메뉴 건너뛰기




Volumn 23, Issue 4, 2010, Pages 489-494

Will newer tyrosine kinase inhibitors have an impact in AML?

Author keywords

AC220; Acute myeloid leukemia; AML; FLT3; Inhibitor; KW 2449; Lestaurtinib; Midostaurin; Sorafenib

Indexed keywords

AC 220; CD135 ANTIGEN; KW 2449; LESTAURTINIB; MIDOSTAURIN; PROTEIN TYROSINE KINASE INHIBITOR; SORAFENIB; UNCLASSIFIED DRUG;

EID: 78649931161     PISSN: 15216926     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.beha.2010.09.008     Document Type: Review
Times cited : (10)

References (38)
  • 1
    • 0030451722 scopus 로고    scopus 로고
    • Internal tandem duplication of the flt3 gene found in acute myeloid leukemia
    • M. Nakao, S. Yokota, and T. Iwai Internal tandem duplication of the flt3 gene found in acute myeloid leukemia Leukemia 10 1996 1911 1918
    • (1996) Leukemia , vol.10 , pp. 1911-1918
    • Nakao, M.1    Yokota, S.2    Iwai, T.3
  • 2
    • 0031686409 scopus 로고    scopus 로고
    • Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product
    • H. Kiyoi, M. Towatari, and S. Yokota Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product Leukemia 12 1998 1333 1337
    • (1998) Leukemia , vol.12 , pp. 1333-1337
    • Kiyoi, H.1    Towatari, M.2    Yokota, S.3
  • 3
    • 0035885955 scopus 로고    scopus 로고
    • The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
    • P.D. Kottaridis, R.E. Gale, and M.E. Frew The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials Blood 98 2001 1752 1759
    • (2001) Blood , vol.98 , pp. 1752-1759
    • Kottaridis, P.D.1    Gale, R.E.2    Frew, M.E.3
  • 4
    • 0035476264 scopus 로고    scopus 로고
    • Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: A cancer and leukemia group B study
    • S.P. Whitman, K.J. Archer, and L. Feng Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study Cancer Res 61 2001 7233 7239
    • (2001) Cancer Res , vol.61 , pp. 7233-7239
    • Whitman, S.P.1    Archer, K.J.2    Feng, L.3
  • 5
    • 0036659931 scopus 로고    scopus 로고
    • Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: Correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease
    • S. Schnittger, C. Schoch, and M. Dugas Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease Blood 100 2002 59 66
    • (2002) Blood , vol.100 , pp. 59-66
    • Schnittger, S.1    Schoch, C.2    Dugas, M.3
  • 6
    • 0037097716 scopus 로고    scopus 로고
    • Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis
    • C. Thiede, C. Steudel, and B. Mohr Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis Blood 99 2002 4326 4335
    • (2002) Blood , vol.99 , pp. 4326-4335
    • Thiede, C.1    Steudel, C.2    Mohr, B.3
  • 7
    • 0141836914 scopus 로고    scopus 로고
    • FLT3: ITDoes matter in leukemia
    • M. Levis, and D. Small FLT3: ITDoes matter in leukemia Leukemia 17 2003 1738 1752
    • (2003) Leukemia , vol.17 , pp. 1738-1752
    • Levis, M.1    Small, D.2
  • 8
    • 77954750384 scopus 로고    scopus 로고
    • Bench to bedside targeting of FLT3 in acute leukemia
    • K.W. Pratz, and M.J. Levis Bench to bedside targeting of FLT3 in acute leukemia Curr Drug Targets 11 2010 781 789
    • (2010) Curr Drug Targets , vol.11 , pp. 781-789
    • Pratz, K.W.1    Levis, M.J.2
  • 9
    • 0027955112 scopus 로고
    • STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells
    • D. Small, M. Levenstein, and E. Kim STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells Proc Natl Acad Sci U S A 91 1994 459 463
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 459-463
    • Small, D.1    Levenstein, M.2    Kim, E.3
  • 10
    • 0033134792 scopus 로고    scopus 로고
    • Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia
