-
2
-
-
0028217535
-
Lower serum prolyl endopeptidase enzyme activity in major depression: Further evidence that peptidases play a role in the pathophysiology of depression
-
Maes M, Goossens F, Scharpe S, Meltzer HY, D'Hondt P, Cosyns P. Lower serum prolyl endopeptidase enzyme activity in major depression: Further evidence that peptidases play a role in the pathophysiology of depression. Biol Psychiatry 1994;35:545-52.
-
(1994)
Biol Psychiatry
, vol.35
, pp. 545-552
-
-
Maes, M.1
Goossens, F.2
Scharpe, S.3
Meltzer, H.Y.4
D'Hondt, P.5
Cosyns, P.6
-
3
-
-
0028802506
-
Alterations in plasma prolyl endopeptidase activity in depression, mania, and schizophrenia: Effects of antidepressants, mood stabilizers, and antipsychotic drugs
-
Maes M, Goossens F, Scharpe S, Calabrese J, Desnyder R, Meltzer HY. Alterations in plasma prolyl endopeptidase activity in depression, mania, and schizophrenia: Effects of antidepressants, mood stabilizers, and antipsychotic drugs. Psychiatry Res 1995;58:217-25.
-
(1995)
Psychiatry Res
, vol.58
, pp. 217-225
-
-
Maes, M.1
Goossens, F.2
Scharpe, S.3
Calabrese, J.4
Desnyder, R.5
Meltzer, H.Y.6
-
4
-
-
0017085135
-
Post-proline cleaving enzyme. Purification of this endopeptidase by affinity chromatography
-
Koida M, Walter R. Post-proline cleaving enzyme. Purification of this endopeptidase by affinity chromatography. J Biol Chem 1976;251:7593-9.
-
(1976)
J Biol Chem
, vol.251
, pp. 7593-7599
-
-
Koida, M.1
Walter, R.2
-
5
-
-
0033577733
-
Loss of a prolyl oligopeptidase confers resistance to lithium by elevation of inositol (1,4,5) trisphosphate
-
Williams RS, Eames M, Ryves WJ, Viggars J, Harwood AJ. Loss of a prolyl oligopeptidase confers resistance to lithium by elevation of inositol (1, 4, 5) trisphosphate. EMBO J 1999;18:2734-45.
-
(1999)
EMBO J
, vol.18
, pp. 2734-2745
-
-
Williams, R.S.1
Eames, M.2
Ryves, W.J.3
Viggars, J.4
Harwood, A.J.5
-
6
-
-
0024341795
-
Neural and developmental actions of lithium: A unifying hypothesis
-
Berridge MJ, Downes CP, Hanley MR. Neural and developmental actions of lithium: A unifying hypothesis. Cell 1989;59:411-9.
-
(1989)
Cell
, vol.59
, pp. 411-419
-
-
Berridge, M.J.1
Downes, C.P.2
Hanley, M.R.3
-
7
-
-
0037118050
-
A common mechanism of action for three mood-stabilizing drugs
-
Williams RS, Cheng L, Mudge AW, Harwood AJ. A common mechanism of action for three mood-stabilizing drugs. Nature 2002;417:292-5.
-
(2002)
Nature
, vol.417
, pp. 292-295
-
-
Williams, R.S.1
Cheng, L.2
Mudge, A.W.3
Harwood, A.J.4
-
8
-
-
0041559904
-
Neurodevelopment and mood stabilizers
-
Harwood AJ. Neurodevelopment and mood stabilizers. Curr Mol Med 2003;3:472-82.
-
(2003)
Curr Mol Med
, vol.3
, pp. 472-482
-
-
Harwood, A.J.1
-
9
-
-
0038771254
-
Search for a common mechanism of mood stabilizers
-
Harwood AJ, Agam G. Search for a common mechanism of mood stabilizers. Biochem Pharmacol 2003;66:179-89.
