Anterior visceral endoderm SMAD4 signaling specifies anterior embryonic patterning and head induction in mice

International Journal of Biological Sciences

Volumn 6, Issue 6, 2010, Pages 569-583

  Li, Cuiling ^a   Li, Yi Ping ^b   Fu, Xin Yuan ^c   Deng, Chu Xia ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b FORSYTH INSTITUTE   (United States)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Ave; Epiblast; Mesoderm patterning; Smad4; Tgf beta

Indexed keywords

MUS;

EID: 78650074909     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.6.569     Document Type: Article

References (53)

1. Nakaya Y, Sheng G. Epithelial to mesenchymal transition during gastrulation: an embryological view. Dev Growth Differ. 2008; 50:755-766.
2. Chenoweth JG, McKay RD, Tesar PJ. Epiblast stem cells contribute new insight into pluripotency and gastrulation. Dev Growth Differ. 2010; 52:293-301.
3. Arnold SJ, Robertson EJ. Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo. Nat Rev Mol Cell Biol. 2009; 10:91-103.
4. Tam PP, Loebel DA, Tanaka SS. Building the mouse gastrula: signals, asymmetry and lineages. Curr Opin Genet Dev. 2006; 16:419-425.
5. Chea HK, Wright CV, Swalla BJ. Nodal signaling and the evolution of deuterostome gastrulation. Dev Dyn. 2005; 234:269-278.
6. Perea-Gomez A, Rhinn M, Ang SL. Role of the anterior visceral endoderm in restricting posterior signals in the mouse embryo. Int J Dev Biol. 2001; 45:311-320.
7. Weinstein M, Yang X, Deng C. Functions of mammalian smad genes as revealed by targeted gene disruption in mice [In Process Citation]. Cytokine Growth Factor Rev. 2000; 11:49-58.
8. Heldin CH, Miyazono K, ten Dijke P. TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature. 1997; 390:465-471.
9. Massague J. TGF-beta signal transduction. Ann Rev Biochem. 1998; 67:753-791.
10. Weinstein M, Deng CX. Genetic disruptions within the murine genome reveal the numerous roles of the Smad gene family in development, disease, and cancer. In: Dijke PT and Heldin CH, eds. Smad signal Transduction: Smads in proliferation, differentiation and disease. US: Springer. 2006:151-171.
11. Wu MY, Hill CS. Tgf-beta superfamily signaling in embryonic development and homeostasis. Dev Cell. 2009; 16:329-343.
12. Gu Z, Nomura M, Simpson BB, et al. The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse. Genes Dev. 1998; 12:844-857.
13. Song J, Oh SP, Schrewe H, et al. The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice. Dev Biol. 1999; 213:157-169.
14. Winnier G, Blessing M, Labosky PA, et al. Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev. 1995; 9:2105-2116.
15. Zhou X, Sasaki H, Lowe L, et al. Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation. Nature. 1993; 361:543-547.
16. Moustakas A, Heldin CH. The regulation of TGFbeta signal transduction. Development. 2009; 136:3699-3714.
17. Howe JR, Roth S, Ringold JC, et al. Mutations in the SMAD4/DPC4 gene in juvenile polyposis [see comments]. Science. 1998; 280:1086-1088.
18. Hahn SA, Hoque AT, Moskaluk CA, et al. Homozygous deletion map at 18q21.1 in pancreatic cancer. Cancer Res. 1996; 56:490-494.
19. Friedl W, Kruse R, Uhlhaas S, et al. Frequent 4-bp deletion in exon 9 of the SMAD4/MADH4 gene in familial juvenile polyposis patients. Genes Chromosomes Cancer. 1999; 25:403-406.
20. Li W, Qiao W, Chen L, et al. Squamous cell carcinoma and mammary abscess formation through squamous metaplasia in Smad4/Dpc4 conditional knockout mice. Development. 2003; 130:6143-6153.
21. Bornstein S, White R, Malkoski S, et al. Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation. J Clin Invest. 2009; 119:3408-3419.
22. Yang G, Yang X. Smad4-mediated TGF-beta signaling in tumorigenesis. Int J Biol Sci. 2010; 6:1-8.
23. Xu X, Ehdaie B, Ohara N, et al. Synergistic action of Smad4 and Pten in suppressing pancreatic ductal adenocarcinoma formation in mice. Oncogene. 2010; 29:674-686.
24. Xu X, Kobayashi S, Qiao W, et al. Induction of intrahepatic cholangiocellular carcinoma by liver specific disruption of Smad4 and Pten in mice. Journal of Clinic Investigation. 2006; in press
