer Res. 1989;49:1802-1809.