Inhibition of aberrant androgen receptor induction of prostate specific antigen gene expression, cell proliferation and tumor growth by 17α-estradiol in prostate cancer

Journal of Urology

Volumn 185, Issue 1, 2011, Pages 305-314

  Qiao, Yaming ^a   Wang, Lu ^a   Cai, Li Qun ^a   Tan, Chen ^a   Imperato Mcginley, Julianne ^a   Zhu, Yuan Shan ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Estradiol; Mutation; Prostate; Prostatic neoplasms; Receptors, androgen

Indexed keywords

17ALPHA ESTRADIOL; ANDROGEN RECEPTOR; ANDROSTANOLONE; CHOLESTEROL; CYPROTERONE ACETATE; ESTRADIOL; ESTROGEN RECEPTOR BETA; HYDROCORTISONE; PROSTATE SPECIFIC ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CELL STRAIN LNCAP; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; GENE EXPRESSION REGULATION; GENE MUTATION; GENETIC TRANSFECTION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE TUMOR; PROTEIN INDUCTION; RECEPTOR GENE; TUMOR GROWTH; TUMOR VOLUME; TUMOR XENOGRAFT;

ANDROGEN RECEPTOR ANTAGONISTS; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; ESTRADIOL; ESTROGENS; HUMANS; MALE; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 78649988536     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.juro.2010.09.008     Document Type: Article

References (30)

1. A. Jemal, R. Siegel, and E. Ward Cancer statistics, 2008 CA Cancer J Clin 58 2008 71
2. C. Huggins, and C.V. Hodges Studies on prostatic cancer I the effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate Cancer Res 1 1941 293
3. P.R. Carroll, P.W. Kantoff, and S.P. Balk Overview consensus statement Newer approaches to androgen deprivation therapy in prostate cancer Urology 60 2002 1
4. K.E. Knudsen, and H.I. Scher Starving the addiction: new opportunities for durable suppression of AR signaling in prostate cancer Clin Cancer Res 15 2009 4792
5. J.D. Debes, and D.J. Tindall Mechanisms of androgen-refractory prostate cancer N Engl J Med 351 2004 1488
6. M.E. Taplin, G.J. Bubley, and T.D. Shuster Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer N Engl J Med 332 1995 1393
7. J. Veldscholte, C. Ris-Stalpers, and G.G. Kuiper A mutation in the ligand binding domain of the androgen receptor of human LNCaP cells affects steroid binding characteristics and response to anti-androgens Biochem Biophys Res Commun 173 1990 534
8. X.Y. Zhao, P.J. Malloy, and A.V. Krishnan Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor Nat Med 6 2000 703
9. Treatment and survival of patients with cancer of the prostate The Veterans Administration Co-operative Urological Research Group Surg Gynecol Obstet 124 1967 1011
10. The Coronary Drug Project: findings leading to discontinuation of the 2.5-mg day estrogen group The Coronary Drug Project Research Group JAMA 226 1973 652
11. J.J. Li, S.A. Li, and T.D. Oberley Carcinogenic activities of various steroidal and nonsteroidal estrogens in the hamster kidney: relation to hormonal activity and cell proliferation Cancer Res 55 1995 4347
12. J.J. Li, and S.A. Li Estrogen carcinogenesis in Syrian hamster tissues: role of metabolism Fed Proc 46 1987 1858
13. Y.J. Ko, and S.P. Balk Targeting steroid hormone receptor pathways in the treatment of hormone dependent cancers Curr Pharm Biotechnol 5 2004 459
14. D.B. Lubahn, K.S. McCarty Jr, and K.S. McCarty Sr Electrophoretic characterization of purified bovine, porcine, murine, rat, and human uterine estrogen receptors J Biol Chem 260 1985 2515
15. Y.S. Zhu, L.Q. Cai, and Y. Huang Receptor isoform and ligand-specific modulation of dihydrotestosterone-induced prostate specific antigen gene expression and prostate tumor cell growth by estrogens J Androl 26 2005 500
16. Y. Qiao, Z.K. Zhang, and L.Q. Cai 17Alpha-estradiol inhibits LAPC-4 prostatic tumor cell proliferation in cell cultures and tumor growth in xenograft animals Prostate 67 2007 1719
17. Y.S. Zhu, P.M. Yen, and W.W. Chin Estrogen and thyroid hormone interaction on regulation of gene expression Proc Natl Acad Sci U S A 93 1996 12587
18. X.Y. Zhao, D.M. Peehl, and N.M. Navone 1Alpha,25-dihydroxyvitamin D3 inhibits prostate cancer cell growth by androgen-dependent and androgen-independent mechanisms Endocrinology 141 2000 2548
19. Y.S. Zhu, L.Q. Cai, and X. You Androgen-induced PSA gene expression is mediated via DHT in LNCaP cells J Androl 24 2003 681
20. C. Tan, L.Q. Cai, and W. Wu NSC606985, a novel camptothecin analog, induces apoptosis and growth arrest in prostate tumor cells Cancer Chemother Pharmacol 63 2009 303
21. C. Lee, D.M. Sutkowski, and J.A. Sensibar Regulation of proliferation and production of prostate-specific antigen in androgen-sensitive prostatic cancer cells, LNCaP, by dihydrotestosterone Endocrinology 136 1995 796
22. K.M. Lau, M. LaSpina, and J. Long Expression of estrogen receptor (ER)-alpha and ER-beta in normal and malignant prostatic epithelial cells: regulation by methylation and involvement in growth regulation Cancer Res 60 2000 3175
23. J.T. Arnold, X. Liu, and J.D. Allen Androgen receptor or estrogen receptor-beta blockade alters DHEA-, DHT-, and E(2)-induced proliferation and PSA production in human prostate cancer cells Prostate 67 2007 1152
24. J. Veldscholte, C.A. Berrevoets, and C. Ris-Stalpers The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens J Steroid Biochem Mol Biol 41 1992 665
25. C.A. Heinlein, and C. Chang Androgen receptor in prostate cancer Endocr Rev 25 2004 276
26. S.A. Li, S.J. Weroha, and O. Tawfik Prevention of solely estrogen-induced mammary tumors in female aci rats by tamoxifen: evidence for estrogen receptor mediation J Endocrinol 175 2002 297
27. M.V. Kumar, M.E. Leo, and D.J. Tindall Modulation of androgen receptor transcriptional activity by the estrogen receptor J Androl 15 1994 534
28. G.G. Kuiper, E. Enmark, and M. Pelto-Huikko Cloning of a novel receptor expressed in rat prostate and ovary Proc Natl Acad Sci U S A 93 1996 5925
29. W.H. Moos, J.A. Dykens, and D. Nohynek Review of the effects of 17α-estradiol in humans: a less feminizing estrogen with neuroprotective potential Drug Devel Res 70 2009 1
30. A.D. Freay, S.W. Curtis, and K.S. Korach Mechanism of vascular smooth muscle relaxation by estrogen in depolarized rat and mouse aorta Role of nuclear estrogen receptor and Ca2+ uptake Circ Res 81 1997 242