Role of the C-terminal di-leucine motif of 5-HT1A and 5-HT1B serotonin receptors in plasma membrane targeting

Journal of Cell Science

Volumn 119, Issue 20, 2006, Pages 4276-4284

  Carrel, Damien ^a   Hamon, Michel ^a   Darmon, Michèle ^a  

^a INSERM   (France)

Author keywords

5 HT1A; 5 HT1B; Di leucine motif; Endoplasmic reticulum; Folding; Palmitoylation

Indexed keywords

ALANINE; CYSTEINE; LEUCINE; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL STRAIN COS7; CONTROLLED STUDY; DRUG RECEPTOR BINDING; ENDOPLASMIC RETICULUM; INTRACELLULAR TRANSPORT; LIGAND BINDING; NERVE CELL CULTURE; NONHUMAN; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN MOTIF; RAT; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL MEMBRANE; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; CYSTEINE; ENDOPLASMIC RETICULUM; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; LEUCINE; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN TRANSPORT; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTOR, SEROTONIN, 5-HT1B; SEROTONIN AGONISTS; SWINE;

EID: 33751160783     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.03189     Document Type: Article

References (41)

1. Albert, P. R., Zhou, Q. Y., Van Tol, H. H., Bunzow, J. R. and Civelli, O. (1990), Cloning, functional expression, and mRNA tissue distribution of the rat 5-hydroxytryptaminel A receptor gene. J Biol. Chem, 265, 5825-5832.
2. 35S]GTPgammaS binding in rat hippocampal membranes. Eur. J. Pharmacol. 343, 303-312.
3. Barlowe, C. (2003). Signals for COPII-dependent export from the ER: what's the ticket out? Trends Cell Biol. 13, 295-300.
4. Barnes, N. M. and Sharp, T. (1999). A review of central 5-HT receptors and their function. Neuropharmacology 38, 1083-1152.
5. Bermak, J. C., Li, M., Bullock, C. and Zhou, Q. Y. (2001). Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein. Nat. Cell Biol. 3, 492-498.
6. 1B receptors expressed in epithelial LLC-PK1 cells. J. Neurochem. 71, 2294-2303.
7. 1A receptor-mediated Erk activation requires calcium/ calmodulin-dependent receptor endocytosis. J. Biol. Chem. 274, 4749-4753.
8. Doi, T., Sugimoto, H., Arimoto, L, Hiroaki, Y. and Fujiyoshi, Y. (1999). Interactions of endothelin receptor subtypes A and B with Gi, Go, and Gq in reconstituted phospholipid vesicles. Biochemistry 38, 3090-3099.
9. Duvernay, M. T., Zhou, F. and Wu, G. (2004). A conserved motif for the transport of G protein-coupled receptors from the endoplasmic reticulum to the cell surface. J. Biol. Chem. 279, 30741-30750.
10. 1A receptor antibodies in rabbits injected with a synthetic peptide. Neurosci. Lett. 118, 189-192.
11. Ercolani, L., Stow, J. L., Boyle, J. F., Holtzman, E. J., Lin, H., Grove, J. R. and Ausiello, D. A. (1990). Membrane localization of the pertussis toxin-sensitive G-protein subunits alpha i-2 and alpha i-3 and expression of a metallothionein-alpha i-2 fusion gene in LLC-PK1 cells. Proc. Natl. Acad. Sci. USA 87, 4635-4639.
12. 1A receptors in the rat brain. Eur J. Pharmacol. 337, 297-308.
13. 1B receptors in knock-out mice lacking the 5-HT transporter. Eur. J. Neurosci. 12, 2299-2310.
14. Fan, G. H., Yang, W., Wang, X. J., Qian, Q. and Richmond, A. (2001). Identification of a motif in the carboxyl terminus of CXCR2 that is involved in adaptin 2 binding and receptor internalization. Biochemistry 40, 791-800.
15. Gabilondo, A. M., Hegler, J., Krasel, C., Boivin-Jahns, V., Hein, L. and Lohse, M. J. (1997). A dileucine motif in the C terminus of the beta2-adrenergic receptor is involved in receptor internalization. Proc. Natl. Acad. Sci. USA 94, 12285-12290.
16. 1A receptor via a G protein beta gamma-subunit-initiated pathway. Biochemistry 35, 13716-13722.
17. Gaudreau, R., Beaulieu, M. E., Chen, Z., Le Gouill, C., Lavigne, P., Stankova, J. and Rola-Pleszczynski, M. (2004). Structural determinants regulating expression of the high affinity leukotriene B4 receptor: involvement of dileucine motifs and alpha-helix VIII. J. Biol. Chem. 279, 10338-10345.
18. Goslin, K., Asmussen, H. and Banker, G. (1998). Rat hippocampal neurons in low-density culture. In Culturing Nerve Cells (ed. G. Banker and K. Goslin), pp. 339-370. Cambridge, MA: MIT Press.
