High factor XI, recurrent pregnancy loss, enoxaparin

Fertility and Sterility

Volumn 94, Issue 7, 2010, Pages 2828-2831

  Glueck, Charles J ^a   Pranikoff, Joel ^a   Khan, Naseer ^a   Riaz, Kashif ^a   Chavan, Kirti ^a   Raj, Pavithra ^a   Umar, Muhammad ^a   Wang, Ping ^a  

^a JEWISH HOSPITAL   (United States)

Author keywords

enoxaparin; Factor XI; recurrent pregnancy loss; thrombophilia

Indexed keywords

BLOOD CLOTTING FACTOR 11; ENOXAPARIN;

ARTICLE; BIRTH RATE; BLOOD CLOTTING DISORDER; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HUMAN; LIVE BIRTH; PREGNANCY TERMINATION; PRIORITY JOURNAL; RECURRENT ABORTION; SPONTANEOUS ABORTION; TERM BIRTH;

ABORTION, HABITUAL; ANTICOAGULANTS; COHORT STUDIES; EMBRYO LOSS; ENOXAPARIN; FACTOR XI; FEMALE; HOMOZYGOTE; HUMANS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MUTATION, MISSENSE; PREGNANCY; PREGNANCY COMPLICATIONS, HEMATOLOGIC; PREGNANCY RATE; UP-REGULATION;

EID: 78650197891     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2009.12.084     Document Type: Article

References (70)

