Sustained lung activity of a novel chimeric protein, SOD2/3, after intratracheal administration

Free Radical Biology and Medicine

Volumn 49, Issue 12, 2010, Pages 2032-2039

  Clarke, Margaret B ^a   Wright, Rachel ^a   Irwin, David ^b   Bose, Swapan ^b   Van Rheen, Zachary ^a   Birari, Rahul ^a   Stenmark, Kurt R ^a,b   McCord, Joe M ^b   Nozik Grayck, Eva ^a,b  

^a Children's Hospital Colorado   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Acute hypoxic pulmonary vasoconstriction; Free radicals; SOD2 3; Superoxide dismutase

Indexed keywords

CHIMERIC PROTEIN; CHIMERIC PROTEIN SUPEROXIDE DISMUTASE 2 3; EXTRACELLULAR SUPEROXIDE DISMUTASE; FREE RADICAL; MANGANESE SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CHIMERA; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG EFFECT; DRUG HALF LIFE; ENZYME ACTIVITY; HYPOXIA; IMMUNOHISTOCHEMISTRY; LUNG BLOOD VESSEL; LUNG CIRCULATION; LUNG HOMOGENATE; LUNG VASOCONSTRICTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SYSTEMIC CIRCULATION; TISSUE DISTRIBUTION; VASODILATATION; WESTERN BLOTTING;

ANIMALS; ANOXIA; BLOOD CIRCULATION; BLOOD PRESSURE; DRUG ADMINISTRATION ROUTES; EPITHELIAL CELLS; LUNG; MALE; RATS; RATS, INBRED WKY; RECOMBINANT FUSION PROTEINS; SUPEROXIDE DISMUTASE; TRACHEA; VASOCONSTRICTION;

RATTUS;

EID: 78650178773     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.09.028     Document Type: Article

References (34)

