Uptake of predictive testing among relatives of BRCA1 and BRCA2 families: A multicenter study in northeastern Spain

Familial Cancer

Volumn 9, Issue 3, 2010, Pages 297-304

  Sanz, Judit ^a,b   Ramón Y Cajal, Teresa ^a   Torres, Asunción ^b   Darder, Esther ^c,d   Gadea, Neus ^e   Velasco, Angela ^c,d   Fortuny, Daniel ^e   López, Consol ^a   Fisas, David ^a   Brunet, Joan ^c,d   Alonso, M Carmen ^a   Balmaña, Judith ^e  

^a HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^b HOSPITAL UNIVERSITARI SANT JOAN DE REUS   (Spain)

^c HOSPITAL JOSEP TRUETA   (Spain)

^d GIRONA BIOMEDICAL RESEARCH INSTITUTE IDIBGI   (Spain)

^e HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

BRCA1; BRCA2; Factors; Predictive testing; Relatives; Uptake

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER DIAGNOSIS; CANCER RISK; CLINICAL TRIAL; COHORT ANALYSIS; CONTROLLED STUDY; DEMOGRAPHY; EDUCATIONAL STATUS; FAMILIAL CANCER; FAMILY; FEMALE; GENE MUTATION; GENETIC SCREENING; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OVARY CANCER; PRIORITY JOURNAL; PROGENY; PROSTATE CANCER; PROTEIN TRANSPORT; RELATIVE; RETROSPECTIVE STUDY; RISK FACTOR; SPAIN; UNIVERSITY HOSPITAL;

ADULT; BREAST NEOPLASMS; BREAST NEOPLASMS, MALE; FEMALE; GENES, BRCA1; GENES, BRCA2; GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; HUMANS; MALE; MIDDLE AGED; MUTATION; OVARIAN NEOPLASMS; PEDIGREE; RETROSPECTIVE STUDIES; SOCIOECONOMIC FACTORS; SPAIN;

EID: 78650201374     PISSN: 13899600     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10689-009-9313-1     Document Type: Article

References (26)

