Synthesis and positive inotropic evaluation of 2-(4-(4-substituted benzyloxy)-3-methoxybenzyl)-1,4-diazepan-1-yl-n-(4,5-dihydro-1-methyl[1,2,4] triazolo[4,3-a]quinolin-7-yl)-acetamides

Archiv der Pharmazie

Volumn 341, Issue 12, 2008, Pages 794-799

  Li, Jing Yuan ^a   Cui, Xun ^a   Liu, Xue Kun ^a   Hong, Lan ^a   Quan, Zhe Shan ^a   Piao, Hu Ri ^a  

^a YANBIAN UNIVERSITY   (China)

Author keywords

1,4 Diazepane; 1,2,4 Triazolo 4,3 a quinolines; Positive inotropic activity; Stroke volume

Indexed keywords

2 (4 (4 (2 BROMOBENZYLOXY) 3 METHOXYBENZYL) 1,4 DIAZEPAN 1 YL] N (4,5 DIHYDRO 1 METHYL[1,2,4]TRIAZOLO[4,3 A]QUINOLIN 7 YL)ACETAMIDE; 2 (4 (4 (2 CHLOROBENZYLOXY) 3 METHOXYBENZYL) 1,4 DIAZEPAN 1 YL] N (4,5 DIHYDRO 1 METHYL[1,2,4]TRIAZOLO[4,3 A]QUINOLIN 7 YL)ACETAMIDE; 2 (4 (4 (2 FLUOROBENZYLOXY) 3 METHOXYBENZYL) 1,4 DIAZEPAN 1 YL] N (4,5 DIHYDRO 1 METHYL[1,2,4]TRIAZOLO[4,3 A]QUINOLIN 7 YL)ACETAMIDE; 2 (4 (4 (2 METHOXYBENZYLOXY) 3 METHOXYBENZYL) 1,4 DIAZEPAN 1 YL] N (4,5 DIHYDRO 1 METHYL[1,2,4]TRIAZOLO[4,3 A]QUINOLIN 7 YL)ACETAMIDE; 2 (4 (4 (2,6 DICHLOROBENZYLOXY) 3 METHOXYBENZYL) 1,4 DIAZEPAN 1 YL] N (4,5 DIHYDRO 1 METHYL[1,2,4]TRIAZOLO[4,3 A]QUINOLIN 7 YL)ACETAMIDE; 2 (4 (4 (3 FLUOROBENZYLOXY) 3 METHOXYBENZYL) 1,4 DIAZEPAN 1 YL] N (4,5 DIHYDRO 1 METHYL[1,2,4]TRIAZOLO[4,3 A]QUINOLIN 7 YL)ACETAMIDE; 2 (4 (4 (3,4 DICHLOROBENZYLOXY) 3 METHOXYBENZYL) 1,4 DIAZEPAN 1 YL] N (4,5 DIHYDRO 1 METHYL[1,2,4]TRIAZOLO[4,3 A]QUINOLIN 7 YL)ACETAMIDE; 2 (4 (4 (3,4 DIMETHOXYBENZYLOXY) 3 METHOXYBENZYL) 1,4 DIAZEPAN 1 YL] N (4,5 DIHYDRO 1 METHYL[1,2,4]TRIAZOLO[4,3 A]QUINOLIN 7 YL)ACETAMIDE; 2 (4 (4 (4 CHLOROBENZYLOXY) 3 METHOXYBENZYL) 1,4 DIAZEPAN 1 YL] N (4,5 DIHYDRO 1 METHYL[1,2,4]TRIAZOLO[4,3 A]QUINOLIN 7 YL)ACETAMIDE; 2 (4 (4 (4 FLUOROBENZYLOXY) 3 METHOXYBENZYL) 1,4 DIAZEPAN 1 YL] N (4,5 DIHYDRO 1 METHYL[1,2,4]TRIAZOLO[4,3 A]QUINOLIN 7 YL)ACETAMIDE; 2 (4 (4 (4 METHOXYBENZYLOXY) 3 METHOXYBENZYL) 1,4 DIAZEPAN 1 YL] N (4,5 DIHYDRO 1 METHYL[1,2,4]TRIAZOLO[4,3 A]QUINOLIN 7 YL)ACETAMIDE; 2 (4 (4 (4 METHYLBENZYLOXY) 3 METHOXYBENZYL) 1,4 DIAZEPAN 1 YL] N (4,5 DIHYDRO 1 METHYL[1,2,4]TRIAZOLO[4,3 A]QUINOLIN 7 YL)ACETAMIDE; 2 (4 (4 BENZYLOXY 3 METHOXYBENZYL) 1,4 DIAZEPAN 1 YL] N (4,5 DIHYDRO 1 METHYL[1,2,4]TRIAZOLO[4,3 A]QUINOLIN 7 YL)ACETAMIDE; 2 (4 BENZYLPIPERAZIN 1 YL) N (3,4 DIHYDRO 2(1H)QUINOLINON 6 YL)ACETAMIDE; 2 CHLORO N (4,5 DIHYDRO 1 METHYL[1,2,4]TRIAZOLO[4,3 A]QUINOLIN 7 YL)ACETAMIDE; ACETAMIDE DERIVATIVE; CARDIOTONIC AGENT; LEVOSIMENDAN; MILRINONE; PIPERANOMETOZINE; TOBORINONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONOTROPISM; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; HEART LEFT ATRIUM; HEART STROKE VOLUME; IN VITRO STUDY; INOTROPISM; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ACETAMIDES; ANIMALS; CARDIOTONIC AGENTS; HEART; QUINOLINES; RABBITS; STROKE VOLUME;

