A novel cell permeant peptide inhibitor of MAPKAP kinase II inhibits intimal hyperplasia in a human saphenous vein organ culture model

Journal of Vascular Surgery

Volumn 52, Issue 6, 2010, Pages 1596-1607

  Lopes, Luciana B ^a,e   Brophy, Colleen M ^a,b,c   Flynn, Charles R ^a,b   Yi, Zhengping ^a   Bowen, Benjamin P ^a   Smoke, Christopher ^a   Seal, Brandon ^d   Panitch, Alyssa ^d   Komalavilas, Padmini ^a,b,c  

^a ARIZONA STATE UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d PURDUE UNIVERSITY   (United States)

^e ALBANY COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ARSENIC TRIOXIDE; BOVINE SERUM ALBUMIN; CELL PENETRATING PEPTIDE; COLLAGEN; CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTIN; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 27; HYBRID PROTEIN; LYSOPHOSPHATIDIC ACID; MAPKAP KINASE II; TRANSFORMING GROWTH FACTOR; TRYPTOPHYLLEUCYLARGINYLARGINYLISOLEUCYLLYSYLALANYLTRYPTOPHYLLEUCYLARGINYLARGINYLISOLEUCYLLYSYLALANYLLEUCYLASPARAGINYLARGINYLGLUTAMINYLLEUCYLGLYCYLVALYLALANYLALANINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTERY INTIMA PROLIFERATION; ARTICLE; CELL CULTURE; CELL MIGRATION; CELL STIMULATION; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; DRUG ACTIVITY; DRUG EFFECT; EMBRYO; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNOBLOTTING; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MICROSCOPY; NONHUMAN; ORGAN CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SAPHENOUS VEIN; SEQUENCE ANALYSIS;

ANIMALS; AORTA; ARSENITES; CELL MOVEMENT; CELLS, CULTURED; COLLAGEN; CONNECTIVE TISSUE GROWTH FACTOR; ENZYME INHIBITORS; FIBRONECTINS; HSP27 HEAT-SHOCK PROTEINS; HUMANS; HYPERPLASIA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LYSOPHOSPHOLIPIDS; MICROSCOPY, CONFOCAL; MUSCLE, SMOOTH, VASCULAR; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PEPTIDES; PHOSPHORYLATION; PROTEIN ARRAY ANALYSIS; PROTEIN-SERINE-THREONINE KINASES; RATS; SAPHENOUS VEIN; SODIUM COMPOUNDS; TISSUE CULTURE TECHNIQUES; TUNICA INTIMA;

EID: 78650220146     PISSN: 07415214     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jvs.2010.06.168     Document Type: Article

References (39)