    • H. Kiyoi, T. Naoe, and Y. Nakano Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia Blood 93 1999 3074 3080
    • (1999) Blood , vol.93 , pp. 3074-3080
    • Kiyoi, H.1    Naoe, T.2    Nakano, Y.3
  • 11
    • 33745298429 scopus 로고    scopus 로고
    • Rational design of inhibitors that bind to inactive kinase conformations
    • Y. Liu, and N.S. Gray Rational design of inhibitors that bind to inactive kinase conformations Nat Chem Biol 2 2006 358 364
    • (2006) Nat Chem Biol , vol.2 , pp. 358-364
    • Liu, Y.1    Gray, N.S.2
  • 12
    • 24144454630 scopus 로고    scopus 로고
    • FLT3 tyrosine kinase inhibitors
    • M. Levis, and D. Small FLT3 tyrosine kinase inhibitors Int J Hematol 82 2005 100 107
    • (2005) Int J Hematol , vol.82 , pp. 100-107
    • Levis, M.1    Small, D.2
  • 13
    • 33751170444 scopus 로고    scopus 로고
    • Plasma inhibitory activity (PIA): A pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors
    • M. Levis, P. Brown, and B.D. Smith Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors Blood 108 2006 3477 3483
    • (2006) Blood , vol.108 , pp. 3477-3483
    • Levis, M.1    Brown, P.2    Smith, B.D.3
  • 14
    • 1842420032 scopus 로고    scopus 로고
    • Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia
    • B.D. Smith, M. Levis, and M. Beran Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia Blood 103 2004 3669 3676
    • (2004) Blood , vol.103 , pp. 3669-3676
    • Smith, B.D.1    Levis, M.2    Beran, M.3
  • 15
    • 33751173636 scopus 로고    scopus 로고
    • A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy
    • S. Knapper, A.K. Burnett, and T. Littlewood A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy Blood 108 2006 3262 3270
    • (2006) Blood , vol.108 , pp. 3262-3270
    • Knapper, S.1    Burnett, A.K.2    Littlewood, T.3
  • 16
    • 62949087552 scopus 로고    scopus 로고
    • A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response
    • K.W. Pratz, J. Cortes, and G.J. Roboz A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response Blood 113 2009 3938 3946
    • (2009) Blood , vol.113 , pp. 3938-3946
    • Pratz, K.W.1    Cortes, J.2    Roboz, G.J.3
  • 17
    • 77955714871 scopus 로고    scopus 로고
    • A pharmacodynamic study of sorafenib in patients with relapsed and refractory acute leukemias
    • K.W. Pratz, E. Cho, and M.J. Levis A pharmacodynamic study of sorafenib in patients with relapsed and refractory acute leukemias Leukemia 2010
    • (2010) Leukemia
    • Pratz, K.W.1    Cho, E.2    Levis, M.J.3
  • 18
    • 77951645227 scopus 로고    scopus 로고
    • Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia
    • F. Ravandi, J.E. Cortes, and D. Jones Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia J Clin Oncol 28 2010 1856 1862
    • (2010) J Clin Oncol , vol.28 , pp. 1856-1862
    • Ravandi, F.1    Cortes, J.E.2    Jones, D.3
  • 19
    • 0036624916 scopus 로고    scopus 로고
    • A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo
    • M. Levis, J. Allebach, and K.F. Tse A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo Blood 99 2002 3885 3891
    • (2002) Blood , vol.99 , pp. 3885-3891
    • Levis, M.1    Allebach, J.2    Tse, K.F.3
  • 20
    • 0036595143 scopus 로고    scopus 로고
    • Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412
    • E. Weisberg, C. Boulton, and L.M. Kelly Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412 Cancer Cell 1 2002 433 443
    • (2002) Cancer Cell , vol.1 , pp. 433-443
    • Weisberg, E.1    Boulton, C.2    Kelly, L.M.3
  • 21
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis
    • S.M. Wilhelm, C. Carter, and L. Tang BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis Cancer Res 64 2004 7099 7109
