Mechanism of inactivation of escherichia coli aspartate aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid

Biochemistry

Volumn 49, Issue 49, 2010, Pages 10507-10515

  Liu, Dali ^a   Pozharski, Edwin ^a,c   Fu, Mengmeng ^b,d   Silverman, Richard B ^b   Ringe, Dagmar ^a  

^a BRANDEIS UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF MARYLAND   (United States)

^d PLLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2-FURANCARBOXYLIC ACID; ACTIVE SITE; AMINO GROUP; AMINOBUTYRIC ACIDS; AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BINDING CONFIGURATION; CATALYTIC LYSINE; COCRYSTALLIZATION; COMPLEX STRUCTURE; E. COLI; ENZYME COMPLEXES; KETIMINES; NEUROLOGICAL DISEASE; PLP-DEPENDENT ENZYMES; POTENTIAL DRUG; STRUCTURAL STUDIES; TRANSAMINATION REACTION;

AMINO ACIDS; ENZYMES; ESCHERICHIA COLI;

REACTION INTERMEDIATES;

4 AMINO 4,5 DIHYDRO 2 FUROIC ACID; 4 AMINOBUTYRIC ACID; ASPARTATE AMINOTRANSFERASE; CARBOXYLIC ACID; PYRIDOXAMINE PHOSPHATE; QUINONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; COVALENT BOND; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG ACTIVITY; DRUG BINDING; ENZYME INACTIVATION; ESCHERICHIA COLI; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTON TRANSPORT; STRUCTURE ANALYSIS;

ASPARTATE AMINOTRANSFERASES; CRYSTALLIZATION; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FURANS; THIOPHENES;

ESCHERICHIA COLI;

EID: 78650091551     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi101325z     Document Type: Article

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