-
(2003)
Biochem Pharmacol
, vol.66
, pp. 179-189
-
-
Harwood, A.J.1
Agam, G.2
-
10
-
-
33846589762
-
Suppressive effect of clozapine but not haloperidol on the increases of neuropeptide-degrading enzymes and glial cells in MK-801-treated rat brain regions
-
Arif M, Chikuma T, Ahmed MM, Yoshida S, Kato T. Suppressive effect of clozapine but not haloperidol on the increases of neuropeptide-degrading enzymes and glial cells in MK-801-treated rat brain regions. Neurosci Res 2007;57:248-58.
-
(2007)
Neurosci Res
, vol.57
, pp. 248-258
-
-
Arif, M.1
Chikuma, T.2
Ahmed, M.M.3
Yoshida, S.4
Kato, T.5
-
11
-
-
19444377984
-
How can the mood stabilizer VPA limit both mania and depression?
-
Cheng L, Lumb M, Polgar L, Mudge AW. How can the mood stabilizer VPA limit both mania and depression? Mol Cell Neurosci 2005;29:155-61.
-
(2005)
Mol Cell Neurosci
, vol.29
, pp. 155-161
-
-
Cheng, L.1
Lumb, M.2
Polgar, L.3
Mudge, A.W.4
-
12
-
-
0036683705
-
Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819
-
Venäläinen JI, Juvonen RO, Forsberg MM, García-Horsman A, Poso A, Wallén EA et al. Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819. Biochem Pharmacol 2002;64:463-71.
-
(2002)
Biochem Pharmacol
, vol.64
, pp. 463-471
-
-
Venäläinen, J.I.1
Juvonen, R.O.2
Forsberg, M.M.3
García-Horsman, A.4
Poso, A.5
Wallén, E.A.6
-
13
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-54.
-
(1976)
Anal Biochem
, vol.72
, pp. 248-254
-
-
Bradford, M.1
-
14
-
-
23944514165
-
Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists
-
In: Copeland RA (ed.). John Wiley & Sons, Inc., Hoboken
-
Copeland RA. Lead optimization and structure-activity relationships for reversible inhibitors. In: Copeland RA (ed.). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists. John Wiley & Sons, Inc., Hoboken, 2005;111-40.
-
(2005)
Lead optimization and structure-activity relationships for reversible inhibitors
, pp. 111-140
-
-
Copeland, R.A.1
-
15
-
-
0016700753
-
Tight-binding inhibitors-I. Kinetic behavior
-
Cha S. Tight-binding inhibitors-I. Kinetic behavior. Biochem Pharmacol 1975;24:2177-85.
-
(1975)
Biochem Pharmacol
, vol.24
, pp. 2177-2185
-
-
Cha, S.1
-
16
-
-
66949120705
-
Prolyl oligopeptidase binds to GAP-43 and functions without its peptidase activity
-
Di Daniel E, Glover CP, Grot E, Chan MK, Sanderson TH, White JH et al. Prolyl oligopeptidase binds to GAP-43 and functions without its peptidase activity. Mol Cell Neurosci 2009;41:373-82.
-
(2009)
Mol Cell Neurosci
, vol.41
, pp. 373-382
-
-
Di Daniel, E.1
Glover, C.P.2
Grot, E.3
Chan, M.K.4
Sanderson, T.H.5
White, J.H.6
-
17
-
-
0033504474
-
Drug levels: Therapeutic and toxic serum/plasma concentrations of common drugs
-
Regenthal R, Krueger M, Koeppel C, Preiss R. Drug levels: Therapeutic and toxic serum/plasma concentrations of common drugs. J Clin Monit Comput 1999;15:529-44.
-
(1999)
J Clin Monit Comput
, vol.15
, pp. 529-544
-
-
Regenthal, R.1
Krueger, M.2
Koeppel, C.3
Preiss, R.4
-
18
-
-
0020526594
-
Metabolism and kinetics of bupropion
-
Schroeder DH. Metabolism and kinetics of bupropion. J Clin Psychiatry 1983;44:79-81.
