Enhanced biochemical and biomechanical properties of scaffolds generated by flock technology for cartilage tissue engineering

Tissue Engineering - Part A

Volumn 16, Issue 12, 2010, Pages 3697-3707

  Steck, Eric ^a   Bertram, Helge ^a   Walther, Anja ^b   Brohm, Kathrin ^a   Mrozik, Birgit ^c   Rathmann, Maxi ^a   Merle, Christian ^a   Gelinsky, Michael ^b   Richter, Wiltrud ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b Institute for Materials Science   (Germany)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANISOTROPY; BIOMECHANICS; BODY FLUIDS; CARTILAGE; CELL CULTURE; COLLAGEN; FIBERS; GELS; GLYCOPROTEINS; HARDNESS; HARDNESS TESTING; LIGAMENTS; STEM CELLS; TISSUE ENGINEERING;

ANISOTROPIC FIBER; ARTICULAR CHONDROCYTES; AUTOLOGOUS CHONDROCYTE IMPLANTATIONS; BIO-COMPOSITES; BIOCHEMICAL COMPOSITION; BIOMECHANICAL PROPERTIES; BIOMECHANICAL TESTING; CARTILAGE REPAIR; CARTILAGE TISSUE ENGINEERING; CHONDROGENESIS; CHONDROGENIC; COLLAGEN FIBER; COLLAGEN TYPE I; CONFOCAL LASER SCAN MICROSCOPIES; FIBER ORIENTATIONS; FLOCK TECHNOLOGY; IN-VITRO; MATRIX; MESENCHYMAL STEM CELL; MINERALIZED COLLAGEN; PARALLEL FIBERS; PROTEOGLYCANS; SCAFFOLD CONSTRUCTS; TYPE II;

SCAFFOLDS;

TISSUE SCAFFOLD;

ANIMAL; ARTICLE; ARTICULAR CARTILAGE; BIOMECHANICS; CARTILAGE CELL; CELL ADHESION; CELL CULTURE; CELL PROLIFERATION; CELL SURVIVAL; CONFOCAL MICROSCOPY; CYTOLOGY; GENETICS; HUMAN; MESENCHYMAL STEM CELL; METHODOLOGY; PHYSIOLOGY; SWINE; TISSUE ENGINEERING;

ANIMALS; BIOMECHANICS; CARTILAGE, ARTICULAR; CELL ADHESION; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CHONDROCYTES; HUMANS; MESENCHYMAL STEM CELLS; MICROSCOPY, CONFOCAL; SWINE; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 78650059090     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2009.0817     Document Type: Article

References (61)

