Management of spontaneous nontraumatic intracranial hemorrhage

Journal of Pharmacy Practice

Volumn 23, Issue 5, 2010, Pages 398-407

  Parker Jr , Dennis ^a   Rhoney, Denise H ^a   Xi, Liu Deryke ^b  

^a WAYNE STATE UNIVERSITY   (United States)

^b ORLANDO REGIONAL MEDICAL CENTER   (United States)

Author keywords

hematoma; hypertension; intracerebral hemorrhage; treatment

Indexed keywords

ACETYLSALICYLIC ACID; ACTIVATED PROTHROMBIN COMPLEX; AMINOCAPROIC ACID; ANTICOAGULANT AGENT; ANTICONVULSIVE AGENT; ANTITHROMBOCYTIC AGENT; ATORVASTATIN; BLOOD CLOTTING FACTOR 9 COMPLEX; CLOPIDOGREL; DALTEPARIN; ENALAPRIL; ENOXAPARIN; ESMOLOL; FRESH FROZEN PLASMA; HEPARIN; HYDRALAZINE; INSULIN; LABETALOL; LOW MOLECULAR WEIGHT HEPARIN; NICARDIPINE; NITROPRUSSIDE SODIUM; PLACEBO; PROTHROMBIN COMPLEX; RECOMBINANT BLOOD CLOTTING FACTOR 7A; TISSUE PLASMINOGEN ACTIVATOR; VITAMIN K GROUP; WARFARIN;

ACUTE HEART INFARCTION; ANTICOAGULATION; BLEEDING DISORDER; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CLINICAL FEATURE; CLINICAL TRIAL; CRANIOTOMY; DIAGNOSTIC TEST; DOSE RESPONSE; DRUG EFFICACY; DRUG HALF LIFE; DRUG MEGADOSE; DRUG SAFETY; DRUG WITHDRAWAL; FEVER; FLUID RESUSCITATION; HEMATOMA; HEMOSTASIS; HUMAN; HYPERGLYCEMIA; HYPERTENSION; INCIDENCE; INTERNATIONAL NORMALIZED RATIO; MEDICAL SOCIETY; PATHOPHYSIOLOGY; PHARMACOLOGY; PRACTICE GUIDELINE; REVIEW; RISK FACTOR; SEIZURE; STROKE; TREATMENT PLANNING; VENOUS THROMBOEMBOLISM;

EID: 78649943162     PISSN: 08971900     EISSN: 15311937     Source Type: Journal    
DOI: 10.1177/0897190010372320     Document Type: Review

References (75)

