DNA topoisomerase I inhibitor, ergosterol peroxide from Penicillium oxalicum

Planta Medica

Volumn 71, Issue 1, 2005, Pages 77-79

  Kuo, Li Ming Yang ^a   Chen, Kuei Yuh ^d   Hwang, Shy Yuan ^b   Chen, Jin Liang ^c   Liu, Yen Yin ^d   Liaw, Chia Ching ^a   Ye, Po Ho ^e   Chou, Cheng Jen ^a   Shen, Chien Chang ^a   Kuo, Yao Haur ^a  

^a NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^b ENDEMIC SPECIES RESEARCH INSTITUTE   (Taiwan)

^c CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

^d CHINESE CULTURE UNIVERSITY   (Taiwan)

^e NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE INHIBITOR; ERGOSTEROL; ERGOSTEROL PEROXIDE; LINOLEIC ACID; PALMITOLEIC ACID; PENICILLIUM OXALICUM EXTRACT; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; HUMAN; HUMAN CELL; INHIBITION KINETICS; MYCELIUM; PENICILLIUM; PENICILLIUM OXALICUM; STRUCTURE ANALYSIS;

AROMATASE INHIBITORS; DNA TOPOISOMERASES, TYPE I; ERGOSTEROL; HUMANS; PENICILLIUM; PHYTOTHERAPY; PLANT EXTRACTS;

EID: 13544251488     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-837755     Document Type: Article

References (15)

1. Wang JC. DNA topoisomerases. Annual Review of Biochemistry 1996; 65: 635-92
2. Heck MM, Hittelman WN, Eamshaw WC. Differential expression of DNA topoisomerases I and II during the eukaryotic cell cycle. Proceedings of National Academy of Science of the United States of America 1988; 85: 1086-90
3. van der Zee AG, Hollema H, de Jong S, Boonstra H, Gouw A, Willemse PH, Zijlstra JG, De Vries EG. P-glycoprotein expression and DNA topoisomerase I and II activity in benign tumors of the ovary and in malignant tumors of the ovary, before and after platinum/cyclophosphamide chemotherapy. Cancer Research 1991; 51: 5915-20
4. Verwij J. Topoisomerase I inhibitors and other new cytotoxic drugs. European Journal of Cancer 1995; 31A: 828-30
5. Valenti M, Nieves-Neira W, Kohlhagen G, Kohn KW, Wall ME, Wani MC, Pommier Y. Novel 7-alkylmethylenedioxy-camptothecinderivatives exhibit increased cytotoxicity and induce persistent cleavable complexes both with purified mammalian topoisomerase I and in human colon carcinoma SW620 cells. Molecular Pharmacology 1997; 52: 82-7
6. Takaishi Y, Uda M, Ohashi T, Nakano K, Murakami K, Tomimatsu T. Glycosides of ergosterol derivatives from Hericum erinacens. Phytochemistry 1991; 30: 4117-20
7. Takaishi Y, Adachi R, Murakami T, Ohashi T, Nakano K, Tomimatsu T. A polyoxygenated steroid from Lasiosphaera nipponica. Phytochemistry 1992; 31: 243-6
8. Rubinstein I, Goad LJ, Clague ADH, Mulheirn LJ. The 220 MHz NMR spectra of phytosterols. Pytochemistry 1976; 15: 195-200
9. Leslie Gunatilaka AA, Gopichand Y, Schmitz FJ, Djerassi C. Minor and trace sterols in marine invertebrates. 26. Isolation and structure elucidation of nine new 5 α,8 β-epidioxy sterols from four marine organisms. Journal of Organic Chemistry 1981; 46: 3860-6
10. Pouchert CJ, Behnke J. The Aldrich Library of 13C and 1H FT NMR Spectra, 1st edn. Milwaukee WI: Aldrich Chemical Co, 1993; Vol. 1: pp 782 and 785
11. Kahlos K, Kangas L, Hiltunen R. Ergosterol peroxide, an active compound from Inonotus radiatus. Planta Med 1989; 55: 389-90
12. Narbe G, Lindequist U, Teuscher E, Franke P, Vainiotalo P, Basner R. The chemistry of immunosuppressive acting fractions of Meripilus giganteus (Pers ex.Fr.) Karst., the giant spore. Pharmazie 1991; 46: 738-40
13. Yasukawa K, Akihisa T, Kanno H, Kaminaga T, Izumida M, Sakoh T, Tamura T, Takido M. Inhibitory effects of sterols isolated from Chlorella vulgaris on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation and tumor promotion in mouse skin. Biol. Pharm Bull 1996; 19: 573-6
14. Kuo YH, Li SY, Shen YC, Huang HC, Hsu YW, Tseng RJ, Ou JC, Chen CF. Sesquiterpene polyol esters and triterpenes from Celastrus punctatus. Chinese Pharmaceutical Journal 2001; 53: 257-68
15. Sutapa R, Banasri H, Bidyottam M, Aditi D, Hemanta KM. Diospyrin, a bisnaphthoquinone: a novel inhibitor of type 1 DNA topoisomerase of Leishmania donovani. Molecular Pharmacology 1998; 54: 994-9