Distribution and pharmacokinetics of methamphetamine in the human body: Clinical implications

PLoS ONE

Volumn 5, Issue 12, 2010, Pages

  Volkow, Nora D ^a,b   Fowler, Joanna S ^c   Wang, Gene Jack ^c   Shumay, Elena ^c   Telang, Frank ^b   Thanos, Peter K ^b   Alexoff, David ^c  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^c BROOKHAVEN NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 11; METHAMPHETAMINE; CENTRAL STIMULANT AGENT;

ADULT; AFRICAN AMERICAN; AREA UNDER THE CURVE; ARTICLE; BRAIN; CAUCASIAN; DRUG ABUSE; DRUG ACCUMULATION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG UPTAKE; HUMAN; HUMAN EXPERIMENT; INFECTION SENSITIVITY; KIDNEY; LIVER; LUNG; NORMAL HUMAN; ORGAN DISTRIBUTION; PANCREAS; POSITRON EMISSION TOMOGRAPHY; PULMONARY HYPERTENSION; SPLEEN; TUBERCULOSIS; CASE CONTROL STUDY; ETHNOLOGY; IMAGE PROCESSING; LUNG TUBERCULOSIS; MALE; METHODOLOGY; TISSUE DISTRIBUTION;

ADULT; AFRICAN AMERICANS; AMPHETAMINE-RELATED DISORDERS; AREA UNDER CURVE; CASE-CONTROL STUDIES; CENTRAL NERVOUS SYSTEM STIMULANTS; EUROPEAN CONTINENTAL ANCESTRY GROUP; HUMANS; HYPERTENSION, PULMONARY; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; METHAMPHETAMINE; POSITRON-EMISSION TOMOGRAPHY; TISSUE DISTRIBUTION; TUBERCULOSIS, PULMONARY;

EID: 78650110591     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015269     Document Type: Article

References (37)