1. Rincon F., Mayer SA Clinical review: critical care management of spontaneous intracerebral hemorrhage. Crit Care. 2008 ; 12 (6). 237.
2. Holloway RG, Witter DM Jr, Lawton KB, et al. Inpatient costs of specific cerebrovascular events at five academic medical centers. Neurology. 1996 ; 46 (3). 854-860.
3. Steiner T., Kaste M., Forsting M., et al. Recommendations for the management of intracranial haemorrhage-part I: spontaneous intracerebral haemorrhage. The European Stroke Initiative Writing Committee and the Writing Committee for the EUSI Executive Committee. Cerebrovasc Dis. 2006 ; 22 (4). 294-316.
4. PROGRESS Collaborative Group. Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack. Lancet. 2001 ; 358 (9287). 1033-1041.
5. Broderick J., Connolly S., Feldmann E., et al. Guidelines for the management of spontaneous intracerebral hemorrhage in adults: 2007 update: a guideline from the American Heart Association/ American Stroke Association Stroke Council, High Blood Pressure Research Council, and the Quality of Care and Outcomes in Research Interdisciplinary Working Group. Circulation. 2007 ; 116 (16). e391 - e413.
6. Greenberg SM, Eng JA, Ning M., et al. Hemorrhage burden predicts recurrent intracerebral hemorrhage after lobar hemorrhage. Stroke. 2004 ; 35 (6). 1415-1420.
7. Woo D., Sauerbeck LR, Kissela BM, et al. Genetic and environmental risk factors for intracerebral hemorrhage: preliminary results of a population-based study. Stroke. 2002 ; 33 (5). 1190-1195.
8. Flaherty ML, Kissela B., Woo D., et al. The increasing incidence of anticoagulant-associated intracerebral hemorrhage. Neurology. 2007 ; 68 (2). 116-121.
9. Newman DH, Zhitomirsky I. The prevalence of nontherapeutic and dangerous international normalized ratios among patients receiving warfarin in the emergency department. Ann Emerg Med. 2006 ; 48 (2). 182-189, 189.e1.
10. Rosand J., Eckman MH, Knudsen KA, et al. The effect of warfarin and intensity of anticoagulation on outcome of intracerebral hemorrhage. Arch Intern Med. 2004 ; 164 (8). 880-884.
11. Flibotte JJ, Hagan N., O'Donnell J., et al. Warfarin, hematoma expansion, and outcome of intracerebral hemorrhage. Neurology. 2004 ; 63 (6). 1059-1064.
12. Testai FD, Aiyagari V. Acute hemorrhagic stroke pathophysiology and medical interventions: blood pressure control, management of anticoagulant-associated brain hemorrhage and general management principles. Neurol Clin. 2008 ; 26 (4). 963-985, viii - ix.
13. Hacke W., Kaste M., Bluhmki E., et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 2008 ; 359 (13). 1317-1329.
14. Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med. 1995 ; 333 (24). 1581-1587.
15. Garg R., Chaudhuri A., Munschauer F., et al. Hyperglycemia, insulin, and acute ischemic stroke: a mechanistic justification for a trial of insulin infusion therapy. Stroke. 2006 ; 37 (1). 267-273.
16. Demchuk AM, Morgenstern LB, Krieger DW, et al. Serum glucose level and diabetes predict tissue plasminogen activator-related intracerebral hemorrhage in acute ischemic stroke. Stroke. 1999 ; 30 (1). 34-39.
17. Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet. 2002 ; 360 (9326). 7-22.
18. Amarenco P., Bogousslavsky J., Callahan AIII, et al. High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med. 2006 ; 355 (6). 549-559.
19. He J., Whelton PK, Vu B., et al. Aspirin and risk of hemorrhagic stroke: a meta-analysis of randomized controlled trials. JAMA. 1998 ; 280 (22). 1930-1935.
20. Diener HC, Bogousslavsky J., Brass LM, et al. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet. 2004 ; 364 (9431). 331-337.
21. Dentali F., Douketis JD, Lim W., et al. Combined aspirin-oral anticoagulant therapy compared with oral anticoagulant therapy alone among patients at risk for cardiovascular disease: a meta-analysis of randomized trials. Arch Intern Med. 2007 ; 167 (2). 117-124.
22. Davis SM, Broderick J., Hennerici M., et al. Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage. Neurology. 2006 ; 66 (8). 1175-1181.
23. Xi G., Keep RF, Hoff JT Pathophysiology of brain edema formation. Neurosurg Clin N Am. 2002 ; 13 (3). 371-383.
24. Sahni R., Weinberger J. Management of intracerebral hemorrhage. Vasc Health Risk Manag. 2007 ; 3 (5). 701-709.
25. Mayer SA, Rincon F. Treatment of intracerebral haemorrhage. Lancet Neurol. 2005 ; 4 (10). 662-672.
26. Hemphill JC III, Bonovich DC, Besmertis L., et al. The ICH score: a simple, reliable grading scale for intracerebral hemorrhage. Stroke. 2001 ; 32 (4). 891-897.
