Enhancement of docosahexaenoic acid production by Schizochytrium sp. using a two-stage oxygen supply control strategy based on oxygen transfer coefficient

Letters in Applied Microbiology

Volumn 52, Issue 1, 2011, Pages 22-27

  Qu, L ^a   Ji, X J ^a   Ren, L J ^a   Nie, Z K ^a   Feng, Y ^a   Wu, W J ^a   Ouyang, P K ^a   Huang, H ^a  

^a NANJING TECH UNIVERSITY   (China)

Author keywords

Docosahexaenoic acid; Oxygen transfer; Schizochytrium sp.; Two stage strategy

Indexed keywords

PHYSIOLOGY; UNSATURATED FATTY ACIDS;

ACID PRODUCTION; CONTROL STRATEGIES; DOCOSAHEXAENOIC ACID; HIGH PRODUCTIVITY; MICROBIAL PHYSIOLOGY; OXYGEN TRANSFER; SCHIZOCHYTRIA SP.; SCHIZOCHYTRIUM; SUPPLY CONTROL; TWO-STAGE STRATEGY;

OXYGEN SUPPLY;

DOCOSAHEXAENOIC ACID;

BACTERIUM; BIOTECHNOLOGY; CONTROL SYSTEM; EXPERIMENTAL STUDY; FATTY ACID; OXYGEN; PHYSIOLOGY;

ALGAL GROWTH; ARTICLE; CELL GROWTH; CONTROLLED STUDY; FATTY ACID SYNTHESIS; FERMENTATION; MICROALGA; NONHUMAN; OXYGEN SUPPLY; OXYGEN TRANSPORT; PARAMETER; SCALE UP; SCHIZOCHYTRIUM;

SCHIZOCHYTRIUM;

EID: 78650077683     PISSN: 02668254     EISSN: 1472765X     Source Type: Journal    
DOI: 10.1111/j.1472-765X.2010.02960.x     Document Type: Article

References (17)

1. Bailey, R.B., DiMasi, D., Hansen, J.M., Mirrasoul, P.J., Ruecker, C.M., Veeder, G.T. III, Kaneko, T. and Barclay, W.R. (2003) Enhanced production of lipids containing polyenoic fatty acid by very high density cultures of eukaryotic microbes in fermentors. US Patent 6607900.
2. Chi, Z.Y., Hu, B., Liu, Y., Frear, C., Wen, Z.Y. and Chen, S.L. (2007) Production of ω-3 Polyunsaturated Fatty Acids From Cull Potato Using an Algae Culture Process. Appl Microbiol Biotechnol 134-140, 805-815.
3. Chi, Z.Y., Liu, Y., Frear, C. and Chen, S.L. (2009) Study of a two-stage growth of DHA-producing marine algae Schizochytrium limacinum SR21 with shifting dissolved oxygen level. Appl Microbiol Biotechnol 81, 1141-1148.
4. Huang, H., Ren, L.J., Xiao, A.H., Jin, L.J. and Li, J. (2009) A kind of Schizotrium sp. and the method for DHA-rich oil production using thereof. Chinese Patent (in Chinese), 200910033869.5.
5. Jakobsen, A.N., Aasen, I.M., Josefsen, K.D. and Strom, A.R. (2008) Accumulation of docosahexaenoic acid-rich lipid in thraustochytrid Aurantiochytrium sp. strain T66: effects of N and P starvation and O2 limitation. Appl Microbiol Biotechnol 80, 297-306.
6. Ji, X.J., Huang, H., Du, J., Zhu, J.G., Ren, L.J., Hu, N. and Li, S. (2009) Enhanced 2, 3-butanediol production by Klebsiella oxytoca using a two-stage agitation speed control strategy. Bioresour Technol 100, 3410-3414.
7. Lauritzen, L., Hansen, H.S., Jorgensen, M.H. and Michaelsen, K.F. (2001) The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina. Prog Lipid Res 40, 1-94.
8. Metz, J.G., Roessler, P., Facciotti, D., Levering, C., Dittrich, F., Lassner, M., Valentine, R., Lardizabal, K. et al. (2001) Production of polyunsaturated fatty acids by polyketide synthases in both prokaryotes and eukaryotes. Science 293, 290-293.
9. Nordoy, A., Marchioli, R., Arnesen, H. and Videbaek, J. (2001) n-3 polyunsaturated fatty acids and cardiovascular diseases. Lipids 36, 127-129.
10. Perveen, Z., Ando, H., Ueno, A., Ito, Y., Yamamoto, Y., Yamada, Y., Takagi, T., Kaneko, T. et al. (2006) Isolation and characterization of a novel thraustochytrid-like microorganism that efficiently produces docosahexaenoic acid. Biotechnol Lett 28, 197-202.
11. Puskeiler, R. and Weuster-Botz, D. (2005) Combined sulfite method for the measurement of the oxygen transfer coefficient KLa in bioreactors. J Biotechnol 120, 438.
12. Ratledge, C. (2004) Fatty acid biosynthesis in microorganisms being used for Single Cell Oil production. Biochimie 86, 807-815.
13. Ren, L.J., Huang, H., Xiao, A.H., Lian, M. and Ji, X.J. (2009) Enhanced docosahexaenoic acid production by reinforcing acetyl-CoA and NADPH supply in Schizochytrium sp. HX-308. Bioprocess Biosyst Eng 32, 837-843.
14. Ren, L.J., Ji, X.J., Huang, H., Feng, Y., Qu, L., Tong, Q.Q. and Ouyang, P.K. (2010) Development of a stepwise aeration control strategy for efficient docosahexaenoic acid production by Schizochytrium sp. Appl Microbiol Biotechnol 87, 1649-1656.
15. Sijtsma, L. and De Swaaf, M.E. (2004) Biotechnological production and applications of the ω-3 polyunsaturated fatty acid docosahexaenoic acid. Appl Microbiol Biotechnol 64, 146-153.
16. Unagul, P., Assantachai, C., Phadungruengluij, S., Pongsuteeragul, T., Suphantharika, M. and Verduyn, C. (2006) Biomass and docosahexaenoic acid formation by Schizochytrium mangrovei Sk-02 at low salt concentrations. Bot Mar 49, 182-190.
17. Yaguchi, T., Tanaka, S., Yokochi, T., Nakahara, T. and Higashihara, T. (1997) Production of high yields of docosahexaenoic acid by Schizochytrium sp. strain SR21. J Am Oil Chem Soc 74, 1431-1434.