Capacity to make medical treatment decisions in multiple sclerosis: A potentially remediable deficit

Journal of Clinical and Experimental Neuropsychology

Volumn 32, Issue 10, 2010, Pages 1050-1061

  Basso, Michael R ^a   Candilis, Philip J ^b   Johnson, Jay ^c   Ghormley, Courtney ^d   Combs, Dennis R ^e   Ward, Taeh ^a  

^a UNIVERSITY OF TULSA   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c Neurological Associates of Tulsa   (United States)

^d Arkansas Neuropsychology   (United States)

^e UNIVERSITY OF TEXAS AT TYLER   (United States)

Author keywords

Decision making; Informed consent; Multiple sclerosis; Neuropsychological function

Indexed keywords

ADULT; ARTICLE; COGNITIVE DEFECT; DECISION MAKING; DISABILITY; EXECUTIVE FUNCTION; FEMALE; HUMAN; INFORMED CONSENT; INTERPERSONAL COMMUNICATION; LEARNING; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; NEUROPSYCHOLOGICAL TEST; PSYCHOLOGICAL ASPECT; STATISTICAL ANALYSIS;

ADULT; COGNITION DISORDERS; DATA INTERPRETATION, STATISTICAL; DECISION MAKING; DISABILITY EVALUATION; DISCLOSURE; EXECUTIVE FUNCTION; FEMALE; HUMANS; INFORMED CONSENT; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; NEUROPSYCHOLOGICAL TESTS; VERBAL LEARNING;

EID: 78650114016     PISSN: 13803395     EISSN: 1744411X     Source Type: Journal    
DOI: 10.1080/13803391003683062     Document Type: Article

References (74)

