Gabapentin for the treatment of cancer-related pain syndromes

Reviews on Recent Clinical Trials

Volumn 5, Issue 3, 2010, Pages 174-178

  Bar Ad, Voichita ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cancer related pain syndromes; Gabapentin

Indexed keywords

GABAPENTIN; MORPHINE; OPIATE DERIVATIVE;

ANALGESIA; CANCER PAIN; CLINICAL TRIAL; CONTROLLED STUDY; DAILY LIFE ACTIVITY; DIABETIC NEUROPATHY; DRUG DOSE INCREASE; DRUG DOSE TITRATION; DRUG EFFICACY; HUMAN; MOOD; NEUROPATHIC PAIN; POSTHERPETIC NEURALGIA; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; SLEEP;

AMINES; ANALGESICS; CHRONIC DISEASE; CYCLOHEXANECARBOXYLIC ACIDS; GAMMA-AMINOBUTYRIC ACID; HUMANS; NEOPLASMS; PAIN; PAIN MEASUREMENT; PERIPHERAL NERVOUS SYSTEM DISEASES; SYNDROME; TREATMENT OUTCOME;

EID: 78650011802     PISSN: 15748871     EISSN: None     Source Type: Journal    
DOI: 10.2174/157488710792007310     Document Type: Review

References (39)