1. Buckwalter, J.A., and Mankin, H.J. Articular cartilage repair and transplantation. Arthritis Rheum 41, 1331, 1998.
2. Hunziker, E.B., Quinn, T.M., and Hauselmann, H.J. Quantitative structural organization of normal adult human articular cartilage. Osteoarthritis Cartilage 10, 564, 2002.
3. Poole, A.R., Kojima, T., Yasuda, T., Mwale, F., Kobayashi, M., and Laverty, S. Composition and structure of articular cartilage: a template for tissue repair. Clin Orthop Relat Res 391 Suppl, S26, 2001.
4. Poole, A.R., Pidoux, I., Reiner, A., and Rosenberg, L. An immunoelectron microscope study of the organization of proteoglycan monomer, link protein, and collagen in the matrix of articular cartilage. J Cell Biol 93, 921, 1982.
5. Muehleman, C., Majumdar, S., Issever, A.S., Arfelli, F., Menk, R.H., Rigon, L., Heitner, G., Reime, B., Metge, J., Wagner, A., Kuettner, K.E., and Mollenhauer, J. X-ray detection of structural orientation in human articular cartilage. Osteoarthritis Cartilage 12, 97, 2004.
6. Van Breuseghem, I. Ultrastructural MR imaging techniques of the knee articular cartilage: problems for routine clinical application. Eur Radiol 14, 184, 2004.
7. Kaab, M.J., Gwynn, I.A., and Notzli, H.P. Collagen fibre arrangement in the tibial plateau articular cartilage of man and other mammalian species. J Anat 193 (Pt 1), 23, 1998.
8. Mow, V.C., and Wang, C.C. Some bioengineering considerations for tissue engineering of articular cartilage. Clin Orthop Relat Res 367 Suppl, S204, 1999.
9. Wu, J.Z., and Herzog, W. Elastic anisotropy of articular cartilage is associated with the microstructures of collagen fibers and chondrocytes. J Biomech 35, 931, 2002.
10. Leddy, H.A., Haider, M.A., and Guilak, F. Diffusional anisotropy in collagenous tissues: fluorescence imaging of continuous point photobleaching. Biophys J 91, 311, 2006.
11. Richter, W. Cell-based cartilage repair: illusion or solution for osteoarthritis. Curr Opin Rheumatol 19, 451, 2007.
12. Kaps, C., Frauenschuh, S., Endres, M., Ringe, J., Haisch, A., Lauber, J., Buer, J., Krenn, V., Haupl, T., Burmester, G.R., and Sittinger, M. Gene expression profiling of human articular cartilage grafts generated by tissue engineering. Bio-materials 27, 3617, 2006.
13. Steck, E., Fischer, J., Lorenz, H., Gotterbarm, T., Jung, M., and Richter, W. Mesenchymal stem cell differentiation in an experimental cartilage defect: restriction of hypertrophy to bone-close neocartilage. Stem Cells Dev 18, 969, 2009.
14. Jung, M., Kaszap, B., Redohl, A., Steck, E., Breusch, S., Richter, W., and Gotterbarm, T. Enhanced early tissue regeneration after matrix-assisted autologous mesenchymal stem cell transplantation in full thickness chondral defects in a minipig model. Cell Transplant 18, 923, 2009.
15. Bartlett, W., Skinner, J.A., Gooding, C.R., Carrington, R.W., Flanagan, A.M., Briggs, T.W., and Bentley, G. Autologous chondrocyte implantation versus matrix-induced autolo-gous chondrocyte implantation for osteochondral defects of the knee: a prospective, randomised study. J Bone Joint Surg Br 87, 640, 2005.
16. Marlovits, S., Zeller, P., Singer, P., Resinger, C., and Vecsei, V. Cartilage repair: generations of autologous chondrocyte transplantation. Eur J Radiol 57, 24, 2006.
17. Roberts, S., Menage, J., Sandell, L.J., Evans, E.H., and Richardson, J.B. Immunohistochemical study of collagen types I and II and procollagen IIA in human cartilage repair tissue following autologous chondrocyte implantation. Knee 16, 398, 2009.
18. Sharma, A., Wood, L.D., Richardson, J.B., Roberts, S., and Kuiper, N.J. Glycosaminoglycan profiles of repair tissue formed following autologous chondrocyte implantation differ from control cartilage. Arthritis Res Ther 9, R79, 2007.
19. Grigolo, B., Roseti, L., De Franceschi, L., Piacentini, A., Cattini, L., Manfredini, M., Faccini, R., and Facchini, A. Molecular and immunohistological characterization of human cartilage two years following autologous cell transplantation. J Bone Joint Surg Am 87, 46, 2005.
20. Mainil-Varlet, P., Aigner, T., Brittberg, M., Bullough, P., Hollander, A., Hunziker, E., Kandel, R., Nehrer, S., Pritzker, K., Roberts, S., and Stauffer, E. Histological assessment of cartilage repair: a report by the Histology Endpoint Committee of the International Cartilage Repair Society (ICRS). J Bone Joint Surg Am 85-A Suppl 2, 45, 2003.
