The therapeutic potential of engineered human neovessels for cell-based gene therapy

Expert Opinion on Biological Therapy

Volumn 11, Issue 1, 2011, Pages 67-76

  Álvarez Vallina, Luís ^a   Sanz, Laura ^a  

^a HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

Author keywords

angiogenesis; animal model; microvessel engineering

Indexed keywords

ANTIBODY; APOLIPOPROTEIN E; BLOOD CLOTTING FACTOR 8; CARCINOEBRYONIC ANTIGEN ANTIBODY; CD133 ANTIGEN; CD3 ANTIBODY; CD34 ANTIGEN; COLLAGEN; ENHANCED GREEN FLUORESCENT PROTEIN; HUMAN GROWTH HORMONE; LUCIFERASE; MATRIGEL; PROTEIN BCL 2; SEMAXANIB; SMOOTH MUSCLE ACTIN; TELOMERASE REVERSE TRANSCRIPTASE; TISSUE SCAFFOLD; UNCLASSIFIED DRUG;

ANGIOGENESIS; BASEMENT MEMBRANE; CELL BASED GENE THERAPY; DNA MODIFICATION; EMBRYONIC STEM CELL; ENDOTHELIUM CELL; FIBROBLAST; HEMOPHILIA A; HUMAN; IMMUNE DEFICIENCY; IN VIVO STUDY; MESENCHYMAL STEM CELL; MICROVASCULATURE; PERICYTE; PLURIPOTENT STEM CELL; PROTEIN SECRETION; PROTEIN SYNTHESIS; REVIEW; SAPHENOUS VEIN; SMOOTH MUSCLE FIBER; TISSUE ENGINEERING; VASCULAR ENDOTHELIUM;

ANIMALS; BLOOD VESSELS; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; GENE THERAPY; HUMANS; MICE; TISSUE ENGINEERING;

ANIMALIA;

EID: 78650073098     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.2011.538378     Document Type: Review

References (62)

