-
1
-
-
0037441624
-
A 5-decade analysis of 13715 carcinoid tumors
-
Modlin IM, Lye KD, Kidd M A 5-decade analysis of 13715 carcinoid tumors. Cancer 2003, 97:934-959.
-
(2003)
Cancer
, vol.97
, pp. 934-959
-
-
Modlin, I.M.1
Lye, K.D.2
Kidd, M.3
-
2
-
-
37449029464
-
Gastroenteropancreatic neuroendocrine tumours
-
Modlin IM, Oberg K, Chung DC, et al. Gastroenteropancreatic neuroendocrine tumours. Lancet Oncol 2008, 9:61-72.
-
(2008)
Lancet Oncol
, vol.9
, pp. 61-72
-
-
Modlin, I.M.1
Oberg, K.2
Chung, D.C.3
-
3
-
-
46449110634
-
One hundred years after 'carcinoid': epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States
-
Yao JC, Hassan M, Phan A, et al. One hundred years after 'carcinoid': epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol 2008, 26:3063-3072.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3063-3072
-
-
Yao, J.C.1
Hassan, M.2
Phan, A.3
-
4
-
-
2942675021
-
The diagnosis and medical management of advanced endocrine tumors
-
Kaltsas GA, Besser GM, Grossman AB The diagnosis and medical management of advanced endocrine tumors. Endocr Rev 2004, 25:458-511.
-
(2004)
Endocr Rev
, vol.25
, pp. 458-511
-
-
Kaltsas, G.A.1
Besser, G.M.2
Grossman, A.B.3
-
6
-
-
33749032826
-
TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system
-
Rindi G, Klöppel G, Alhman H, et al. TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system. Virchows Arch 2006, 449:395-401.
-
(2006)
Virchows Arch
, vol.449
, pp. 395-401
-
-
Rindi, G.1
Klöppel, G.2
Alhman, H.3
-
7
-
-
34848828173
-
TNM staging of midgut and hindgut (neuro)endocrine tumors: a consensus proposal including a grading system
-
Rindi G, Klöppel G, Couvelard A, et al. TNM staging of midgut and hindgut (neuro)endocrine tumors: a consensus proposal including a grading system. Virchows Arch 2007, 451:757-762.
-
(2007)
Virchows Arch
, vol.451
, pp. 757-762
-
-
Rindi, G.1
Klöppel, G.2
Couvelard, A.3
-
8
-
-
37349015326
-
Consensus guidelines for the management of patients with liver metastases from digestive (neuro)endocrine tumors: foregut, midgut, hindgut, and unknown primary
-
Steinmuller T, Kianmanesh R, Falconi M, et al. Consensus guidelines for the management of patients with liver metastases from digestive (neuro)endocrine tumors: foregut, midgut, hindgut, and unknown primary. Neuroendocrinology 2008, 87:47-62.
-
(2008)
Neuroendocrinology
, vol.87
, pp. 47-62
-
-
Steinmuller, T.1
Kianmanesh, R.2
Falconi, M.3
-
9
-
-
0035152480
-
Rougier The treatment of undifferentiated neuroendocrine tumors
-
Mitry E, Rougier The treatment of undifferentiated neuroendocrine tumors. Critical Rev Oncol Hematol 2001, 37:47-51.
-
(2001)
Critical Rev Oncol Hematol
, vol.37
, pp. 47-51
-
-
Mitry, E.1
-
10
-
-
58249123467
-
Prognostic factors of long-term outcome in gastroenteropancreatic neuroendocrine tumours
-
Pape UF, Berndt U, Mueller-Nordhorn J, et al. Prognostic factors of long-term outcome in gastroenteropancreatic neuroendocrine tumours. Endocr Relat Cancer 2008, 15:10-83-10-97.
-
(2008)
Endocr Relat Cancer
, vol.15
-
-
Pape, U.F.1
Berndt, U.2
Mueller-Nordhorn, J.3
-
11
-
-
0032780823
-
Somatostatin and its receptor family
-
Patel YC Somatostatin and its receptor family. Front Neuroendocrinol 1999, 20:157-198.
-
(1999)
Front Neuroendocrinol
, vol.20
, pp. 157-198
-
-
Patel, Y.C.1
-
12
-
-
0030612281
-
Molecular pharmacology of somatostatin receptor subtypes
-
Patel YC Molecular pharmacology of somatostatin receptor subtypes. J Endocrinol Invest 1997, 20:348-367.