1. R.L. Auten, M.A. O'Reilly, T.D. Oury, E. Nozik-Grayck, and M.H. Whorton Transgenic extracellular superoxide dismutase protects postnatal alveolar epithelial proliferation and development during hyperoxia Am. J. Physiol. Lung Cell. Mol. Physiol. 290 2006 L32 L40
2. R.P. Bowler, M. Nicks, K. Tran, G. Tanner, L.Y. Chang, S.K. Young, and G.S. Worthen Extracellular superoxide dismutase attenuates lipopolysaccharide- induced neutrophilic inflammation Am. J. Respir. Cell Mol. Biol. 31 2004 432 439
3. C.L. Fattman, L.Y. Chang, T.A. Termin, L. Petersen, J.J. Enghild, and T.D. Oury Enhanced bleomycin-induced pulmonary damage in mice lacking extracellular superoxide dismutase Free Radic. Biol. Med. 35 2003 763 771
4. R.J. Folz, A.M. Abushamaa, and H.B. Suliman Extracellular superoxide dismutase in the airways of transgenic mice reduces inflammation and attenuates lung toxicity following hyperoxia J. Clin. Invest. 103 1999 1055 1066
5. Z.N. Rabbani, M.S. Anscher, R.J. Folz, E. Archer, H. Huang, L. Chen, M.L. Golson, T.S. Samulski, M.W. Dewhirst, and Z. Vujaskovic Overexpression of extracellular superoxide dismutase reduces acute radiation induced lung toxicity BMC Cancer 5 2005 59
6. E. Nozik-Grayck, H.B. Suliman, S. Majka, J. Albietz, Z. Van Rheen, K. Roush, and K.R. Stenmark Lung EC-SOD overexpression attenuates hypoxic induction of Egr-1 and chronic hypoxic pulmonary vascular remodeling Am. J. Physiol. Lung Cell. Mol. Physiol. 295 2008 L422 L430
7. J.M. McCord, and M.A. Edeas SOD, oxidative stress and human pathologies: a brief history and a future vision Biomed. Pharmacother. 59 2005 139 142
8. J. Litvan, A. Briva, M.S. Wilson, G.R. Budinger, J.I. Sznajder, and K.M. Ridge Beta-adrenergic receptor stimulation and adenoviral overexpression of superoxide dismutase prevent the hypoxia-mediated decrease in Na, K-ATPase and alveolar fluid reabsorption J. Biol. Chem. 281 2006 19892 19898
9. •-, TGF-β, and VEGF production by macrophages Free Radic. Res. 41 2007 8 14
10. R.P. Jankov, A. Negus, and A.K. Tanswell Antioxidants as therapy in the newborn: some words of caution Pediatr. Res. 50 2001 681 687
11. F. Kamezaki, H. Tasaki, K. Yamashita, M. Tsutsui, S. Koide, S. Nakata, A. Tanimoto, M. Okazaki, Y. Sasaguri, T. Adachi, and Y. Otsuji Gene transfer of extracellular superoxide dismutase ameliorates pulmonary hypertension in rats Am. J. Respir. Crit. Care Med. 177 2008 219 226
12. B. Gao, S.C. Flores, J.A. Leff, S.K. Bose, and J.M. McCord Synthesis and anti-inflammatory activity of a chimeric recombinant superoxide dismutase: SOD2/3 Am. J. Physiol. Lung Cell. Mol. Physiol. 284 2003 L917 L925
13. H. Harada, I.N. Hines, S. Flores, B. Gao, J. McCord, H. Scheerens, and M.B. Grisham Role of NADPH oxidase-derived superoxide in reduced size liver ischemia and reperfusion injury Arch. Biochem. Biophys. 423 2004 103 108
14. E.S. Ng, D. Jourd'heuil, J.M. McCord, D. Hernandez, M. Yasui, D. Knight, and P. Kubes Enhanced S-nitroso-albumin formation from inhaled NO during ischemia/reperfusion Circ. Res. 94 2004 559 565
15. S.K. Nelson, B. Gao, S. Bose, M. Rizeq, and J.M. McCord A novel heparin-binding, human chimeric, superoxide dismutase improves myocardial preservation and protects from ischemia-reperfusion injury J. Heart Lung Transplant. 21 2002 1296 1303
16. W.H. Cerwinka, D. Cooper, C.F. Krieglstein, C.R. Ross, J.M. McCord, and D.N. Granger Superoxide mediates endotoxin-induced platelet-endothelial cell adhesion in intestinal venules Am. J. Physiol. Heart Circ. Physiol. 284 2003 H535 H541
17. S.K. Nelson, S. Bose, M. Rizeq, and J.M. McCord Oxidative stress in organ preservation: a multifaceted approach to cardioplegia Biomed. Pharmacother. 59 2005 149 157
18. D. Hernandez-Saavedra, H. Zhou, and J.M. McCord Anti-inflammatory properties of a chimeric recombinant superoxide dismutase: SOD2/3 Biomed. Pharmacother. 59 2005 204 208
19. J.M. McCord Analysis of superoxide dismutase activity. See Basic Protocol 2 J.S. Bus, Current Protocols in Toxicology 1999 Wiley New York 7.3.1 7.3.9
20. D.C. Irwin, B. Foreman, K. Morris, M. White, T. Sullivan, R. Jacobs, E. Monnet, T. Hackett, M.C. TissotvanPatot, K.L. Hamilton, and R.W. Gotshall Polymerized bovine hemoglobin decreases oxygen delivery during normoxia and acute hypoxia in the rat Am. J. Physiol. Heart Circ. Physiol. 295 2008 H1090 H1099
21. O. Uzun, O. Balbay, N.U. Comunoglu, O. Yavuz, A. Nihat Annakkaya, S. Guler, C. Silan, M. Erbas, and P. Arbak Hypobaric-hypoxia-induced pulmonary damage in rats ameliorated by antioxidant erdosteine Acta Histochem. 108 2006 59 68
22. F. Zhang, P.A. Woodmansey, and A.H. Morice Acute hypoxic vasoconstriction in isolated rat small and large pulmonary arteries Physiol. Res. 44 1995 7 18
23. N. Weissmann, S. Winterhalder, M. Nollen, R. Voswinckel, K. Quanz, H.A. Ghofrani, R.T. Schermuly, W. Seeger, and F. Grimminger NO and reactive oxygen species are involved in biphasic hypoxic vasoconstriction of isolated rabbit lungs Am. J. Physiol. Lung Cell. Mol. Physiol. 280 2001 L638 L645
24. V.V. Shuvaev, M. Christofidou-Solomidou, F. Bhora, K. Laude, H. Cai, S. Dikalov, E. Arguiri, C.C. Solomides, S.M. Albelda, D.G. Harrison, and V.R. Muzykantov Targeted detoxification of selected reactive oxygen species in the vascular endothelium J. Pharmacol. Exp. Ther. 331 2009 404 411
25. M.K. Reddy, and V. Labhasetwar Nanoparticle-mediated delivery of superoxide dismutase to the brain: an effective strategy to reduce ischemia-reperfusion injury FASEB J. 23 2009 1384 1395
26. K. Karlsson, J. Sandstrom, A. Edlund, T. Edlund, and S.L. Marklund Pharmacokinetics of extracellular-superoxide dismutase in the vascular system Free Radic. Biol. Med. 14 1993 185 190
27. K. Juul, A. Tybjaerg-Hansen, S. Marklund, P. Lange, and B.G. Nordestgaard Genetically increased antioxidative protection and decreased chronic obstructive pulmonary disease Am. J. Respir. Crit. Care Med. 173 2006 858 864
28. S.L. Archer, D. Peterson, D.P. Nelson, E.G. DeMaster, B. Kelly, J.W. Eaton, and E.K. Weir Oxygen radicals and antioxidant enzymes alter pulmonary vascular reactivity in the rat lung J. Appl. Physiol. 66 1989 102 111
29. Liochev, S. I.; Fridovich, I. Mechanism of the peroxidase activity of Cu,Zn superoxide dismutase. Free Radic. Biol. Med. 48:1565-1569; 2007.
30. K. Yamaguchi, K. Asano, T. Takasugi, M. Mori, H. Fujita, Y. Oyamada, K. Suzuki, A. Miyata, T. Aoki, and Y. Suzuki Modulation of hypoxic pulmonary vasoconstriction by antioxidant enzymes in red blood cells Am. J. Respir. Crit. Care Med. 153 1996 211 217
31. R.H. Steinhorn, G. Albert, D.D. Swartz, J.A. Russell, C.R. Levine, and J.M. Davis Recombinant human superoxide dismutase enhances the effect of inhaled nitric oxide in persistent pulmonary hypertension Am. J. Respir. Crit. Care Med. 164 2001 834 839
32. J.P. Kinsella, T.A. Parker, J.M. Davis, and S.H. Abman Superoxide dismutase improves gas exchange and pulmonary hemodynamics in premature lambs Am. J. Respir. Crit. Care Med. 172 2005 745 749
33. 2 formation Free Radic. Biol. Med. 42 2007 1465 1469
34. T.M. Burke, and M.S. Wolin Hydrogen peroxide elicits pulmonary arterial relaxation and guanylate cyclase activation Am. J. Physiol. 252 1987 H721 H732