Oxidative phosphorylation induces de novo expression of the MHC class I in tumor cells through the ERK5 pathway

Journal of Immunology

Volumn 185, Issue 6, 2010, Pages 3498-3503

  Charni, Seyma ^a,b   De Bettignies, Geoffroy ^a,b   Rathore, Moeez G ^a,b   Aguilo, Juan I ^c   Van Den Elsen, Peter J ^g   Haouzi, Delphine ^a,b   Hipskind, Robert A ^a,b   Enriquez, José Antonio ^c,e   Sanchez Beato, Margarita ^f   Pardo, Julián ^c,d   Anel, Alberto ^c   Villalba, Martin ^a,b  

^a CNRS   (France)

^b UNIV MONTPELLIER   (France)

^c UNIVERSITY OF ZARAGOZA   (Spain)

^d Fundacion Aragon I D   (Spain)

^e CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^f Centro Nacional de Investigaciones Oncológicas   (Spain)

^g LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MITOGEN ACTIVATED PROTEIN KINASE 7; SHORT HAIRPIN RNA;

ANIMAL CELL; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CELL METABOLISM; CELL RESPIRATION; CELL SURFACE; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; FERMENTATION; GENETIC TRANSCRIPTION; LEUKEMIA CELL; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION REGULATION; TRANSIENT TRANSFECTION; UPREGULATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; DOWN-REGULATION; GENE EXPRESSION REGULATION; GLUTAMINE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; JURKAT CELLS; LEUKEMIA L1210; LEUKEMIA, B-CELL; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 7; OXIDATIVE PHOSPHORYLATION; UP-REGULATION;

EID: 78649829433     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1001250     Document Type: Article

References (26)