27. Clarke JL, Johnston SC, Farrant M., et al. External validation of the ICH score. Neurocrit Care. 2004 ; 1 (1). 53-60.
28. Hemphill JC III, Farrant M., Neill TA Jr. Prospective validation of the ICH Score for 12-month functional outcome. Neurology. 2009 ; 73 (14). 1088-1094.
29. Brott T., Broderick J., Kothari R., et al. Early hemorrhage growth in patients with intracerebral hemorrhage. Stroke. 1997 ; 28 (1). 1-5.
30. Piriyawat P., Morgenstern LB, Yawn DH, et al. Treatment of acute intracerebral hemorrhage with epsilon-aminocaproic acid: a pilot study. Neurocrit Care. 2004 ; 1 (1). 47-51.
31. Dutton RP, Conti BM The role of recombinant-activated factor VII in bleeding trauma patients. Curr Opin Anaesthesiol. 2009 ; 22 (2). 299-304.
32. Ranucci M., Isgro G., Soro G., et al. Efficacy and safety of recombinant activated factor vii in major surgical procedures: systematic review and meta-analysis of randomized clinical trials. Arch Surg. 2008 ; 143 (3). 296-304 ; discussion.
33. Mayer SA, Brun NC, Begtrup K., et al. Recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med. 2005 ; 352 (8). 777-785.
34. Mayer SA, Brun NC, Begtrup K., et al. Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med. 2008 ; 358 (20). 2127-2137.
35. Mayer SA, Davis SM, Skolnick BE, et al. Can a subset of intracerebral hemorrhage patients benefit from hemostatic therapy with recombinant activated factor VII? Stroke. 2009 ; 40 (3). 833-840.
36. Hemphill JC III. Treating warfarin-related intracerebral hemorrhage: is fresh frozen plasma enough? Stroke. 2006 ; 37 (1). 6-7.
37. Leissinger CA, Blatt PM, Hoots WK, et al. Role of prothrombin complex concentrates in reversing warfarin anticoagulation: a review of the literature. Am J Hematol. 2008 ; 83 (2). 137-143.
38. Lee SB, Manno EM, Layton KF, et al. Progression of warfarin-associated intracerebral hemorrhage after INR normalization with FFP. Neurology. 2006 ; 67 (7). 1272-1274.
39. Levy JH, Tanaka KA, Dietrich W. Perioperative hemostatic management of patients treated with vitamin K antagonists. Anesthesiology. 2008 ; 109 (5). 918-926.
40. Huttner HB, Schellinger PD, Hartmann M., et al. Hematoma growth and outcome in treated neurocritical care patients with intracerebral hemorrhage related to oral anticoagulant therapy: comparison of acute treatment strategies using vitamin K, fresh frozen plasma, and prothrombin complex concentrates. Stroke. 2006 ; 37 (6). 1465-1470.
41. Brody DL, Aiyagari V., Shackleford AM, et al. Use of recombinant factor VIIa in patients with warfarin-associated intracranial hemorrhage. Neurocrit Care. 2005 ; 2 (3). 263-267.
42. Steiner T., Rosand J., Diringer M. Intracerebral hemorrhage associated with oral anticoagulant therapy: current practices and unresolved questions. Stroke. 2006 ; 37 (1). 256-262.
43. Vemmos KN, Tsivgoulis G., Spengos K., et al. U-shaped relationship between mortality and admission blood pressure in patients with acute stroke. J Intern Med. 2004 ; 255 (2). 257-265.
44. Ohwaki K., Yano E., Nagashima H., et al. Blood pressure management in acute intracerebral hemorrhage: relationship between elevated blood pressure and hematoma enlargement. Stroke. 2004 ; 35 (6). 1364-1367.
45. Fujii Y., Takeuchi S., Sasaki O., et al. Multivariate analysis of predictors of hematoma enlargement in spontaneous intracerebral hemorrhage. Stroke. 1998 ; 29 (6). 1160-1166.
46. Powers WJ, Zazulia AR, Videen TO, et al. Autoregulation of cerebral blood flow surrounding acute (6 to 22 hours) intracerebral hemorrhage. Neurology. 2001 ; 57 (1). 18-24.
47. Carhuapoma JR, Wang PY, Beauchamp NJ, et al. Diffusion-weighted MRI and proton MR spectroscopic imaging in the study of secondary neuronal injury after intracerebral hemorrhage. Stroke. 2000 ; 31 (3). 726-732.
48. Antihypertensive Treatment of Acute Cerebral Hemorrhage (ATACH) investigators. Antihypertensive treatment of acute cerebral hemorrhage. Crit Care Med. 2010 ; 38 (2). 637-648.
49. Anderson CS, Huang Y., Wang JG, et al. Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial. Lancet Neurol. 2008 ; 7 (5). 391-399.
50. Qureshi AI, Mendelow AD, Hanley DF Intracerebral haemorrhage. Lancet. 2009 ; 373 (9675). 1632-1644.
51. Mendelow AD, Gregson BA, Fernandes HM, et al. Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial. Lancet. 2005 ; 365 (9457). 387-397.