-
(1997)
J Endocrinol Invest
, vol.20
, pp. 348-367
-
-
Patel, Y.C.1
-
14
-
-
34249698776
-
The incidence of somatostatin receptors in human neoplasms in the light of ex vivo-in vitro studies
-
Pawlikowski M The incidence of somatostatin receptors in human neoplasms in the light of ex vivo-in vitro studies. Pol J Endocrinol 2006, 57:238-243.
-
(2006)
Pol J Endocrinol
, vol.57
, pp. 238-243
-
-
Pawlikowski, M.1
-
15
-
-
0028280635
-
Identification of somatostatin receptor subtypes and an implication for the efficacy of somatostatin analogue SMS 201-995 in treatment of human endocrine tumors
-
Kubota A, Yamada Y, Kagimoto S, et al. Identification of somatostatin receptor subtypes and an implication for the efficacy of somatostatin analogue SMS 201-995 in treatment of human endocrine tumors. J Clin Invest 1994, 93:1321-1325.
-
(1994)
J Clin Invest
, vol.93
, pp. 1321-1325
-
-
Kubota, A.1
Yamada, Y.2
Kagimoto, S.3
-
16
-
-
0028888586
-
Expression of mRNA for all five human somatostatin receptors (hSSTR1-5) in pituitary tumors
-
Panetta R, Patel YC Expression of mRNA for all five human somatostatin receptors (hSSTR1-5) in pituitary tumors. Life Sci 1995, 56:333-342.
-
(1995)
Life Sci
, vol.56
, pp. 333-342
-
-
Panetta, R.1
Patel, Y.C.2
-
17
-
-
0346458489
-
Somatostatin receptors in gastroenteropancreatic neuroendocrine tumours
-
De Herder WW, Hofland LJ, van der Lely AJ, Lamberts SWJ Somatostatin receptors in gastroenteropancreatic neuroendocrine tumours. End Rel Cancer 2003, 10:451-458.
-
(2003)
End Rel Cancer
, vol.10
, pp. 451-458
-
-
De Herder, W.W.1
Hofland, L.J.2
van der Lely, A.J.3
Lamberts, S.W.J.4
-
18
-
-
0036271475
-
Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis
-
Papotti M, Bongiovanni M, Volante M, et al. Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis. Virchows Arch 2002, 440:461-475.
-
(2002)
Virchows Arch
, vol.440
, pp. 461-475
-
-
Papotti, M.1
Bongiovanni, M.2
Volante, M.3
-
19
-
-
77954353625
-
SSTR1 and SSTR5 subtypes are the dominant forms of somatostatin receptor in neuroendocrine tumors
-
Pisarek H, Pawlikowski M, Kunert-Radek J, Kubiak R, Winczyk K SSTR1 and SSTR5 subtypes are the dominant forms of somatostatin receptor in neuroendocrine tumors. Folia Hyst Cytol 2010, 48:142-147.
-
(2010)
Folia Hyst Cytol
, vol.48
, pp. 142-147
-
-
Pisarek, H.1
Pawlikowski, M.2
Kunert-Radek, J.3
Kubiak, R.4
Winczyk, K.5
-
20
-
-
0036135375
-
Identification of somatostatin receptor subtypes 1, 2A, 3, and 5 in neuroendocrine tumours with specific antibodies
-
Kulaksis H, Eissele R, Rossler D, et al. Identification of somatostatin receptor subtypes 1, 2A, 3, and 5 in neuroendocrine tumours with specific antibodies. Gut 2002, 50:52-60.
-
(2002)
Gut
, vol.50
, pp. 52-60
-
-
Kulaksis, H.1
Eissele, R.2
Rossler, D.3
-
21
-
-
0027517429
-
Somatostatin receptor scintigraphy with [111In-DTPA-D-Phe1]- and [123I-Tyr3]-octreotide: the Rotterdam experience with more than 1000 patients
-
Krenning EP, Kwekkeboom DJ, Bakker WH, et al. Somatostatin receptor scintigraphy with [111In-DTPA-D-Phe1]- and [123I-Tyr3]-octreotide: the Rotterdam experience with more than 1000 patients. Eur J Nucl Med 1993, 20:716-731.
