Effect of orally administered phenethyl isothiocyanate on hepatic gene expression in rats

Molecular Nutrition and Food Research

Volumn 54, Issue 12, 2010, Pages 1802-1806

  Telang, Urvi ^a   Morris, Marilyn E ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Cancer prevention; Gene expression; Nicotinamide N methyltransferase; Phenethyl isothiocyanate; UDP glucuronosyltransferase

Indexed keywords

ANTINEOPLASTIC AGENT; CARCINOGEN; GLUCURONOSYLTRANSFERASE; ISOTHIOCYANIC ACID DERIVATIVE; NICOTINAMIDE METHYLTRANSFERASE; PHENETHYL ISOTHIOCYANATE; UDP GLUCURONOSYLTRANSFERASE, UGT1A6; UDP-GLUCURONOSYLTRANSFERASE, UGT1A6;

ANIMAL; ARTICLE; DNA MICROARRAY; DOWN REGULATION; DRUG EFFECT; FEMALE; GENE EXPRESSION; GENETICS; LIVER; LIVER TUMOR; METABOLISM; ORAL DRUG ADMINISTRATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; STATISTICAL MODEL; UPREGULATION;

ADMINISTRATION, ORAL; ANIMALS; ANTICARCINOGENIC AGENTS; CARCINOGENS; DOWN-REGULATION; FEMALE; GENE EXPRESSION; GLUCURONOSYLTRANSFERASE; ISOTHIOCYANATES; LINEAR MODELS; LIVER; LIVER NEOPLASMS; NICOTINAMIDE N-METHYLTRANSFERASE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UP-REGULATION;

RATTUS;

EID: 78649887556     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.200900607     Document Type: Article

References (30)