1. Appelbaum, P. S., & Grisso, T. (1988). Assessing patients' capacities to consent to treatment. New England Journal of Medicine, 319, 1635-1638.
2. Appelbaum, P. S., & Grisso, T. (1995). The MacArthur treatment competence study: I. Mental illness and competence to consent to treatment. Law and Human Behavior, 19, 105-126.
3. Appelbaum, P. S., & Grisso, T. (1997). Capacities of hospitalized, medically ill patients to consent to treatment. Psychosomatics, 38, 119-125.
4. Appelbaum, P. S., Grisso, T., Frank, E., O'Donnell, S., & Kupfer, D. J. (1999). Competence of depressed patients for consent to research. American Journal of Psychiatry, 156, 1380-1384.
5. Appelbaum, P. S., Lidz, C. W., & Meisel, A. (1987). Informed consent: Legal theory and clinical practice. New York: Oxford.
6. Appelbaum, P., & Roth, L. (1982). Competency to consent to research: A psychiatric overview. Archives of General Psychiatry, 39, 951-958.
7. Arnett, P. A., Higginson, C. I., & Randolph, J. J. (2001). Depression in multiple sclerosis: Relationship to planning ability. Journal of the International Neuropsychological Society, 7, 665-674.
8. Bambara, J. K., Griffith, H. R., Martic, R. C., Faught, E., Wadley, V. G., & Marson, D. C. (2007). Medical decision-making abilities in older adults with chronic partial epilepsy. Epilepsy & Behavior, 10, 63-68.
9. Beatty, W. W., Goretti, B., Siracusa, G., Zipoli, V., Portaccio, E., & Amato, M. P. (2003). Changes in neuropsychological test performance over the workday in multiple sclerosis. The Clinical Neuropsychologist, 17, 551-560.
10. Beatty, W. W., Wilbanks, S. L., Blanco, C. R., Hames, K. A., Tivis, R., & Paul, R. H. (1996). Memory disturbance in multiple sclerosis: Reconsideration of patterns of performance on the selective reminding test. Journal of Clinical and Experimental Neuropsychology, 18, 56-62.
11. Benedict, R. H., Wahlig, E., Bakshi, R., Fishman, I., Munschauer, F., Zivadinov, R., et al. (2005). Predicting quality of life in multiple sclerosis: Accounting for physical disability, fatigue, cognition, mood disorder, personality, and behavior change. Journal of Neurological Sciences, 231, 29-34.
12. Benton, A. L., Sivan, A. B., Hamsher, K. deS., Varney, N. R., & Spreen, O. (1994). Contributions to neuropsychological assessment: A clinical manual (2nd ed.). New York: Oxford University Press.
13. Bobholz, J. A., & Rao, S. M. (2003). Cognitive dysfunction in multiple sclerosis: A review of recent developments. Current Opinion in Neurology, 16, 283-288.
14. Candilis, P. J., Fletcher, K., Geppert, C., Lidz, C. W., & Appelbaum, P. S. (2008). A direct comparison of research decisionmaking capacity: Schizophrenia/schizoaffective, medically ill, and non-ill subjects. Schizophrenia Research, 99, 350-358.
15. Candilis, P. J., Geppert, C. M., Fletcher, K. E., Lidz, C. W., & Appelbaum, P. S. (2006). Willingness of subjects with thought disorder to participate in research. Schizophrenia Bulletin, 32, 159-165.
16. Carpenter, W. T., Gold, J. M., Lahti, A. C., Queern, C. A., Conley, R. R., Bartko, J. J., et al. (2000). Decisional capacity for informed consent in schizophrenia research. Archives of General Psychiatry, 57, 533-538.
17. Cohen, B. J., McGarvey, E. L., Pinkerton, R. C., & Kryzhanivska, L. (2004). Willingness and competence of depressed and schizophrenic inpatients to consent to research. Journal of the American Academy of Psychiatry and the Law, 32, 134-143.
18. Combs, D. R., Adams, S. D., Wood, T. D., Basso, M. R., & Gouvier, W. D. (2005). Informed consent in schizophrenia: The use of cues in the assessment of understanding. Schizophrenia Research, 77, 59-63.
19. Delis, D. C., Kramer, J. H., Kaplan, E., & Ober, B. A. (2000). California Verbal Learning Test-II. San Antonio, TX: The Psychological Corporation.
20. DeLuca, J., Barbieri-Berger, S., & Johnson, S. K. (1994). The nature of memory impairments in multiple sclerosis: Acquisition versus retrieval. Journal of Clinical and Experimental Neuropsychology, 16, 183-189.
21. Dunn, L. B., Candilis, P. J., & Roberts, L. W. (2006a). Emerging empirical evidence on the ethics of schizophrenia research. Schizophrenia Bulletin, 32, 47-68.
22. Dunn, L. B., & Jeste, D. V. (2001). Enhancing informed consent for research and treatment. Neuropsychopharmacology, 24, 595-607.
23. Dunn, L. B., Lindamer, L. A., Palmer, B. W., Golshan, S., Schneiderman, L. J., & Jeste, P. V. (2002). Improving understanding of research consent in middle-aged and elderly patients with psychotic disorders. American Journal of Geriatric Psychiatry, 10, 142-150.
24. Dunn, L. B., Nowrangi, M. A., Palmer, B. W., Jeste, D. V., & Saks, E. R. (2006b). Assessing decisional capacity for clinical research or treatment: A review of instruments. American Journal of Psychiatry, 163, 1323-1334.
25. Dunn, L. B., Palmer, B. W., Appelbaum, P. S., Sakes, E. R., Aarons, G. A., & Jeste, D. V. (2007). Prevalence and correlates of adequate performance on a measure of abilities related to decisional capacity: Differences among three standards for the MacCAT-CR in patients with schizophrenia. Schizophrenia Research, 89, 110-118.