1. B. Brenner, and M.J. Kupferminc Inherited thrombophilia and poor pregnancy outcome Best Pract Res Clin Obstet Gynaecol 17 2003 427 439
2. M.J. Kupferminc Thrombophilia and pregnancy Reprod Biol Endocrinol 1 2003 111 133
3. M.J. Kupferminc, H. Peri, E. Zwang, Y. Yaron, I. Wolman, and A. Eldor High prevalence of the prothrombin gene mutation in women with intrauterine growth retardation, abruptio placentae and second trimester loss Acta Obstet Gynecol Scand 79 2000 963 967
4. M.J. Kupferminc, and A. Eldor Inherited thrombophilia and gestational vascular complications Semin Thromb Hemost 29 2003 185 194
5. M.J. Kupferminc, A. Eldor, N. Steinman, A. Many, A. Bar-Am, and A. Jaffa Increased frequency of genetic thrombophilia in women with complications of pregnancy N Engl J Med 340 1999 9 13
6. M.J. Kupferminc, A. Many, A. Bar-Am, J.B. Lessing, and J. Ascher-Landsberg Mid-trimester severe intrauterine growth restriction is associated with a high prevalence of thrombophilia Br J Obstet Gynaecol 109 2002 1373 1376
7. C.J. Glueck, M.J. Kupferminc, R.N. Fontaine, P. Wang, B.B. Weksler, and A. Eldor Genetic hypofibrinolysis in complicated pregnancies Obstet Gynecol 97 2001 44 48
8. A. Eldor Thrombophilia and its treatment in pregnancy J Thromb Thrombolysis 12 2001 23 30
9. C.J. Glueck, S. Gogenini, J. Munjal, T. Tracy, J. Pranikoff, and P. Wang Factor V Leiden mutation: a treatable etiology for sporadic and recurrent pregnancy loss Fertil Steril 89 2008 410 416
10. E. Rey, S.R. Kahn, M. David, and I. Shrier Thrombophilic disorders and fetal loss: a meta-analysis Lancet 361 2003 901 908
11. C.J. Glueck, P. Wang, S. Bornovali, N. Goldenberg, and L. Sieve Polycystic ovary syndrome, the G1691A factor V Leiden mutation, and plasminogen activator inhibitor activity: associations with recurrent pregnancy loss Metabolism 52 2003 1627 1632
12. P.M. Ridker, J.P. Miletich, J.E. Buring, A.A. Ariyo, D.T. Price, and J.E. Manson Factor V Leiden mutation as a risk factor for recurrent pregnancy loss Ann Intern Med 128 1998 1000 1003
13. C.S. Goodman, C.B. Coulam, R.S. Jeyendran, V.A. Acosta, and R. Roussev Which thrombophilic gene mutations are risk factors for recurrent pregnancy loss? Am J Reprod Immunol 56 2006 230 236
14. S. Sehirali, M.M. Inal, Y. Yildirim, Z. Balim, B. Kosova, and T. Karamizrak Prothrombin G20210A mutation in cases with recurrent miscarriage: a study of the Mediterranean population Arch Gynecol Obstet 273 2005 170 173
15. H. Cardona, W. Cardona-Maya, J.G. Gomez, S. Castaneda, J.M. Gomez, and G. Bedoya [Relationship between methylenetetrahydrofolate reductase polymorphism and homocysteine levels in women with recurrent pregnancy loss: a nutrigenetic perspective] Nutr Hosp 23 2008 277 282
16. I. Subrt, Z. Ulcova-Gallova, K. Bibkova, Z. Micanova, M. Hejnalova, and M. Cerna Recurrent pregnancy loss and frequency of eight antiphospholipid antibodies and genetic thrombophilic factors in Czech women Am J Reprod Immunol 59 2008 193 200
17. G. Mitic, M. Kovac, L. Povazan, Z. Magic, V. Djordjevic, and I. Salatic Inherited thrombophilia is associated with pregnancy losses that occur after 12th gestational week in Serbian population Clin Appl Thromb Hemost 2009 [Epub ahead of print.]
18. C.J. Glueck, L. Sieve, B. Zhu, and P. Wang Plasminogen activator inhibitor activity, 4G5G polymorphism of the plasminogen activator inhibitor 1 gene, and first-trimester miscarriage in women with polycystic ovary syndrome Metabolism 55 2006 345 352
19. A. Dossenbach-Glaninger, M. van Trotsenburg, M. Dossenbach, C. Oberkanins, A. Moritz, and W. Krugluger Plasminogen activator inhibitor 1 4G/5G polymorphism and coagulation factor XIII Val34Leu polymorphism: impaired fibrinolysis and early pregnancy loss Clin Chem 49 2003 1081 1086
20. T. Buchholz, P. Lohse, N. Rogenhofer, E. Kosian, R. Pihusch, and C.J. Thaler Polymorphisms in the ACE and PAI-1 genes are associated with recurrent spontaneous miscarriages Hum Reprod 18 2003 2473 2477
21. C.J. Glueck, H. Phillips, D. Cameron, P. Wang, R.N. Fontaine, and S.K. Moore The 4G/4G polymorphism of the hypofibrinolytic plasminogen activator inhibitor type 1 gene: an independent risk factor for serious pregnancy complications Metabolism 49 2000 845 852
22. B. Brenner, R. Hoffman, Z. Blumenfeld, Z. Weiner, and J.S. Younis Gestational outcome in thrombophilic women with recurrent pregnancy loss treated by enoxaparin Thromb Haemost 83 2000 693 697
23. R.L. Bick Recurrent miscarriage syndrome due to blood coagulation protein/platelet defects: prevalence, treatment and outcome results. DRW Metroplex Recurrent Miscarriage Syndrome Cooperative Group Clin Appl Thromb Hemost 6 2000 115 125
