Green tea catechins improve human forearm vascular function and have potent anti-inflammatory and anti-apoptotic effects in smokers

Internal Medicine

Volumn 49, Issue 23, 2010, Pages 2553-2559

  Oyama, Jun Ichi ^a   Maeda, Toyoki ^a   Sasaki, Makoto ^a   Kozuma, Kazuya ^b   Ochiai, Ryuji ^b   Tokimitsu, Ichiro ^b   Taguchi, Sachiyo ^a   Higuchi, Yoshihiro ^a   Makino, Naoki ^a  

^a KYUSHU UNIVERSITY BEPPU HOSPITAL   (Japan)

^b KAO CORPORATION   (Japan)

Author keywords

Apoptosis; Endothelial dysfunction; Green tea catechin; Inflammation; Smoking

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CATECHIN; CHLORIDE; CHOLESTEROL; EPICATECHIN; EPICATECHIN GALLATE; EPIGALLOCATECHIN; EPIGALLOCATECHIN GALLATE; FAS LIGAND; GALLOCATECHIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 1BETA; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN CHOLESTEROL; POTASSIUM; SODIUM; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARM BLOOD FLOW; ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; FOREARM; HEART RATE; HUMAN; HYPEREMIA; MALE; OXIDATIVE STRESS; SMOKING; SYSTOLIC BLOOD PRESSURE; TEA; VASODILATATION; VEIN OCCLUSION PLETHYSMOGRAPHY;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; CATECHIN; FOREARM; HUMANS; MALE; REGIONAL BLOOD FLOW; SMOKING; TEA;

EID: 78649800949     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.49.4048     Document Type: Article

References (37)

