Synthesis and positive inotropic activity of N-(4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)-2-(piperazin-1-yl)ac etamide derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 16, 2008, Pages 4606-4609

  Zhang, Chun Bo ^a   Cui, Xun ^a   Hong, Lan ^a   Quan, Zhe Shan ^a   Piao, Hu Ri ^a  

^a YANBIAN UNIVERSITY   (China)

Author keywords

1,2,4 Triazolo 4,3 a quinolines; Positive inotropic activity; Stroke volume

Indexed keywords

INOTROPIC AGENT; MILRINONE; N (4,5 DIHYDRO 1,2,4 TRIAZOLO[4,3 A]QUINOLIN 7 YL) 2 (PIPERAZIN 1 YL)ACETAMIDE DERIVATIVE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHRONOTROPISM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HEART; HEART LEFT ATRIUM; HEART STROKE VOLUME; INOTROPISM; NONHUMAN; RABBIT;

ACETAMIDES; ANIMALS; CARDIOTONIC AGENTS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; HEART; HEART ATRIA; HEART RATE; MILRINONE; MODELS, CHEMICAL; MYOCARDIUM; OXAZOLIDINONES; RABBITS; STROKE VOLUME; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

ORYCTOLAGUS CUNICULUS;

EID: 48849100907     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.07.026     Document Type: Article

References (9)

1. Neubauer S. N. Eng. J. Med. 356 (2007) 1140
2. Harada K., Supriatno, Yoshida H., and Sato M. Int. J. Oncol. 27 (2005) 1489
3. Piao H.R., Quan Z.S., Xu M.X., and Deng D.W. Chin. J. Med. Chem. 9 (1999) 79
4. Piao H.R., Quan Z.S., Jiang Y.Z., Xu M.X., and Deng D.W. Chin. J. Mod. Appl. Pharm. 3 (2000) 206
5. Zhang C.B., Piao H.R., and Quan Z.S. Chem. Res. Appl. 5 (2002) 618
6. 3: C, 65.20; H, 6.13; N, 18.25. Found: C, 65.00; H, 6.23; N, 18.52.
7. Cho K.W., Kim S.H., Kim C.H., and Seul K.H. Am. J. Physiol. 268 (1995) 1129
8. Lee S.J., Kim S.Z., Cui X., Kim S.H., Lee K.S., Chung Y.J., and Cho K.W. Am. J. Physiol. Heart Circ. Physiol. 278 (2000) H208
9. Cui X., Wen J.F., Jin J.Y., Xu W.X., Kim S.Z., Kim S.H., Lee H.S., and Cho K.W. Am. J. Physiol. Regul. Integr. Comp. Physiol. 282 (2002) R1477