1. Desai RI, Paronis CA, Martin J, Desai R, Bergman J (2010) Monoaminergic psychomotor stimulants: discriminative stimulus effects and dopamine efflux. J Pharmacol Exp Ther 333(3): 834-843.
2. Darke S, Kaye S, McKetin R, Duflou J (2008) Major physical and psychological harms of methamphetamine use. Drug Alcohol Rev 27(3): 253-262.
3. Gonzales R, Mooney L, Rawson RA (2010) The methamphetamine problem in the United States. Annu Rev Public Health 31: 385-398.
4. McKetin R, Kozel N, Douglas J, Ali R, Vickasingam B, et al. (2008) The rise of methamphetamine in Southeast and East Asia. Drug Alcohol Rev 27: 220-228.
5. Karch SB, Stephens BG, Ho CH (1999) Methamphetamine-related deaths in San Francisco: demographic, pathologic, and toxicologic profiles. J Forensic Sci 44(2): 359-368.
6. Mooney LJ, Glasner-Edwards S, Rawson RA, Ling W (2009) Medical effects of methamphetamine use. In Methamphetamine Addiction: From Basic Science to Treatment, Roll JM, Rawson RA, Ling W, Shoptaw S, eds. New York: Guilford. pp 117-42.
7. Ishigami A, Tokunaga I, Gotohda T, Kubo S (2003) Immunohistochemical study of myoglobin and oxidative injury-related markers in the kidney of MAMP abusers. Leg Med (Tokyo) 5: 42-48.
8. Fowler JS, Kroll C, Ferrieri R, Alexoff D, Logan J, et al. (2007) PET studies of dmethamphetamine pharmacokinetics in primates: comparison with l-methamphetamine and(-)-cocaine. J Nucl Med 48: 1724-1732.
9. Substance Abuse and Mental Health Services Administration, Office of Applied Studies Drug Abuse Warning Network 2005: national estimates of drug-related emergency department visits Substance Abuse and Mental Health Services Administration, Office of Applied Studies, Rockville, MD - DAWN Series D- 29, DHHS Publication no. (SMA) 07-4256, 2007.
10. Sexton RL, Carlson RG, Siegal HA, Falck RS, Leukefeld C, et al. (2005) Barriers and pathways to diffusion of methamphetamine use among African Americans in the rural South: preliminary ethnographic findings. J Ethn Subst Abuse 4: 77-103.
11. Shiue CY, Shiue GG, Rysavy JA, Pleus RC, Huang H, et al. (1993) Fluorine-18 and carbon-11 labeled amphetamine analogs-synthesis, distribution, binding characteristics in mice and rats and a PET study in monkey. Nucl Med Biol 20: 973-981.
12. Ishiyama I, Mukaida M, Yoshii T, Suyama H (1987) Histochemical demonstration of methamphetamine by immunocytochemistry. J Forensic Sci 32(3): 658-672.
13. Volkow ND, Fowler JS, Wolf AP, Wang G-J, Logan J, et al. (1992) Distribution and kinetics of carbon-11-cocaine in the human body measured with PET. J Nucl Med 33(4): 521-525.
14. Kuczenski R, Segal DS, Cho AK, Melega W (1995) Hippocampus norepinephrine, caudate dopamine and serotonin, and behavioral responses to the stereoisomers of amphetamine and methamphetamine. J Neurosci 15: 1308-1317.
15. Chin KM, Channick RN, Rubin LJ (2006) Is methamphetamine use associated with idiopathic pulmonary arterial hypertension? Chest 130: 1657-1663.
16. Pevzner ES, Robison S, Donovan J, Allis D, Spitters C, et al. (2010) Tuberculosis transmission and use of methamphetamines and other drugs in Snohomish County, WA, 1991-2006. Am J Public Health, Feb 18. [Epub ahead of print].
17. Mankatittham W, Likanonsakul S, Thawornwan U, Kongsanan P, Kittikraisak W, et al. (2009) Characteristics of HIV-infected tuberculosis patients in Thailand. Southeast Asian J Trop Med Public Health 40(1): 93-103.
18. Cook CE, Jeffcoat AR, Hill JM, et al. (1993) Pharmacokinetics of methamphetamine self-administered to human subjects by smoking S-(+)-methamphetamine hydrochloride. Drug Metab Dispos 21: 717-723.
19. Kim I, Oyler JM, Moolchan ET, Cone EJ, Huestis MA (2004) Urinary pharmacokinetics of methamphetamine and its metabolite, amphetamine following controlled oral administration to humans. Ther Drug Monit Dec; 26(6): 664-672.
20. Eisenhofer G (2001) The role of neuronal and extraneuronal plasma membrane transporters in the inactivation of peripheral catecholamines. Pharmacol Ther 91(1): 35-62.
21. McMahon EM, Andersen DK, Feldman JM, Schanberg SM (1971) Methamphetamine- induced insulin release. Science 174(4): 66-68.
22. Citron BP, Halpern M, Miller L (1972) Abnormal carbohydrate metabolism associated with drug abuse. Clin Res 20: 236 (Abstr.).
23. Martinez LR, Mihu MR, Gácser A, Santambrogio L, Nosanchuk JD (2009) Methamphetamine enhances histoplasmosis by immunosuppression of the host. J Infect Dis 200(1): 131-141.
24. Saito M, Terada M, Kawata T, Ito H, Shigematsu N, et al. (2008) Effects of single or repeated administrations of methamphetamine on immune response in mice. Exp Anim 57(1): 35-43.
25. Kaye S, McKetin R, Duflou J, Darke S (2007) Methamphetamine and cardiovascular pathology: a review of the evidence. Addiction 102(8): 1204-1211.
26. Newton TF, De La Garza R 2nd, Kalechstein AD, Nestor L (2005) Cocaine and methamphetamine produce different patterns of subjective and cardiovascular effects. Pharmacol Biochem Behav 82(1): 90-97.
27. McGee SM, McGee DN, McGee MB (2004) Spontaneous intracerebral hemorrhage related to methamphetamine abuse: autopsy findings and clinical correlation. Am J Forensic Med Pathol 25(4): 334-337.
28. Cadet JL, Krasnova IN (2009) Molecular bases of methamphetamine-induced neurodegeneration. Int Rev Neurobiol 88: 101-119.
29. Caldwell J, Dring LG, Williams RT (1972) Biliary excretion of amphetamine and methamphetamine in the rat. Biochem J 129(1): 25-29.
30. Merki HS, Witzel L, Walt RP, Cohnen E, Harre K, et al. (1988) Day-to-day variation of 24-hour intragastric acidity. Gastroenterology 94(4): 887-891.
31. Volkow ND, Li TK (2004) Drug addiction: the neurobiology of behaviour gone awry. Nat Rev Neurosci 5(12): 963-970.
32. Wheeler JM, Reed C, Burkhart-Kasch S, Li N, Cunningham CL, et al. (2009) Genetically correlated effects of selective breeding for high and low methamphetamine consumption. Genes Brain Behav 8(8): 758-771.
33. Fowler JS, Kroll C, Ferrieri R, Alexoff D, Logan J, et al. (2007) PET studies of dmethamphetamine pharmacokinetics in primates: comparison with l-methamphetamine and (-)-cocaine. J Nucl Med 48(10): 1724-1732.
34. Takano A, Ito H, Sudo Y, Inoue M, Ichimiya T, et al. (2007) Effects of smoking on the lung accumulation of [11C]McN5652. Ann Nucl Med 21(6): 349-354.
35. Fowler JS, Volkow ND, Logan J, Alexoff D, Telang F, et al. (2008) Fast uptake and long-lasting binding of methamphetamine in the human brain: comparison with cocaine. Neuroimage 43: 756-763.
36. Dean D, Herbener TE (2000) Cross-sectional human anatomy. Philadelphia: Lippincott Williams & Wilkins. pp 8-59.
37. de la Grandmaison GL, Clairand I, Durigon M (2001) Organ weight in 684 adult autopsies: new tables for a Caucasoid population. Forensic Sci Int 119(2): 149-154.