-
(1993)
Eur J Nucl Med
, vol.20
, pp. 716-731
-
-
Krenning, E.P.1
Kwekkeboom, D.J.2
Bakker, W.H.3
-
22
-
-
0033622158
-
111In-Pentetreotide scintography in the detection of insulinomas: importance of SPECT imaging
-
111In-Pentetreotide scintography in the detection of insulinomas: importance of SPECT imaging. J Nucl Med 2000, 41:459-462.
-
(2000)
J Nucl Med
, vol.41
, pp. 459-462
-
-
Schillaci, O.1
Massa, R.2
Scopinaro, F.3
-
23
-
-
33750044299
-
When translation meets transformation: the mTOR story
-
Averous J, Proud CG When translation meets transformation: the mTOR story. Oncogene 2006, 25:6423-6435.
-
(2006)
Oncogene
, vol.25
, pp. 6423-6435
-
-
Averous, J.1
Proud, C.G.2
-
24
-
-
33750072949
-
MTOR and cancer therapy
-
Easton JB, Houghton PJ mTOR and cancer therapy. Oncogene 2006, 25:6436-6446.
-
(2006)
Oncogene
, vol.25
, pp. 6436-6446
-
-
Easton, J.B.1
Houghton, P.J.2
-
25
-
-
34547134517
-
Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif
-
Land SC, Tee AR Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif. J Biol Chem 2007, 282:20534-20543.
-
(2007)
J Biol Chem
, vol.282
, pp. 20534-20543
-
-
Land, S.C.1
Tee, A.R.2
-
26
-
-
1542751639
-
The molecular target of rapamycin (mTOR) as a therapeutic target against cancer
-
Mita MM, Mita A, Rowinsky EK The molecular target of rapamycin (mTOR) as a therapeutic target against cancer. Cancer Biol Ther 2003, 4(Suppl 1):S169-S177.
-
(2003)
Cancer Biol Ther
, vol.4
, Issue.1 SUPPL
-
-
Mita, M.M.1
Mita, A.2
Rowinsky, E.K.3
-
27
-
-
0141794463
-
Malignant pancreatic endocrine tumor in a child with tuberous sclerosis
-
Francalanci P, Diomedi-Camassei F, Purificato C, et al. Malignant pancreatic endocrine tumor in a child with tuberous sclerosis. Am J Surg Pathol 2003, 27:1386-1389.
-
(2003)
Am J Surg Pathol
, vol.27
, pp. 1386-1389
-
-
Francalanci, P.1
Diomedi-Camassei, F.2
Purificato, C.3
-
28
-
-
0036001209
-
Differential expression of the PTEN tumor suppressor protein in fetal and adult neuroendocrine tissues and tumors: progressive loss of PTEN expression in poorly differentiated neuroendocrine neoplasms
-
Wang L, Ignat A, Axiotis CA Differential expression of the PTEN tumor suppressor protein in fetal and adult neuroendocrine tissues and tumors: progressive loss of PTEN expression in poorly differentiated neuroendocrine neoplasms. Appl Immunohistochem Mol Morphol 2002, 10:139-146.
-
(2002)
Appl Immunohistochem Mol Morphol
, vol.10
, pp. 139-146
-
-
Wang, L.1
Ignat, A.2
Axiotis, C.A.3
-
29
-
-
20844435467
-
The NF1 tumor suppressor critically regulates TSC2 and mTOR
-
Johannessen CM, Reczek EE, James MF, Brems H, Legius E, Cichowski K The NF1 tumor suppressor critically regulates TSC2 and mTOR. Proc Natl Acad Sci USA 2005, 102:8573-8578.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 8573-8578
-
-
Johannessen, C.M.1
Reczek, E.E.2
James, M.F.3
Brems, H.4
Legius, E.5
Cichowski, K.6
-
30
-
-
36549022020
-
Clinical, genetic and radiographic analysis of 108 patients with von Hippel-Lindau disease (VHL) manifested by pancreatic neuroendocrine neoplasms (PNETs)
-
Blansfield JA, Choyke L, Morita SY, et al. Clinical, genetic and radiographic analysis of 108 patients with von Hippel-Lindau disease (VHL) manifested by pancreatic neuroendocrine neoplasms (PNETs). Surgery 2007, 142:814-818.
-
(2007)
Surgery
, vol.142
, pp. 814-818
-
-
Blansfield, J.A.1
Choyke, L.2
Morita, S.Y.3
-
31
-
-
74949122343
-
Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathway
-
Missiaglia E, Dalai I, Barbi S, et al. Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathway. J Clin Oncol 2010, 28:245-255.
