FAK pathway regulates PGE2 production in compressed periodontal ligament cells

Journal of Dental Research

Volumn 89, Issue 12, 2010, Pages 1444-1449

  Kang, Y G ^a   Nam, J H ^a   Kim, K H ^a   Lee, K S ^a  

^a Kyung Hee University   (South Korea)

Author keywords

focal adhesion kinase; mechanical stress; periodontal ligament; prostaglandin E2

Indexed keywords

CYCLOOXYGENASE 2; FOCAL ADHESION KINASE 1; PROSTAGLANDIN E2; PTGS2 PROTEIN, HUMAN; PTK2 PROTEIN, HUMAN; SMALL INTERFERING RNA;

ARTICLE; BIOMECHANICS; CELL CULTURE; CELL SURVIVAL; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE SILENCING; GENETIC TRANSCRIPTION; GENETICS; HUMAN; MECHANICAL STRESS; MECHANORECEPTOR; MECHANOTRANSDUCTION; METABOLISM; PERIODONTAL LIGAMENT; PHOSPHORYLATION; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN PROCESSING; TIME; UPREGULATION; WESTERN BLOTTING;

BIOMECHANICS; BLOTTING, WESTERN; CELL SURVIVAL; CELLS, CULTURED; CYCLOOXYGENASE 2; DINOPROSTONE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FOCAL ADHESION KINASE 1; GENE KNOCKDOWN TECHNIQUES; HUMANS; MECHANORECEPTORS; MECHANOTRANSDUCTION, CELLULAR; PERIODONTAL LIGAMENT; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA, SMALL INTERFERING; STRESS, MECHANICAL; TIME FACTORS; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 78650166770     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034510378521     Document Type: Article

References (22)

1. Ando J., Yamamoto K. (2009). Vascular mechanobiology: endothelial cell responses to fluid shear stress. Circ J 73: 1983-1992.
2. Aubin JE, Bonnelye E. (2000). Osteoprotegerin and its ligand: a new paradigm for regulation of osteoclastogenesis and bone resorption. Osteoporos Int 11: 905-913.
3. Bershadsky AD, Balaban NQ, Geiger B. (2003). Adhesion-dependent cell mechanosensitivity. Annu Rev Cell Dev Biol 19: 677-695.
4. Bumann A., Carvalho RS, Schwarzer CL, Yen EH (1997). Collagen synthesis from human PDL cells following orthodontic tooth movement. Eur J Orthod 19: 29-37.
5. Chiba M., Mitani H. (2004). Cytoskeletal changes and the system of regulation of alkaline phosphatase activity in human periodontal ligament cells induced by mechanical stress. Cell Biochem Funct 22: 249-256.
6. Kanzaki H., Chiba M., Shimizu Y., Mitani H. (2002). Periodontal ligament cells under mechanical stress induce osteoclastogenesis by receptor activator of nuclear factor kappaB ligand up-regulation via prostaglandin E2 synthesis. J Bone Miner Res 17: 210-220.
7. Katsumi A., Orr AW, Tzima E., Schwartz MA (2004). Integrins in mechanotransduction. J Biol Chem 279: 12001-12004.
8. Kim JB, Leucht P., Luppen CA, Park YJ, Beggs HE, Damsky CH, et al. (2007). Reconciling the roles of FAK in osteoblast differentiation, osteoclast remodeling, and bone regeneration. Bone 41: 39-51.
9. Kim JW, Lee KS, Nahm JH, Kang YG (2009). Effects of compressive stress on the expression of M-CSF, IL-1b, RANKL and OPG mRNA in periodontal ligament cells. Korean J Orthod 39: 248-256.
10. Knight MM, McGlashan SR, Garcia M., Jensen CG, Poole CA (2009). Articular chondrocytes express connexin 43 hemichannels and P2 receptors-a putative mechanoreceptor complex involving the primary cilium? J Anat 214: 275-283.
11. Liedert A., Kaspar D., Blakytny R., Claes L., Ignatius A. (2006). Signal transduction pathways involved in mechanotransduction in bone cells. Biochem Biophys Res Commun 349: 1-5.
12. Mayahara K., Kobayashi Y., Takimoto K., Suzuki N., Mitsui N., Shimizu N. (2007). Aging stimulates cyclooxygenase-2 expression and prostaglandin E2 production in human periodontal ligament cells after the application of compressive force. J Periodontal Res 42: 8-14.
13. Molina T., Kabsch K., Alonso A., Kohl A., Komposch G., Tomakidi P. (2001). Topographic changes of focal adhesion components and modulation of p125FAK activation in stretched human periodontal ligament fibroblasts. J Dent Res 80: 1984-1989.
14. Papachristou DJ, Papachroni KK, Basdra EK, Papavassiliou AG (2009). Signaling networks and transcription factors regulating mechanotransduction in bone. Bioessays 31: 794-804.
15. Papachroni KK, Karatzas DN, Papavassiliou KA, Basdra EK, Papavassiliou AG (2009). Mechanotransduction in osteoblast regulation and bone disease. Trends Mol Med 15: 208-216.
16. Raisz LG, Pilbeam CC, Fall PM (1993). Prostaglandins: mechanisms of action and regulation of production in bone. Osteoporos Int 3 (Suppl 1). 136-140.
17. Robinson JA, Chatterjee-Kishore M., Yaworsky PJ, Cullen DM, Zhao W., Li C., et al. (2006). Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone. J Biol Chem 281: 31720-31728.
18. Rubin J., Rubin C., Jacobs CR (2006). Molecular pathways mediating mechanical signaling in bone. Gene 367: 1-16.
19. van der Flier A., Sonnenberg A. (2001). Function and interactions of integrins. Cell Tissue Res 305: 285-298.
20. Wada N., Maeda H., Tanabe K., Tsuda E., Yano K., Nakamuta H., et al. (2001). Periodontal ligament cells secrete the factor that inhibits osteoclastic differentiation and function: the factor is osteoprotegerin/osteoclastogenesis inhibitory factor. J Periodontal Res 36: 56-63.
21. Yamamoto T., Kita M., Kimura I., Oseko F., Terauchi R., Takahashi K., et al. (2006). Mechanical stress induces expression of cytokines in human periodontal ligament cells. Oral Dis 12: 171-175.
22. Ziegler N., Alonso A., Steinberg T., Woodnutt D., Kohl A., Mussig E., et al. (2010). Mechano-transduction in periodontal ligament cells identifies activated states of MAP-kinases p42/44 and p38-stress kinase as a mechanism for MMP-13 expression. BMC Cell Biol 11: 10.