26. Dymek, M. P., Atchison, P., Harrell, L., & Marson, D. C. (2001). Competency to consent to medical treatment in cognitively impaired patients with Parkinson's disease. Neurology, 56, 17-24.
27. Fischer, J. S., Jak, A. J., Kniker, J. E., & Rudick, R. A. (2001). Multiple sclerosis functional composite: Administration and scoring manual. New York: National Multiple Sclerosis Society.
28. Gaudino, E. A., Chiaravalloti, N. D., DeLuca, J., & Diamond, B. J. (2001). A comparison of memory performance in relapsing-remitting, primary progressive and secondary progressive, multiple sclerosis. Neuropsychiatry, Neuropsychology, & Behavioral Neurology, 14, 32-44.
29. Geisler, M. W., Sliwinski, M., Coyle, P. K., Masur, D. M., Doscher, C., & Krupp, L. B. (1996). The effects of amantadine and pemoline on cognitive functioning in multiple sclerosis. Archives of Neurology, 53, 185-188.
30. Grafman, J., Rao, S., Bernardin, L., & Leo, G. J. (1991). Automatic memory processes in patients with multiple sclerosis. Archives of Neurology, 48, 1072-1075.
31. Griffith, H. R., Dymek, M. P., Atchison, P., Harrell, L., & Marson, D. C. (2005). Medical decision-making in neurodegenerative disease: Mild AD and PD with cognitive impairment. Neurology, 65, 483-485.
32. Grisso, T. (1986). Evaluating competencies: Forensic assessments and instruments. New York: Plenum Press.
33. Grisso, T., & Appelbaum, P. S. (1995). The MacArthur Treatment Competence Study: III. Abilities of patients to consent to psychiatric and medical treatments. Law and Human Behavior, 19, 149-174.
34. Grisso, T., & Appelbaum, P. S. (1998). Assessing competence to consent to treatment: A guide for physicians and other health professionals. New York: Oxford University Press.
35. Grisso, T., Appelbaum, P. S., Mulvey, E. P., & Fletcher, K. (1995). The MacArthur Treatment Competence Study: II. Law and Human Behavior, 19, 127-149.
36. Gurrera, R. J., Moye, J., Karel, M. J., Azar, A. R., & Armesto, J. C. (2006). Cognitive performance predicts treatment decisional abilities in mild to moderate dementia. Neurology, 66, 1367-1372.
37. Hauser, S. L., Dawson, D. M., Lehrich, J. R., Beal, M. F., Kevy, S. V., Propper, R. D., et al. (1983). Intensive immunosuppression in progressive multiple sclerosis: A randomized, three-arm study of high-dose intravenous cyclophosphamide, plasma exchange, and ACTH. New England Journal of Medicine, 308, 173-180.
38. Howe, V., Foister, K., Jenkins, K., Skene, L., Copolov, D., & Keks, N. (2005). Competence to give informed consent in acute psychosis is associated with symptoms rather than diagnosis. Schizophrenia Research, 77, 211-214.
39. Jensen, A. B., Madsen, B., Andersen, P., & Rose, C. (1993). Information for cancer patients entering a clinical trial-an evaluation of an information strategy. European Journal of Cancer, 29, 2235-2238.
40. Kessler, H. R., Cohen, R. A., Lauer, K., & Kausch, D. F. (1992). The relationship between disability and memory dysfunction in multiple sclerosis. International Journal of Neuroscience, 62, 17-34.
41. Kim, S. Y. (2006). When does decisional impairment become decisional incompetence? Ethical and methodological issues in capacity research in schizophrenia. Schizophrenia Bulletin, 32, 92-97.
42. Kim, S. Y., Caine, E. D., Currier, G. W., Leibovici, A., & Ryan, J. M. (2001). Assessing the competence of persons with Alzheimer's disease in providing informed consent for participation in research. American Journal of Psychiatry, 158, 712-717.
43. Kim, S. Y., Cox, C., & Caine, E. D. (2002). Impaired decisionmaking ability in subjects with Alzheimer's disease and willingness to participate in research. American Journal of Psychiatry, 159, 797-802.
44. Kongs, S. K., Thompson, L. L., Iverson, G. L., & Heaton, R. K. (2000). Wisconsin Card Sorting Test-64 Card Version. Lutz, FL: Psychological Assessment Resources.
45. Kovnick, J. A., Appelbaum, P. S., Hoge, S. K., & Leadbetter, R. A. (2003). Competence to consent to research among long-stay inpatients with chronic schizophrenia. Psychiatric Services, 54, 1247-1252.
46. Kujala, P., Portin, R., & Ruutiainen, J. (1996). Memory deficits and early cognitive deterioration in MS. Acta Neurologica Scandinavica, 93, 329-335.
47. Marson, D. C., Chatterjee, A., Ingram, K. K., & Harrell, L. E. (1996). Toward a neurologic model of competency: Cognitive predictors of capacity to consent in Alzheimer's disease using three different legal standards. Neurology, 46, 666-672.
48. Marson, D., & Harrell, L. (1999). Executive dysfunction and loss of capacity to consent to medical treatment in patients with Alzheimer's disease. Seminars in Clinical Neuropsychiatry, 4, 41-49.
49. Marson, D. C., Ingram, K. K., Cody, H. A., & Harrell, L. E. (1995). Assessing the competency of patients with Alzheimer's disease under different legal standards: A prototype instrument. Archives of Neurology, 52, 949-954.
50. Marson, D. C., Schmitt, F. A., Ingram, K. K., & Harrell, L. E. (1994). Determining the competency of Alzheimer patients to consent to treatment and research. Alzheimer Disease and Associated Disorders, 8 (Suppl. 4), 5-18.