1. International Association for the Study of Pain. Subcommittee on Taxonomy: Pain terms: A list with definitions and notes on usage. Pain 1980; 8: 249-52.
2. Cherny NI, Portenoy RK. The management of cancer pain. CA Cancer J Clin 1994; 44: 263-303.
3. DeLeo JA. Basic science of pain. J Bone Joint Surg Am 2006; 88: 56-62.
4. Melzack R, Wall PD. Pain mechanisms: a new theory. Science 1965; 150: 971-9.
5. Nicholson B. Gabapentin use in neuropathic pain syndromes. Acta Neurol Scand 2000; 101: 359-71.
6. Baron R. Neuropathic pain: a clinical perspective. Handb Exp Pharmacol 2009; 194: 3-30.
7. Gonzales GR, Elliot KJ, Portenoy RK, Foley KM. The impact of a comprehensive evaluation in the management of cancer pain. Pain 1991; 47: 141-4.
8. Portenoy RK, Miransky J, Thaler HT, et al. Pain in ambulatory patients with lung or colon cancer: prevalence, characteristics, and effect. Cancer 1992; 70: 1616-24.
9. Ventafridda V, DeConno F, Ripamonti C, Gamba A, Tamburini M. Quality-of-life assessment during a palliative care programme. Ann Oncol 1990; 1(6): 415-20.
10. Epstein JB, Wilkie DJ, Fisher DJ, Kim YO, Villines D. Neuropathic and nociceptive pain in head and neck cancer patients receiving radiation therapy. Head Neck Oncol 2009; 1: 26.
11. Christo PJ, Mazloomdoost D. Cancer pain and analgesia. Ann NY Acad Sci 2008; 1138: 278-98.
12. Cherny NI, Thaler HT, Friedlander-Klar H, et al. Opioid responsiveness of cancer pain syndromes caused by neuropathic or nociceptive mechanisms: A combined analysis of controlled, singledose studies. Neurology 1994; 44: 857-61.
13. Jadad AR, Carroll D, Glynn CJ, Moore RA, McQuay HJ. Morphine responsiveness of chronic pain: double-blind randomized crossover study with patient-controlled analgesia. Lancet 1992; 339: 1367-71.
14. Matthews EA, Dickenson AH. A combination of gabapentin and morphine mediates enhanced inhibitory effects on dorsal horn neuronal responses in a rat model of neuropathy. Anesthesiology 2002; 96: 633-40.
15. Arner S, Meyerson BA. Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain. Pain 1988; 33: 11-23.
16. Likar R, Spendel MC, Amberger W, Kepplinger B, Supanz S, Sadjak A. Long-term intraspinal infusions of opioids with a new implantable medication pump. Arzneimittelforschung 1999; 49: 489-93.
17. Rose MA, Kam PC. Gabapentin: pharmacology and its use in pain management. Anaesthesia 2002; 57: 451-62.
18. Taylor CP, Angelotti T, Fauman E. Pharmacology and mechanism of action of pregabalin: the calcium channel α2-δ (alpha2-delta) subunit as a target for antiepileptic drug discovery. Epilepsy Res 2007; 73: 137-50.
19. Dooley DJ, Taylor CP, Donevan S, Feltner D. Ca2+ channel alpha 2 delta ligands: novel modulators of neurotransmission. Trends Pharmacol Sci 2007; 28: 75-82.
20. Goa KL, Sorkin EM. Gabapentin: a review of its pharmacological properties and clinical potential in epilepsy. Drugs 1993; 46: 409-27.
21. McLean MJ, Morrell MJ, Willmore LJ, et al. Safety and tolerability of gabapentin as adjunctive therapy in a large, multicenter study. Epilepsia 1999; 40: 965-72.
22. Portenoy RK. Tolerance to opioid analgesics clinical aspects. Cancer Surv 1994; 21: 49-65.
23. De la O-Arciniega M, Diaz-Reval MI, Cortes-Arroyo AR, Dominguez- Ramirez AM, Lopez-Munoz FJ. Anti-nociceptive synergism of morphine and gabapentine in neuropathic pain induced by chronic constriction injury. Pharmacol Biochem Behav 2009; 92: 457-64.
24. Backonja M, Beydoun A, Edwards KR, et al. Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled study. JAMA 1998; 280: 1831-36.
25. Vinik A. Clinical review: use of antiepileptic drugs in the treatment of chronic painful diabetic neuropathy. J Clin Endocrinol Metab 2005; 90: 4936-45.
26. Rowbotham M, Harden N, Stacey B, Bernstein P, Magnus-Miller L. Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial. JAMA 1998; 280: 1837-42.
27. Caraceni A, Zecca E, Bonezzi C, et al. Gabapentin for neuropathic cancer pain: a randomized controlled trial from the Gabapentin Cancer Pain Study Group. J Clin Oncol 2004; 22: 2909-17.
28. Keskinbora K, Pekel AF, Aydinli I. Gabapentin and an opioid combination versus opioid alone for the management of neuropathic cancer pain: a randomized open trial. J Pain Symp Manage 2007; 34: 183-9.
29. Bosnjak S, Jelic S, Susnjar S, Luki V. Gabapentin for relief of neuropathic pain related to anticancer treatment: a preliminary study. J Chemother 2002; 14: 214-9.
30. Lossignol DA, Plehiers B, Body JJ. Gabapentin (Neurontin) and cancer pain: a pilot study. Rev Med Brux 2004; 25: 429-35.
31. Eckhardt K, Ammon S, Hofmann U, Riebe A, Gugeler N, Mikus G. Gabapentin enhances the analgesic effect of morphine in healthy volunteers. Anesth Analg 2000; 91:185-91.
32. Gilron I, Bailey JM, Tu D, Holden RR, Weaver DF, Houlden RL. Morphine, gabapentin, or their combination for neuropathic pain. N Engl J Med 2005; 352: 1324-34.
33. Trotti A, Bellm LA, Epstein JB, et al. Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: a systematic review. Radiother Oncol 2003; 66: 253-62.
34. Russo G, Haddad R, Posner M, Machtay M. Radiation treatment breaks and ulcerative mucositis in head and neck cancer. Oncologist 2008; 13: 886-98.
35. Lalla RV, Sonis ST, Peterson DE. Management of oral mucositis in patients who have cancer. Dent Clin North Am 2008; 52: 61-77.
36. Treister N, Sonis S. Mucositis: biology and management. Curr Opin Otolaryngol Head Neck Surg 2007; 15: 123-9.
37. Bar Ad V, Weinstein G, Dutta PR, Chalian A, Both S, Quon H. Gabapentin for the treatment of pain related to radiation-induced mucositis in patients with head and neck tumors treated with intensity- modulated radiation therapy. Head Neck 2010; 32:173-7.
38. Bar Ad V, Weinstein G, Dutta PR, et al. Gabapentin for the treatment of pain syndrome related to radiation-induced mucositis in patients with head and neck cancer treated with concurrent chemoradiotherapy. Cancer 2010 (in press).
39. Backonja M, Glazman RL. Gabapentin for neuropathic pain: evidence from randomized, placebo-controlled clinical trials. Clin Ther 2003; 25: 81-104.