-
3
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
Llovet J.M., Ricci S., Mazzaferro V., et al. Sorafenib in advanced hepatocellular carcinoma. N. Engl. J. Med. 2008, 359:378-390.
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
-
4
-
-
57749189578
-
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial
-
Cheng A.L., Kang Y.K., Chen Z., et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol. 2009, 10:25-34.
-
(2009)
Lancet Oncol.
, vol.10
, pp. 25-34
-
-
Cheng, A.L.1
Kang, Y.K.2
Chen, Z.3
-
5
-
-
0036534375
-
Tumor microvessel density as a predictor of recurrence after resection of hepatocellular carcinoma: a prospective study
-
Poon R.T.P., Ng I.O., Lau C., et al. Tumor microvessel density as a predictor of recurrence after resection of hepatocellular carcinoma: a prospective study. J. Clin. Oncol. 2002, 20:1775-1785.
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 1775-1785
-
-
Poon, R.T.P.1
Ng, I.O.2
Lau, C.3
-
6
-
-
0036161144
-
The mechanisms of angiogenesis in hepatocellular carcinoma: angiogenic switch during tumor progression
-
Sugimachi K., Tanaka S., Terashi T., Taguchi K., Rikimaru T., Sugimachi K. The mechanisms of angiogenesis in hepatocellular carcinoma: angiogenic switch during tumor progression. Surgery 2002, 131:S135-S141.
-
(2002)
Surgery
, vol.131
-
-
Sugimachi, K.1
Tanaka, S.2
Terashi, T.3
Taguchi, K.4
Rikimaru, T.5
Sugimachi, K.6
-
7
-
-
53949085322
-
Sinusoidal tumor angiogenesis is a key component in hepatocellular carcinoma metastasis
-
Sugino T., Yamaguchi T., Hoshi N., et al. Sinusoidal tumor angiogenesis is a key component in hepatocellular carcinoma metastasis. Clin. Exp. Metastasis 2008, 25:835-841.
-
(2008)
Clin. Exp. Metastasis
, vol.25
, pp. 835-841
-
-
Sugino, T.1
Yamaguchi, T.2
Hoshi, N.3
-
8
-
-
0031778206
-
Clinical significance of microvessel density and vascular endothelial growth factor expression in hepatocellular carcinoma and surrounding liver: possible involvement of vascular endothelial growth factor in the angiogenesis of cirrhotic liver
-
El-Assal O.N., Yamanoi A., Soda Y., et al. Clinical significance of microvessel density and vascular endothelial growth factor expression in hepatocellular carcinoma and surrounding liver: possible involvement of vascular endothelial growth factor in the angiogenesis of cirrhotic liver. Hepatology 1998, 27:1554-1562.
-
(1998)
Hepatology
, vol.27
, pp. 1554-1562
-
-
El-Assal, O.N.1
Yamanoi, A.2
Soda, Y.3
-
9
-
-
0035190559
-
Microvessel density, vascular endothelial growth factor and its receptors Flt-1 and Flk-1/KDR in hepatocellular carcinoma
-
Ng I.O., Poon R.T., Lee J.M., Fan S.T., Ng M., Tso W.K. Microvessel density, vascular endothelial growth factor and its receptors Flt-1 and Flk-1/KDR in hepatocellular carcinoma. Am. J. Clin. Pathol. 2001, 116:838-845.
-
(2001)
Am. J. Clin. Pathol.
, vol.116
, pp. 838-845
-
-
Ng, I.O.1
Poon, R.T.2
Lee, J.M.3
Fan, S.T.4
Ng, M.5
Tso, W.K.6
-
10
-
-
0035164117
-
Dual mechanism of vascular endothelial growth factor upregulation by hypoxia in human hepatocellular carcinoma
-
von Marschall Z., Cramer T., Höcker M., Finkenzeller G., Wiedenmann B., Rosewicz S. Dual mechanism of vascular endothelial growth factor upregulation by hypoxia in human hepatocellular carcinoma. Gut 2001, 48:87-96.