21. Bersev, J.N., and Liebscher, U. Elektrostatisches Beflocken. Leipzig, Germany: Fachbuchverlag, 1983.
22. Walther, A., Bernhardt, A., Pompe, W., Gelinsky, M., Mro-zik, B., Hoffmann, G., Cherif, C., Bertram, H., Richter, W., and Schmack, G. Development of novel scaffolds for tissue engineering by flock technology. Textile Res J 77, 892, 2007.
23. Friedenstein, A.J., Chailakhyan, R.K., Latsinik, N.V., Pana-syuk, A.F., and Keiliss-Borok, I.V. Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo. Transplantation 17, 331, 1974.
24. Pittenger, M.F., Mackay, A.M., Beck, S.C., Jaiswal, R.K., Douglas, R., Mosca, J.D., Moorman, M.A., Simonetti, D.W., Craig, S., and Marshak, D.R. Multilineage potential of adult human mesenchymal stem cells. Science 284, 143, 1999.
25. Zuk, P.A., Zhu, M., Mizuno, H., Huang, J., Futrell, J.W., Katz, A.J., Benhaim, P., Lorenz, H.P., and Hedrick, M.H. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 7, 211, 2001.
26. Caplan, A.I., Elyaderani, M., Mochizuki, Y., Wakitani, S., and Goldberg, V.M. Principles of cartilage repair and regeneration. Clin Orthop Relat Res 342, 254, 1997.
27. Noth, U., Osyczka, A.M., Tuli, R., Hickok, N.J., Danielson, K.G., and Tuan, R.S. Multilineage mesenchymal differentiation potential of human trabecular bone-derived cells. J Orthop Res 20, 1060, 2002.
28. Noth, U., Tuli, R., Osyczka, A.M., Danielson, K.G., and Tuan, R.S. In vitro engineered cartilage constructs produced by press-coating biodegradable polymer with human mes-enchymal stem cells. Tissue Eng 8, 131, 2002.
29. Tuli, R., Tuli, S., Nandi, S., Huang, X., Manner, P.A., Hozack, W.J., Danielson, K.G., Hall, D.J., and Tuan, R.S. Transforming growth factor-beta-mediated chondrogenesis of human mesenchymal progenitor cells involves N-cadherin and mi-togen-activated protein kinase and Wnt signaling cross-talk. J Biol Chem 278, 41227, 2003.
30. Caplan, A.I., and Dennis, J.E. Mesenchymal stem cells as trophic mediators. J Cell Biochem 98, 1076, 2006.
31. Mackay, A.M., Beck, S.C., Murphy, J.M., Barry, F.P., Chi-chester, C.O., and Pittenger, M.F. Chondrogenic differentiation of cultured human mesenchymal stem cells from marrow. Tissue Eng 4, 415, 1998.
32. Winter, A., Breit, S., Parsch, D., Benz, K., Steck, E., Hauner, H., Weber, R.M., Ewerbeck, V., and Richter, W. Cartilagelike gene expression in differentiated human stem cell spheroids: a comparison of bone marrow-derived and adipose tissue-derived stromal cells. Arthritis Rheum 48, 418, 2003.
33. Steck, E., Bertram, H., Abel, R., Chen, B., Winter, A., and Richter, W. Induction of intervertebral disc-like cells from adult mesenchymal stem cells. Stem Cells 23, 403, 2005.
34. Bradt, J.H., Mertig, M., Teresiak, A., and Pompe, W. Bio-mimetic mineralization of collagen by combined fibril assembly and calcium phosphate formation. Chem Mater 11, 2694, 1999.
35. Bernhardt, A., Lode, A., Boxberger, S., Pompe, W., and Gelinsky, M. Mineralised collagen- an artificial, extracellular bone matrix- improves osteogenic differentiation of bone marrow stromal cells. J Mater Sci Mater Med 19, 269, 2008.
36. Benz, K., Breit, S., Lukoschek, M., Mau, H., and Richter, W. Molecular analysis of expansion, differentiation, and growth factor treatment of human chondrocytes identifies differentiation markers and growth-related genes. Biochem Biophys Res Commun 293, 284, 2002.
37. Bernhardt, A., Lode, A., Mietrach, C., Hempel, U., Hanke, T., and Gelinsky, M. In vitro osteogenic potential of human bone marrow stromal cells cultivated in porous scaffolds from mineralized collagen. J Biomed Mater Res A 90, 852, 2009.
38. Haynesworth, S.E., Goshima, J., Goldberg, V.M., and Ca-plan, A.I. Characterization of cells with osteogenic potential from human marrow. Bone 13, 81, 1992.
39. Bertram, H., Boeuf, S., Wachters, J., Boehmer, S., Heisel, C., Hofmann, M.W., Piecha, D., and Richter, W. Matrix me-talloprotease inhibitors suppress initiation and progression of chondrogenic differentiation of mesenchymal stromal cells in vitro. Stem Cells Dev 18, 881, 2009.
40. Johnstone, B., Hering, T.M., Caplan, A.I., Goldberg, V.M., and Yoo, J.U. In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp Cell Res 238, 265, 1998.