-
(2010)
J Clin Oncol
, vol.28
, pp. 245-255
-
-
Missiaglia, E.1
Dalai, I.2
Barbi, S.3
-
32
-
-
0031906775
-
Expression of vascular endothelial growth factor in digestive neuroendocrine tumours
-
Terris B, Scoazec JY, Rubbia L, et al. Expression of vascular endothelial growth factor in digestive neuroendocrine tumours. Histopathology 1998, 32:133-138.
-
(1998)
Histopathology
, vol.32
, pp. 133-138
-
-
Terris, B.1
Scoazec, J.Y.2
Rubbia, L.3
-
33
-
-
0037258782
-
Localization of vascular endothelial growth factor and its receptors in digestive endocrine tumors: correlation with microvessel density and clinicopathologic features
-
La Rosa S, Uccella S, Finzi G, Albarello L, Sessa F, Capella C Localization of vascular endothelial growth factor and its receptors in digestive endocrine tumors: correlation with microvessel density and clinicopathologic features. Hum Pathol 2003, 34:18-27.
-
(2003)
Hum Pathol
, vol.34
, pp. 18-27
-
-
La Rosa, S.1
Uccella, S.2
Finzi, G.3
Albarello, L.4
Sessa, F.5
Capella, C.6
-
34
-
-
33645989468
-
The insulinlike growth factor receptor 1 is a promising target for novel treatment approaches in neuroendocrine gastrointestinal tumours
-
Hopfner M, Baradari V, Huether A, Schofl C, Scherubl H The insulinlike growth factor receptor 1 is a promising target for novel treatment approaches in neuroendocrine gastrointestinal tumours. Endocrine Relat Cancer 2006, 13:135-149.
-
(2006)
Endocrine Relat Cancer
, vol.13
, pp. 135-149
-
-
Hopfner, M.1
Baradari, V.2
Huether, A.3
Schofl, C.4
Scherubl, H.5
-
35
-
-
0027269918
-
Expression of growth factor peptides and their receptors in neuroendocrine tumors of the digestive system
-
Chaudhry A, Funa K, Oberg K Expression of growth factor peptides and their receptors in neuroendocrine tumors of the digestive system. Acta Oncol 1993, 32:107-114.
-
(1993)
Acta Oncol
, vol.32
, pp. 107-114
-
-
Chaudhry, A.1
Funa, K.2
Oberg, K.3
-
36
-
-
0028567762
-
Expression of transforming growth factors beta 1, beta 2, beta 3 in neuroendocrine tumors of the digestive system
-
Chaudhry A, Oberg K, Gobl A, Heldin CH, Funa K Expression of transforming growth factors beta 1, beta 2, beta 3 in neuroendocrine tumors of the digestive system. Anticancer Res 1994, 14:2085-2091.
-
(1994)
Anticancer Res
, vol.14
, pp. 2085-2091
-
-
Chaudhry, A.1
Oberg, K.2
Gobl, A.3
Heldin, C.H.4
Funa, K.5
-
37
-
-
0028856096
-
Vascular endothelial growth factor and its receptors, flt-1 and flk-1, are expressed in normal pancreatic islets and throughout islet cell tumorigenesis
-
Christofori G, Naik P, Hanahan D Vascular endothelial growth factor and its receptors, flt-1 and flk-1, are expressed in normal pancreatic islets and throughout islet cell tumorigenesis. Mol Endocrinol 1995, 9:1760-1770.
-
(1995)
Mol Endocrinol
, vol.9
, pp. 1760-1770
-
-
Christofori, G.1
Naik, P.2
Hanahan, D.3
-
38
-
-
0026526078
-
Presence of IGF-I in human midgut carcinoid tumours - an autocrine regulator of carcinoid tumour growth?
-
Nilsson O, Wängberg B, Theodorsson E, Skottner A, Ahlman H Presence of IGF-I in human midgut carcinoid tumours - an autocrine regulator of carcinoid tumour growth?. Int J Cancer 1992, 51:195-203.
-
(1992)
Int J Cancer
, vol.51
, pp. 195-203
-
-
Nilsson, O.1
Wängberg, B.2
Theodorsson, E.3
Skottner, A.4
Ahlman, H.5
-
39
-
-
33645457528
-
Epidermal growth factor receptor expression and activation in neuroendocrine tumours
-
Shah T, Hochhauser D, Frow R, Quaglia A, Dhillon AP, Caplin ME Epidermal growth factor receptor expression and activation in neuroendocrine tumours. J Neuroendocrinol 2006, 18:355-360.
