Organophosphate Ester Flame Retardant-Induced Acute Intoxications in Dogs

Journal of Medical Toxicology

Volumn 6, Issue 4, 2010, Pages 448-458

  Lehner, Andreas F ^a   Samsing, Francisca ^b   Rumbeiha, Wilson K ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b UNIVERSIDAD MAYOR   (Chile)

Author keywords

Dogs; Organophosphorus flame retardants; Seizures; Tris(1 chloro 2 propyl) phosphate (TCPP); Tris(2 chloroethyl) phosphate (TCEP)

Indexed keywords

ACTIVATED CARBON; ANTICOAGULANT AGENT; ATROPINE; BIS(1 CHLORO 2 PROPYL)(3 CHLORO 1 PROPYL)PHOSPHATE; BIS(2 CHLOROETHYL) 2 (CHLOROETHOXY)ETHYLPHOSPHATE; BIS(3 CHLORO 1 PROPYL)(1 CHLORO 2 PROPYL)PHOSPHATE; BROMETHALIN; BUMETRIZOLE; CARBAMATE PESTICIDE; ESCULIN; FLAME RETARDANT; INFUSION FLUID; LEAD; METALDEHYDE; METHYLXANTHINE; MYCOTOXIN; ORGANOCHLORINE PESTICIDE; ORGANOPHOSPHATE; ORGANOPHOSPHATE PESTICIDE; OXYBENZONE; PENITREM A; PENTOBARBITAL; PHOSPHORIC ACID TRIS(2 CHLOROETHYL) ESTER; PLANT TOXIN; PYRETHROID; RODENTICIDE; ROQUEFORTINE; STRYCHNINE; TRIS(1 CHLORO 2 PROPYL)PHOSPHATE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ARTICLE; AUTOPSY; BLADDER; BLOOD ANALYSIS; BLOOD CLOTTING; CAR SEAT CUSHION; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM STIMULATION; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CYANOSIS; DEATH; DISEASE SEVERITY; DOG; EPISTAXIS; EXCITATION; FEVER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INGESTION; KIDNEY CAPSULE; KIDNEY INJURY; LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY MASS SPECTROMETRY; LIVER CONGESTION; LUNG EDEMA; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; MOLECULAR WEIGHT; NONHUMAN; PROTECTIVE EQUIPMENT; QUALITATIVE ANALYSIS; SEIZURE; STOMACH CONTENT; THIN LAYER CHROMATOGRAPHY; THORACIC CAVITY;

ACUTE DISEASE; ADMINISTRATION, ORAL; ANIMALS; DOG DISEASES; DOGS; ESTERS; FATAL OUTCOME; FEMALE; FLAME RETARDANTS; MALE; NEUROTOXICITY SYNDROMES; PHOSPHINES; POISONING; SEIZURES;

EID: 78650038771     PISSN: 15569039     EISSN: 19376995     Source Type: Journal    
DOI: 10.1007/s13181-010-0105-7     Document Type: Article

References (52)

