Replicative and transcriptional activities of hepatitis B virus in patients coinfected with hepatitis B and hepatitis delta viruses

Journal of Virology

Volumn 85, Issue 1, 2011, Pages 432-439

  Pollicino, Teresa ^a   Raffa, Giuseppina ^a   Santantonio, Teresa ^b   Gaeta, Giovanni Battista ^c   Iannello, Giuliano ^d   Alibrandi, Angela ^e   Squadrito, Giovanni ^a   Cacciola, Irene ^a   Calvi, Chiara ^f   Colucci, Giuseppe ^g   Levrero, Massimo ^h   Raimondo, Giovanni ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF FOGGIA   (Italy)

^c SECOND UNIVERSITY OF NAPLES   (Italy)

^d Independent Statistician   (Italy)

^e UNIVERSITY OF MESSINA   (Italy)

^f Roche Diagnostics   (Italy)

^g Roche Molecular Systems   (Switzerland)

^h SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CIRCULAR DNA; COVALENTLY CLOSED CIRCULAR DNA; GENOMIC RNA; HEPATITIS B SURFACE ANTIGEN; PREGENOMIC RNA; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS ENVELOPE PROTEIN; VIRUS RNA;

ADOLESCENT; ADULT; AGED; ARTICLE; CHRONIC LIVER DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DELTA AGENT HEPATITIS; FEMALE; GENE DELETION; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS DELTA VIRUS; HUMAN; HUMAN TISSUE; LIVER BIOPSY; MALE; MIXED INFECTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; VIREMIA; VIRUS GENOME; VIRUS REPLICATION; VIRUS TRANSCRIPTION;

ADOLESCENT; ADULT; BASE SEQUENCE; BIOPSY; DNA, CIRCULAR; DNA, VIRAL; FEMALE; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HEPATITIS D, CHRONIC; HEPATITIS DELTA VIRUS; HUMANS; LIVER; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; RNA, VIRAL; TRANSCRIPTION, GENETIC; VIREMIA; VIRUS REPLICATION; YOUNG ADULT;

HEPATITIS B VIRUS; HEPATITIS DELTA VIRUS;

EID: 78650040589     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01609-10     Document Type: Article

References (40)