-
(1983)
J Clin Psychiatry
, vol.44
, pp. 79-81
-
-
Schroeder, D.H.1
-
19
-
-
0027538206
-
Postmortem concentrations of phenobarbital, carbamazepine, and its metabolite carbamazepine-10,11-epoxide in different regions of the brain and in the serum: Analysis of autoptic specimens from 51 epileptic patients
-
Rambeck B, Schnabel R, May T, Jurgens U, Villagran R. Postmortem concentrations of phenobarbital, carbamazepine, and its metabolite carbamazepine-10, 11-epoxide in different regions of the brain and in the serum: Analysis of autoptic specimens from 51 epileptic patients. Ther Drug Monit 1993;15:91-8.
-
(1993)
Ther Drug Monit
, vol.15
, pp. 91-98
-
-
Rambeck, B.1
Schnabel, R.2
May, T.3
Jurgens, U.4
Villagran, R.5
-
20
-
-
0028905671
-
Brain, liver and blood distribution kinetics of carbamazepine and its metabolic interaction with clomipramine in rats: A quantitative microdialysis study
-
Van Belle K, Sarre S, Ebinger G, Michotte Y. Brain, liver and blood distribution kinetics of carbamazepine and its metabolic interaction with clomipramine in rats: A quantitative microdialysis study. J Pharmacol Exp Ther 1995;272:1217-22.
-
(1995)
J Pharmacol Exp Ther
, vol.272
, pp. 1217-1222
-
-
Van Belle, K.1
Sarre, S.2
Ebinger, G.3
Michotte, Y.4
-
21
-
-
0026441418
-
Drug distribution between blood and brain as a determinant of antipsychotic drug effects
-
Tsuneizumi T, Babb SM, Cohen BM. Drug distribution between blood and brain as a determinant of antipsychotic drug effects. Biol Psychiatry 1992;32:817-24.
-
(1992)
Biol Psychiatry
, vol.32
, pp. 817-824
-
-
Tsuneizumi, T.1
Babb, S.M.2
Cohen, B.M.3
-
22
-
-
0021368802
-
Biochemical effects and drug levels in rats after long-term treatment with the specific 5-HT-uptake inhibitor, citalopram
-
Hyttel J, Overo KF, Arnt J. Biochemical effects and drug levels in rats after long-term treatment with the specific 5-HT-uptake inhibitor, citalopram. Psychopharmacology (Berl) 1984;83:20-7.
-
(1984)
Psychopharmacology (Berl)
, vol.83
, pp. 20-27
-
-
Hyttel, J.1
Overo, K.F.2
Arnt, J.3
-
23
-
-
0032703284
-
Pharmacokinetic and pharmacodynamic responses to chronic administration of the selective serotonin reuptake inhibitor citalopram in rats
-
Wikell C, Apelqvist G, Carlsson B, Hjorth S, Bergqvist PB, Kugelberg FC et al. Pharmacokinetic and pharmacodynamic responses to chronic administration of the selective serotonin reuptake inhibitor citalopram in rats. Clin Neuropharmacol 1999;22:327-36.
-
(1999)
Clin Neuropharmacol
, vol.22
, pp. 327-336
-
-
Wikell, C.1
Apelqvist, G.2
Carlsson, B.3
Hjorth, S.4
Bergqvist, P.B.5
Kugelberg, F.C.6
-
24
-
-
0027321081
-
Tissue concentrations of clozapine and its metabolites in the rat
-
Baldessarini RJ, Centorrino F, Flood JG, Volpicelli SA, Huston-Lyons D, Cohen BM. Tissue concentrations of clozapine and its metabolites in the rat. Neuropsychopharmacology 1993;9:117-24.
-
(1993)
Neuropsychopharmacology
, vol.9
, pp. 117-124
-
-
Baldessarini, R.J.1
Centorrino, F.2
Flood, J.G.3
Volpicelli, S.A.4
Huston-Lyons, D.5
Cohen, B.M.6
-
25
-
-
0019497321
-
Brain distribution and kinetics of desipramine in the rat
-
Hrdina PD, Dubas TC. Brain distribution and kinetics of desipramine in the rat. Can J Physiol Pharmacol 1981;59:163-7.