1. International Program on Chemical Safety (IPCS) (1997) Environmental Health Criteria no. 192. Flame retardants: a general introduction. World Health Organization, Geneva.
2. Reemtsma T, Quintana JB, Rodil R, García-López M, Rodríguez I (2008) Organophosphorus flame retardants and plasticizers in water and air. I. Occurrence and fate. Trends Analyt Chem 27: 727-737.
3. Hardy ML (2002) The toxicology of the three commercial polybrominated diphenyl oxide (ether) flame retardants. Chemosphere 46: 757-777.
4. Mikula P, Svóbodova Z (2006) Brominated flame retardants in the environment: their sources and effects (a review). Acta Vet Brno 75: 587-599.
5. Darnerud PO, Eriksen GS, Jóhannesson T, Larsen PB, Viluksela M (2001) Polybrominated diphenyl ethers: occurrence, dietary exposure, and toxicology. Environ Health Perspect 109 (Suppl 1): 49-68.
6. Darnerud PO (2003) Toxic effects of brominated flame retardants in man and in wildlife. Environ Int 29: 841-853.
7. Marklund A, Andersson B, Haglund P (2003) Screening of organophosphorus compounds and their distribution in various indoor environments. Chemosphere 53: 1137-1146.
8. García-López M, Rodrígueza I, Celaa R, Kroening KK, Caruso JA (2009) Determination of organophosphate flame retardants and plasticizers in sediment samples using microwave-assisted extraction and gas chromatography with inductively coupled plasma mass spectrometry. Talanta 79: 824-829.
9. Sakamoto T, Sawada Y, Nishide K, Sadamitsu D, Yoshioka T, Sugimoto T, Nishii S, Kishi H (1984) Delayed neurotoxicity produced by an organophosphorous compound (Sumithion). Arch Toxicol 56: 136-138, Including comments by Chuecos JM, Violan JS. Arch. Toxicol. 1985; 58: 123-124 and Sakamoto T, Arch. Toxicol. 58: 124.
10. Valvassori SS, Fortunato JJ, Gomes KM, Reus GZ, Martins MR, Gavioli EC, Schetinger MRC, Dal-Pizzol F, Quevedo J (2007) Acute and subacute exposure to malathion impairs aversive but not non-associative memory in rats. Neurotox Res 12: 71-80.
11. Schmidt G, Gruetzmacher J (1969) Late effects on respiration and circulation following successful treatment of Para-oxon (organophosphate) poisoning with cholinesterase reactivators and atropine in cats. Archiv fuer Toxikologie 24: 102-122.
12. Lee J-C, Lin K-L, Lin J-J, Hsia S-H, Wu C-T (2010) Non-accidental chlorpyrifos poisoning-an unusual cause of profound unconsciousness. Eur J Pediatr 169: 509-511.
13. Sheftel VO (2000) Indirect food additives and polymers. Migration and toxicology. Lewis, Boca Raton, p 220.
14. Lefaux R (1968) Practical toxicology of plastics. CRC, Cleveland, p 336.
15. Laham S, Long G, Schrader K, Szabo J (1984) Induction of electrophysiological and morphological changes in Sprague-Dawley rats fed tributoxyethyl phosphate. J Appl Toxicol 4: 42-48.
16. Saitoh M, Umemura T, Kawasaki Y, Momma J, Matusuhima Y, Matusumoto M et al (1994) Subchronic toxicity study of tributoxyethyl phosphate in Wistar rats. Bull Natl Inst Hyg Sci 112: 27-39.
17. Carrington CD, Lapadula DM, Othman M, Farr C, Nair RS, Johannse F et al (1996) Assessment of the delayed neurotoxicity of tributyl phosphate, tributoxyethyl phosphate and dibutylphenyl phosphate. Int J Occup Med Tox 5: 61-68.
18. Sato T, Watanabe K, Nagase H, Kito H, Niikawa M, Yoshioka Y (1997) Investigation of the hemolytic effects of various organophosphoric acid triesters (OPEs) and their structure-activity relationship. Toxicol Environ Chem 59: 305-313.
19. Laham S, Broxup BR, Long GW (1985) Subchronic oral toxicity of tributoxyethyl phosphate in the Sprague-Dawley rat. Arch Environ Health 40: 12-17.
20. Ingerowski G, Firedle A, Thumulla J (2001) Chlorinated ethyl and isopropyl phosphoric acid triesters in the indoor environment-an interlaboratory exposure study. Indoor Air 11: 145-149.
21. Hartmann PC, Bürgi D, Giger W (2004) Organophosphate flame retardants and plasticizers in indoor air. Chemospher 57: 781-787.
22. Tilson HA, Veronesi B, McLamb RL, Matthews HB (1990) Acute exposure to tris(2-chloroethyl)phosphate produces hippocampal neuronal loss and impairs learning in rats. Toxicol Appl Pharmacol 106: 254-269.
23. Umezu T, Yonemoto J, Soma Y, Susuki T (1998) Tris(2-chloroethyl)phosphate increases ambulatory activity in mice: pharmacological analyses of its neurochemical mechanism. Toxicol Appl Pharmacol 148: 109-116.
24. International Program on Chemical Safety (IPCS) (1998) Environmental Health Criteria no. 209. Flame retardants: tris(chloropropyl) phosphate and tris(2-chloroethyl) phosphate. World Health Organization, Geneva.
25. Hughes MF, Edwards BC, Mitchell CT, Bhooshan B (2001) In vitro dermal absorption of flame retardant chemicals. Food Chem Toxicol 39: 1263-1270.
26. Gregory NG, Constantine E (1996) Hyperthermia in dogs left in cars. Vet Rec 139: 349-350.