1. A.W. Clowes, and M.A. Reidy Prevention of stenosis after vascular reconstruction: pharmacologic control of intimal hyperplasia: a review J Vasc Surg 13 1991 885 891
2. M.S. Conte Technical factors in lower-extremity vein bypass surgery: how can we improve outcomes? Semin Vasc Surg 22 2009 227 233
3. M. Fu, J. Zhang, Y.H. Tseng, T. Cui, X. Zhu, and Y. Xiao Rad GTPase attenuates vascular lesion formation by inhibition of vascular smooth muscle cell migration Circulation 111 2005 1071 1077
4. J.C. Hedges, M.A. Dechert, I.A. Yamboliev, J.L. Martin, E. Hickey, and L.A. Weber A role for p38(MAPK)/HSP27 pathway in smooth muscle cell migration J Biol Chem 274 1999 24211 24219
5. S. Hirano, E.A. Shelden, and R.R. Gilmont HSP27 regulates fibroblast adhesion, motility, and matrix contraction Cell Stress Chaperones 9 2004 29 37
6. J.N. Lavoie, H. Lambert, E. Hickey, L.A. Weber, and J. Landry Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27 Mol Cell Biol 15 1995 505 516
7. J. Rouse, P. Cohen, S. Trigon, M. Morange, A. Alonso-Llamazares, and D. Zamanillo A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins Cell 78 1994 1027 1037
8. J. Heusinger-Ribeiro, M. Eberlein, N.A. Wahab, and M. Goppelt-Struebe Expression of connective tissue growth factor in human renal fibroblasts: regulatory roles of RhoA and cAMP J Am Soc Nephrol 12 2001 1853 1861
9. C. Ott, D. Iwanciw, A. Graness, K. Giehl, and M. Goppelt-Struebe Modulation of the expression of connective tissue growth factor by alterations of the cytoskeleton J Biol Chem 278 2003 44305 44311
10. L.B. Lopes, E.J. Furnish, P. Komalavilas, C.R. Flynn, P. Ashby, and A. Hansen Cell permeant peptide analogues of the small heat shock protein, HSP20, reduce TGF-beta1-induced CTGF expression in keloid fibroblasts J Invest Dermatol 129 2009 590 598
11. M. Gaestel MAPKAP kinases - MKs two's company, three's a crowd Nat Rev Mol Cell Biol 7 2006 120 130
12. K. Hayess, and R. Benndorf Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase Biochem Pharmacol 53 1997 1239 1247
13. C.R. Flynn, P. Komalavilas, D. Tessier, J. Thresher, E.E. Niederkofler, and C.M. Dreiza Transduction of biologically active motifs of the small heat shock- related protein, HSP20, leads to relaxation of vascular smooth muscle Faseb J 10 2003 1358 1360
14. S. Ai, M. Kuzuya, T. Koike, T. Asai, S. Kanda, and K. Maeda Rho-Rho kinase is involved in smooth muscle cell migration through myosin light chain phosphorylation-dependent and independent pathways Atherosclerosis 155 2001 321 327
15. P. Komalavilas, and L. DaCosta Lysophosphatidic acid induces phosphorylation of heat shock protein 27 Medimond International Proceedings 2005 133 138
16. M.R. Rossi, S. Somji, S.H. Garrett, M.A. Sens, J. Nath, and D.A. Sens Expression of HSP 27, HSP 60, HSC 70, and HSP 70 stress response genes in cultured human urothelial cells (UROtsa) exposed to lethal and sublethal concentrations of sodium arsenite Environ Health Perspect 110 2002 1225 1232
17. J. Soderholm, and R. Heald Scratch n' screen for inhibitors of cell migration Chem Biol 12 2005 263 265
18. Z. Jiang, P. Yu, M. Tao, C. Fernandez, C. Ifantides, and O. Moloye TGF-beta- and CTGF-mediated fibroblast recruitment influences early outward vein graft remodeling Am J Physiol Heart Circ Physiol 293 2007 H482 H488
19. L.B. Lopes, C. Flynn, P. Komalavilas, A. Panitch, C.M. Brophy, and B.L. Seal Inhibition of HSP27 phosphorylation by a cell-permeant MAPKAP kinase 2 inhibitor Biochem Biophys Res Commun 382 2009 535 539
20. K. Hojlund, Z. Yi, H. Hwang, B. Bowen, N. Lefort, and C.R. Flynn Characterization of the human skeletal muscle proteome by one-dimensional gel electrophoresis and HPLC-ESI-MS/MS Mol Cell Proteomics 7 2008 257 267
21. L.J. Foster, A. Rudich, I. Talior, N. Patel, X. Huang, and L.M. Furtado Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC) J Proteome Res 5 2006 64 75
