Site-specific modification of calmodulin Ca2+ affinity tunes the skeletal muscle ryanodine receptor activation profile

Biochemical Journal

Volumn 432, Issue 1, 2010, Pages 89-99

  Jiang, Jie ^a   Zhou, Yubin ^a   Zou, Jin ^a   Chen, Yanyi ^a   Patel, Priya ^b   Yang, Jenny J ^a   Balog, Edward M ^b  

^a GEORGIA STATE UNIVERSITY   (United States)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Calcium signalling; Calcium binding protein; EF hand; Excitation contraction coupling; Sarcoplasmic reticulum

Indexed keywords

ACIDIC RESIDUES; BI-PHASIC; BINDING AFFINITIES; C-TERMINAL DOMAINS; CALCIUM-BINDING PROTEIN; CHANNEL INHIBITOR; CHANNEL OPENING; DOMAIN SPECIFIC; EF-HAND; EXCITATION-CONTRACTION COUPLING; FLUORESCENCE TITRATIONS; ION CHANNEL; ISOFORMS; N-TERMINAL DOMAINS; RYANODINE RECEPTORS; SARCOPLASMIC RETICULUM; SITE-SPECIFIC MODIFICATIONS; SKELETAL MUSCLE; WILD TYPES;

BINDING ENERGY; BINDING SITES; BIOCHEMISTRY; CALCIUM; CAMS; CHEMICAL ACTIVATION; INSECTICIDES; MUSCLE;

CALMODULIN;

CALCIUM ION; CALMODULIN; PHENYLALANINE; RYANODINE RECEPTOR 1; TYROSINE;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; SKELETAL MUSCLE; SWINE; WILD TYPE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CALCIUM; CALMODULIN; CIRCULAR DICHROISM; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUSCLE, SKELETAL; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RYANODINE; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; SEQUENCE HOMOLOGY, AMINO ACID; SWINE; TRITIUM;

EID: 78649756849     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20100505     Document Type: Article

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