-
(2006)
J Neuroendocrinol
, vol.18
, pp. 355-360
-
-
Shah, T.1
Hochhauser, D.2
Frow, R.3
Quaglia, A.4
Dhillon, A.P.5
Caplin, M.E.6
-
40
-
-
0025019999
-
Expression of platelet derived growth factor beta-receptors on stromal tissue cells in human carcinoid tumors
-
Funa K, Papanicolaou V, Juhlin C, et al. Expression of platelet derived growth factor beta-receptors on stromal tissue cells in human carcinoid tumors. Cancer Res 1990, 50:748-753.
-
(1990)
Cancer Res
, vol.50
, pp. 748-753
-
-
Funa, K.1
Papanicolaou, V.2
Juhlin, C.3
-
41
-
-
0036559535
-
Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis
-
Lopez T, Hanahan D Elevated levels of IGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis. Cancer Cell 2002, 1:339-353.
-
(2002)
Cancer Cell
, vol.1
, pp. 339-353
-
-
Lopez, T.1
Hanahan, D.2
-
42
-
-
6044232026
-
Lymphatic vessel density and vascular endothelial growth factor-C expression correlate with malignant behavior in human pancreatic endocrine tumors
-
Rubbia-Brandt L, Terris B, Giostra E, Dousset B, Morel P, Pepper MS Lymphatic vessel density and vascular endothelial growth factor-C expression correlate with malignant behavior in human pancreatic endocrine tumors. Clin Cancer Res 2004, 10:6919-6928.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 6919-6928
-
-
Rubbia-Brandt, L.1
Terris, B.2
Giostra, E.3
Dousset, B.4
Morel, P.5
Pepper, M.S.6
-
43
-
-
34247162696
-
Elevated expression of vascular endothelial growth factor correlates with increased angiogenesis and decreased progression-free survival among patients with low-grade neuroendocrine tumors
-
Zhang J, Jia Z, Li Q, et al. Elevated expression of vascular endothelial growth factor correlates with increased angiogenesis and decreased progression-free survival among patients with low-grade neuroendocrine tumors. Cancer 2007, 109:1478-1486.
-
(2007)
Cancer
, vol.109
, pp. 1478-1486
-
-
Zhang, J.1
Jia, Z.2
Li, Q.3
-
44
-
-
47849130260
-
Treatment of gastrointestinal neuroendocrine tumors with inhibitors of growth factor recpetors and their signaling pathways: recent advances and future perspectives
-
Hopfner M, Schuppan D, Scherubl H Treatment of gastrointestinal neuroendocrine tumors with inhibitors of growth factor recpetors and their signaling pathways: recent advances and future perspectives. World J Gastroenterol 2008, 14:2461-2473.
-
(2008)
World J Gastroenterol
, vol.14
, pp. 2461-2473
-
-
Hopfner, M.1
Schuppan, D.2
Scherubl, H.3
-
45
-
-
0030054029
-
Octreotide
-
Lamberts SW, van der Lely AJ, de Herder WW, Hofland LJ Octreotide. N Engl J Med 1996, 334:246-254.
-
(1996)
N Engl J Med
, vol.334
, pp. 246-254
-
-
Lamberts, S.W.1
van der Lely, A.J.2
de Herder, W.W.3
Hofland, L.J.4
-
46
-
-
33846473731
-
Interferon-alpha and somatostatin analog in patients with gastroenteropancreatic neuroendocrine carcinoma: single agent or combination
-
Fazio N, de Braud F, Delle Fave G, Oberg K Interferon-alpha and somatostatin analog in patients with gastroenteropancreatic neuroendocrine carcinoma: single agent or combination. Ann Oncol 2007, 18:13-19.
-
(2007)
Ann Oncol
, vol.18
, pp. 13-19
-
-
Fazio, N.1
de Braud, F.2
Delle Fave, G.3
Oberg, K.4
-
47
-
-
0028877850
-
Sandostatin LAR: pharmaco-kinetics, pharmacodynamics, efficacy and tolerability in acromegalic patients
-
Lancranjan I, Bruns C, Grass P, et al. Sandostatin LAR: pharmaco-kinetics, pharmacodynamics, efficacy and tolerability in acromegalic patients. Metabolism 1995, 44:18-26.