1. Jain RK. Molecular regulation of vessel maturation. Nat Med 2003;9:685-93
2. Kalluri R. Basement membranes: Structure, assembly and role in tumour angiogenesis. Nat Rev Cancer 2003;3:422-33
3. Sanz L, Alvarez-Vallina L. The extracellular matrix: A new turn-of-thescrew for anti-angiogenic strategies. Trends Mol Med 2003;9:256-62
4. Kubota Y, Kleinman HK, Martin GR, Lawley TJ. Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures. J Cell Biol 1988;107:1589-98
5. Kleinman HK, McGarvey ML, Hassell JR, et al. Basement membrane complexes with biological activity. Biochemistry 1986;25:312-18
6. Arnaoutova I, George J, Kleinman HK, Benton G. The endothelial cell tube formation assay on basement membrane turns 20: State of the science and the art. Angiogenesis 2009;12:267-74
7. Kibbey MC, Grant DS, Kleinman HK. Role of the SIKVAV site of laminin in promotion of angiogenesis and tumor growth: An in vivo Matrigel model. J Natl Cancer Inst 1992;84:1633-8
8. Passaniti A, Taylor RM, Pili R, et al. A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor. Lab Invest 1992;67:519-28
9. Andrade SP, Machado RD, Teixeira AS, et al. Sponge-induced angiogenesis in mice and the pharmacological reactivity of the neovasculature quantitated by a fluorimetric method. Microvasc Res 1997;54:253-61
10. Andrade SP, Ferreira MA. The sponge implant model of angiogenesis. Methods Mol Biol 2009;467:295-304
11. Thompson JA, Anderson KD, DiPietro JM, et al. Site-directed neovessel formation in vivo. Science 1988;241:1349-52
12. Norrby K. In vivo models of angiogenesis. J Cell Mol Med 2006;10:588-612
13. Staton CA, Reed MW, Brown NJ. A critical analysis of current in vitro and in vivo angiogenesis assays. Int J Exp Pathol 2009;90:195-221
14. Nor JE, Christensen J, Mooney DJ, Polverini PJ. Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression. Am J Pathol 1999;154:375-84
15. Nor JE, Peters MC, Christensen JB, et al. Engineering and characterization of functional human microvessels in immunodeficient mice. Lab Invest 2001;81:453-63
16. Enis DR, Shepherd BR, Wang Y, et al. Induction, differentiation, and remodeling of blood vessels after transplantation of Bcl-2-transduced endothelial cells. Proc Natl Acad Sci USA 2005;102:425-30
17. Schechner JS, Nath AK, Zheng L, et al. In vivo formation of complex microvessels lined by human endothelial cells in an immunodeficient mouse. Proc Natl Acad Sci USA 2000;97:9191-6
18. Lokmic Z, Mitchell GM. Engineering the microcirculation. Tissue Eng B Rev 2008;14:87-103
19. Yang J, Nagavarapu U, Relloma K, et al. Telomerized human microvasculature is functional in vivo. Nat Biotechnol 2001;19:219-24
20. Skovseth DK, Yamanaka T, Brandtzaeg P, et al. Vascular morphogenesis and differentiation after adoptive transfer of human endothelial cells to immunodeficient mice. Am J Pathol 2002;160:1629-37
21. Bagley RG, Walter-Yohrling J, Cao X, et al. Endothelial precursor cells as a model of tumor endothelium: Characterization and comparison with mature endothelial cells. Cancer Res 2003;63:5866-73
22. Sieminski AL, Padera RF, Blunk T, Gooch KJ. Systemic delivery of human growth hormone using genetically modified tissue-engineered microvascular networks: Prolonged delivery and endothelial survival with inclusion of nonendothelial cells. Tissue Eng 2002;8:1057-69
23. Koike N, Fukumura D, Gralla O, et al. Tissue engineering: Creation of long-lasting blood vessels. Nature 2004;428:138-9
24. Hirschi KK, Rohovsky SA, D'Amore PA. PDGF, TGF-beta, and heterotypic cell-cell interactions mediate endothelial cell-induced recruitment of 10T1/2 cells and their differentiation to a smooth muscle fate. J Cell Biol 1998;141:805-14
25. Wang ZZ, Au P, Chen T, et al. Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo. Nat Biotechnol 2007;25:317-18
26. Ferreira LS, Gerecht S, Shieh HF, et al. Vascular progenitor cells isolated from human embryonic stem cells give rise to endothelial and smooth muscle like cells and form vascular networks in vivo. Circ Res 2007;101:286-94
27. Levenberg S, Rouwkema J, Macdonald M, et al. Engineering vascularized skeletal muscle tissue. Nat Biotechnol 2005;23:879-84
28. Black AF, Berthod F, L'heureux N, et al. In vitro reconstruction of a human capillary-like network in a tissue-engineered skin equivalent. FASEB J 1998;12:1331-40
29. Rouwkema J, de Boer J, van Blitterswijk CA. Endothelial cells assemble into a 3-dimensional prevascular network in a bone tissue engineering construct. Tissue Eng 2006;12:2685-93
30. Laschke MW, Vollmar B, Menger MD. Inosculation: Connecting the life-sustaining pipelines. Tissue Eng B Rev 2009;15:455-65
31. Rouwkema J, Rivron NC, van Blitterswijk CA. Vascularization in tissue engineering. Trends Biotechnol 2008;26:434-41
32. Melero-Martin JM, Khan ZA, Picard A, et al. In vivo vasculogenic potential of human blood-derived endothelial progenitor cells. Blood 2007;109:4761-8
