An effective synthesis of trifluoromethyl-substituted 1,4-dihydropyridines with phosphorus oxychloride / pyridine adsorbed on silica gel

Tetrahedron Letters

Volumn 37, Issue 24, 1996, Pages 4177-4178

  Katsuyama, Isamu ^a   Funabiki, Kazumasa ^a   Matsui, Masaki ^a   Muramatsu, Hiroshige ^a   Shibata, Katsuyoshi ^a  

^a GIFU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDROPYRIDINE DERIVATIVE; CHLORIDE; CROTONIC ACID DERIVATIVE; KETONE DERIVATIVE; PYRIDINE; PYRIDINE DERIVATIVE; SILICA GEL;

ARTICLE; DEHYDRATION; SYNTHESIS;

EID: 0029975542     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)00788-5     Document Type: Article

References (11)

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4. Kumadaki, I. Reviews on Heteroatom Chemistry 1993, 9, 181-204.
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6. a) McInally, T.; Tinker, A. C. J. Chem. Soc., Perkin Trans. 1 1988, 1837-1844.
7. b) Lee, L. F.; Stikes, G. L.; Molyneaux, J. M.; Sing, Y. L.; Chupp, J. P.; Woodard, S. S. J. Org. Chem., 1990, 55, 2872-2877.
8. Kim, D. H. J. Heterocycl. Chem. 1986, 23, 1523-1525.
9. Ketones 1 were prepared by using the method described in our previous paper. See Katsuyama, I.; Funabiki, K.; Matsui, M.; Muramatsu, H; Shibata, K. Chem. Lett. 1996, 179.
10. 2 (50 ml) was slowly added silica gel (Merck Art. 7734, 20 g) while being cooled. The mixture was stirred for 1 h at room temperature. After removal of the solvent, the residue was dried in a rotary evaporator over a period of several hours.
11. +, 5 %).