-
(1995)
Metabolism
, vol.44
, pp. 18-26
-
-
Lancranjan, I.1
Bruns, C.2
Grass, P.3
-
48
-
-
2242442524
-
Somatuline® Autogel ®, a new formulation of lanreotide for the treatment of acromegalic patients
-
S24
-
Caron P Somatuline® Autogel ®, a new formulation of lanreotide for the treatment of acromegalic patients. Ann Endocrinol 2002, 63(2 pt3):2S19. S24.
-
(2002)
Ann Endocrinol
, vol.63
, Issue.2 PART 3
-
-
Caron, P.1
-
49
-
-
0024569197
-
Somatostatin and somatostatin analogue (SMS 201-995) in treatment of hormone-secreting tumors of the pituitary and gastrointestinal tract and non-neoplastic diseases of the gut
-
Gorden PH, Comi RJ, Maton PN, Go WLW Somatostatin and somatostatin analogue (SMS 201-995) in treatment of hormone-secreting tumors of the pituitary and gastrointestinal tract and non-neoplastic diseases of the gut. Ann Intern Med 1989, 110:35-50.
-
(1989)
Ann Intern Med
, vol.110
, pp. 35-50
-
-
Gorden, P.H.1
Comi, R.J.2
Maton, P.N.3
Go, W.L.W.4
-
50
-
-
0033839620
-
Treatment of neuroendocrine GEP tumours with somatostatin analogues
-
Arnold R, Simon B, Wield M Treatment of neuroendocrine GEP tumours with somatostatin analogues. Digestion 2000, 62(Suppl 1):84-91.
-
(2000)
Digestion
, vol.62
, Issue.1 SUPPL
, pp. 84-91
-
-
Arnold, R.1
Simon, B.2
Wield, M.3
-
51
-
-
0026041670
-
The role of somatostatin and its analogs in the diagnosis and treatments of tumors
-
Lamberts SWJ, Krenning EP, Reubi JC The role of somatostatin and its analogs in the diagnosis and treatments of tumors. Endocrinol Rev 1991, 12:450-482.
-
(1991)
Endocrinol Rev
, vol.12
, pp. 450-482
-
-
Lamberts, S.W.J.1
Krenning, E.P.2
Reubi, J.C.3
-
52
-
-
0032836448
-
Epidermal growth factor inhibits somatostatin-induced apoptosis
-
Thompson JS Epidermal growth factor inhibits somatostatin-induced apoptosis. J Surg Res 1999, 81:95-100.
-
(1999)
J Surg Res
, vol.81
, pp. 95-100
-
-
Thompson, J.S.1
-
53
-
-
0034737646
-
Caspase-8-mediated intracellular acidification precedes mitochondrial dysfunction in somatostatin-induced apoptosis
-
Liu D, Martino G, Thangaraju M, et al. Caspase-8-mediated intracellular acidification precedes mitochondrial dysfunction in somatostatin-induced apoptosis. J Biol Chem 2000, 275:9244-9250.
-
(2000)
J Biol Chem
, vol.275
, pp. 9244-9250
-
-
Liu, D.1
Martino, G.2
Thangaraju, M.3
-
54
-
-
2342499960
-
Molecular signalling of somatostatin receptors
-
Lahlou H, Guillermet J, Hortala M, et al. Molecular signalling of somatostatin receptors. Ann NY Acad Sci 2004, 1014:121-131.
-
(2004)
Ann NY Acad Sci
, vol.1014
, pp. 121-131
-
-
Lahlou, H.1
Guillermet, J.2
Hortala, M.3
-
55
-
-
18244366076
-
Increased expression of insulin-like growth factor I and/or its receptor in gastrinomas is associated with low curability, increased growth, and development of metastases
-
Furukawa M, Raffeld M, mateo C, et al. Increased expression of insulin-like growth factor I and/or its receptor in gastrinomas is associated with low curability, increased growth, and development of metastases. Clin Cancer Res 2005, 11:3233-3242.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 3233-3242
-
-
Furukawa, M.1
Raffeld, M.2
mateo, C.3
-
56
-
-
53849134827
-
Somatostatin analogues in the control of neuroendocrine tumours: efficacy and mechanism
-
Grozinsky-Glasberg S, Shimon I, Korbonits M, Grossman AB Somatostatin analogues in the control of neuroendocrine tumours: efficacy and mechanism. End Relat Cancer 2008, 15:701-720.
