Isolation and structure determination of a cholesterol esterase inhibitor from Ganoderma lucidum

Journal of Microbiology and Biotechnology

Volumn 20, Issue 11, 2010, Pages 1521-1523

  Kim, Shin Duk ^a  

^a Seokyung University   (South Korea)

Author keywords

Cholesterol esterase inhibitor; Ergosterol peroxide; Ganoderma lucidum; Hypocholesterolemic effect

Indexed keywords

5ALPHA,8ALPHA EPIDIOXYERGOSTA 6,22 DIEN 3BETA OL; CHOLESTEROL ESTERASE; ESTERASE INHIBITOR; GANODERMA LUCIDUM EXTRACT; HYPOCHOLESTEROLEMIC AGENT; METHANOL; UNCLASSIFIED DRUG;

ARTICLE; BIOASSAY; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; DRUG STRUCTURE; ENZYME INHIBITION; HYPOCHOLESTEROLEMIC EFFECT; IC 50; NONHUMAN; PHYSICAL CHEMISTRY; STRUCTURE ANALYSIS; THIN LAYER CHROMATOGRAPHY; ULTRAVIOLET SPECTROSCOPY;

ANIMALS; ENZYME INHIBITORS; ERGOSTEROL; KINETICS; MOLECULAR STRUCTURE; REISHI; STEROL ESTERASE; SWINE;

GANODERMA LUCIDUM;

EID: 78649860411     PISSN: 10177825     EISSN: 17388872     Source Type: Journal    
DOI: 10.4014/jmb.1006.06037     Document Type: Article

References (19)

1. Bailey, J. M., L. Gallo, and J. Gillespie. 1995. Inhibition of dietary cholesterol ester absorption by 3-BCP, a suicide inhibitor of cholesterol esterase. Biochem. Soc. Trans. 23: 408S.
2. Bhat, S. G. and H. L. Brockman. 1982. The role of cholesteryl ester hydrolysis and synthesis in cholesterol transport across rat intestinal mucosal membrane. A new concept. Biochem. Biophys. Res. Commun. 109: 486-492.
3. Bojana, B., M. Berovic, J. Zhang, and L. Zhi-Bin. 2007. Ganoderma lucidum and its pharmaceutically active compounds. Biotech. Annu. Rev. 13: 265-301.
4. Cateni, F., B. Dolijak, M. Zacchigna, M. Anderluh, A. Piltaver, G. Scialino, and E. Banfi. 2007. New biologically active epidioxysterols from Stereum hirsutum. Bioorg. Med. Chem. Lett. 17: 6330-6334.
5. Gallo, L. L., S. B. Clark, S. Myers, and G. V. Vahouny. 1984. Cholesterol absorption in rat intestine: Role of cholesterol esterase and acyl coenzyme A:cholesterol acyltransferase. J. Lipid Res. 25: 604-612.
6. Grundy, S. M. 1983. Absorption and metabolism of dietary cholesterol. Annu. Rev. Nutr. 3: 71-96.
7. Hosie, L., L. D. Sutton, and D. M. Quinn. 1987. p-Nitrophenyl and cholesteryl-N-alkyl carbamates as inhibitors of cholesterol esterase. J. Biol. Chem. 262: 260-264.
8. Howles, P. N., C. P. Carter, and D. Y. Hui. 1996. Dietary free and esterified cholesterol absorption in cholesterol esterase (bile salt-stimulated lipase) gene-targeted mice. J. Biol. Chem. 271: 7196-7202.
9. Huang, Y. and D. Y. Hui. 1990. Metabolic fate of pancreasderived cholesterol esterase in intestine: An in vitro study using Caco-2 cells. J. Lipid Res. 31: 2029-2037.
10. Hui, D. Y. 1996. Molecular biology of enzymes involved with cholesterol ester hydrolysis in mammalian tissues. Biochim. Biophys. Acta 1303: 1-14.
11. Ikeda, I., R. Matsuoka, T. Hamada, K. Mitsui, S. Imabayashi, A. Uchino, et al. 2002. Cholesterol esterase accelerates intestinal cholesterol absorption. Biochim. Biophys. Acta 1571: 34-44.
12. Kim, D. H., S. J. Jung, I. S. Chung, Y. H. Lee, D. K. Kim, S. H. Kim, et al. 2005. Ergosterol peroxide from flowers of Erigeron annuus L. as an anti-atherosclerosis agent. Arch. Pharm. Res. 28: 541-545.
13. Krause, B. R., D. R. Sliskovic, M. Anderson, and R. Homan. 1998. Lipid-lowering effects of WAY-121898, an inhibitor of pancreatic cholesteryl ester hydrolase. Lipids 33: 489-498.
14. Krzyczkowski, W., E. Malinowska, P. Suchocki, J. Kleps, M. Olejnik, and F. Herold. 2008. Isolation and quantitative determination of ergosterol peroxide in various edible mushroom species. Food Chem. 113: 351-355.
15. Kuo, L. M., K.Y. Chen, S. Y. Hwang, J. L. Chen, Y. Y. Liu, C. C. Liaw, et al. 2005. DNA topoisomerase I inhibitor, ergosterol peroxide from Penicillium oxalicum. Planta Med. 71: 77-78.
16. Nam, K. S., Y. S. Jo, Y. H. Kim, J. W. Hyun, and H. W. Kim. 2001. Cytotoxic activities of acetoxyscirpenediol and ergosterol peroxide from Paecilomyces tenuipes. Life Sci. 69: 229-237.
17. Paterson, R. R. M. 2006. Ganoderma - A therapeutic fungal biofactory. Phytochemistry 67: 1985-2001.
18. Shamir, R., W. J. Johnson, R. Zolfaghari, H. S. Lee, and E. A. Fisher. 1995. Role of bile salt-dependent cholesteryl ester hydrolase in the uptake of micellar cholesterol by intestinal cells. Biochemistry 34: 6351-6358.
19. Yang, B. K., S. C. Jeong, and C. H. Song. 2002. Hypolipidemic effect of exo- and endo-biopolymers produced from submerged mycelial culture of Ganoderma lucidum in rats. J. Microbiol. Biotechnol. 12: 872-877.