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Volumn 52, Issue 1, 2011, Pages 122-124

Practical and efficient synthesis of N-fused tricyclic indoles

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; INDOLE DERIVATIVE; METHYL 6,7,8,9 TETRAHYDROPYRIDO[1,2 A]INDOL 10 YLACETATE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 78649892557     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2010.10.155     Document Type: Article
Times cited : (3)

References (21)
  • 1
    • 78649868080 scopus 로고    scopus 로고
    • PCT International Patent Application WO 2010031182
    • Wang, Z. PCT International Patent Application WO 2010031182, 2010.
    • (2010)
    • Wang, Z.1
  • 2
    • 78649856226 scopus 로고    scopus 로고
    • M. H. PCT International Patent Application WO 2010031183
    • Colucci, J.; Boyd, M.; Zaghdane, M. H. PCT International Patent Application WO 2010031183, 2010.
    • (2010)
    • Colucci, J.1    Boyd, M.2    Zaghdane3
  • 19
    • 78649828822 scopus 로고    scopus 로고
    • 3-Bromo-4-fluorobenzonitrile 1a (2.0 g, 10 mmol), 2-piperidinemethanol 2a (1.4 g, 12 mmol), and cesium carbonate (3.9 g, 12 mmol) were combined in DMSO (20 mL) and heated to 40 °C for 24 h. These reaction conditions gave a trace amount of the desired N-arylated piperidinemethanol 3a. Significant amount of O-arylated piperidinemethanol 3f was isolated (1.9 g, 64% yield)
    • 3-Bromo-4-fluorobenzonitrile 1a (2.0 g, 10 mmol), 2-piperidinemethanol 2a (1.4 g, 12 mmol), and cesium carbonate (3.9 g, 12 mmol) were combined in DMSO (20 mL) and heated to 40 °C for 24 h. These reaction conditions gave a trace amount of the desired N-arylated piperidinemethanol 3a. Significant amount of O-arylated piperidinemethanol 3f was isolated (1.9 g, 64% yield).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.