Synthesis and in-vitro inotropic evaluation of 2-(4-substitutedbenzyl-1,4- diazepan-1-yl)-N-(4,5-dihydro-1-phenyl-[1,2,4]triazolo[4,3-a]quinolin-7-yl) acetamides

Archiv der Pharmazie

Volumn 343, Issue 11-12, 2010, Pages 700-705

  Jiang, Sheng Ming ^a   Ye, Bai Jun ^a   Liu, Xue Kun ^a   Zhang, Tian Yi ^a   Cui, Xun ^a   Piao, Hu Ri ^a  

^a YANBIAN UNIVERSITY   (China)

Author keywords

1,4 Diazepane; 1,2,4 Triazolo 4,3 a quinolines; Positive inotropic activity; Stroke volume

Indexed keywords

2 (4 BENZYL 1,4 DIAZEPAN 1 YL) N [4,5 DIHYDRO 1 PHENYL (1,2,4)TRIAZOLO(4,3-A)QUINOLIN 7 YL]ACETAMIDE; 2 [4 (2 BROMOBENZYL) 1,4 DIAZEPAN 1 YL] N [4,5 DIHYDRO 1 PHENYL (1,2,4)TRIAZOLO(4,3 A)QUINOLIN 7 YL]ACETAMIDE; 2 [4 (2 CHLOROBENZYL) 1,4 DIAZEPAN 1 YL] N [4,5 DIHYDRO 1 PHENYL (1,2,4)TRIAZOLO(4,3 A)QUINOLIN 7 YL]ACETAMIDE; 2 [4 (2 FLUOROBENZYL) 1,4 DIAZEPAN 1 YL] N [4,5 DIHYDRO 1 PHENYL (1,2,4)TRIAZOLO(4,3 A)QUINOLIN 7 YL]ACETAMIDE; 2 [4 (2 METHOXYBENZYL) 1,4 DIAZEPAN 1 YL] N [4,5 DIHYDRO 1 PHENYL (1,2,4)TRIAZOLO(4,3 A)QUINOLIN 7 YL]ACETAMIDE; 2 [4 (2 NITROBENZYL) 1,4 DIAZEPAN 1 YL] N [4,5 DIHYDRO 1 PHENYL (1,2,4)TRIAZOLO(4,3 A)QUINOLIN 7 YL]ACETAMIDE; 2 [4 (3 BROMOBENZYL) 1,4 DIAZEPAN 1 YL] N [4,5 DIHYDRO 1 PHENYL (1,2,4)TRIAZOLO(4,3 A)QUINOLIN 7 YL]ACETAMIDE; 2 [4 (3 CHLOROBENZYL) 1,4 DIAZEPAN 1 YL] N [4,5 DIHYDRO 1 PHENYL (1,2,4)TRIAZOLO(4,3 A)QUINOLIN 7 YL]ACETAMIDE; 2 [4 (3 FLUOROBENZYL) 1,4 DIAZEPAN 1 YL] N [4,5 DIHYDRO 1 PHENYL (1,2,4)TRIAZOLO(4,3 A)QUINOLIN 7 YL]ACETAMIDE; 2 [4 (3 METHOXYBENZYL) 1,4 DIAZEPAN 1 YL] N [4,5 DIHYDRO 1 PHENYL (1,2,4TRIAZOLO(4,3 A)QUINOLIN 7 YL]ACETAMIDE; 2 [4 (3,4 DICHLOROBENZYL) 1,4 DIAZEPAN 1 YL] N [4,5 DIHYDRO 1 PHENYL (1,2,4)TRIAZOLO(4,3 A)QUINOLIN 7 YL]ACETAMIDE; 2 [4 (3,4 DIMETHOXYBENZYL) 1,4 DIAZEPAN 1 YL] N [4,5 DIHYDRO 1 PHENYL (1,2,4)TRIAZOLO(4,3 A)QUINOLIN 7 YL]ACETAMIDE; 2 [4 (4 CHLOROBENZYL) 1,4 DIAZEPAN 1 YL] N [4,5 DIHYDRO 1 PHENYL (1,2,4)TRIAZOLO(4,3 A)QUINOLIN 7 YL]ACETAMIDE; 2 [4 (4 FLUOROBENZYL) 1,4 DIAZEPAN 1 YL] N [4,5 DIHYDRO 1 PHENYL (1,2,4)TRIAZOLO(4,3 A)QUINOLIN 7 YL]ACETAMIDE; 2 [4 (4 METHOXYBENZYL) 1,4 DIAZEPAN 1 YL] N [4,5 DIHYDRO 1 PHENYL (1,2,4)TRIAZOLO(4,3 A)QUINOLIN 7 YL]ACETAMIDE; 2 [4 (4 METHYLBENZYL) 1,4 DIAZEPAN 1 YL] N [4,5 DIHYDRO 1 PHENYL (1,2,4)TRIAZOLO(4,3 A)QUINOLIN 7 YL]ACETAMIDE; ACETAMIDE DERIVATIVE; INOTROPIC AGENT; MILRINONE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHRONOTROPISM; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HEART ATRIUM; HEART STROKE VOLUME; IN VITRO STUDY; INOTROPISM; ISOLATED HEART; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ACETAMIDES; ANIMALS; CARDIOTONIC AGENTS; HEART; HEART RATE; QUINOLINES; RABBITS; STROKE VOLUME; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78649867710     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201000032     Document Type: Article

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