EID: 57049100541     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200800132     Document Type: Article

References (15)

1. The Digitalis Investigation Group. N. Engl. J. Med. 1997, 336, 525-533.
2. M. Packer, J. R. Carver, R. J. Rodeheffer, R. J. Ivanhoe, et al., N. Engl. J. Med. 1991, 325, 1468-1475.
3. J. N. Cohn, S. O. Goldstein, B. H. Greenberg, B.H. Lorell, et al., N. Engl. J. Med. 1998, 339, 1810-1816.
4. K. Harada, Supriatno, H. Yoshida, M. Sato, Int. J. Oncol. 2005, 27, 1489-1497.
5. A. Fedman, T. H. Pak, C. C. Wu, H. L. Haber, et al., Circulation, 1996, 93, 474-483.
6. B. Swynghedauw, D. Charlemagne, Eur. Heart J. Suppl. 2002, 4, D43-D49.
7. M. T. Slawsky, W. S. Colucci, S. S. Gottlieb, B. H. Greenberg, et al., Circulation, 2000, 102, 2222-2227.
8. N. Gauthier, A. H. Anselm, H. Handdad, Curr. Opin. Cardiol. 2008, 23, 134-140.
9. S. Neubauer, N. Eng. J. Med. 2007, 356, 1140-1151.
10. H. R. Piao, Z. S. Quan, M. X. Xu, D. W. Deng, Chin. J. Med. Chem. 1999, 9, 79-83.
11. C. B. Zhang, H. R. Piao, Z. S. Quan, Chem. Res. & Appl. 2002, 5, 618-619.
12. X. C. Liao, Chin. J. Pharm. 1993, 1, 21-22.
13. K. W. Cho, S. H. Kim, C. H. Kim, K. H. Seul, Am. J. Physiol. 1995, 268, 1129-1136.
14. S. J. Lee, S. J. Kim, Am. J. Physiol. Heart Circ. Physiol. 2000, 278, H208-221.
15. X. Cui, J. Y. Jin, W. X. Xu, Am. J. Physiol. Regul. Integr. Comp. Physiol. 2002, 282, R1477-R1489.