The hydroxyl functional group of N-(4-hydroxyphenyl)retinamide mediates cellular uptake and cytotoxicity in premalignant and malignant human epithelial cells

Free Radical Biology and Medicine

Volumn 49, Issue 12, 2010, Pages 2001-2009

  Hail Jr , Numsen ^a   Chen, Ping ^a   Wempe, Michael F ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

4HPR; Alkylphenol; Apoptosis; Cellular uptake; Dihydroorotate dehydrogenase; Fenretinide; Free radicals; N (4 hydroxyphenyl)retinamide; N (4 methoxyphenyl) retinamide; Reactive oxygen species

Indexed keywords

DIHYDROOROTATE DEHYDROGENASE; DRUG METABOLITE; FENRETINIDE; HYDROXYL GROUP; N (4 METHOXYPHENYL)RETINAMIDE; N (4 TRIFLUOROMETHYLPHENYL)RETINAMIDE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BIOENERGY; BREAST CARCINOMA; BREAST EPITHELIUM; CARCINOMA CELL; CELL MEMBRANE PERMEABILITY; CELL SIZE; CELL TRANSDIFFERENTIATION; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG PENETRATION; DRUG UPTAKE; EPITHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MITOCHONDRION; PRECANCER; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROSTATE EPITHELIUM; PROTEIN EXPRESSION; SKIN CARCINOMA; SKIN EPITHELIUM;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CELL SHAPE; CELL TRANSFORMATION, NEOPLASTIC; DNA FRAGMENTATION; ELECTRON TRANSPORT COMPLEX IV; EPITHELIAL CELLS; FENRETINIDE; HUMANS; HYDROXIDES; MITOCHONDRIA; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PERMEABILITY; REACTIVE OXYGEN SPECIES; TRETINOIN;

EID: 78650178712     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.09.032     Document Type: Article

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