1. Bordier, B. B., J. Ohkanda, P. Liu, S. Y. Lee, F. H. Salazar, P. L. Marion, K. Ohashi, L. Meuse, M. A. Kay, J. L. Casey, S. M. Sebti, A. D. Hamilton, and J. S. Glenn. 2003. In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus. J. Clin. Invest. 112:407-414.
2. Chen, P. J., P. M. Yang, C. R. Chen, and D. S. Chen. 1989. Characterization of the transcripts of hepatitis D and B viruses in infected human livers. J. Infect. Dis. 160:944-947.
3. Chulanov, V. P., G. A. Shipulin, S. Schaefer, and W. H. Gerlich. 2003. Kinetics of HBV DNA and HBsAg in acute hepatitis B patients with and without coinfection by other hepatitis viruses. J. Med. Virol. 69:313-323.
4. Dandri, M., J. M. Murray, M. Lutgehetmann, T. Volz, A. W. Lohse, and J. Petersen. 2008. Virion half-life in chronic hepatitis B infection is strongly correlated with levels of viremia. Hepatology 48:1079-1086.
5. Farci, P., L. Chessa, C. Balestrieri, G. Serra, and M. E. Lai. 2007. Treatment of chronic hepatitis D. J. Viral Hepat. 14(Suppl. 1):58-63.
6. Feitelson, M. A., and J. Lee. 2007. Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis. Cancer Lett. 252:157-170. (Pubitemid 46809787)
7. Galibert, F., E. Mandart, F. Fitoussi, P. Tiollais, and P. Charnay. 1979. Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli. Nature 281:646-650. (Pubitemid 10249039)
8. Gerin, J. L. 2001. Animal models of hepatitis delta virus infection and disease. ILAR J. 42:103-106. (Pubitemid 33708701)
9. Heidrich, B., K. Deterding, H. L. Tillmann, R. Raupach, M. P. Manns, and H. Wedemeyer. 2009. Virological and clinical characteristics of delta hepatitis in Central Europe. J. Viral Hepat. 16:883-894.
10. Jardi, R., F. Rodriguez, M. Buti, X. Costa, M. Cotrina, R. Galimany, R. Esteban, and J. Guardia. 2001. Role of hepatitis B, C, and D viruses in dual and triple infection: influence of viral genotypes and hepatitis B precore and basal core promoter mutations on viral replicative interference. Hepatology 34:404-410.
11. Laras, A., J. Koskinas, E. Dimou, A. Kostamena, and S. J. Hadziyannis. 2006. Intrahepatic levels and replicative activity of covalently closed circular hepatitis B virus DNA in chronically infected patients. Hepatology 44:694-702.
12. Lopez-Talavera, J. C., M. Buti, J. Casacuberta, H. Allende, R. Jardi, R. Esteban, and J. Guardia. 1993. Detection of hepatitis delta virus RNA in human liver tissue by non-radioactive in situ hybridization. J. Hepatol. 17:199-203. (Pubitemid 23054487)
13. Manesis, E. K., M. Schina, F. Le Gal, O. Agelopoulou, C. Papaioannou, C. Kalligeros, V. Arseniou, S. Manolakopoulos, E. S. Hadziyannis, E. Gault, J. Koskinas, G. Papatheodoridis, and A. J. Archimandritis. 2007. Quantitative analysis of hepatitis D virus RNA and hepatitis B surface antigen serum levels in chronic delta hepatitis improves treatment monitoring. Antivir. Ther. 12:381-388.
14. Nassal, M. 2008. Hepatitis B viruses: reverse transcription a different way. Virus Res. 134:235-249.
15. Netter, H. J., K. Kajino, and J. M. Taylor. 1993. Experimental transmission of human hepatitis delta virus to the laboratory mouse. J. Virol. 67:3357-3362.
16. Pollicino, T., G. Raffa, L. Costantino, A. Lisa, C. Campello, G. Squadrito, M. Levrero, and G. Raimondo. 2007. Molecular and functional analysis of occult hepatitis B virus isolates from patients with hepatocellular carcinoma. Hepatology 45:277-285. (Pubitemid 46374584)
17. Radjef, N., E. Gordien, V. Ivaniushina, E. Gault, P. Anais, T. Drugan, J. C. Trinchet, D. Roulot, M. Tamby, M. C. Milinkovitch, and P. Deny. 2004. Molecular phylogenetic analyses indicate a wide and ancient radiation of African hepatitis delta virus, suggesting a deltavirus genus of at least seven major clades. J. Virol. 78:2537-2544.
18. Raimondo, G., M. R. Brunetto, P. Pontisso, A. Smedile, A. M. Maina, C. Saitta, G. Squadrito, and N. Tono. 2006. Longitudinal evaluation reveals a complex spectrum of virological profiles in hepatitis B virus/hepatitis C virus-coinfected patients. Hepatology 43:100-107.
19. Raimondo, G., T. Pollicino, I. Cacciola, and G. Squadrito. 2007. Occult hepatitis B virus infection. J. Hepatol. 46:160-170.
20. Rizzetto, M. 2010. Hepatitis D: clinical features and therapy. Dig. Dis. 28:139-143.