1. Zhao, B. S. A., Lee, E. J., Poh, W. T., The, M. et al., Dietary isothiocyanates, glutathione S-transferase -M1, -T1 polymorphisms and lung cancer risk among Chinese women in Singapore. Cancer Epidemiol. Biomarkers Prev. 2001, 10, 1063-1067.
2. Hecht, S. S., Carmella, S. G., Murphy, S. E., Effects of watercress consumption on urinary metabolites of nicotine in smokers. Cancer Epidemiol. Biomarkers Prev. 1999, 8, 907-913.
3. Basten, G. P., Bao, Y., Williamson, G., Sulforaphane and its glutathione conjugate but not sulforaphane nitrile induce UDP-glucuronosyl transferase (UGT1A1) and glutathione transferase (GSTA1) in cultured cells. Carcinogenesis 2002, 23, 1399-1404.
4. Zhang, Y., Tang, L., Gonzalez, V., Selected isothiocyanates rapidly induce growth inhibition of cancer cells. Mol. Cancer Ther. 2003, 2, 1045-1052.
5. Izzotti, A., Larghero, P., Cartiglia, C., Longobardi, M. et al., Modulation of microRNA expression by budesonide, phenethyl isothiocyanate, and cigarette smoke in mouse liver and lung. Carcinogenesis 2010, 31, 894-901.
6. Ji, Y., Morris, M. E., Determination of phenethyl isothiocyanate in human plasma and urine by ammonia derivatization and liquid chromatography-tandem mass spectrometry. Anal. Biochem. 2003, 323, 39-47.
7. Ji, Y., Kuo, Y., Morris, M. E., Pharmacokinetics of dietary phenethyl isothiocyanate in rats. Pharm. Res. 2005, 22, 1658-1666.
8. Guo, Z., Smith, T. J., Wang, E., Sadrieh, N. et al., Effects of phenethyl isothiocyanate, a carcinogenesis inhibitor, on xenobiotic-metabolizing enzymes and nitrosamine metabolism in rats. Carcinogenesis 1992, 13, 2205-2210.
9. Dingley, K. H., Ubick, E. A., Chiarappa-Zucca, M. L., Nowell, S. et al., Effect of dietary constituents with chemopreventive potential on adduct formation of a low dose of the heterocyclic amines PhIP and IQ and phase II hepatic enzymes. Nutr. Cancer 2003, 46, 212-221.
10. Tusher, V. G., Tibshirani, R., Chu, G., Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. USA 2001, 98, 5116-5121.
11. Ambrosone, C. B., McCann, S. E., Freudenheim, J. L., Marshall, J. R. et al., Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype. J. Nutr. 2004, 134, 1134-1138.
12. Fowke, J. H., Chung, F.-L., Jin, F., Qi, D. et al., Urinary isothiocyanate levels, brassica, and human breast cancer. Cancer Res. 2003, 63, 3980-3986.
13. Giovannucci, E., Rimm, E. B., Liu, Y., Stampfer, M. J., Willett, W. C., A prospective study of cruciferous vegetables and prostate cancer. Cancer Epidemiol. Biomarkers Prev. 2003, 12, 1403-1409.
14. Aksoy, S., Szumlanski, C. L., Weinshilboum, R. M., Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization. J. Biol. Chem. 1994, 269, 14835-14840.
15. Tomida, M., Ohtake, H., Yokota, T., Kobayashi, Y., Kurosumi, M., Stat3 up-regulates expression of nicotinamide N-methyltransferase in human cancer cells. J. Cancer Res. Clin. Oncol. 2008, 134, 551-559.
16. Aoyama, K., Matsubara, K., Kondo, M., Murakawa, Y. et al., Nicotinamide-N-methyltransferase is higher in the lumbar cerebrospinal fluid of patients with Parkinson's disease. Neurosci. Lett. 2001, 298, 78-80.
17. Tomida, M., Mikami, I., Takeuchi, S., Nishimura, H., Akiyama, H., Serum levels of nicotinamide N-methyltransferase in patients with lung cancer. J. Cancer Res. Clin. Oncol. 2009, 135, 1223-1229.
18. Kim, J., Hong, S. J., Lim, E. K., Yu, Y. S. et al., Expression of nicotinamide N-methyltransferase in hepatocellular carcinoma is associated with poor prognosis. J. Exp. Clin. Cancer Res. 2009, 28, 20.
19. Sartini, D., Santarelli, A., Rossi, V., Goteri, G. et al., Nicotinamide N-methyltransferase upregulation inversely correlates with lymph node metastasis in oral squamous cell carcinoma. Mol. Med. 2007, 13, 415-421.
20. Roessler, M., Rollinger, W., Palme, S., Hagmann, M. L. et al., Identification of nicotinamide N-methyltransferase as a novel serum tumor marker for colorectal cancer. Clin. Cancer Res. 2005, 11, 6550-6557.
21. Dostalek, M., Hardy, K. D., Milne, G. L., Morrow, J. D. et al., Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems. J. Biol. Chem. 2008, 283, 17147-17157.
22. Wu, Y., Siadaty, M. S., Berens, M. E., Hampton, G. M., Theodorescu, D., Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration. Oncogene 2008, 27, 6679-6689.
23. Xu, J., Capezzone, M., Xu, X., Hershman, J. M., Activation of nicotinamide N-methyltransferase gene promoter by hepatocyte nuclear factor-1beta in human papillary thyroid cancer cells. Mol. Endocrinol. 2005, 19, 527-539.
24. Sahu, R. P., Srivastava, S. K., The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate. J. Natl. Cancer Inst. 2009, 101, 176-193.
25. Bock, K. W., Kohle, C., UDP-glucuronosyltransferase 1A6: structural, functional, and regulatory aspects. Methods Enzymol. 2005, 400, 57-75.
26. Bae, I. H., Park, M. J., Yoon, S. H., Kang, S. W. et al., Bcl-w promotes gastric cancer cell invasion by inducing matrix metalloproteinase-2 expression via phosphoinositide 3-kinase, Akt, and Sp1. Cancer Res. 2006, 66, 4991-4995.
27. Wilson, J. W., Nostro, M. C., Balzi, M., Faraoni, P. et al., Bcl-w expression in colorectal adenocarcinoma. Br. J. Cancer 2000, 82, 178-185.
28. Lee, H. W., Lee, S. S., Lee, S. J., Um, H. D., Bcl-w is expressed in a majority of infiltrative gastric adenocarcinomas and suppresses the cancer cell death by blocking stress-activated protein kinase/c-Jun NH2-terminal kinase activation. Cancer Res. 2003, 63, 1093-1100.
29. Papa, S., Zazzeroni, F., Fu, Y. X., Bubici, C. et al., Gadd45beta promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling. J. Clin. Invest. 2008, 118, 1911-1923.
30. Beere, H. M., "The stress of dying": the role of heat shock proteins in the regulation of apoptosis. J. Cell Sci. 2004, 117, 2641-2651.