Neural retina leucine-zipper regulates the expression of Ppp2r5c, the regulatory subunit of protein phosphatase 2A, in photoreceptor development

FEBS Journal

Volumn 277, Issue 24, 2010, Pages 5051-5060

  Kim, Jung Woong ^a   Jang, Sang Min ^a   Kim, Chul Hong ^a   An, Joo Hee ^a   Kang, Eun Jin ^a   Choi, Kyung Hee ^a  

^a Chung Ang University   (South Korea)

Author keywords

neural retina leucine zipper; photoreceptor development; PP2A regulatory subunit; Ppp2r5c; target gene

Indexed keywords

LEUCINE ZIPPER PROTEIN; PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B GAMMA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; GENE ACTIVITY; GENE EXPRESSION REGULATION; GENE SEQUENCE; GENETIC CONSERVATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; PROMOTER REGION; RETINA DEVELOPMENT;

ANIMALS; BASE SEQUENCE; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; BINDING SITES; CONSERVED SEQUENCE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; EYE PROTEINS; GENE EXPRESSION REGULATION; MICE; MOLECULAR SEQUENCE DATA; PHOTORECEPTOR CELLS, VERTEBRATE; PROMOTER REGIONS, GENETIC; PROTEIN PHOSPHATASE 2; RETINA; RNA, MESSENGER; SEQUENCE HOMOLOGY, NUCLEIC ACID;

EID: 78649986068     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2010.07910.x     Document Type: Article

References (38)