25. Yang L, Mao C, Teng Y, et al. Targeted disruption of Smad4 in mouse epidermis results in failure of hair follicle cycling and formation of skin tumors. Cancer Res. 2005; 65:8671-8678.
26. Qiao W, Li AG, Owens P, et al. Hair follicle defects and squamous cell carcinoma formation in Smad4 conditional knockout mouse skin. Oncogene. 2006; 25:207-217.
27. Weinstein M, Monga SP, Liu Y, et al. Smad proteins and hepatocyte growth factor control parallel regulatory pathways that converge on beta1-integrin to promote normal liver development. Mol Cell Biol. 2001; 21:5122-5131.
28. Sirard C, de la Pompa JL, Elia A, et al. The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev. 1998; 12:107-119.
29. Yang X, Li C, Xu X, et al. The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice. Proc Natl Acad Sci U S A. 1998; 95:3667-3672.
30. Chu GC, Dunn NR, Anderson DC, et al. Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo. Development. 2004; 131:3501-3512.
31. Soriano P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet. 1999; 21:70-71.
32. Yang X, Li C, Herrera PL, et al. Generation of Smad4/Dpc4 conditional knockout mice. Genesis. 2002; 32:80-81.
33. de Souza FS, Niehrs C. Anterior endoderm and head induction in early vertebrate embryos. Cell Tissue Res. 2000; 300:207-217.
34. Beddington RS, Robertson EJ. Axis development and early asymmetry in mammals. Cell. 1999; 96:195-209.
35. Shawlot W, Deng JM, Behringer RR. Expression of the mouse cerberus-related gene, Cerr1, suggests a role in anterior neural induction and somitogenesis. Proc Natl Acad Sci U S A. 1998; 95:6198-6203.
36. Shawlot W, Behringer RR. Requirement for Lim1 in head-organizer function. Nature. 1995; 374:425-430.
37. Nagy A, Gocza E, Diaz EM, et al. Embryonic stem cells alone are able to support fetal development in the mouse. Development. 1990; 110:815-821.
38. Li C, Guo H, Xu X, et al. Fibroblast growth factor receptor 2 (Fgfr2) pl ays an i mportant rol e i n eyeli d and ski n formati on and patterning. Dev Dyn. 2001; 222:471-483.
39. Tallquist MD, Soriano P. Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra- embryonic gene function. Genesis. 2000; 26:113-115.
40. Hayashi S, Lewis P, Pevny L, et al. Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Gene Expr Patterns. 2002; 2:93-97.
41. Thorey IS, Meneses JJ, Neznanov N, et al. Embryonic expression of human keratin 18 and K18-beta-galactosidase fusion genes in transgenic mice. Dev Biol. 1993; 160:519-534.
42. Soudais C, Bielinska M, Heikinheimo M, et al. Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro. Development. 1995; 121:3877-3888.
43. Abe K, Niwa H, Iwase K, et al. Endoderm-specific gene expression in embryonic stem cells differentiated to embryoid bodies. Exp Cell Res. 1996; 229:27-34.
44. Kwon GS, Hadjantonakis AK. Transthyretin mouse transgenes direct RFP expression or Cre-mediated recombination throughout the visceral endoderm. Genesis. 2009; 47:447-455.
45. Costa RH, Van Dyke TA, Yan C, et al. Similarities in transthyretin gene expression and differences in transcription factors: liver and yolk sac compared to choroid plexus. Proc Natl Acad Sci U S A. 1990; 87:6589-6593.
46. Srinivas S. The anterior visceral endoderm-turning heads. Genesis. 2006; 44:565-572.
47. Weinstein M, Yang X, Li C, et al. Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2. Proc Natl Acad Sci U S A. 1998; 95:9378-9383.
48. Ang SL, Rossant J. HNF-3 beta is essential for node and notochord formation in mouse development. Cell. 1994; 78:561-574.
49. Meno C, Shimono A, Saijoh Y, et al. lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal. Cell. 1998; 94:287-297.
50. Acampora D, Mazan S, Lallemand Y, et al. Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation. Development. 1995; 121:3279-3290.
51. Riddle RD, Johnson RL, Laufer E, et al. Sonic-hedgehog mediates the polarizing activity of the zpa. Cell. 1993; 75:1401-1416.
52. Xiong JW, Battaglino R, Leahy A, et al. Large-scale screening for developmental genes in embryonic stem cells and embryoid bodies using retroviral entrapment vectors. Dev Dyn. 1998; 212:181-197.
53. Mansour SL, Goddard JM, Capecchi MR. Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear. Development. 1993; 117:13-28.