Safety of multiple-dose intravenous acetaminophen in adult inpatients

Pain Medicine

Volumn 11, Issue 12, 2010, Pages 1841-1848

  Candiotti, Keith A ^a   Bergese, Sergio D ^b   Viscusi, Eugene R ^c   Singla, Sonia K ^d   Royal, Mike A ^e   Singla, Neil Kumar ^f  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d Glendale Adventist Medical Center   (United States)

^e Cadence Pharmaceuticals Inc   (United States)

^f HUNTINGTON MEMORIAL HOSPITAL   (United States)

Author keywords

Acute Pain; Anesthesiology; Chronic Pain; Pain Medicine

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; GAMMA GLUTAMYLTRANSFERASE; NON PRESCRIPTION DRUG; OFIRMEV; PARACETAMOL; UNCLASSIFIED DRUG;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANEMIA; ANXIETY DISORDER; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CLINICAL TRIAL; COMORBIDITY; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; FEVER; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HEADACHE; HOSPITAL PATIENT; HOT FLUSH; HUMAN; HYPERGLYCEMIA; HYPERTENSION; HYPOCALCEMIA; HYPOMAGNESEMIA; HYPOTENSION; INJECTION SITE PAIN; INSOMNIA; LEUKOCYTOSIS; LIVER FUNCTION TEST; LIVER TOXICITY; MAJOR CLINICAL STUDY; NAUSEA; PAIN; PATIENT COMPLIANCE; PATIENT SATISFACTION; PERIPHERAL EDEMA; PHLEBITIS; POSTOPERATIVE PAIN; PRESCRIPTION; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; REPEATED DRUG DOSE; SIDE EFFECT; SUBJECT GLOBAL EVALUATIONS; TACHYCARDIA; THROMBOCYTE COUNT; VOMITING;

EID: 78650157542     PISSN: 15262375     EISSN: 15264637     Source Type: Journal    
DOI: 10.1111/j.1526-4637.2010.00991.x     Document Type: Article

References (19)

1. Kaufman DW, Kelly JP, Rosenberg L, Anderson TE, Mitchell AA. Recent patterns of medication use in the ambulatory adult population of the United States: The Slone survey. JAMA 2002;287(3):337-44.
2. Smith HS. Potential analgesic mechanisms of acetaminophen. Pain Physician 2009;12(1):269-80.
3. Duggan ST, Scott LJ. Intravenous paracetamol (acetaminophen). Drugs 2009;69(1):101-13.
4. Van Lingen RA, Deinum JT, Ouak JME, et al. Pharmacokinetics and metabolism of rectally administered paracetamol in preterm neonates. Arch Dis Child Fetal Neonatal Ed 1999;80:F59-F63.
5. Petterson PH, Jakobsson J, Owall A. Intravenous acetaminophen reduced the use of opioids compared with oral administration after coronary artery bypass grafting. J Cardiothorac Vasc Anesth 2005;19:306-9.
6. Petterson PH, Jakobsson J, Owall A. Plasma concentrations following repeated rectal or intravenous administration of paracetamol after heart surgery. Acta Anaesthesiol Scand 2006;50:673-7.
7. Allegeaert K, Rayyan M, De Rijdt T, Van Beek F, Naulaers G. Hepatic tolerance of repeated intravenous paracetamol administration in neonates. Paediatr Anaesth 2008;18:388-92.
8. Koppert W, Frötsch K, Huzurudin H, et al. The effects of paracetamol and parecoxib on kidney function in elderly patients undergoing orthopedic surgery. Anesth Analg 2006;103(5):1170-6.
9. Hirate J, Zhu CY, Horikoshi I, Bhargava VO. First-pass metabolism of acetaminophen in rats after low and high doses. Biopharm Drug Dispos 1990;11(3):245-52.
10. Lin JH, Chiba M, Baillie TA. Is the role of the small intestine in first-pass metabolism overemphasized? Pharmacol Rev 1999;51(2):135-58.
11. Kumpulainen E, Kokki H, Halonen T, et al. Paracetamol (acetaminophen) penetrates readily into the cerebrospinal fluid of children after intravenous administration. Pediatrics 2007;119(4):766-71.
12. Gregoire N, Hovsepian L, Gualano V, et al. Safety and pharmacokinetics of paracetamol following intravenous administration of 5 g during the first 24 hours with a 2-g starting dose. Clin Pharmacol Ther 2007;81(3):401-5.
13. Royal MA, Gosselin NH, Pan CP, Moukassi MS, Breitmeyer JB. Route of administration may significantly impact hepatic acetaminophen exposure (Abstract) [ASRA Fall 2009 Annual Pain Medicine Meeting and Workshops, San Antonio, TX, November 19-22, 2009]. Reg Anesth Pain Med 2009;PS1:17.
14. Benson GD, Koff RS, Tolman KG. The therapeutic use of acetaminophen in patients with liver disease. Am J Ther 2005;12(2):133-41.
15. Rumack BH. Acetaminophen hepatotoxicity: The first 35 years. J Toxicol Clin Toxicol 2002;40(1):3-20.
16. White PF. The role of non-opioid analgesic techniques in the management of pain after ambulatory surgery. Anesth Analg 2002;94(3):577-85.
17. White PF. The changing role of non-opioid analgesic techniques in the management of postoperative pain. Anesth Analg 2005;101(5 Suppl):S5-22.
18. Macario A, Royal M. A systematic literature review of randomized clinical trials of intravenous acetaminophen (paracetamol) for acute postoperative pain. Poster presentation at the ASRA Fall 2009 Annual Pain Medicine Meeting and Workshops, November 19-22, 2009. San Antonio, TX.
19. Oscier CD, Milner QJW. Peri-operative use of paracetamol. Anaesthesia 2009;64:65-72.