1. Janssens V, &, Goris J, (2001) Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem J 353, 417-439.
2. Mumby M, (2007) PP2A: unveiling a reluctant tumor suppressor. Cell 130, 21-24.
3. Mayer-Jaekel RE, &, Hemmings BA, (1994) Protein phosphatase 2A-a 'menage a trois'. Trends Cell Biol 4, 287-291.
4. Healy AM, Zolnierowicz S, Stapleton AE, Goebl M, DePaoli-Roach AA, &, Pringle JR, (1991) CDC55, a Saccharomyces cerevisiae gene involved in cellular morphogenesis: identification, characterization, and homology to the B subunit of mammalian type 2A protein phosphatase. Mol Cell Biol 11, 5767-5780.
5. Mayer RE, Hendrix P, Cron P, Matthies R, Stone SR, Goris J, Merlevede W, Hofsteenge J, &, Hemmings BA, (1991) Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform. Biochemistry 30, 3589-3597.
6. Strack S, Chang D, Zaucha JA, Colbran RJ, &, Wadzinski BE, (1999) Cloning and characterization of B delta, a novel regulatory subunit of protein phosphatase 2A. FEBS Lett 460, 462-466.
7. Zolnierowicz S, Csortos C, Bondor J, Verin A, Mumby MC, &, DePaoli-Roach AA, (1994) Diversity in the regulatory B-subunits of protein phosphatase 2A: identification of a novel isoform highly expressed in brain. Biochemistry 33, 11858-11867.
8. Csortos C, Zolnierowicz S, Bako E, Durbin SD, &, DePaoli-Roach AA, (1996) High complexity in the expression of the B′ subunit of protein phosphatase 2A0. Evidence for the existence of at least seven novel isoforms. J Biol Chem 271, 2578-2588.
9. McCright B, Rivers AM, Audlin S, &, Virshup DM, (1996) The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. J Biol Chem 271, 22081-22089.
10. McCright B, &, Virshup DM, (1995) Identification of a new family of protein phosphatase 2A regulatory subunits. J Biol Chem 270, 26123-26128.
11. Tehrani MA, Mumby MC, &, Kamibayashi C, (1996) Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle. J Biol Chem 271, 5164-5170.
12. Hendrix P, Mayer-Jackel RE, Cron P, Goris J, Hofsteenge J, Merlevede W, &, Hemmings BA, (1993) Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing. J Biol Chem 268, 15267-15276.
13. Tanabe O, Nagase T, Murakami T, Nozaki H, Usui H, Nishito Y, Hayashi H, Kagamiyama H, &, Takeda M, (1996) Molecular cloning of a 74-kDa regulatory subunit (B′′ or delta) of human protein phosphatase 2A. FEBS Lett 379, 107-111.
14. Moreno CS, Park S, Nelson K, Ashby D, Hubalek F, Lane WS, &, Pallas DC, (2000) WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A. J Biol Chem 275, 5257-5263.
15. Seeling JM, Miller JR, Gil R, Moon RT, White R, &, Virshup DM, (1999) Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A. Science 283, 2089-2091.
16. Li X, Yost HJ, Virshup DM, &, Seeling JM, (2001) Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus. EMBO J 20, 4122-4131.
17. Rorick AM, Mei W, Liette NL, Phiel C, El-Hodiri HM, &, Yang J, (2007) PP2A:B56epsilon is required for eye induction and eye field separation. Dev Biol 302, 477-493.
18. Sontag E, (2001) Protein phosphatase 2A: the Trojan Horse of cellular signaling. Cell Signal 13, 7-16.
19. Swaroop A, Xu JZ, Pawar H, Jackson A, Skolnick C, &, Agarwal N, (1992) A conserved retina-specific gene encodes a basic motif/leucine zipper domain. Proc Natl Acad Sci USA 89, 266-270.
20. Akimoto M, Cheng H, Zhu D, Brzezinski JA, Khanna R, Filippova E, Oh EC, Jing Y, Linares JL, Brooks M, et al. (2006) Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptors. Proc Natl Acad Sci USA 103, 3890-3895.
21. Mears AJ, Kondo M, Swain PK, Takada Y, Bush RA, Saunders TL, Sieving PA, &, Swaroop A, (2001) Nrl is required for rod photoreceptor development. Nat Genet 29, 447-452.
22. DeAngelis MM, Grimsby JL, Sandberg MA, Berson EL, &, Dryja TP, (2002) Novel mutations in the NRL gene and associated clinical findings in patients with dominant retinitis pigmentosa. Arch Ophthalmol 120, 369-375.
23. Kanda A, Friedman JS, Nishiguchi KM, &, Swaroop A, (2007) Retinopathy mutations in the bZIP protein NRL alter phosphorylation and transcriptional activity. Hum Mutat 28, 589-598.
24. Mitton KP, Swain PK, Chen S, Xu S, Zack DJ, &, Swaroop A, (2000) The leucine zipper of NRL interacts with the CRX homeodomain. A possible mechanism of transcriptional synergy in rhodopsin regulation. J Biol Chem 275, 29794-29799.
25. Mitton KP, Swain PK, Khanna H, Dowd M, Apel IJ, &, Swaroop A, (2003) Interaction of retinal bZIP transcription factor NRL with Flt3-interacting zinc-finger protein Fiz1: possible role of Fiz1 as a transcriptional repressor. Hum Mol Genet 12, 365-373.
26. Friedman JS, Khanna H, Swain PK, Denicola R, Cheng H, Mitton KP, Weber CH, Hicks D, &, Swaroop A, (2004) The minimal transactivation domain of the basic motif-leucine zipper transcription factor NRL interacts with TATA-binding protein. J Biol Chem 279, 47233-47241.
27. Kumar R, Chen S, Scheurer D, Wang QL, Duh E, Sung CH, Rehemtulla A, Swaroop A, Adler R, &, Zack DJ, (1996) The bZIP transcription factor Nrl stimulates rhodopsin promoter activity in primary retinal cell cultures. J Biol Chem 271, 29612-29618.
28. Oh EC, Cheng H, Hao H, Jia L, Khan NW, &, Swaroop A, (2008) Rod differentiation factor NRL activates the expression of nuclear receptor NR2E3 to suppress the development of cone photoreceptors. Brain Res 1236, 16-29.
29. Pittler SJ, Zhang Y, Chen S, Mears AJ, Zack DJ, Ren Z, Swain PK, Yao S, Swaroop A, &, White JB, (2004) Functional analysis of the rod photoreceptor cGMP phosphodiesterase alpha-subunit gene promoter: Nrl and Crx are required for full transcriptional activity. J Biol Chem 279, 19800-19807.
30. Lerner LE, Gribanova YE, Ji M, Knox BE, &, Farber DB, (2001) Nrl and Sp nuclear proteins mediate transcription of rod-specific cGMP-phosphodiesterase beta-subunit gene: involvement of multiple response elements. J Biol Chem 276, 34999-35007.
31. Peng GH, &, Chen S, (2007) Crx activates opsin transcription by recruiting HAT-containing co-activators and promoting histone acetylation. Hum Mol Genet 16, 2433-2452.
32. Liu WB, Li Y, Zhang L, Chen HG, Sun S, Liu JP, Liu Y, &, Li DW, (2008) Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye. Mol Vis 14, 762-773.
33. Yoshida S, Mears AJ, Friedman JS, Carter T, He S, Oh E, Jing Y, Farjo R, Fleury G, Barlow C, et al. (2004) Expression profiling of the developing and mature Nrl-/- mouse retina: identification of retinal disease candidates and transcriptional regulatory targets of Nrl. Hum Mol Genet 13, 1487-1503.
34. Ramirez M, &, Lamas M, (2009) NMDA receptor mediates proliferation and CREB phosphorylation in postnatal Muller glia-derived retinal progenitors. Mol Vis 15, 713-721.
35. Crawford SE, Qi C, Misra P, Stellmach V, Rao MS, Engel JD, Zhu Y, &, Reddy JK, (2002) Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors. J Biol Chem 277, 3585-3592.
36. Evans TG, Belak Z, Ovsenek N, &, Krone PH, (2007) Heat shock factor 1 is required for constitutive Hsp70 expression and normal lens development in embryonic zebrafish. Comp Biochem Physiol A Mol Integr Physiol 146, 131-140.
37. Livak KJ, &, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2[-Delta Delta C(T)] method. Methods 25, 402-408.
38. Hellman LM, &, Fried MG, (2007) Electrophoretic mobility shift assay (EMSA) for detecting protein-nucleic acid interactions. Nat Protoc 2, 1849-1861.