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 23
    • 39149129114 scopus 로고    scopus 로고
    • Mutant FLT3: A direct target of sorafenib in acute myelogenous leukemia
    • W. Zhang, M. Konopleva, and Y.X. Shi Mutant FLT3: a direct target of sorafenib in acute myelogenous leukemia J Natl Cancer Inst 100 2008 184 198
    • (2008) J Natl Cancer Inst , vol.100 , pp. 184-198
    • Zhang, W.1    Konopleva, M.2    Shi, Y.X.3
  • 24
    • 70349566478 scopus 로고    scopus 로고
    • KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation
    • Y. Shiotsu, H. Kiyoi, and Y. Ishikawa KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation Blood 114 2009 1607 1617
    • (2009) Blood , vol.114 , pp. 1607-1617
    • Shiotsu, Y.1    Kiyoi, H.2    Ishikawa, Y.3
  • 25
    • 70449475105 scopus 로고    scopus 로고
    • AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)
    • P.P. Zarrinkar, R.N. Gunawardane, and M.D. Cramer AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML) Blood 114 2009 2984 2992
    • (2009) Blood , vol.114 , pp. 2984-2992
    • Zarrinkar, P.P.1    Gunawardane, R.N.2    Cramer, M.D.3
  • 26
    • 0035281737 scopus 로고    scopus 로고
    • Phase i and pharmacokinetic study of PKC412, an inhibitor of protein kinase C
    • D.J. Propper, A.C. McDonald, and A. Man Phase I and pharmacokinetic study of PKC412, an inhibitor of protein kinase C J Clin Oncol 19 2001 1485 1492
    • (2001) J Clin Oncol , vol.19 , pp. 1485-1492
    • Propper, D.J.1    McDonald, A.C.2    Man, A.3
  • 27
    • 20844444589 scopus 로고    scopus 로고
    • Phase i trial of orally administered CEP-701, a novel neurotrophin receptor-linked tyrosine kinase inhibitor
    • J.L. Marshall, H. Kindler, and J. Deeken Phase I trial of orally administered CEP-701, a novel neurotrophin receptor-linked tyrosine kinase inhibitor Invest New Drugs 23 2005 31 37
    • (2005) Invest New Drugs , vol.23 , pp. 31-37
    • Marshall, J.L.1    Kindler, H.2    Deeken, J.3
  • 28
    • 38049018155 scopus 로고    scopus 로고
    • A quantitative analysis of kinase inhibitor selectivity
    • M.W. Karaman, S. Herrgard, and D.K. Treiber A quantitative analysis of kinase inhibitor selectivity Nat Biotechnol 26 2008 127 132
    • (2008) Nat Biotechnol , vol.26 , pp. 127-132
    • Karaman, M.W.1    Herrgard, S.2    Treiber, D.K.3
  • 29
    • 0033563119 scopus 로고    scopus 로고
    • Sustained in vivo regression of Dunning H rat prostate cancers treated with combinations of androgen ablation and Trk tyrosine kinase inhibitors, CEP-751 (KT-6587) or CEP-701 (KT-5555)
    • D.J. George, C.A. Dionne, and J. Jani Sustained in vivo regression of Dunning H rat prostate cancers treated with combinations of androgen ablation and Trk tyrosine kinase inhibitors, CEP-751 (KT-6587) or CEP-701 (KT-5555) Cancer Res 59 1999 2395 2401
    • (1999) Cancer Res , vol.59 , pp. 2395-2401
    • George, D.J.1    Dionne, C.A.2    Jani, J.3
  • 30
    • 33747105356 scopus 로고    scopus 로고
    • A Randomized, Open-Label Study of Lestaurtinib (CEP-701), an Oral FLT3 Inhibitor, Administered in Sequence with Chemotherapy in Patients with Relapsed AML Harboring FLT3 Activating Mutations: Clinical Response Correlates with Successful FLT3 Inhibition
    • M. Levis, B.D. Smith, and M. Beran A Randomized, Open-Label Study of Lestaurtinib (CEP-701), an Oral FLT3 Inhibitor, Administered in Sequence with Chemotherapy in Patients with Relapsed AML Harboring FLT3 Activating Mutations: Clinical Response Correlates with Successful FLT3 Inhibition Blood 106 2005 121a
    • (2005) Blood , vol.106
    • Levis, M.1    Smith, B.D.2    Beran, M.3
  • 31
    • 78649967669 scopus 로고    scopus 로고
    • Lestaurtinib FLT3 Inhibitory Activity Is Modulated by Concomitant Azole Therapy and May Influence Relapse Risk