27. Rieders F (1975) Cyanides: type B procedure. In: Sunshine I (ed) Methodology for analytical toxicology. CRC, West Palm Beach, pp 120-122.
28. Reynolds JD (1980) Extraction and identification of ten anticoagulant rodenticides from baits and stomach contents by high pressure liquid chromatography. Proc Annu Meet Am Assoc Vet Lab Diag 23: 187-194.
29. Anderson JJ, Byrd WM, Jr., Camacho VG (1970) Phosphorothioates and their use in flame-retardant polymeric material. Ger. Offen. 59pp. Patent # DE 2024392 19701126. Patent written in German.
30. Mikhailov M, Stoeva S (1978) Preparation of tris(beta, beta', beta-chloroethyl)phosphite and its use as a plasticizer and stabilizer of poly(vinyl chloride). Godishnik Visshiya Khimiko Tekhnologichen Inst Burgas 12: 133-140.
31. Sanchez-Hernandez, Walker CH (2000) In vitro and in vivo cholinesterase inhibition in lacertides by phosphonate- and phosphorothioate-type organophosphates. Pesticide Biochem Physiol 67: 1-12.
32. Amitai G, Moorad D, Adani R, Doctor BP (1998) Inhibition of acetylcholinesterase and butyrylcholinesterase by chlorpyrifos-oxon. Biochem Pharmacol 56: 293-299.
33. Burka LT, Sanders JM, Herr DW, Mathews HB (1991) Metabolism of tris(2-chloroethyl)phosphate in rat and mice. Drug Metab Dispos 19: 443-447.
34. Eldefrawi AT, Mansour NA, Brattsten LB, Ahrens VD, Lisk DJ (1977) Further toxicological studies with commercial and candidate flame retardant chemicals. Part II Bull Environ Contam Toxicol 17: 720-726.
35. Matthews HB, Dixon D, Herr DW, Tilson H (1990) Subchronic toxicity studies indicate that tris(2-chloroethyl) phosphate administration results in lesions in the rat hippocampus. Toxicol Ind Health 1: 1-15.
36. Sprague GL, Sandvik LL, Brookins-Hendricks MJ, Bickford AA (1981) Neurotoxicity of two organophosphorus ester flame retardants in hens. J Toxicol Environ Health 8: 507-518.
37. Ben-Ari Y (2002) Excitatory actions of GABA during development: the nature of the nurture. Nat Rev Neurosci 3: 728-739.
38. Rogawski MA, Loscher W (2004) The neurobiology of antiepileptic drugs. Nat Rev Neurosci 5: 553-564.
39. Minegishi K, Kurebayashi H, Nambaru S, Morimoto K, Takahashi T, Yamaha T (1988) Comparative studies on absorption, distribution, and excretion of halogenated alkyl phosphate flame retardants in rats. Eisei Kagaku 34: 102-114.
40. Föllmann W, Wober J (2006) Investigation of cytotoxic, genotoxic, mutagenic, and estrogenic effects of the flame retardants tris-(2-chloroethyl)-phosphate (TCEP) and tris-(2-chloropropyl)-phosphate (TCPP) in vitro. Toxicol Lett 161: 124-134.
41. United Nations Environment Programme (2005) International Programme on Chemical Safety Monograph [webpage on the Internet]. Tris(1-chloro-2-propyl)phosphate CAS No. 13674-84-5. United Nations Environment Programme, Geneva. http://www. inchem. org/documents/sids/sids/13674845. pdf.
42. Himmelsbach M, Buchberger W, Reingruber E (2009) Determination of polymer additives by liquid chromatography coupled with mass spectrometry. A comparison of atmospheric pressure photoionization (APPI), atmospheric pressure chemical ionization (APCI), and electrospray ionization (ESI). Polym Degrad Stab 94: 1213-1219.
43. Stimberg HJ, Galinke J, Gruenberger E (1970) Polyurethane foam. (Henkel und Cie. G. m. b. H.). Ger. Offen. 11 pp. Patent # DE 1800460. Patent written in German.
44. Anonymous (1971) Self-extinguishable rigid foams based on polyurethanes and addition compounds of urea and formaldehyde. (Crediplast). Fr. 14 pp. Patent # FR 2051948 Patent written in French.
45. Iordanskaya OA, Shoshtaeva MV, Turetskii LV, Kalinin BA (1979) Rigid polyurethane foam compositions. (USSR). U. S. S. R. Patent # SU 642327 19790115 Patent written in Russian.
46. Anonymous (1979) Improvements in or relating to the production of polyurethane foam. (Tenneco Chemicals, Inc., USA). Brit. 11 pp. Patent # GB 1546705 19790531 Patent written in English.
47. Kennedy RB. Polyurethane foams. (USA) (1983) PCT Int. Appl. 29 pp. Patent # WO 8302120. Patent written in English.
48. Yasui S, Nagata K (1985) Polyurethane foams. (Sanyo Chemical Industries Ltd., Japan). Jpn. Kokai Tokkyo Koho. 8 pp. Patent # JP 60133020. Patent written in Japanese.
49. Buchanan MS, Davis GB, Greenhouse WVV (1989) Polyurethane foams containing organofunctional silanes. (William T. Burnett and Co., Inc., USA). U. S. 7 pp. Patent # US 4839393. Patent written in English.
50. Wurpel JN, Hirt PC, Bidanset JH (1993) Amygdala kindling in immature rats: proconvulsant effect of the organophosphate insecticide-chlorpyrifos. Neurotoxicology 14: 429-436.
51. Karanth S, Pope C (2003) In vitro inhibition of blood cholinesterase activities from horse, cow, and rat by tetrachlorvinphos. Int J Toxicol 22: 429-433.
52. Gromysz-Kałkowska K, Szubartowska EL (1993) Toxicity of tetrachlorvinphos to Rana temporaria L. Comp Biochem Physiol C 105: 285-290.