Chemotherapeutic evaluation of 4-hydroxybenzylretinone (4-HBR), a nonhydrolyzable c-linked analog of n-(4-hydroxyphenyl) retinamide (4-HPR) against mammary carcinogenesis

Anticancer Research

Volumn 21, Issue 6 A, 2001, Pages 3839-3844

  Abou Issa, Hussein ^a   Curley Jr , Robert W ^a   Alshafie, Galal A ^a   Weiss, Kevin L ^a   Clagett Dame, Margaret ^a   Chapman, Jason S ^a   Mershon, Serena M ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Breast cancer; Cancer chemotherapy; Fenretinide; Mammary tumors; Retinoids

Indexed keywords

4 HYDROXYBENZYLRETINONE; DIMETHYLBENZ[A]ANTHRACENE; FENRETINIDE; RETINOIC ACID; RETINOIC ACID DERIVATIVE; RETINOIC ACID RECEPTOR; RETINOID X RECEPTOR; RETINOL; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOGENESIS; BREAST CARCINOMA; CONTROLLED STUDY; DRUG POTENCY; FEMALE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANTICARCINOGENIC AGENTS; ANTINEOPLASTIC AGENTS; CARCINOGENS; FEMALE; FENRETINIDE; MAMMARY NEOPLASMS, EXPERIMENTAL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, RETINOIC ACID; VITAMIN A;

EID: 0035569150     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. A decade of molecular biology of retinoic acid receptors
2. Retinoids and apoptosis; implications for chemoprevention and therapy
3. Cancer chemoprevention progress and promise
4. Retinoids and cancer in experimental animals
5. Anticarcinogenic effect of retinoids on 7,12-dimethylbenz(a)anthracene-induced mammary tumor induction, and its relationship to cyclic AMP-dependent protein kinase
6. In vivo use of N-(4-hydroxyphenyl)retinamide-O-glucuronide as a breast cancer chemopreventive agent
7. Prospects of chemoprevention of human cancers with the synthetic retinoid fenrehinide
8. N-(4-hydroxyphenyl)retinamide, a new retinoid for prevention of breast cancer in rats
9. Clinical development plan; N-(4-hydroxyphenyl)retinamide
10. Abnormal retinal function associated with fenretinide, a synthetic retinoid
11. Tolerability of the synthetic retinoid, fenretinide (HPR)
12. Five year administration of fenretinide, pharmakokinetics and effects on plasma retinol concentration
13. 4-Hydroxyphenylretinamide is a highly selective activator of retinoid receptors
14. Comparison of N-(4-hydroxyphenyl)retinamide and all-trans retinoic acid in the regulation of retinoid receptor-mediated gene expression in human breast cancer cell lines
15. N-(4-hydroxyphenyl) retinamide(4-HPR)-mediated biological actions involve retinoid receptor-independent pathways in human breast carcinoma
16. N-(4-hydroxyphenyl) retinamide induces apoptosis of malignant hemopoietic cell lines including those unresponsive to retinoic acid
17. Chemopreventive activity of a C-glucuronide analog of N-(4-hydroxyphenyl)retinamide-O-glucuronide against mammary tumor development and growth
18. N-(4-hydroxyphenyl)all-transretinamide pharmakokinetics in female rats and mice
19. Biotransformation and biological activity of N-(4-hydroxyphenyl)retinamide derivatives in rodents
20. An unhydrolyzable analog of N-(4-hydroxyphenyl)retinamide: Synthesis and preliminary biological studies
21. Reactivity umpolung methods
22. Potential photoaffinity labels for tubulin. Synthesis and evaluation of diazocyclohexadienone and azide analogs of colchicine, combretastatin, and 3,4,5-trimethoxybiphenyl
23. Chemopreventive activities of C-glucuronide/glycoside analog of retinoid-O-glucuronides against breast cancer development and growth
24. Chemotherapeutic evaluation of N-(4-hydroxyphenyl)retinamide-O-Glucuronide in the rat mammary tumor model
25. Methods for generating and characterizing retinoid receptors from E. Coli and insect cell expression systems
26. All-trans retinol is a ligand for the retinoic acid receptors
27. One step immunoaffinity purification of recombinant human retinoic acid receptor γ
28. Simultaneous determination of endogenous retinoic acid isomers and retinol in human plasma by isocratic normal-phase HPLC with ultraviolet detection
29. Determination of degree of energy restriction necessary to reduce DMBA-induced mammary tumorigenesis in rats during the promotion phase
30. Teratogenicity of N-(4-hydroxyphenyl)-all-trans-retinamide in rats and rabbits
31. Plasma retinol level reduction by the synthetic retinoid, fenretinide; a one year follow-up study of breast cancer patients
32. Alteration of retinolbinding protein concentrations by the synthetic retinoid, fenretinide in healthy human subjects
33. N-(4-hydroxyphenyl)retinamide (4-HPR) lowers plasma retinol levels in rats
34. Enzymatic hydrolysis of retinamides
35. 9 embryonal carcinoma cells