Statistical analysis of low molecular mass heparin Nanoencapsulation

Acta Pharmaceutica

Volumn 60, Issue 3, 2010, Pages 281-293

  Ganti, Vaishnavi ^a   Mengesha, Abebe ^a   Marszalek, Jacob ^a   Youan, Bi Botti ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

Box Behnken design; encapsulation efficiency; heparin; nanoparticle

Indexed keywords

LOW MOLECULAR WEIGHT HEPARIN; NANOPARTICLE; POLYMER; POLYVINYL ALCOHOL; SOLVENT;

ARTICLE; DRUG DESIGN; DRUG FORMULATION; EMULSION; LIGHT SCATTERING; MOLECULAR WEIGHT; NANOENCAPSULATION; PARTICLE SIZE; SPECTROPHOTOMETRY; STATIC ELECTRICITY; STATISTICAL ANALYSIS;

EID: 78650090127     PISSN: 13300075     EISSN: 18469558     Source Type: Journal    
DOI: 10.2478/v10007-010-0022-y     Document Type: Article

References (15)

1. R. A. Lionberger, S. L. Lee, A. Raw and L. X. Yu, Quality by design: concepts for ANDAs, AAPS Journal 10 (2008) 268-276; DOI: 10.1208/s12248-008- 9026-7.
2. L. C. Du Toit, V. Pillay, M. P. Danckwerts and C. Penny, Formulation and statistical optimization of a novel crosslinked polymeric anti-tuberculosis drug delivery system, J. Pharm. Sci. 97 (2008) 2176-2207; DOI: 10.1002/jps.21159.
3. P. S. Damus, M. Hicks and R. D. Rosenberg, Anticoagulant action of heparin, Nature 246 (1973) 355-357; DOI: 10.1038/246355a0.
4. L. B. Jacques, Heparin: an old drug with a new paradigm, Science 206 (1979) 528-533; DOI: 10. 1126/science.386509.
5. M. Meysman and P. Haentjens, Pulmonary embolism: current treatment options, Curr. Treat. Options Cardiovas. Med. 7 (2005) 483-490; DOI: 10.1007/s11936-005-0034-y.
6. N. A. Motlekar and B. B. Youan, The quest for non-invasive delivery of bioactive macromole-cules: a focus on heparins, J. Control. Rel. 113 (2006) 91-101; DOI: 10.1016/j.jconrel.2006.04.008.
7. G. E. P. Box and D. W. Behnken, Some new three level designs for the study of quantitative variables, Technometrics 2 (1960) 455-476; DOI: 10.2307/1266454.
8. A. Lamprecht, N. Ubrich, M. Hombreiro Perez, C. Lehr, M. Hoffman and P. Maincent, Influences of process parameters on nanoparticle preparation performed by a double emulsion pressure homogenization technique, Int. J. Pharm. 196 (2000) 177-182; DOI: 10.1016/S0378-5173(99) 00422-6.
9. L. H. Lam, J. E. Silbert and R. D. Rosenberg, The separation of active and inactive forms of hepa-rin, Biochem. Biophys. Res. Commun. 69 (1976) 570-577; DOI: 10.1016/0006-291X(76)90558-1.
10. S. K. Sahoo, J. Panyam, S. Prabha and V. Labhasetwar, Residual polyvinyl alcohol associated with poly (D,L-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake, J. Control. Rel. 82 (2002) 105-114; DOI: 10.1016/S0168-3659(02)00127-X.
11. Y. Jiao, N. Ubrich, M. Marchand-Arvier, C. Vigneron, M. Hoffman, T. Lecompte and P. Main-cent, In vitro and in vivo evaluation of oral heparin-loaded polymeric nanoparticles in rabbits, Circulation 105 (2002) 230-235; DOI: 10.1161/hc0202.101988.
12. W. Abdelwahed, G. Degobert and H. Fessi, A pilot study of freeze drying of poly(epsilon-caprolactone) nanocapsules stabilized by poly(vinyl alcohol): formulation and process optimization, Int. J. Pharm. 309 (2006) 178-188; DOI: 10.1016/j.ijpharm.2005.10.003.
13. M. F. Zambaux, F. Bonneaux, R. Gref, P. Maincent, E. Dellacherie, M. J. Alonso, P. Labrude and C. Vigneron, Influence of experimental parameters on the characteristics of poly(lactic acid) nanoparticles prepared by a double emulsion method, J. Control. Rel. 50 (1998) 31-40; DOI: 10. 1016/S0168-3659(97)00106-5.
14. D. Quintanar-Guerrero, H. Fessi, E. Allemann and R. E. Doelke, Influence of stabilizing agents and preparative variables on the formation of poly(D,L-lactic acid) nanoparticles by an emulsification-diffusion technique, Int. J. Pharm. 143 (1996) 133-141; DOI: 10.1016/S0378-5173(96) 04697-2.
15. Y. Liu, K. Kathan, W. Saad and R. K. Prud'homme, Ostwald ripening of beta-carotene nano-particles, Phys. Rev. Lett. 98 (2007) 036102; DOI: 10.1103/PhysRevLett.98.036102.