52. Prasad K., Mendelow AD, Gregson B. Surgery for primary supratentorial intracerebral hematoma. a meta-analysis of 10 randomized controlled trials. Stroke. 2009 ; 40: e624 - e626.
53. Morgan T., Zuccarello M., Narayan R., et al. Preliminary findings of the minimally-invasive surgery plus rtPA for intracerebral hemorrhage evacuation (MISTIE) clinical trial. Acta Neurochir Suppl. 2008 ; 105: 147-151.
54. Godoy DA, Pinero GR, Svampa S., et al. Hyperglycemia and short-term outcome in patients with spontaneous intracerebral hemorrhage. Neurocrit Care. 2008 ; 9 (2). 217-229.
55. Passero S., Ciacci G., Ulivelli M. The influence of diabetes and hyperglycemia on clinical course after intracerebral hemorrhage. Neurology. 2003 ; 61 (10). 1351-1356.
56. Mase G., Zorzon M., Biasutti E., et al. Immediate prognosis of primary intracerebral hemorrhage using an easy model for the prediction of survival. Acta Neurol Scand. 1995 ; 91 (4). 306-309.
57. Kimura K., Iguchi Y., Inoue T., et al. Hyperglycemia independently increases the risk of early death in acute spontaneous intracerebral hemorrhage. J Neurol Sci. 2007 ; 255 (1-2). 90-94.
58. Oddo M., Schmidt JM, Mayer SA, et al. Glucose control after severe brain injury. Curr Opin Clin Nutr Metab Care. 2008 ; 11 (2). 134-139.
59. Vespa PM, McArthur D., O'Phelan K., et al. Persistently low extracellular glucose correlates with poor outcome 6 months after human traumatic brain injury despite a lack of increased lactate: a microdialysis study. J Cereb Blood Flow Metab. 2003 ; 23 (7). 865-877.
60. Vespa P., Boonyaputthikul R., McArthur DL, et al. Intensive insulin therapy reduces microdialysis glucose values without altering glucose utilization or improving the lactate/pyruvate ratio after traumatic brain injury. Crit Care Med. 2006 ; 34 (3). 850-856.
61. Oddo M., Schmidt JM, Carrera E., et al. Impact of tight glycemic control on cerebral glucose metabolism after severe brain injury: a microdialysis study. Crit Care Med. 2008 ; 36 (12). 3233-3238.
62. Jacka MJ, Torok-Both CJ, Bagshaw SM Blood glucose control among critically ill patients with brain injury. Can J Neurol Sci. 2009 ; 36 (4). 436-442.
63. Egi M., Bellomo R., Stachowski E., et al. Variability of blood glucose concentration and short-term mortality in critically ill patients. Anesthesiology. 2006 ; 105 (2). 244-252.
64. Egi M., Bellomo R., Reade MC Is reducing variability of blood glucose the real but hidden target of intensive insulin therapy? Crit Care. 2009 ; 13 (2). 302.
65. Tetri S., Hakala J., Juvela S., et al. Safety of low-dose subcutaneous enoxaparin for the prevention of venous thromboembolism after primary intracerebral haemorrhage. Thromb Res. 2008 ; 123 (2). 206-212.
66. Kim KS, Brophy GM Symptomatic venous thromboembolism: incidence and risk factors in patients with spontaneous or traumatic intracranial hemorrhage. Neurocrit Care. 2009 ; 11 (1). 28-33.
67. Goldstein JN, Fazen LE, Wendell L., et al. Risk of thromboembolism following acute intracerebral hemorrhage. Neurocrit Care. 2009 ; 10 (1). 28-34.
68. Lacut K., Bressollette L., Le Gal G., et al. Prevention of venous thrombosis in patients with acute intracerebral hemorrhage. Neurology. 2005 ; 65 (6). 865-869. (Pubitemid 41362131)
69. Geerts WH, Bergqvist D., Pineo GF, et al. Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8 th Edition). Chest. 2008 ; 133 (6 suppl). 381S - 453S.
70. Christensen MC, Dawson J., Vincent C. Risk of thromboembolic complications after intracerebral hemorrhage according to ethnicity. Adv Ther. 2008 ; 25 (9). 831-841.
71. Albers GW, Amarenco P., Easton JD, et al. Antithrombotic and thrombolytic therapy for ischemic stroke: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8 th Edition). Chest. 2008 ; 133 (6 suppl). 630S - 669S.
72. Boeer A., Voth E., Henze T., et al. Early heparin therapy in patients with spontaneous intracerebral haemorrhage. J Neurol Neurosurg Psychiatry. 1991 ; 54 (5). 466-467.
73. Kiphuth IC, Staykov D., Kohrmann M., et al. Early administration of low molecular weight heparin after spontaneous intracerebral hemorrhage. A safety analysis Cerebrovasc Dis. 2009 ; 27 (2). 146-150.
74. Eckman MH, Rosand J., Knudsen KA, et al. Can patients be anticoagulated after intracerebral hemorrhage? A decision analysis. Stroke. 2003 ; 34 (7). 1710-1716.
75. Vespa PM, O'Phelan K., Shah M., et al. Acute seizures after intracerebral hemorrhage: a factor in progressive midline shift and outcome. Neurology. 2003 ; 60 (9). 1441-1446.