-
(2001)
Gut
, vol.48
, pp. 87-96
-
-
von Marschall, Z.1
Cramer, T.2
Höcker, M.3
Finkenzeller, G.4
Wiedenmann, B.5
Rosewicz, S.6
-
11
-
-
13044283423
-
NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas
-
Yu Y., Xu F., Peng H., et al. NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas. Proc. Natl. Acad. Sci. USA 1999, 96:214-219.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 214-219
-
-
Yu, Y.1
Xu, F.2
Peng, H.3
-
12
-
-
33744829237
-
CCI-779 inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/Hif-1alpha/VEGF signaling
-
Wan X., Shen N., Mendoza A., Khanna C., Helman L.J. CCI-779 inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/Hif-1alpha/VEGF signaling. Neoplasia 2006, 8:394-401.
-
(2006)
Neoplasia
, vol.8
, pp. 394-401
-
-
Wan, X.1
Shen, N.2
Mendoza, A.3
Khanna, C.4
Helman, L.J.5
-
13
-
-
6044243632
-
Effect of rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancer
-
Stephan S., Datta K., Wang E., et al. Effect of rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancer. Clin. Cancer Res. 2004, 10:6993-7000.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 6993-7000
-
-
Stephan, S.1
Datta, K.2
Wang, E.3
-
14
-
-
0041920901
-
TSC2 regulates VEGF through mTOR-dependent and -independent pathways
-
Brugarolas J.B., Vazquez F., Reddy A., Sellers W.R., Kaelin W.G. TSC2 regulates VEGF through mTOR-dependent and -independent pathways. Cancer Cell 2003, 4:147-158.
-
(2003)
Cancer Cell
, vol.4
, pp. 147-158
-
-
Brugarolas, J.B.1
Vazquez, F.2
Reddy, A.3
Sellers, W.R.4
Kaelin, W.G.5
-
15
-
-
0036174289
-
Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor
-
Guba M., von Breitenbuch P., Steinbauer M., et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat. Med. 2002, 8:128-135.
-
(2002)
Nat. Med.
, vol.8
, pp. 128-135
-
-
Guba, M.1
von Breitenbuch, P.2
Steinbauer, M.3
-
16
-
-
11244297916
-
Dysregulation of the TSC-mTOR pathway in human disease
-
Inoki K., Corradetti M.N., Guan K.L. Dysregulation of the TSC-mTOR pathway in human disease. Nat. Genet. 2005, 37:19-24.
-
(2005)
Nat. Genet.
, vol.37
, pp. 19-24
-
-
Inoki, K.1
Corradetti, M.N.2
Guan, K.L.3
-
17
-
-
0038697607
-
ARHI is a Ras-related small G-protein with a novel N-terminal extension that inhibits growth of ovarian and breast cancers
-
Luo R.Z., Fang X., Marquez R., et al. ARHI is a Ras-related small G-protein with a novel N-terminal extension that inhibits growth of ovarian and breast cancers. Oncogene 2003, 22:2897-2909.
-
(2003)
Oncogene
, vol.22
, pp. 2897-2909
-
-
Luo, R.Z.1
Fang, X.2
Marquez, R.3
-
18
-
-
0037354548
-
Epigenetic regulation of ARHI in breast and ovarian cancer cells
-
Yu Y., Fujii S., Yuan J., et al. Epigenetic regulation of ARHI in breast and ovarian cancer cells. Ann. N. Y. Acad. Sci. 2003, 983:268-277.
-
(2003)
Ann. N. Y. Acad. Sci.