-
(1981)
Can J Physiol Pharmacol
, vol.59
, pp. 163-167
-
-
Hrdina, P.D.1
Dubas, T.C.2
-
26
-
-
0028818163
-
Brain-plasma distribution of free and total benzodiazepines in dogs physically dependent on different doses of diazepam
-
Wala EP, Martin WR, Sloan JW. Brain-plasma distribution of free and total benzodiazepines in dogs physically dependent on different doses of diazepam. Pharmacol Biochem Behav 1995;52:707-13.
-
(1995)
Pharmacol Biochem Behav
, vol.52
, pp. 707-713
-
-
Wala, E.P.1
Martin, W.R.2
Sloan, J.W.3
-
27
-
-
0035079542
-
Assessment of the serotonin and norepinephrine reuptake blocking properties of duloxetine in healthy subjects
-
Turcotte JE, Debonnel G, de Montigny C, Hebert C, Blier P. Assessment of the serotonin and norepinephrine reuptake blocking properties of duloxetine in healthy subjects. Neuropsychopharmacology 2001;24:511-21.
-
(2001)
Neuropsychopharmacology
, vol.24
, pp. 511-521
-
-
Turcotte, J.E.1
Debonnel, G.2
de Montigny, C.3
Hebert, C.4
Blier, P.5
-
28
-
-
33947728974
-
The clinical pharmacokinetics of escitalopram
-
Rao N. The clinical pharmacokinetics of escitalopram. Clin Pharmacokinet 2007;46:281-90.
-
(2007)
Clin Pharmacokinet
, vol.46
, pp. 281-290
-
-
Rao, N.1
-
29
-
-
23844454579
-
A comparison of brain and serum pharmacokinetics of R-fluoxetine and racemic fluoxetine: A 19-F MRS study
-
Henry ME, Schmidt ME, Hennen J, Villafuerte RA, Butman ML, Tran P et al. A comparison of brain and serum pharmacokinetics of R-fluoxetine and racemic fluoxetine: A 19-F MRS study. Neuropsychopharmacology 2005;30:1576-83.
-
(2005)
Neuropsychopharmacology
, vol.30
, pp. 1576-1583
-
-
Henry, M.E.1
Schmidt, M.E.2
Hennen, J.3
Villafuerte, R.A.4
Butman, M.L.5
Tran, P.6
-
30
-
-
0026768367
-
Accumulation of fluoxetine and norfluoxetine in human brain during therapeutic administration
-
Renshaw PF, Guimaraes AR, Fava M, Rosenbaum JF, Pearlman JD, Flood JG et al. Accumulation of fluoxetine and norfluoxetine in human brain during therapeutic administration. Am J Psychiatry 1992;149:1592-4.
-
(1992)
Am J Psychiatry
, vol.149
, pp. 1592-1594
-
-
Renshaw, P.F.1
Guimaraes, A.R.2
Fava, M.3
Rosenbaum, J.F.4
Pearlman, J.D.5
Flood, J.G.6
-
31
-
-
74049121617
-
Determination of antidepressants in human postmortem blood, brain tissue, and hair using gas chromatography-mass spectrometry
-
Wille SM, De Letter EA, Piette MH, Van Overschelde LK, Van Peteghem CH, Lambert WE. Determination of antidepressants in human postmortem blood, brain tissue, and hair using gas chromatography-mass spectrometry. Int J Legal Med 2009;123:451-8.
-
(2009)
Int J Legal Med
, vol.123
, pp. 451-458
-
-
Wille, S.M.1
De Letter, E.A.2
Piette, M.H.3
Van Overschelde, L.K.4
Van Peteghem, C.H.5
Lambert, W.E.6
-
32
-
-
0033828077
-
Brain pharmacokinetics and tissue distribution in vivo of fluvoxamine and fluoxetine by fluorine magnetic resonance spectroscopy
-
Bolo NR, Hode Y, Nedelec JF, Laine E, Wagner G, Macher JP. Brain pharmacokinetics and tissue distribution in vivo of fluvoxamine and fluoxetine by fluorine magnetic resonance spectroscopy. Neuropsychopharmacology 2000;23:428-38.