33. Au P, Daheron LM, Duda DG, et al. Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels. Blood 2008;111:1302-5
34. Ingram DA, Mead LE, Tanaka H, et al. Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood. Blood 2004;104:2752-60
35. Sanz L, Santos-Valle P, Alonso-Camino V, et al. Long-term in vivo imaging of human angiogenesis: Critical role of bone marrow-derived mesenchymal stem cells for the generation of durable blood vessels. Microvasc Res 2008;75:308-14
36. Dong Z, Neiva KG, Jin T, et al. Quantification of human angiogenesis in immunodeficient mice using a photon counting-based method. Biotechniques 2007;43:73-7
37. Au P, Tam J, Fukumura D, Jain RK. Bone marrow-derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature. Blood 2008;111:4551-8
38. Melero-Martin JM, De Obaldia ME, Kang SY, et al. Engineering robust and functional vascular networks in vivo with human adult and cord blood-derived progenitor cells. Circ Res 2008;103:194-202
39. Traktuev DO, Prater DN, Merfeld-Clauss S, et al. Robust functional vascular network formation in vivo by cooperation of adipose progenitor and endothelial cells. Circ Res 2009;104:1410-20
40. Traktuev DO, Merfeld-Clauss S, Li J, et al. A population of multipotent CD34-positive adipose stromal cells share pericyte and mesenchymal surface markers, reside in a periendothelial location, and stabilize endothelial networks. Circ Res 2008;102:77-85
41. Merfeld-Clauss S, Gollahalli N, March KL, Traktuev DO. Adipose tissue progenitor cells directly interact with endothelial cells to induce vascular network formation. Tissue Eng A 2010;16:2953-66
42. Alajati A, Laib AM, Weber H, et al. Spheroid-based engineering of a human vasculature in mice. Nat Methods 2008;5:439-45
43. Korff T, Augustin HG. Integration of endothelial cells in multicellular spheroids prevents apoptosis and induces differentiation. J Cell Biol 1998;143:1341-52
44. Callow AD. The vascular endothelial cell as a vehicle for gene therapy. J Vasc Surg 1990;11:793-8
45. Zwiebel JA, Freeman SM, Kantoff PW, et al. High-level recombinant gene expression in rabbit endothelial cells transduced by retroviral vectors. Science 1989;243:220-2
46. Squinto SP, Madri JA, Kennedy S, Springhorn J. The ENCEL system: A somatic cell protein delivery system. In Vivo 1994;8:771-80
47. Wei Y, Quertermous T, Wagner TE. Directed endothelial differentiation of cultured embryonic yolk sac cells in vivo provides a novel cell-based system for gene therapy. Stem Cells 1995;13:541-7
48. Wei Y, Li J, Wagner TE. Long-term expression of human growth hormone (hGH) in mice containing allogeneic yolk sac cell derived neovascular implants expressing hGH. Stem Cells 1996;14:232-8
49. Cioffi L, Sturtz FG, Wittmer S, et al. A novel endothelial cell-based gene therapy platform for the in vivo delivery of apolipoprotein E. Gene Ther 1999;6:1153-9
50. Matsui H, Shibata M, Brown B, et al. Ex vivo gene therapy for hemophilia A that enhances safe delivery and sustained in vivo factor VIII expression from lentivirally engineered endothelial progenitors. Stem Cells 2007;25:2660-9
51. Compte M, Alonso-Camino V, Santos-Valle P, et al. Factory neovessels: Engineered human blood vessels secreting therapeutic proteins as a new drug delivery system. Gene Ther 2010;17:745-51
52. Compte M, Cuesta AM, Sanchez-Martin D, et al. Tumor immunotherapy using gene-modified human mesenchymal stem cells loaded into synthetic extracellular matrix scaffolds. Stem Cells 2009;27:753-60
53. Aboody KS, Najbauer J, Danks MK. Stem and progenitor cell-mediated tumor selective gene therapy. Gene Ther 2008;15:739-52
54. Bexell D, Scheding S, Bengzon J. Toward brain tumor gene therapy using multipotent mesenchymal stromal cell vectors. Mol Ther 2010;18:1067-75
55. Menon LG, Shi VJ, Carroll RS. Mesenchymal stromal cells as a drug delivery system. StemBook. Harvard Stem Cell Institute, Cambridge (MA); 2008-2009
56. Xu D, Alipio Z, Fink LM, et al. Phenotypic correction of murine hemophilia A using an iPS cell-based therapy. Proc Natl Acad Sci USA 2009;106:808-13
57. Asahara T, Murohara T, Sullivan A, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997;275:964-7
58. Lin Y, Weisdorf DJ, Solovey A, Hebbel RP. Origins of circulating endothelial cells and endothelial outgrowth from blood. J Clin Invest 2000;105:71-7
59. Debatin KM, Wei J, Beltinger C. Endothelial progenitor cells for cancer gene therapy. Gene Ther 2008;15:780-6
60. Murohara T. Cord blood-derived early outgrowth endothelial progenitor cells. Microvasc Res 2010;79:174-7
61. Critser PJ, Kreger ST, Voytik-Harbin SL, Yoder MC. Collagen matrix physical properties modulate endothelial colony forming cell-derived vessels in vivo. Microvasc Res 2010;80:23-30
62. Moon JJ, Saik JE, Poche RA, et al. Biomimetic hydrogels with pro-angiogenic properties. Biomaterials 2010;31:3840-7