Assessment of the serotonin and norepinephrine reuptake blocking properties of duloxetine in healthy subjects

Neuropsychopharmacology

Volumn 24, Issue 5, 2001, Pages 511-521

  Turcotte, Julie E ^a   Debonnel, Guy ^a   De Montigny, Claude ^a   Hébert, Chantal ^a   Blier, Pierre ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Antidepressants; Clomipramine; Duloxetine; Platelets; Reuptake inhibition; Tyramine

Indexed keywords

CLOMIPRAMINE; DULOXETINE; NORADRENALIN; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; TYRAMINE;

ADULT; ARTICLE; BLOOD ANALYSIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; HUMAN; MALE; NORADRENALIN RELEASE; NORMAL HUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEROTONIN BLOOD LEVEL; SEROTONIN UPTAKE; SYSTOLIC BLOOD PRESSURE;

ADOLESCENT; ADRENERGIC UPTAKE INHIBITORS; ADULT; BLOOD PRESSURE; BRAIN; BRAIN CHEMISTRY; CLOMIPRAMINE; DEPRESSION; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MALE; NOREPINEPHRINE; REFERENCE VALUES; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; THIOPHENES; TYRAMINE;

EID: 0035079542     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(00)00220-7     Document Type: Article

References (37)

1. Serotonin in body fluids: Characterization of human plasmatic and cerebrospinal fluid pools by means of a new HPLC method
2. Blockade of 5-hydroxytryptamine and norepinephrine uptake by venlafaxine: Comparative study with paroxetine and desipramine
3. Venlafaxine: Discrepancy between in vivo serotonin and norepinephrine reuptake blockade and affinity for reuptake sites
4. An open-label study of duloxetine hydrochloride, a mixed serotonin and noradrenaline reuptake inhibitor, in patients with DSM-III-R major depressive disorder
5. Serotonin and drug-induced therapeutic responses in major depression, obsessive-compulsive and panic disorders
6. Peripheral alpha-adrenoreceptor and central dopamine receptor activity in depressive patients
7. Comparison of the effects of low and of high doses of venlafaxine on serotonin and norepinephrine reuptake processes in patients with major depression and healthy volunteers
8. Tryptophan-depletion challenge in depressed patients treated with desipramine or fluoxetine: Implications for the role of serotonin in the mechanism of antidepressant action
9. Indoleamine compartmentalization in human blood
10. Venlafaxine: Measuring the onset of antidepressant action
11. Simultaneous increases of extracellular monoamines in microdyalisates from hypothalamus of conscious rats by duloxetine, a dual serotonin and norepinephrine uptake inhibitor
12. Biochemical changes during clomipramine treatment of childhood obsessive-compulsive disorder
13. Does receptor supersensitivity accompany depressive illness?
14. Effects of duloxetine, an antidepressant drug candidate, on concentrations of monoamines and their metabolites in rats and mice
15. Tyramine pressor test: Implications and limitations
16. Studies of the interactions of desmethylimipramine with tyramine in man after a single oral dose and its correlation with the plasma concentrations
17. Intravenous tyramine pressor response in depression
18. Catecholamines and sympathomimetic drugs
19. Simultaneous monitoring of inhibition of serotonin uptake by platelets and plasma drug concentrations following administration of duloxetine, a new antidepressant candidate, to healthy volunteers
20. High placebo response rate versus clinical impression with the new antidepressant duloxetine
21. Blockade of the serotonin and norepinephrine uptake processes by duloxetine: In vitro and in vivo studies in the rat brain
22. Effects of duloxetine, a new serotonin and norepinephrine uptake inhibitor, on extracellular monoamine levels in rat frontal cortex
23. Reduced levels of norepinephrine transporters in the locus coeruleus in major depression
24. Antidepressant biochemical profile of the novel bicyclic compound WY-45,030, an ethyl cyclohexanol derivative
25. A preliminary open study of the combination of fluoxetine and desipramine for rapid treatment of depression
26. Synergistic effects of serotoninergic and noradrenergic antidepressants
27. Venlafaxine for treatment-resistant unipolar depression
28. Metabolism, transfer and storage of 5-hydroxytryptamine in blood platelets
29. Venlafaxine and paroxetine in treatment-resistant depression. Double-blind, randomized comparison
30. Influence of adrenoceptor and muscarinic blockade on the cardiovascular effects of exogenous noradrenaline and of endogenous noradrenaline released by infused tyramine
31. Combination treatment with noradrenaline and serotonin reuptake inhibitors in resistant depression
32. Pharmacokinetics and safety of duloxetine, a dual-serotonin and norepinephrine reuptake inhibitor
33. Duloxetine (LY 248686): An inhibitor of serotonin and noradrenaline uptake and an antidepressant drug candidate
34. LY248686, a new inhibitor of serotonin and norepinephrine uptake
35. 2-Phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives: Synthesis and antidepressant activity
36. Serotonin (5-hydroxytryptamine): Haematologic aspects