51. Martin, R., Hohlfeld, R., & McFarland, H. F. (1996). Multiple sclerosis. In T. Brandt, L. R. Caplan, J. Dichgans, H. C. Diener, & C. Kennard (Eds.), Neurological disorders: Course and treatment (pp. 483-506). New York: Academic Press.
52. Moser, D. J., Reese, R. L., Hey, C. T., Schultz, S. K., Arndt, S., Beglinger, L. J., et al. (2006). Using a brief intervention to improve decisional capacity in schizophrenia research. Schizophrenia Bulletin, 32, 116-120.
53. Moser, D., Schultz, S., Arndt, S., Benjamin, M., Fleming, F., Brems, C., et al. (2002). Capacity to provide informed consent for participation in schizophrenia and HIV research. American Journal of Psychiatry, 159, 1201-1207.
54. Moye, J., Gurrera, R. J., Karel, M. J., Edelstein, B., & O'Connell, C. (2006). Empirical advances in the assessment of the capacity to consent to medical treatment: Clinical implications and research needs. Clinical Psychology Review, 26, 1054-1077.
55. Okonkwo, O. C., Griffith, H. R., Belue, K., Lanza, S., Zamrini, E. Y., Harrell, L. E., et al. (2008). Cognitive models of medical decision-making capacity in patients with mild cognitive impairment. Journal of the International Neuropsychological Society, 14, 297-308.
56. Palmer, B. W., Dunn, L. B., Appelbaum, P. S., & Jeste, D. V. (2004). Correlates of treatment-related decision-making capacity among middle-aged and older patients with schizophrenia. Archives of General Psychiatry, 61, 230-236.
57. Palmer, B. W., Dunn, L. B., Appelbaum, P. S., Mudaliar, S., Thal, L., Henry, R., et al. (2005). Assessment of capacity to consent to research among older persons with schizophrenia, Alzheimer disease, or diabetes mellitus: Comparison of a 3-item questionnaire with a comprehensive standardized capacity instrument. Archives of General Psychiatry, 62, 726-733.
58. Palmer, B. W., Dunn, L. B., Depp, C. A., Eyler, L. T., & Jeste, D. V. (2007). Decisional capacity to consent to research among patients with bipolar disorder: Comparison with schizophrenia patients and healthy controls. Journal of Clinical Psychiatry, 68, 689-696.
59. Palmer, B. W., & Jeste, D. V. (2006). Relationship of individual cognitive abilities to specific components of decisional capacity among middle-aged and older patients with schizophrenia. Schizophrenia Bulletin, 32, 98-106.
60. Palmer, B. W., & Savla, G. N. (2007). The association of specific neuropsychological deficits with capacity to consent to research or treatment. Journal of the International Neuropsychological Society, 13, 1047-1059.
61. Pliskin, N. H., Hamer, D. P., Goldstein, D. S., Towle, V. L., Reder, A. T., Noronha, A., et al. (1996). Improved delayed visual reproduction test performance in multiple sclerosis patients receiving interferon beta-1b. Neurology, 47, 1463-1468.
62. Polman, C. H., Reingold, S. C., Edan, G., Filippi, M., Hartung, H. P., Kappos, L., et al. (2005). Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria." Annals of Neurology, 58, 840-846.
63. Poser, C. M., Paty, D. W., Scheinberg, L., McDonald, W. I., Davis, F. A., Ebers, G. C., et al. (1983). New diagnostic criteria for multiple sclerosis: Guidelines for research protocols. Annals of Neurology, 13, 227-231.
64. Pruchno, R. A., Smyer, M. A., Rose, M. S., Hartman-Stein, P. E., & Laribee-Henderson, D. L. (1995). Competence of long-term care residents to participate in decisions about their medical care: A brief objective assessment. The Gerontologist, 35, 622-629.
65. Rao, S. M., Leo, G. J., Bernardin, L., & Unverzagt, F. (1991a). Cognitive dysfunction in multiple sclerosis: I. Frequency, patterns, and prediction. Neurology, 41, 685-691.
66. Rao, S. M., Leo, G. J., Ellington, L., Nauertz, T., Bernardin, L., & Unverzagt, F. (1991b). Cognitive dysfunction in multiple sclerosis: II. Impact on employment and social functioning. Neurology, 41, 692-696.
67. Reitan, R. M., & Wolfson, D. (1993). The Halstead-Reitan Neuropsychological Test Battery: Theory and clinical interpretation. Tucson, AZ: Neuropsychology Press.
68. Roth, L. H., Meisel, A., & Lidz, C. W. (1977). Tests of competency to consent to treatment. American Journal of Psychiatry, 134, 279-284.
69. Stevens, J. (1996). Applied multivariate statistics for the social sciences (3rd ed.). Mahwah, NJ: Lawrence Erlbaum Associates.
70. Stroup, T. S., McEvoy, J. P., Swartz, M. S., Byerly, M. J., Glick, I. D., Canive, J. M., et al. (2003). The National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project: Schizophrenia trial design and protocol development. Schizophrenia Bulletin, 29, 15-31.
71. Tsolaki, M., Drevelegas, A., Karachristianou, S., Kapinas, K., Divanoglou, D., & Routsonis, K. (1994). Correlation of dementia, neuropsychological and MRI findings in multiple sclerosis. Dementia, 5, 48-52.
72. Voss, W. D., Arnett, P. A., Higginson, C. I., Randolph, J. J., Campos, M. D., & Dyck, D. G. (2002). Archives of Clinical Neuropsychology, 17, 103-115.
73. Wechsler, D. (1997). Wechsler Adult Intelligence Scale-III. San Antonio, TX: The Psychological Corporation.
74. Wirshing, D. A., Wirshing, W. C., Marder, S. R., Liberman, R. P., & Mintz, J. (1998). Informed consent: Assessment of comprehension. American Journal of Psychiatry, 155, 1508-1511.