19. 1A autoreceptor interactions in the rat dorsal raphe nucleus: an in vitro electrophysiological study. Neuroscience 41, 495-505.
20. 1D serotonin receptors in rat: Structural and pharmacological comparison of the two cloned receptors. Mol. Cell. Neurosci, 3, 578-587.
21. Hunziker, W. and Fumey, C. (1994). A di-leucine motif mediates endocytosis and basolateral sorting of macrophage IgG Fc receptors in MDCK cells. EMBO J. 13, 2963-2969.
22. Jaskolski, F., Coussen, F., Nagarajan, N., Normand, E., Rosenmund, C. and Mulle, C. (2004). Subunit composition and alternative splicing regulate membrane delivery of kainate receptors. J. Neurosci. 24, 2506-2515.
23. 1B receptor in axonal-apical targeting. J. Neurosci. 20, 9111-9118.
24. Kia, H. K., Miquel, M. C., Brisorgueil, M. J., Daval, G., Riad, M., El Mestikawy, S., Hamon, M. and Vergé, D. (1996). Immunocytochemical localization of serotoninlA receptors in the rat central nervous system. J. Comp. Neurol. 365, 289-305.
25. Kornfeld, R. and Kornfeld, S. (1995). Assembly of asparagine-linked oligosaccharides. Annu. Rev. Biochem. 54, 631-664.
26. Laemmli, U. K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
27. Letourneur, F. and Klausner, R. D. (1992). A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting andocytosis of CD3 chains. Cell 69, 1143-1157.
28. Ng, G. Y., George, S. R., Zastawny, R. L., Caron, M., Bouvier, M., Dennis, M. and O'Dowd, B. F. (1993). Human serotonin1B receptor expression in Sf9 cells: phosphorylation, palmitoylation, and adenylyl cyclase inhibition. Biochemistry 32, 11727-11733.
29. Oksche, A., Dehe, M., Schülein, R., Wiesner, B. and Rosenthal, W. (1998). Folding and cell surface expression of the vasopressin V2 receptor: requirement of the intracellular C-terminus. FEBS Lett. 424, 57-62.
30. Orsini, M. J., Parent, J. L., Mundell, S. J., Benovic, J. L. and Marchese, A. (1999). Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization. J. Biol. Chem. 274, 31076-31086.
31. Pankevych, H., Korkhov, V., Freissmuth, M. and Nanoff, C. (2003). Truncation of the A1 adenosine receptor reveals distinct roles of the membrane-proximal carboxyl terminus in receptor folding and G protein coupling. J. Biol. Chem. 278, 30283-30293.
32. Papoucheva, E., Dumuis, A., Sebben, M., Richter, D. W. and Ponimaskin, E. G. (2004). The 5-hydroxytryptamine (1A) receptor is stably palmitoylated, and acylation is critical for communication of receptor with Gi protein. J. Biol. Chem. 279, 3280-3291.
33. Qanbar, R. and Bouvier, M. (2003). Role of palmitoylation/ depalmitoylation reactions in G-protein-coupled receptor function. Pharmacol. Ther 97, 1-33.
34. 1B serotonin receptors in adult rat brain. J. Comp. Neurol. 417, 181-194.
35. Robert, J., Clauser, E., Petit, P. X. and Ventura, M. A. (2005). A novel C-terminal motif is necessary for the export of the vasopressin V1b/V3 receptor to the plasma membrane. J. Biol. Chem. 280, 2300-2308.
36. Rodriguez, M. C., Xie, Y. B., Wang, H., Collison, K. and Segaloff, D. L. (1992). Effects of truncations of the cytoplasmic tail of the luteinizing hormone/chorionic gonadotropin receptor on receptor- mediated hormone internalization. Mol. Endocrinol. 6, 327-336.
37. 1B receptors: from protein to physiological function and behavior. Neurosci. Biobehav. Rev. 28, 565-582.
38. Sari, Y., Miquel, M. C., Brisorgueil, M. J.. Ruiz, G., Doucet, E., Hamon, M. and Vergé, D. (1999). Cellular and subcellular localization of 5-hydroxytryptamine1B receptors in the rat central nervous system: immunocytochemical, autoradiographic and lesion studies. Neuroscience 88, 899-915.
39. Schülein, R., Hermosilla, R., Oksche, A., Dehe, M., Wiesner, B., Krause, G. and Rosenthal, W. (1998). A dileucine sequence and an upstream glutamate residue in the intracellular carboxyl terminus of the vasopressin V2 receptor are essential for cell surface transport in COS.M6 cells. Mol. Pharmacol. 54, 525-535.
40. Tai, A. W., Chuang, J. Z., Bode, C., Wolfrum, U. and Sung, C. H. (1999). Rhodopsin's carboxy-terminal cytoplasmic tail acts as a membrane receptor for cytoplasmic dynein by binding to the dynein light chain Tctex-1. Cell 97, 877-887.
41. Werry, T. D., Sexton, P. M. and Christopoulos, A. (2005). "Ins and outs" of seven-transmembrane receptor signalling to ERK. Trends Endocrinol. Metab. 16, 26-33.