    • S. Knapper, A. Burnett, and R.K. Hills Lestaurtinib FLT3 Inhibitory Activity Is Modulated by Concomitant Azole Therapy and May Influence Relapse Risk Blood 114 2009 326a
    • (2009) Blood , vol.114
    • Knapper, S.1    Burnett, A.2    Hills, R.K.3
  • 32
    • 33747378382 scopus 로고    scopus 로고
    • Phase IB Study of PKC412, an Oral FLT3 Kinase Inhibitor, in Sequential and Simultaneous Combinations with Daunorubicin and Cytarabine (DA) Induction and High-Dose Cytarabine Consolidation in Newly Diagnosed Patients with AML
    • R.M. Stone, T. Fischer, and R. Paquette Phase IB Study of PKC412, an Oral FLT3 Kinase Inhibitor, in Sequential and Simultaneous Combinations with Daunorubicin and Cytarabine (DA) Induction and High-Dose Cytarabine Consolidation in Newly Diagnosed Patients with AML Blood 106 2005 121a
    • (2005) Blood , vol.106
    • Stone, R.M.1    Fischer, T.2    Paquette, R.3
  • 33
    • 50649095250 scopus 로고    scopus 로고
    • Phase II trial of sorafenib in advanced thyroid cancer
    • V. Gupta-Abramson, A.B. Troxel, and A. Nellore Phase II trial of sorafenib in advanced thyroid cancer J Clin Oncol 26 2008 4714 4719
    • (2008) J Clin Oncol , vol.26 , pp. 4714-4719
    • Gupta-Abramson, V.1    Troxel, A.B.2    Nellore, A.3
  • 34
    • 33749017926 scopus 로고    scopus 로고
    • Phase II study of sorafenib in patients with advanced hepatocellular carcinoma
    • G.K. Abou-Alfa, L. Schwartz, and S. Ricci Phase II study of sorafenib in patients with advanced hepatocellular carcinoma J Clin Oncol 24 2006 4293 4300
    • (2006) J Clin Oncol , vol.24 , pp. 4293-4300
    • Abou-Alfa, G.K.1    Schwartz, L.2    Ricci, S.3
  • 35
    • 69249221392 scopus 로고    scopus 로고
    • Compassionate use of sorafenib in FLT3-ITD-positive acute myeloid leukemia: Sustained regression before and after allogeneic stem cell transplantation
    • S. Metzelder, Y. Wang, and E. Wollmer Compassionate use of sorafenib in FLT3-ITD-positive acute myeloid leukemia: sustained regression before and after allogeneic stem cell transplantation Blood 113 2009 6567 6571
    • (2009) Blood , vol.113 , pp. 6567-6571
    • Metzelder, S.1    Wang, Y.2    Wollmer, E.3
  • 36
    • 77955981259 scopus 로고    scopus 로고
    • Sorafenib induces sustained molecular remission in FLT3-ITD positive AML with relapse after second allogeneic stem cell transplantation without exacerbation of acute GVHD: A case report
    • J. Winkler, D. Rech, and S. Kallert Sorafenib induces sustained molecular remission in FLT3-ITD positive AML with relapse after second allogeneic stem cell transplantation without exacerbation of acute GVHD: A case report Leuk Res 34 2010 e270 e272
    • (2010) Leuk Res , vol.34
    • Winkler, J.1    Rech, D.2    Kallert, S.3
  • 37
    • 77950421846 scopus 로고    scopus 로고
    • AC220, a Potent, Selective, Second Generation FLT3 Receptor Tyrosine Kinase (RTK) Inhibitor, in a First-in-Human (FIH) Phase 1 AML Study
    • J. Cortes, J. Foran, and D. Ghirdaladze AC220, a Potent, Selective, Second Generation FLT3 Receptor Tyrosine Kinase (RTK) Inhibitor, in a First-in-Human (FIH) Phase 1 AML Study Blood 114 2009 636
    • (2009) Blood , vol.114 , pp. 636
    • Cortes, J.1    Foran, J.2    Ghirdaladze, D.3
  • 38
    • 62949099919 scopus 로고    scopus 로고
    • Human Pharmacokinetics of AC220, a Potent and Selective Class III Receptor Tyrosine Kinase Inhibitor
    • J. Cortes, J. Foran, and M. Devetten Human Pharmacokinetics of AC220, a Potent and Selective Class III Receptor Tyrosine Kinase Inhibitor Blood 110 2007 477a
    • (2007) Blood , vol.110
    • Cortes, J.1    Foran, J.2    Devetten, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.