-
(2000)
Neuropsychopharmacology
, vol.23
, pp. 428-438
-
-
Bolo, N.R.1
Hode, Y.2
Nedelec, J.F.3
Laine, E.4
Wagner, G.5
Macher, J.P.6
-
33
-
-
0027216531
-
Human brain fluoxetine concentrations
-
Karson CN, Newton JE, Livingston R, Jolly JB, Cooper TB, Sprigg J et al. Human brain fluoxetine concentrations. J Neuropsychiatry Clin Neurosci 1993;5:322-9.
-
(1993)
J Neuropsychiatry Clin Neurosci
, vol.5
, pp. 322-329
-
-
Karson, C.N.1
Newton, J.E.2
Livingston, R.3
Jolly, J.B.4
Cooper, T.B.5
Sprigg, J.6
-
34
-
-
0023159769
-
Blood to brain distribution of neuroleptics
-
Sunderland T, Cohen BM. Blood to brain distribution of neuroleptics. Psychiatry Res 1987;20:299-305.
-
(1987)
Psychiatry Res
, vol.20
, pp. 299-305
-
-
Sunderland, T.1
Cohen, B.M.2
-
36
-
-
0020076242
-
A quantitative study in the rat on the relationship between imipramine levels in brain and serum
-
van Wijk M, Korf J. A quantitative study in the rat on the relationship between imipramine levels in brain and serum. Psychopharmacology (Berl) 1982;76:48-51.
-
(1982)
Psychopharmacology (Berl)
, vol.76
, pp. 48-51
-
-
van Wijk, M.1
Korf, J.2
-
37
-
-
0023909240
-
Pharmacokinetics and tissue distribution of ketanserin in rat, rabbit and dog
-
Michiels M, Monbaliu J, Meuldermans W, Hendriks R, Geerts R, Woestenborghs R et al. Pharmacokinetics and tissue distribution of ketanserin in rat, rabbit and dog. Arzneimittelforschung 1988;38:775-84.
-
(1988)
Arzneimittelforschung
, vol.38
, pp. 775-784
-
-
Michiels, M.1
Monbaliu, J.2
Meuldermans, W.3
Hendriks, R.4
Geerts, R.5
Woestenborghs, R.6
-
38
-
-
0027440140
-
Lamotrigine clinical pharmacokinetics
-
Rambeck B, Wolf P. Lamotrigine clinical pharmacokinetics. Clin Pharmacokinet 1993;25:433-43.
-
(1993)
Clin Pharmacokinet
, vol.25
, pp. 433-443
-
-
Rambeck, B.1
Wolf, P.2
-
39
-
-
32044434685
-
Region specific distribution of levomepromazine in the human brain
-
Kornhuber J, Weigmann H, Rohrich J, Wiltfang J, Bleich S, Meineke I et al. Region specific distribution of levomepromazine in the human brain. J Neural Transm 2006;113:387-97.
-
(2006)
J Neural Transm
, vol.113
, pp. 387-397
-
-
Kornhuber, J.1
Weigmann, H.2
Rohrich, J.3
Wiltfang, J.4
Bleich, S.5
Meineke, I.6
-
40
-
-
0035280834
-
Brain lithium concentrations in bipolar disorder patients: Preliminary (7)Li magnetic resonance studies at 3 T
-
Soares JC, Boada F, Spencer S, Mallinger AG, Dippold CS, Wells KF et al. Brain lithium concentrations in bipolar disorder patients: Preliminary (7)Li magnetic resonance studies at 3 T. Biol Psychiatry 2001;49:437-43.
-
(2001)
Biol Psychiatry
, vol.49
, pp. 437-443
-
-
Soares, J.C.1
Boada, F.2
Spencer, S.3
Mallinger, A.G.4
Dippold, C.S.5
Wells, K.F.6
-
42
-
-
0141783736
-
Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-glycoprotein gene disruption
-
Uhr M, Grauer MT, Holsboer F. Differential enhancement of antidepressant penetration into the brain in mice with abcb1ab (mdr1ab) P-glycoprotein gene disruption. Biol Psychiatry 2003;54:840-6.