1. Milne RL, Osorio A, Ramon y Cajal T et al (2008) The average cumulative risks of breast and ovarian cancer for carriers of mutations in BRCA1 and BRCA2 attending genetic counselling units in Spain. Clin Cancer Res 14:2861-2869
2. Lerman C, Daly M, Masny A, Balshem A (1994) Attitudes about genetic testing for breast-ovarian cancer susceptibility. J Clin Oncol 12:843-850
3. Lerman C, Seay J, Balshem A, Audrain J (1995) Interest in genetic testing among first-degree relatives of breast cancer patients. Am J Med Genet 57:385-392
4. Blandy C, Chabal F, Stoppa-Lyonnet D, Julian-Reynier C (2003) Testing participation in BRCA1/2-positive families: initiator role of index cases. Genet Test 7:225-233
5. Bradbury AR, Dignam JJ, Ibe CN et al (2007) How often do BRCA mutation carriers tell their young children of the family's risk for cancer? A study of parental disclosure of BRCA mutations to minors and young adults. J Clin Oncol 25:3705-3711
6. Finlay E, Stopfer JE, Burlingame E et al (2008) Factors determining dissemination of results and uptake of genetic testing in families with known BRCA1/2 mutations. Genet Test 12:81-91
7. Lerman C, Hughes C, Lemon SJ et al (1998) What you don't know can hurt you: adverse psychologic effects in members of BRCA1-linked and BRCA2-linked families who decline genetic testing. J Clin Oncol 16:1650-1654
8. Landsbergen K, Verhaak C, Kraaimaat F, Hoogerbrugge N (2005) Genetic uptake in BRCA-mutation families is related to emotional and behavioral communication characteristics of index patients. Fam Cancer 4:115-119
9. Patenaude AF, Dorval M, DiGianni LS, Schneider KA, Chittenden A, Garber JE (2006) Sharing BRCA1/2 test results with firstdegree relatives: factors predicting who women tell. J Clin Oncol 24:700-706
10. Holloway SM, Bernhard B, Campbell H, Lam WW (2008) Uptake of testing for BRCA1//2 mutations in South East Scotland. Eur Jour Hum Genet 16:906-912
11. Julian-Reynier C, Sobol H, Sévilla C, Noguès C, Bourret P (2000) The French cancer genetic network: uptake of hereditary breast/ovarian cancer genetic testing in a French national sample of BRCA1 families. Psychooncology 9:504-510
12. Lerman C, Narod S, Schulman K et al (1996) BRCA1 testing in families with hereditary breast-ovarian cancer. A prospective study of patient decision making and outcomes. JAMA 275:1885-1892
13. OncoGuia del consell i assessorament genètics en càncer hereditaris. Versió completa. Agència d'Avaluació de Tecnologia i Recerca Mèdiques. Cat Salut. Departament de Salut. Generalitat de Catalunya; Barcelona. Catalunya (Espanya). OG012006. http://www.gencat.net/salut/depsan/units/aatrm/html/en/dir398/index.html (English version) 2006
14. Hagoel L, Dishon S, Almog R, Silman Z, Bisland-Becktell S, Rennert G (2000) Proband family uptake of familial-genetic counselling. Psychooncology 9:522-527
15. Bodd TL, Reichelt J, Heimdal K, Moller P (2003) Uptake of BRCA1 genetic testing in adult sisters and daughters of known mutation carriers in Norway. J Genet Couns 12:405-417
16. Armstrong K, Calzone K, Stopfer J, Fitzgerald G, Coyne J, Weber B (2000) Factors associated with decisions about clinical BRCA1/2 testing. Cancer Epidemiol Biomarkers Prev 9:1251-1254
17. Meijers-Heijboer EJ, Verhoog LC, Brekelmans CT et al (2000) Presymptomatic DNA testing and prophylactic surgery in families with a BRCA1 or BRCA2 mutation. Lancet 355:2015-2020
18. Struewing JP, Lerman C, Kase RG, Giambarresi TR, Tucker MA (1995) Anticipated uptake and impact of genetic testing in hereditary breast and ovarian cancer families. Cancer Epidemiol Biomarkers Prev 4:169-173
19. Godard B, Pratte A, Dumont M, Simard-Lebrun A, Simard J (2007) Factors associated with an individual's decision to withdraw from genetic testing for breast and ovarian cancer susceptibility: implications for counseling. Genet Test 11:45-54
20. Kriege M, Brekelmans CTM, Boetes C et al (2004) Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition. N Engl J Med 351:427-437
21. Foster C, Evans DG, Eeles R et al (2002) Predictive testing for BRCA1/2: attributes, risk perception and management in a multicentre clinical cohort. Br J Cancer 86:1209-1216
22. Geller G, Doksum T, Bernhardt BA, Metz SA (1999) Participation in breast cancer susceptibility testing protocols: influence of recruitment source, altruism, and family involvement on women's decisions. Cancer Epidemiol Biomarkers Prev 8:377-383
23. Lodder LN, Frets PG, Trijsburg RW et al (1999) Presymptomatic testing for BRCA1 and BRCA2: how distressing are the pre-test weeks? Rotterdam/Leiden Genetics Working Group. J Med Genet 36:906-913
24. Molster C, Charles T, Samanek A, O'Leary P (2009) Australian study on public knowledge of human genetics and health. Public Health Genomics 12:84-91
25. Henneman L, Timmermans DR, van der Wal G (2004) Public experiences, knowledge and expectations about medical genetics and the use of genetic information. Community Genet 7:33-43
26. Morren M, Rijken M, Baanders AN, Bensing J (2007) Perceived genetic knowledge, attitudes towards genetic testing, and the relationship between these among patients with a chronic disease. Patient Educ Couns 65:197-204