22. L. Knoepp, A. Beall, D. Woodrum, J.S. Mondy, E. Shaver, and M. Dickinson Cellular stress inhibits vascular smooth muscle relaxation J Vasc Surg 31 2000 343 353
23. N.J. Boerth, N.B. Dey, T.L. Cornwell, and T.M. Lincoln Cyclic GMP-dependent protein kinase regulates vascular smooth muscle cell phenotype J Vasc Res 34 1997 245 259
24. C.M. Brophy, D.A. Woodrum, J. Pollock, M. Dickinson, P. Komalavilas, and T.L. Cornwell cGMP-dependent protein kinase expression restores contractile function in cultured vascular smooth muscle cells J Vasc Res 39 2002 95 103
25. M.J. Cipolla, N.I. Gokina, and G. Osol Pressure-induced actin polymerization in vascular smooth muscle as a mechanism underlying myogenic behavior Faseb J 16 2002 72 76
26. R. Udelsman, M.J. Blake, C.A. Stagg, L. Ding-gang, D.J. Putney, and N.J. Holbrook Vascular heat shock protein expression in response to stress J Clin Invest 91 1993 465 473
27. Y. Shi, J.E. O'Brien Jr, J.D. Mannion, R.C. Morrison, W. Chung, and A. Fard Remodeling of autologous saphenous vein grafts The role of perivascular myofibroblasts Circulation 95 1997 2684 2693
28. E. McGregor, L. Kempster, R. Wait, M. Gosling, M.J. Dunn, and J.T. Powell F-actin capping (CapZ) and other contractile saphenous vein smooth muscle proteins are altered by hemodynamic stress: a proteonomic approach Mol Cell Proteomics 3 2004 115 124
29. P.C. Saunders, G. Pintucci, C.S. Bizekis, R. Sharony, K.M. Hyman, and F. Saponara Vein graft arterialization causes differential activation of mitogen-activated protein kinases J Thorac Cardiovasc Surg 127 2004 1276 1284
30. K.E. Porter, T. Dickinson, and N.J. London Inhibition of neointima formation in an organ culture of human saphenous vein: a comparison of dual endothelin-converting enzyme/neutral endopeptidase and selective neutral endopeptidase inhibition J Vasc Surg 34 2001 548 554
31. C. Colotti, S. Vittorini, V. Ottaviano, M. Maltinti, V. Angeli, and S. Del Ry Nitric oxide treatment reduces neo-intimal formation and modulates osteopontin expression in an ex-vivo human model of intimal hyperplasia Cytokine 46 2009 228 235
32. D.J. Tessier, P. Komalavilas, B. Liu, C.K. Kent, J.S. Thresher, and C.M. Dreiza Transduction of peptide analogs of the small heat shock-related protein HSP20 inhibits intimal hyperplasia J Vasc Surg 40 2004 106 114
33. K.E. Porter, K. Varty, L. Jones, P.R. Bell, and N.J. London Human saphenous vein organ culture: a useful model of intimal hyperplasia? Eur J Vasc Endovasc Surg 11 1996 48 58
34. J.J. Castronuovo Jr, T.J. Smith, and R.M. Price Validation of an in vitro model of human saphenous vein hyperplasia J Vasc Surg 35 2002 152 157
35. Z. Jiang, M. Tao, K.A. O'Malley, D. Wang, C.K. Ozaki, and S.A. Berceli Established neointimal hyperplasia in vein grafts expands via TGF-beta-mediated progressive fibrosis Am J Physiol Heart Circ Physiol 297 2009 H1200 H1207
36. R. Friedl, J. Li, B. Schumacher, H. Hanke, J. Waltenberger, and A. Hannekum Intimal hyperplasia and expression of transforming growth factor-beta1 in saphenous veins and internal mammary arteries before coronary artery surgery Ann Thorac Surg 78 2004 1312 1318
37. A.M. Sousa, T. Liu, O. Guevara, J. Stevens, B.L. Fanburg, and M. Gaestel Smooth muscle alpha-actin expression and myofibroblast differentiation by TGF-beta are dependent upon MK2 J Cell Biochem 100 2007 1581 1592
38. A.I. Willis, D. Pierre-Paul, B.E. Sumpio, and V. Gahtan Vascular smooth muscle cell migration: current research and clinical implications Vasc Endovascular Surg 38 2004 11 23
39. S. Muehlich, I. Cicha, C.D. Garlichs, B. Krueger, G. Posern, and M. Goppelt-Struebe Actin-dependent regulation of connective tissue growth factor Am J Physiol Cell Physiol 292 2007 C1732 C1738