-
(2003)
Biol Psychiatry
, vol.54
, pp. 840-846
-
-
Uhr, M.1
Grauer, M.T.2
Holsboer, F.3
-
43
-
-
0020657144
-
Tissue distribution and hypotensive effect of prazosin in the conscious rat
-
Dynon MK, Jarrott B, Louis WJ. Tissue distribution and hypotensive effect of prazosin in the conscious rat. J Cardiovasc Pharmacol 1983;5:235-9.
-
(1983)
J Cardiovasc Pharmacol
, vol.5
, pp. 235-239
-
-
Dynon, M.K.1
Jarrott, B.2
Louis, W.J.3
-
44
-
-
0017052907
-
The rat brain as a "deep compartment" in the kinetics of a common metabolite of prochlorperazine and perphenazine
-
Jahns I, Breyer U. The rat brain as a "deep compartment" in the kinetics of a common metabolite of prochlorperazine and perphenazine. Drug Metab Dispos 1976;4:522-9.
-
(1976)
Drug Metab Dispos
, vol.4
, pp. 522-529
-
-
Jahns, I.1
Breyer, U.2
-
45
-
-
10644268555
-
The brain entry of risperidone and 9-hydroxyrisperidone is greatly limited by P-glycoprotein
-
Wang JS, Ruan Y, Taylor RM, Donovan JL, Markowitz JS, DeVane CL. The brain entry of risperidone and 9-hydroxyrisperidone is greatly limited by P-glycoprotein. Int J Neuropsychopharmcol 2004;7:415-9.
-
(2004)
Int J Neuropsychopharmcol
, vol.7
, pp. 415-419
-
-
Wang, J.S.1
Ruan, Y.2
Taylor, R.M.3
Donovan, J.L.4
Markowitz, J.S.5
DeVane, C.L.6
-
46
-
-
0035032869
-
Pharmacological properties of (2R)-N-[1-(6-aminopyridin-2-ylmethyl)piperidin-4-yl]-2-[(1R)-3,3-difluoroc yclopentyl]-2-hydro-xy-2-phenylacetamide: A novel mucarinic antagonist with M(2)-sparing antagonistic activity
-
Hirose H, Aoki I, Kimura T, Fujikawa T, Numazawa T, Sasaki K et al. Pharmacological properties of (2R)-N-[1-(6-aminopyridin-2-ylmethyl)piperidin-4-yl]-2-[(1R)-3, 3-difluoroc yclopentyl]-2-hydro-xy-2-phenylacetamide: A novel mucarinic antagonist with M(2)-sparing antagonistic activity. J Pharmacol Exp Ther 2001;297:790-7.
-
(2001)
J Pharmacol Exp Ther
, vol.297
, pp. 790-797
-
-
Hirose, H.1
Aoki, I.2
Kimura, T.3
Fujikawa, T.4
Numazawa, T.5
Sasaki, K.6
-
47
-
-
0345189359
-
A new formulation of selegiline: Improved bioavailability and selectivity for MAO-B inhibition
-
Clarke A, Brewer F, Johnson ES, Mallard N, Hartig F, Taylor S et al. A new formulation of selegiline: Improved bioavailability and selectivity for MAO-B inhibition. J Neural Transm 2003;110:1241-55.
-
(2003)
J Neural Transm
, vol.110
, pp. 1241-1255
-
-
Clarke, A.1
Brewer, F.2
Johnson, E.S.3
Mallard, N.4
Hartig, F.5
Taylor, S.6
-
48
-
-
0025827397
-
Comparison of valproate concentrations in human plasma, CSF and brain tissue after administration of different formulations of valproate or valpromide
-
Wieser HG. Comparison of valproate concentrations in human plasma, CSF and brain tissue after administration of different formulations of valproate or valpromide. Epilepsy Res 1991;9:154-9.
-
(1991)
Epilepsy Res
, vol.9
, pp. 154-159
-
-
Wieser, H.G.1
|