1. Behrendt D, Ganz P. Endothelial function. From vascular biology to clinical applications. Am J Cardiol 90: 40L-48L, 2002.
2. Cannon RO 3rd. Role of nitric oxide in cardiovascular disease: focus on the endothelium. Clin Chem 44: 1809-1819, 1998.
3. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288: 373-376, 1980.
4. Celermajer DS, Sorensen KE, Bull C, Robinson J, Deanfield JE. Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction. J Am Coll Cardiol 24: 1468-1474, 1994.
5. Heitzer T, Just H, Münzel T. Antioxidant vitamin C improves endothelial dysfunction in chronic smokers. Circulation 94: 6-9, 1996.
6. Papamichael C, Karatzis E, Karatzi K, et al. Red wine's antioxidants counteract acute endothelial dysfunction caused by cigarette smoking in healthy nonsmokers. Am Heart J 147: E5, 2004.
7. Heitzer T, Schlinzig T, Krohn K, Meinertz T, Munzel T. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 104: 2673- 2678, 2001.
8. Bugiardini R, Manfrini O, Pizzi C, Fontana F, Morgagni G. Endothelial function predicts future development of coronary artery disease: a study of women with chest pain and normal coronary angiograms. Circulation 109: 2518-2523, 2004.
9. Schachinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 101: 1899-1906, 2000.
10. Cai H, Harrison D. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87: 840-844, 2000.
11. Libby P. Current concepts of the pathogenesis of the acute coronary syndromes. Circulation 104: 365-372, 2001.
12. Ochiai R, Jokura H, Suzuki A, et al. Green coffee bean extract improves human vasoreactivity. Hypertens Res 27: 731-737, 2004.
13. Tagawa T, Imaizumi T, Endo T, Shiramoto M, Harasawa Y, Takeshita A. Role of nitric oxide in reactive hyperemia in human forearm vessels. Circulation 90: 2285-2290, 1994.
14. Hirooka Y, Imaizumi T, Tagawa T, et al. Effects of L-arginine on impaired acetylcholine-induced and ischemic vasodilation of the forearm in patients with heart failure. Circulation 90: 658-668, 1994.
15. Kuriyama S, Shimazu T, Ohmori K, et al. Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan: the Ohsaki study. JAMA 296: 1255-1265, 2006.
16. Sackett DL, Gibson RW, Bross IDJ, Pickren JW. Relation between aortic atherosclerosis and the use of cigarettes and alcohol: an autopsy study. N Engl J Med 279: 1413-1420, 1968.
17. Church DF, Pryor WA. Free radical chemistry of cigarette smoke and its toxicological implications. Environ Health Perspect 64: 111-126, 1985.
18. Higashi Y, Sasaki S, Nakagawa K, Matsuura H, Kajiyama G, Oshima T. Effect of the angiotensin-converting enzyme inhibitor imidapril on reactive hyperemia in patients with essential hypertension: relationship between treatment periods and resistance artery endothelial function. J Am Coll Cardiol 37: 863-870, 2001.
19. Morrow JD, Frei B, Longmire AW, et al. Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. N Engl J Med 332: 1198-1203, 1995.
20. Murohara T, Kugiyama K, Ohgushi M, Sugiyama S, Yasue H. Cigarette smoke extract contracts isolated porcine coronary arteries by superoxide anion-mediated degradation of EDRF. Am J Physiol 266: H874-H880, 1994.
21. Nagao T, Hase T, Tokimitsu I. A green tea extract high in catechins reduces body fat and cardiovascular risks in humans. Obesity 15: 1473-1483, 2007.
22. Yang CS, Chen L, Lee MJ, Balentine D, Kuo MC, Schantz SP. Blood and urine levels of tea catechins after ingestion of different amounts of green tea by human volunteers. Cancer Epidemiol Biomarkers Prev 7: 351-354, 1998.
23. Potenza MA, Marasciulo FL, Tarquinio M, et al. EGCG, a green tea polyphenol, improves endothelial function and insulin sensitivity, reduces blood pressure, and protects against myocardial I/R injury in SHR. Am J Physiol Endocrinol Metab 292: E1378-E 1387, 2007.
24. Lorenz M, Wessler S, Follmann E, et al. A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a phosphatidylinositol-3-OH-kinase-, cAMP-dependent protein kinase-, and Akt-dependent pathway and leads to endothelial-dependent vasorelaxation. J Biol Chem 279: 6190- 6195, 2004.
25. Tanni SE, Pelegrino NR, Angeleli AY, Correa C, Godoy I. Smoking status and tumor necrosis factor-alpha mediated systemic inflammation in COPD patients. J Inflamm 7: 29, 2010.
26. Mol MJ, de Rijke YB, Demacker PN, Stalenhoef AF. Plasma levels of lipid and cholesterol oxidation products and cytokines in diabetes mellitus and cigarette smoking: effects of vitamin E treatment. Atherosclerosis 129: 169-176, 1997.
27. Evans MD, Cooke MS. Factors contributing to the outcome of oxidative damage to nucleic acids. Bioassays 26: 533-542, 2004.
28. Suzuki M, Aoshiba K, Nagai A. Oxidative stress increases Fas ligand expression in endothelial cells. J Inflamm 3: 11, 2006.
29. Blanco-Colio LM, Martín-Ventura JL, Tuñón J, García-Camarero T, Berrazueta JR, Egido J. Soluble Fas ligand plasma levels are associated with forearm reactive hyperemia in subjects with coronary artery disease: a novel biomarker of endothelial function? Atherosclerosis 201: 407-412, 2008.
30. Townsend PA, Scarabelli TM, Pasini E, et al. Epigallocatechin-3- gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia/reperfusion-induced apoptosis. FASEB J 18: 1621- 1623, 2004.
31. Sheng R, Gu ZL, Xie ML, Zhou WX, Guo CY. Epigallocatechin gallate protects H9c2 cardiomyoblasts against hydrogen dioxidesinduced apoptosis and telomere attrition. Eur J Pharmacol 641: 199-206, 2010.
32. Sheng R, Gu ZL, Xie ML, Zhou WX, Guo CY. EGCG inhibits cardiomyocyte apoptosis in pressure overload-induced cardiac hypertrophy and protects cardiomyocytes from oxidative stress in rats. Acta Pharmacol Sin 28: 191-201, 2007.
33. Lambert JD, Elias RJ. The antioxidant and pro-oxidant activities of green tea polyphenols: A role in cancer prevention. Arch Biochem Biophys 501: 65-72, 2010.
34. Butt MS, Sultan MT. Green tea: nature's defense against malignancies. Crit Rev Food Sci Nutr 49: 463-473, 2009.
35. Zhang T, Yang D, Fan Y, Xie P, Li H. Epigallocatechin-3-gallate enhances ischemia/reperfusion-induced apoptosis in human umbilical vein endothelial cells via AKT and MAPK pathways. Apoptosis 14: 1245-1254, 2009.
36. Hertog MG, Feskens EJ, Hollman PC, Katan MB, Kromhout D. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 342: 1007-1011, 1993.
37. Nakachi K, Matsuyama S, Miyake S, Suganuma M, Imai K. Preventive effects of drinking green tea on cancer and cardiovascular disease: epidemiological evidence for multiple targeting prevention. Biofactors 13: 49-54, 2000.