41. Fehrenbacher, A., Steck, E., Roth, W., Pahmeier, A., and Richter, W. Long-term mechanical loading of chondrocyte-chitosan biocomposites in vitro enhanced their proteoglycan and collagen content. Biorheology 43, 709, 2006.
42. Hoemann, C.D., Sun, J., Chrzanowski, V., and Buschmann, M.D. A multivalent assay to detect glycosaminoglycan, protein, collagen, RNA, and DNA content in milligram samples of cartilage or hydrogel-based repair cartilage. Anal Biochem 300, 1, 2002.
43. Bjornsson, S. Simultaneous preparation and quantitation of proteoglycans by precipitation with alcian blue. Anal Bio-chem 210, 282, 1993.
44. Dickhut, A., Dexheimer, V., Martin, K., Lauinger, R., Heisel, C., and Richter, W. Chondrogenesis of human mesenchymal stem cells by local TGF-beta delivery in a biphasic resorbable carrier. Tissue Eng Part A 16, 453, 2010.
45. Aurich, M., Squires, G.R., Reiner, A., Mollenhauer, J.A., Kuettner, K.E., Poole, A.R., and Cole, A.A. Differential matrix degradation and turnover in early cartilage lesions of human knee and ankle joints. Arthritis Rheum 52, 112, 2005.
46. Jennings, L., Wu, L., King, K.B., Hammerle, H., Cs-Szabo, G., and Mollenhauer, J. The effects of collagen fragments on the extracellular matrix metabolism of bovine and human chondrocytes. Connect Tissue Res 42, 71, 2001.
47. Haddo, O., Mahroof, S., Higgs, D., David, L., Pringle, J., Bayliss, M., Cannon, S.R., and Briggs, T.W. The use of chondrogide membrane in autologous chondrocyte implantation. Knee 11, 51, 2004.
48. Fuss, M., Ehlers, E.M., Russlies, M., Rohwedel, J., and Beh-rens, P. Characteristics of human chondrocytes, osteoblasts and fibroblasts seeded onto a type I/III collagen sponge under different culture conditions. A light, scanning and transmission electron microscopy study. Ann Anat 182, 303, 2000.
49. Ossendorf, C., Kaps, C., Kreuz, P.C., Burmester, G.R., Sit-tinger, M., and Erggelet, C. Treatment of posttraumatic and focal osteoarthritic cartilage defects of the knee with autol-ogous polymer-based three-dimensional chondrocyte grafts: 2-year clinical results. Arthritis Res Ther 9, R41, 2007.
50. Benya, P.D., and Shaffer, J.D. Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels. Cell 30, 215, 1982.
51. van Susante, J.L., Buma, P., van Osch, G.J., Versleyen, D., van der Kraan, P.M., van der Berg, W.B., and Homminga, G.N. Culture of chondrocytes in alginate and collagen carrier gels. Acta Orthop Scand 66, 549, 1995.
52. Suh, J.K., and Matthew, H.W. Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: a review. Biomaterials 21, 2589, 2000.
53. Katsube, K., Ochi, M., Uchio, Y., Maniwa, S., Matsusaki, M., Tobita, M., and Iwasa, J. Repair of articular cartilage defects with cultured chondrocytes in atelocollagen gel. Comparison with cultured chondrocytes in suspension. Arch Orthop Trauma Surg 120, 121, 2000.
54. Awad, H.A., Wickham, M.Q., Leddy, H.A., Gimble, J.M., and Guilak, F. Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds. Biomaterials 25, 3211, 2004.
55. Dickhut, A., Gottwald, E., Steck, E., Heisel, C., and Richter, W. Chondrogenesis of mesenchymal stem cells in gel-like biomaterials in vitro und in vivo. Front Biosci 13, 4517, 2008.
56. Vacanti, C.A., Langer, R., Schloo, B., and Vacanti, J.P. Synthetic polymers seeded with chondrocytes provide a template for new cartilage formation. Plast Reconstr Surg 88, 753, 1991.
57. Chu, C.R., Coutts, R.D., Yoshioka, M., Harwood, F.L., Monosov, A.Z., and Amiel, D. Articular cartilage repair using allogeneic perichondrocyte-seeded biodegradable porous polylactic acid (PLA): a tissue-engineering study. J Biomed Mater Res 29, 1147, 1995.
58. Metters, A.T., Anseth, K.S., and Bowman, C.N. Fundamental studies of biodegradable hydrogels as cartilage replacement materials. Biomed Sci Instrum 35, 33, 1999.
59. Grad, S., Kupcsik, L., Gorna, K., Gogolewski, S., and Alini, M. The use of biodegradable polyurethane scaffolds for cartilage tissue engineering: potential and limitations. Bio-materials 24, 5163, 2003.
60. Di Martino, A., Sittinger, M., and Risbud, M.V. Chitosan: a versatile biopolymer for orthopaedic tissue-engineering. Biomaterials 26, 5983, 2005.
61. Tsai, W.B., Chen, C.H., Chen, J.F., and Chang, K.Y. The effects of types of degradable polymers on porcine chon-drocyte adhesion, proliferation and gene expression. J Mater Sci Mater Med 17, 337, 2006.