, vol.983
, pp. 268-277
-
-
Yu, Y.1
Fujii, S.2
Yuan, J.3
-
19
-
-
5144231704
-
Expression of the tumor suppressor gene ARHI in epithelial ovarian cancer is associated with increased expression of p21WAF1/CIP1 and prolonged progression-free survival
-
Rosen D.G., Wang L., Jain A.N., et al. Expression of the tumor suppressor gene ARHI in epithelial ovarian cancer is associated with increased expression of p21WAF1/CIP1 and prolonged progression-free survival. Clin. Cancer Res. 2004, 10:6559-6566.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 6559-6566
-
-
Rosen, D.G.1
Wang, L.2
Jain, A.N.3
-
20
-
-
12444310797
-
Loss of the expression of the tumor suppressor gene ARHI is associated with progression of breast cancer
-
Wang L., Hoque A., Luo R.Z., et al. Loss of the expression of the tumor suppressor gene ARHI is associated with progression of breast cancer. Clin. Cancer Res. 2003, 9:3660-3666.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 3660-3666
-
-
Wang, L.1
Hoque, A.2
Luo, R.Z.3
-
21
-
-
23044503446
-
A Ras homologue member I directly inhibits signal transducers and activators of transcription 3 translocation and activity in human breast and ovarian cancer cells
-
Nishimoto A., Yu Y., Lu Z., et al. A Ras homologue member I directly inhibits signal transducers and activators of transcription 3 translocation and activity in human breast and ovarian cancer cells. Cancer Res. 2005, 65:6701-6710.
-
(2005)
Cancer Res.
, vol.65
, pp. 6701-6710
-
-
Nishimoto, A.1
Yu, Y.2
Lu, Z.3
-
22
-
-
57449121645
-
The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells
-
Lu Z., Luo R.Z., Lu Y., et al. The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells. J. Clin. Invest. 2008, 118:3917-3929.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 3917-3929
-
-
Lu, Z.1
Luo, R.Z.2
Lu, Y.3
-
23
-
-
59849104816
-
ARHI, as a novel suppressor of cell growth and downregulated in human hepatocellular carcinoma, could contribute to hepatocarcinogenesis
-
Huang J., Lin Y., Li L., et al. ARHI, as a novel suppressor of cell growth and downregulated in human hepatocellular carcinoma, could contribute to hepatocarcinogenesis. Mol. Carcinog. 2009, 48:130-140.
-
(2009)
Mol. Carcinog.
, vol.48
, pp. 130-140
-
-
Huang, J.1
Lin, Y.2
Li, L.3
-
24
-
-
14044249581
-
Silencing of the maternally imprinted tumor suppressor ARHI contributes to follicular thyroid carcinogenesis
-
Weber F., Aldred M.A., Morrison C.D., et al. Silencing of the maternally imprinted tumor suppressor ARHI contributes to follicular thyroid carcinogenesis. J. Clin. Endocrinol. Metab. 2005, 90:1149-1155.
-
(2005)
J. Clin. Endocrinol. Metab.
, vol.90
, pp. 1149-1155
-
-
Weber, F.1
Aldred, M.A.2
Morrison, C.D.3
-
27
-
-
34547792388
-
Epigenetic gene silencing in cancer: the DNA hypermethylome
-
Esteller M. Epigenetic gene silencing in cancer: the DNA hypermethylome. Hum. Mol. Genet. 2007, 16:R50-R59.
-
(2007)
Hum. Mol. Genet.
, vol.16
-
-
Esteller, M.1
-
28
-
-
40849139208
-
Epigenetics in cancer
-
Esteller M. Epigenetics in cancer. N. Engl. J. Med. 2008, 358:1148-1159.
-
(2008)
N. Engl. J. Med.
, vol.358
, pp. 1148-1159
-
-
Esteller, M.1
-
29
-
-
0035211504
-
Angiogenesis-dependent diseases
-
Folkman J. Angiogenesis-dependent diseases. Semin. Oncol. 2001, 28:536-542.
-
(2001)
Semin. Oncol.