24. A. Many, R. Elad, Y. Yaron, A. Eldor, J.B. Lessing, and M.J. Kupferminc Third-trimester unexplained intrauterine fetal death is associated with inherited thrombophilia Obstet Gynecol 99 2002 684 687
25. A. Many, L. Schreiber, S. Rosner, J.B. Lessing, A. Eldor, and M.J. Kupferminc Pathologic features of the placenta in women with severe pregnancy complications and thrombophilia Obstet Gynecol 98 2001 1041 1044
26. G. Lavigne, E. Mercier, I. Quere, M. Dauzat, and J.C. Gris Thrombophilic families with inheritably associated high levels of coagulation factors VIII, IX and XI J Thromb Haemost 1 2003 2134 2139
27. C.J. Glueck, W. Ping, R. Hutchins, M.R. Petersen, and K. Golnik Ocular vascular thrombotic events: central retinal vein and central retinal artery occlusions Clin Appl Thromb Hemost 14 2008 286 294
28. Y. Li, I. Bezemer, C.M. Rowland, C.H. Tong, A.R. Arellano, and J.J. Catanese Genetic variants associated with deep vein thrombosis: the F11 locus J Thromb Haemost 7 2009 1802 1808
29. J.C. Meijers, W.L. Tekelenburg, B.N. Bouma, R.M. Bertina, and F.R. Rosendaal High levels of coagulation factor XI as a risk factor for venous thrombosis N Engl J Med 342 2000 696 701
30. I.D. Bezemer, L.A. Bare, C.J. Doggen, A.R. Arellano, C. Tong, and C.M. Rowland Gene variants associated with deep vein thrombosis J Am Med Assoc 299 2008 1306 1314
31. P. Angchaisuksiri, V. Atichartakarn, K. Aryurachai, N. Archararit, B. Rachakom, and K. Atamasirikul Risk factors of venous thromboembolism in Thai patients Int J Hematol 86 2007 397 402
32. A. Siegemund, S. Petros, T. Siegemund, U. Scholz, H.J. Seyfarth, and L. Engelmann The endogenous thrombin potential and high levels of coagulation factor VIII, factor IX and factor XI Blood Coagul Fibrinolysis 15 2004 241 244
33. H. Carp, M. Dolitzky, and A. Inbal Thromboprophylaxis improves the live birth rate in women with consecutive recurrent miscarriages and hereditary thrombophilia J Thromb Haemost 1 2003 433 438
34. M.J. Kupferminc, G. Fait, A. Many, J.B. Lessing, D. Yair, and A. Bar-Am Low-molecular-weight heparin for the prevention of obstetric complications in women with thrombophilias Hypertens Pregnancy 20 2001 35 44
35. J.C. Gris, E. Mercier, I. Quere, G. Lavigne-Lissalde, E. Cochery-Nouvellon, and M. Hoffet Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder Blood 103 2004 3695 3699
36. G. Sarig, Z. Blumenfeld, R. Leiba, N. Lanir, and B. Brenner Modulation of systemic hemostatic parameters by enoxaparin during gestation in women with thrombophilia and pregnancy loss Thromb Haemost 94 2005 980 985
37. J. Bar, B. Cohen-Sacher, M. Hod, D. Blickstein, J. Lahav, and P. Merlob Low-molecular-weight heparin for thrombophilia in pregnant women Int J Gynaecol Obstet 69 2000 209 213
38. B. Brenner, J. Bar, M. Ellis, I. Yarom, D. Yohai, and A. Samueloff Effects of enoxaparin on late pregnancy complications and neonatal outcome in women with recurrent pregnancy loss and thrombophilia: results from the Live-Enox study Fertil Steril 84 2005 770 773
39. S. De Carolis, S. Ferrazzani, V. De Stefano, S. Garofalo, G. Fatigante, and E. Rossi Inherited thrombophilia: treatment during pregnancy Fetal Diagn Ther 21 2006 281 286
40. R.M. Lee, and R.M. Silver Recurrent pregnancy loss: summary and clinical recommendations Semin Reprod Med 18 2000 433 440
41. S. Uehara, M. Hashiyada, K. Sato, Y. Sato, K. Fujimori, and K. Okamura Preferential X-chromosome inactivation in women with idiopathic recurrent pregnancy loss Fertil Steril 76 2001 908 914
42. R.M. Lee, D.W. Branch, and R.M. Silver Immunoglobulin A anti-beta2-glycoprotein antibodies in women who experience unexplained recurrent spontaneous abortion and unexplained fetal death Am J Obstet Gynecol 185 2001 748 753
43. S.J. Babbage, P.D. Arkwright, G.S. Vince, C. Perrey, V. Pravica, and S. Quenby Cytokine promoter gene polymorphisms and idiopathic recurrent pregnancy loss J Reprod Immunol 51 2001 21 27
44. C.J. Glueck, R.A. Freiberg, R.N. Fontaine, T. Tracy, and P. Wang Hypofibrinolysis, thrombophilia, osteonecrosis Clin Orthop 2001 19 33
45. V.V. Balasa, R.A. Gruppo, C.J. Glueck, D. Stroop, A. Becker, and A. Pillow The relationship of mutations in the MTHFR, prothrombin, and PAI-1 genes to plasma levels of homocysteine, prothrombin, and PAI-1 in children and adults Thromb Haemost 81 1999 739 744
46. C.J. Glueck, P. Wang, R.N. Fontaine, L. Sieve-Smith, T. Tracy, and S.K. Moore Plasminogen activator inhibitor activity: an independent risk factor for the high miscarriage rate during pregnancy in women with polycystic ovary syndrome Metabolism 48 1999 1589 1595