1. Warburg, O. 1956. On respiratory impairment in cancer cells. Science 124: 269-270.
2. Burnet, F. M. 1970. The concept of immunological surveillance. Prog. Exp. Tumor Res. 13: 1-27.
3. Dunn, G. P., A. T. Bruce, H. Ikeda, L. J. Old, and R. D. Schreiber. 2002. Cancer immunoediting: from immunosurveillance to tumor escape. Nat. Immunol. 3: 991-998.
4. Dunn, G. P., C. M. Koebel, and R. D. Schreiber. 2006. Interferons, immunity and cancer immunoediting. Nat. Rev. Immunol. 6: 836-848.
5. Aptsiauri, N., T. Cabrera, A. Garcia-Lora, M. A. Lopez-Nevot, F. Ruiz-Cabello, and F. Garrido. 2007. MHC class I antigens and immune surveillance in transformed cells. Int. Rev. Cytol. 256: 139-189.
6. Schweppe, R. E., T. H. Cheung, and N. G. Ahn. 2006. Global gene expression analysis of ERK5 and ERK1/2 signaling reveals a role for HIF-1 in ERK5-mediated responses. J. Biol. Chem. 281: 20993-21003.
7. Wang, X., and C. Tournier. 2006. Regulation of cellular functions by the ERK5 signalling pathway. Cell. Signal. 18: 753-760.
8. Carvajal-Vergara, X., S. Tabera, J. C. Montero, A. Esparís-Ogando, R. López-Pérez, G. Mateo, N. Gutiérrez, M. Parmo-Cabañas, J. Teixidó, J. F. San Miguel, and A. Pandiella. 2005. Multifunctional role of Erk5 in multiple myeloma. Blood 105: 4492-4499.
9. Buschbeck, M., S. Hofbauer, L. Di Croce, G. Keri, and A. Ullrich. 2005. Abl-kinase-sensitive levels of ERK5 and its intrinsic basal activity contribute to leukaemia cell survival. EMBO Rep. 6: 63-69.
10. Garaude, J., S. Kaminski, S. Cherni, R. A. Hipskind, and M. Villalba. 2005. The role of ERK5 in T-cell signalling. Scand. J. Immunol. 62: 515-520.
11. Garaude, J., S. Cherni, S. Kaminski, E. Delepine, C. Chable-Bessia, M. Benkirane, J. Borges, A. Pandiella, M. A. Iñiguez, M. Fresno, et al. 2006. ERK5 activates NF-kappaB in leukemic T cells and is essential for their growth in vivo. J. Immunol. 177: 7607-7617.
12. Charni, S., J. I. Aguilo, J. Garaude, G. de Bettignies, C. Jacquet, R. A. Hipskind, D. Singer, A. Anel, and M. Villalba. 2009. ERK5 knockdown generates mouse leukemia cells with low MHC class I levels that activate NK cells and block tumorigenesis. J. Immunol. 182: 3398-3405.
13. Acín-Pérez, R., M. P. Bayona-Bafaluy, P. Fernández-Silva, R. Moreno-Loshuertos, A. Pérez-Martos, C. Bruno, C. T. Moraes, and J. A. Enríquez. 2004. Respiratory complex III is required to maintain complex I in mammalian mitochondria. Mol. Cell 13: 805-815.
14. Aguilo, J. I., A. Anel, E. Catalan, A. Sebastian, R. Acin-Perez, J. Naval, R. Wallich, M. M. Simon, and J. Pardo. 2010. Granzyme B of cytotoxic T cells induces extramitochondrial reactive oxygen species production via caspase-dependent NADPH oxidase activation. Immunol. Cell Biol. 88: 545-554.
15. Howcroft, T. K., J. D. Weissman, A. Gegonne, and D. S. Singer. 2005. A T lymphocyte-specific transcription complex containing RUNX1 activates MHC class I expression. J. Immunol. 174: 2106-2115.
16. Gobin, S. J., and P. J. van den Elsen. 2000. Transcriptional regulation of the MHC class Ib genes HLA-E, HLA-F, and HLA-G. Hum. Immunol. 61: 1102-1107.
17. Garaude, J., R. Farrás, G. Bossis, S. Charni, M. Piechaczyk, R. A. Hipskind, and M. Villalba. 2008. SUMOylation regulates the transcriptional activity of JunB in T lymphocytes. J. Immunol. 180: 5983-5990.
18. Rozen, S., and H. Skaletsky. 2000. Primer3 on the WWW for general users and for biologist programmers. Methods Mol. Biol. 132: 365-386.
19. Jayaraman, S. 2005. Flow cytometric determination of mitochondrial membrane potential changes during apoptosis of T lymphocytic and pancreatic beta cell lines: comparison of tetramethylrhodamineethylester (TMRE), chloromethyl-X-rosamine (H2-CMX-Ros) and MitoTracker Red 580 (MTR580). J. Immunol. Methods 306: 68-79.
20. Costes, S. V., D. Daelemans, E. H. Cho, Z. Dobbin, G. Pavlakis, and S. Lockett. 2004. Automatic and quantitative measurement of protein-protein colocalization in live cells. Biophys. J. 86: 3993-4003.
21. Reitzer, L. J., B. M. Wice, and D. Kennell. 1979. Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells. J. Biol. Chem. 254: 2669-2676.
22. Rossignol, R., R. Gilkerson, R. Aggeler, K. Yamagata, S. J. Remington, and R. A. Capaldi. 2004. Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells. Cancer Res. 64: 985-993.
23. Whitehouse, S., R. H. Cooper, and P. J. Randle. 1974. Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids. Biochem. J. 141: 761-774.
24. Bartrons, R., and J. Caro. 2007. Hypoxia, glucose metabolism and the Warburg's effect. J. Bioenerg. Biomembr. 39: 223-229.
25. Hayashi, M., S. W. Kim, K. Imanaka-Yoshida, T. Yoshida, E. D. Abel, B. Eliceiri, Y. Yang, R. J. Ulevitch, and J. D. Lee. 2004. Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure. J. Clin. Invest. 113: 1138-1148.
26. Abe, J., M. Kusuhara, R. J. Ulevitch, B. C. Berk, and J. D. Lee. 1996. Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase. J. Biol. Chem. 271: 16586-16590.