, vol.28
, pp. 536-542
-
-
Folkman, J.1
-
30
-
-
14644440555
-
Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
-
Hicklin D.J., Ellis L.M. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J. Clin. Oncol. 2005, 23:1011-1027.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 1011-1027
-
-
Hicklin, D.J.1
Ellis, L.M.2
-
31
-
-
4944234987
-
Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma
-
Poon R.T.P., Ho J.W., Tong C.S., Lau C., Ng I.O., Fan S.T. Prognostic significance of serum vascular endothelial growth factor and endostatin in patients with hepatocellular carcinoma. Br. J. Surg. 2004, 91:1354-1360.
-
(2004)
Br. J. Surg.
, vol.91
, pp. 1354-1360
-
-
Poon, R.T.P.1
Ho, J.W.2
Tong, C.S.3
Lau, C.4
Ng, I.O.5
Fan, S.T.6
-
32
-
-
33846212284
-
Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
-
Liu L., Cao Y., Chen C., et al. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res. 2006, 66:11851-11858.
-
(2006)
Cancer Res.
, vol.66
, pp. 11851-11858
-
-
Liu, L.1
Cao, Y.2
Chen, C.3
-
33
-
-
77952666762
-
Targeting angiogenesis with multitargeted tyrosine kinase inhibitors in the treatment of non-small cell lung cancer
-
Scagliotti G., Govindan R. Targeting angiogenesis with multitargeted tyrosine kinase inhibitors in the treatment of non-small cell lung cancer. Oncologist 2010, 15:436-446.
-
(2010)
Oncologist
, vol.15
, pp. 436-446
-
-
Scagliotti, G.1
Govindan, R.2
-
34
-
-
70350507211
-
Vascular endothelial growth factor in the management of hepatocellular carcinoma: a review of literature
-
Kaseb A.O., Hanbali A., Cotant M., Hassan M.M., Wollner I., Philip P.A. Vascular endothelial growth factor in the management of hepatocellular carcinoma: a review of literature. Cancer 2009, 115:4895-4906.
-
(2009)
Cancer
, vol.115
, pp. 4895-4906
-
-
Kaseb, A.O.1
Hanbali, A.2
Cotant, M.3
Hassan, M.M.4
Wollner, I.5
Philip, P.A.6
-
35
-
-
0029761644
-
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
-
Forsythe J.A., Jiang B.H., Iyer N.V., et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol. 1996, 16:4604-4613.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 4604-4613
-
-
Forsythe, J.A.1
Jiang, B.H.2
Iyer, N.V.3
-
36
-
-
34347220473
-
Defining the role of mTOR in cancer
-
Guertin D.A., Sabatini D.M. Defining the role of mTOR in cancer. Cancer Cell 2007, 12:9-22.
-
(2007)
Cancer Cell
, vol.12
, pp. 9-22
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
37
-
-
34547134517
-
Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif
-
Land S.C., Tee A.R. Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif. J. Biol. Chem. 2007, 282:20534-20543.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 20534-20543
-
-
Land, S.C.1
Tee, A.R.2
-
38
-
-
67651142420
-
RAD001 (everolimus) inhibits tumour growth in xenograft models of human hepatocellular carcinoma
-
Huynh H., Chow K.H., Soo K.C., et al. RAD001 (everolimus) inhibits tumour growth in xenograft models of human hepatocellular carcinoma. J. Cell. Mol. Med. 2009, 13:1371-1380.
-
(2009)
J. Cell. Mol. Med.
, vol.13
, pp. 1371-1380
-
-
Huynh, H.1
Chow, K.H.2
Soo, K.C.3
-
39
-
-
34047118033
-
Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma
-
Semela D., Piguet A.C., Kolev M., et al. Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma. J. Hepatol. 2007, 46:840-848.
-
(2007)
J. Hepatol.
, vol.46
, pp. 840-848
-
-
Semela, D.1
Piguet, A.C.2
Kolev, M.3
|