47. D.M. Adcock, R. Jensen, C.S. Johns, and P.A. Macy Coagulation handbook 2002 Esoterix Corporation Austin, Texas
48. C.J. Glueck, P. Wang, N. Goldenberg, and L. Sieve Pregnancy loss, polycystic ovary syndrome, thrombophilia, hypofibrinolysis, enoxaparin, metformin Clin Appl Thromb Hemost 10 2004 323 334
49. Z. Blumenfeld, and B. Brenner Thrombophilia-associated pregnancy wastage Fertil Steril 72 1999 765 774
50. P.D. Ivanov, R.S. Komsa-Penkova, E.I. Konova, K.S. Kovacheva, M.N. Simeonova, and J.D. Popov Association of inherited thrombophilia with embryonic and postembryonic recurrent pregnancy loss Blood Coagul Fibrinolysis 20 2009 134 140
51. R. Rai, A. Shlebak, H. Cohen, M. Backos, Z. Holmes, and K. Marriott Factor V Leiden and acquired activated protein C resistance among 1000 women with recurrent miscarriage Hum Reprod 16 2001 961 965
52. C.A. Laskin, K.A. Spitzer, C.A. Clark, M.R. Crowther, J.S. Ginsberg, and G.A. Hawker Low molecular weight heparin and aspirin for recurrent pregnancy loss: results from the randomized, controlled HepASA Trial J Rheumatol 36 2009 279 287
53. D. Dizon-Townson, C. Miller, B. Sibai, C.Y. Spong, E. Thom, and G. Wendel Jr. The relationship of the factor V Leiden mutation and pregnancy outcomes for mother and fetus Obstet Gynecol 106 2005 517 524
54. J.S. Younis, B. Brenner, G. Ohel, J. Tal, N. Lanir, and M. Ben-Ami Activated protein C resistance and factor V Leiden mutation can be associated with first-as well as second-trimester recurrent pregnancy loss Am J Reprod Immunol 43 2000 31 35
55. W.H. Kutteh Antiphospholipid antibody-associated recurrent pregnancy loss: treatment with heparin and low-dose aspirin is superior to low-dose aspirin alone Am J Obstet Gynecol 174 1996 1584 1589
56. R. Rai, H. Cohen, M. Dave, and L. Regan Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies) Br Med J 314 1997 253 257
57. J.C. Gris, J.P. Balducchi, I. Quere, M. Hoffet, and P. Mares Enoxaparin sodium improves pregnancy outcome in aspirin-resistant antiphospholipid/ antiprotein antibody syndromes Thromb Haemost 87 2002 536 537
58. J.C. Gris, and P. Mares The long and winding road...towards LMWH for pregnancy loss J Thromb Haemost 3 2005 224 226
59. L.M. Huxtable, M.J. Tafreshi, and S.M. Ondreyco A protocol for the use of enoxaparin during pregnancy: results from 85 pregnancies including 13 multiple gestation pregnancies Clin Appl Thromb Hemost 11 2005 171 181
60. E. Grandone, V. De Stefano, E. Rossi, F. Cappucci, D. Colaizzo, and M. Margaglione Antithrombotic prophylaxis during pregnancy in women with deficiency of natural anticoagulants Blood Coagul Fibrinolysis 19 2008 226 230
61. G. Ramidi, N. Khan, C.J. Glueck, P. Wang, and N. Goldenberg Enoxaparin-metformin and enoxaparin alone may safely reduce pregnancy loss Transl Res 153 2009 33 43
62. E. Lindhoff-Last, H.J. Kreutzenbeck, and H.N. Magnani Treatment of 51 pregnancies with danaparoid because of heparin intolerance Thromb Haemost 93 2005 63 69
63. H. Qublan, Z. Amarin, M. Dabbas, A.E. Farraj, Z. Beni-Merei, and H. Al-Akash Low-molecular-weight heparin in the treatment of recurrent IVF-ET failure and thrombophilia: a prospective randomized placebo-controlled trial Hum Fertil (Camb) 11 2008 246 253
64. S. Kaandorp, M. Di Nisio, M. Goddijn, and S. Middeldorp Aspirin or anticoagulants for treating recurrent miscarriage in women without antiphospholipid syndrome Cochrane Database Syst Rev 2009 CD004734
65. A.B. Irish Plasminogen activator inhibitor-1 activity in chronic renal disease and dialysis Metabolism 46 1997 36 40
66. M. Empson, M. Lassere, J.C. Craig, and J.R. Scott Recurrent pregnancy loss with antiphospholipid antibody: a systematic review of therapeutic trials Obstet Gynecol 99 2002 135 144
67. J.S. Younis, G. Ohel, B. Brenner, S. Haddad, N. Lanir, and M. Ben-Ami The effect of thrombophylaxis on pregnancy outcome in patients with recurrent pregnancy loss associated with factor V Leiden mutation Br J Obstet Gynaecol 107 2000 415 419
68. M. Bazzan, and V. Donvito Low-molecular-weight heparin during pregnancy Thromb Res 101 2001 V175 V186
69. A.E. Sullivan, R.M. Silver, D.Y. LaCoursiere, T.F. Porter, and D.W. Branch Recurrent fetal aneuploidy and recurrent miscarriage Obstet Gynecol 104 2004 784 788
70. D.S. Dizon-Townson, L. Meline, L.M. Nelson, M. Varner, and K. Ward Fetal carriers of the factor V Leiden mutation are prone to miscarriage and placental infarction Am J Obstet Gynecol 177 1997 402 405