Parenteral delivery of HPβCD: Effects on drug-HSA binding

AAPS PharmSciTech

Volumn 11, Issue 3, 2010, Pages 1152-1158

  Kurkov, Sergey V ^a   Loftsson, Thorsteinn ^a   Messner, Martin ^a   Madden, Donna ^b  

^a UNIVERSITY OF ICELAND   (Iceland)

^b Javelin Pharmaceuticals Inc   (United States)

Author keywords

2 hydroxypropyl cyclodextrin; competitive binding; equilibrium dialysis; human serum albumin; parenteral delivery; stability constant

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; ACETAZOLAMIDE; AMOXICILLIN; ATROPINE; DICLOFENAC; HUMAN SERUM ALBUMIN; ISOTONIC SOLUTION; KETOPROFEN; KETOROLAC; LIDOCAINE; PARACETAMOL; PHOSPHATE BUFFERED SALINE;

ARTICLE; DRUG DELIVERY SYSTEM; DRUG PROTEIN BINDING; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; ENVIRONMENTAL TEMPERATURE; EQUILIBRIUM DIALYSIS; IN VITRO STUDY; LIPOPHILICITY; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SINGLE DRUG DOSE;

BETA-CYCLODEXTRINS; HUMANS; INFUSIONS, PARENTERAL; KINETICS; PROTEIN BINDING; SERUM ALBUMIN;

EID: 78649906619     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-010-9482-0     Document Type: Article

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