21. Rizzetto, M. 2009. Hepatitis D: thirty years after. J. Hepatol. 50:1043-1050.
22. Romeo, R., E. Del Ninno, M. Rumi, A. Russo, A. Sangiovanni, R. de Franchis, G. Ronchi, and M. Colombo. 2009. A 28-year study of the course of hepatitis delta infection: a risk factor for cirrhosis and hepatocellular carcinoma. Gastroenterology 136:1629-1638.
23. Sakugawa, H., H. Nakasone, T. Nakayoshi, Y. Kawakami, T. Yamashiro, T. Maeshiro, F. Kinjo, A. Saito, and H. Zukeran. 2001. Hepatitis B virus concentrations in serum determined by sensitive quantitative assays in patients with established chronic hepatitis delta virus infection. J. Med. Virol. 65:478-484.
24. Schaper, M., F. Rodriguez-Frias, R. Jardi, D. Tabernero, M. Homs, G. Ruiz, J. Quer, R. Esteban, and M. Buti. 2010. Quantitative longitudinal evaluations of hepatitis delta virus RNA and hepatitis B virus DNA shows a dynamic, complex replicative profile in chronic hepatitis B and D. J. Hepatol. 52:658-664.
25. Scheuer, P. J. 1991. Classification of chronic viral hepatitis: a need for reassessment. J. Hepatol. 13:372-374.
26. Seeger, C., and W. S. Mason. 2000. Hepatitis B virus biology. Microbiol. Mol. Biol. Rev. 64:51-68.
27. Sheldon, J., B. Ramos, C. Toro, P. Rios, J. Martinez-Alarcon, M. Bottecchia, M. Romero, J. Garcia-Samaniego, and V. Soriano. 2008. Does treatment of hepatitis B virus (HBV) infection reduce hepatitis delta virus (HDV) replication in HIV-HBV-HDV-coinfected patients? Antivir. Ther. 13:97-102.
28. Shih, H. H., K. S. Jeng, W. J. Syu, Y. H. Huang, C. W. Su, W. L. Peng, I. J. Sheen, and J. C. Wu. 2008. Hepatitis B surface antigen levels and sequences of natural hepatitis B virus variants influence the assembly and secretion of hepatitis D virus. J. Virol. 82:2250-2264.
29. Sureau, C., J. Taylor, M. Chao, J. W. Eichberg, and R. E. Lanford. 1989. Cloned hepatitis delta virus cDNA is infectious in the chimpanzee. J. Virol. 63:4292-4297.
30. Taylor, J. M. 2006. Hepatitis delta virus. Virology 344:71-76.
31. Tong, S., K. H. Kim, C. Chante, J. Wands, and J. Li. 2005. Hepatitis B virus e antigen variants. Int. J. Med. Sci. 2:2-7.
32. Volz, T., M. Lutgehetmann, P. Wachtler, A. Jacob, A. Quaas, J. M. Murray, M. Dandri, and J. Petersen. 2007. Impaired intrahepatic hepatitis B virus productivity contributes to low viremia in most HBeAg-negative patients. Gastroenterology 133:843-852.
33. Wang, K. S., Q. L. Choo, A. J. Weiner, J. H. Ou, R. C. Najarian, R. M. Thayer, G. T. Mullenbach, K. J. Denniston, J. L. Gerin, and M. Houghton. 1986. Structure, sequence and expression of the hepatitis delta viral genome. Nature 323:508-514.
34. Wedemeyer, H. 2010. Re-emerging interest in hepatitis delta: new insights into the dynamic interplay between HBV and HDV. J. Hepatol. 52:627-629.
35. Wedemeyer, H., and M. P. Manns. 2010. Epidemiology, pathogenesis and management of hepatitis D: update and challenges ahead. Nat. Rev. Gastroenterol. Hepatol. 7:31-40.
36. Werle-Lapostolle, B., S. Bowden, S. Locarnini, K. Wursthorn, J. Petersen, G. Lau, C. Trepo, P. Marcellin, Z. Goodman, W. E. T. Delaney, S. Xiong, C. L. Brosgart, S. S. Chen, C. S. Gibbs, and F. Zoulim. 2004. Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy. Gastroenterology 126:1750-1758.
37. Williams, V., S. Brichler, N. Radjef, P. Lebon, A. Goffard, D. Hober, R. Fagard, D. Kremsdorf, P. Deny, and E. Gordien. 2009. Hepatitis delta virus proteins repress hepatitis B virus enhancers and activate the alpha/beta interferon-inducible MxA gene. J. Gen. Virol. 90:2759-2767.
38. Wu, J. C., P. J. Chen, M. Y. Kuo, S. D. Lee, D. S. Chen, and L. P. Ting. 1991. Production of hepatitis delta virus and suppression of helper hepatitis B virus in a human hepatoma cell line. J. Virol. 65:1099-1104.
39. Wu, J. C., T. Z. Chen, Y. S. Huang, F. S. Yen, L. T. Ting, W. Y. Sheng, S. H. Tsay, and S. D. Lee. 1995. Natural history of hepatitis D viral superinfection: significance of viremia detected by polymerase chain reaction. Gastroenterology 108:796-802.
40. Zachou, K., C. Yurdaydin, U. Drebber, G. N. Dalekos, A. Erhardt, Y. Cakaloglu, H. Degertekin, S. Gurel, S. Zeuzem, H. Bozkaya, V. Schlaphoff, H. P. Dienes, T. C. Bock, M. P. Manns, and H. Wedemeyer. 2010. Quantitative HBsAg and HDV-RNA levels in chronic delta hepatitis. Liver Int. 30:430-437.