-
(2008)
End Relat Cancer
, vol.15
, pp. 701-720
-
-
Grozinsky-Glasberg, S.1
Shimon, I.2
Korbonits, M.3
Grossman, A.B.4
-
57
-
-
0027198659
-
Octreotide as an antineoplastic agent in the treatment of functional and non-functional neuroendocrine tumours
-
Saltz L, Trochanowsky G, Buckley M, et al. Octreotide as an antineoplastic agent in the treatment of functional and non-functional neuroendocrine tumours. Cancer 1993, 72:244-248.
-
(1993)
Cancer
, vol.72
, pp. 244-248
-
-
Saltz, L.1
Trochanowsky, G.2
Buckley, M.3
-
58
-
-
0029866470
-
Somatostatin analogue octreotide and inhibition of tumour growth in metastatic endocrine gastroenteropancreatic tumors
-
Arnold R, Trautmann ME, Creutzfeldt W, et al. Somatostatin analogue octreotide and inhibition of tumour growth in metastatic endocrine gastroenteropancreatic tumors. Gut 1996, 38:430-438.
-
(1996)
Gut
, vol.38
, pp. 430-438
-
-
Arnold, R.1
Trautmann, M.E.2
Creutzfeldt, W.3
-
59
-
-
13344295073
-
Clinical efficacy of octreotide in the treatment of metastatic neuroendocrine tumors
-
Di Bartolomeo M, Bajetta E, Buzzoni R, et al. Clinical efficacy of octreotide in the treatment of metastatic neuroendocrine tumors. Cancer 1996, 77:402-408.
-
(1996)
Cancer
, vol.77
, pp. 402-408
-
-
Di Bartolomeo, M.1
Bajetta, E.2
Buzzoni, R.3
-
60
-
-
0035040838
-
Antitumor activity of somatostatin analogues in progressive metastatic neuroendocrine tumors
-
Aparicio T, Ducreaux M, Baudin E, et al. Antitumor activity of somatostatin analogues in progressive metastatic neuroendocrine tumors. Eur J Cancer 2001, 37:1014-1019.
-
(2001)
Eur J Cancer
, vol.37
, pp. 1014-1019
-
-
Aparicio, T.1
Ducreaux, M.2
Baudin, E.3
-
61
-
-
67650234535
-
Survival and prognostic factor analysis of 146 metastatic neuroendocrine tumors of the mid-gut
-
Strosberg J, Gardner L, Kvols L Survival and prognostic factor analysis of 146 metastatic neuroendocrine tumors of the mid-gut. Neuroendocrinology 2009, 89:471-476.
-
(2009)
Neuroendocrinology
, vol.89
, pp. 471-476
-
-
Strosberg, J.1
Gardner, L.2
Kvols, L.3
-
63
-
-
70350442637
-
Placebo-controlled, doubleblind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrinemidgut tumors: a report from the PROMID Study Group
-
Rinke A, Muller HH, Schade-Brittinger C, et al. Placebo-controlled, doubleblind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrinemidgut tumors: a report from the PROMID Study Group. J Clin Oncol 2009, 27:4656-4663.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4656-4663
-
-
Rinke, A.1
Muller, H.H.2
Schade-Brittinger, C.3
-
64
-
-
0037323565
-
The pathophysiological consequences of somatostatin receptor internalization and resistance
-
Hofland LJ, Lamberts SW The pathophysiological consequences of somatostatin receptor internalization and resistance. Endocr Rev 2003, 24:28-47.
-
(2003)
Endocr Rev
, vol.24
, pp. 28-47
-
-
Hofland, L.J.1
Lamberts, S.W.2
-
65
-
-
0029029785
-
Octreotide treatment of carcinoid syndrome: analysis of published dose/titration data
-
Harris A, Redfern JS Octreotide treatment of carcinoid syndrome: analysis of published dose/titration data. Aliment Pharmacol Ther 1998, 9:387-394.
-
(1998)
Aliment Pharmacol Ther
, vol.9
, pp. 387-394
-
-
Harris, A.1
Redfern, J.S.2
-
66
-
-
0030667438
-
High-dose treatment with lanreotide of patients with advanced neuroendocrine gastrointestinal tumours: clinical and biological effects
-
Eriksson B, Renstrup J, Imam H, Oberg K High-dose treatment with lanreotide of patients with advanced neuroendocrine gastrointestinal tumours: clinical and biological effects. Ann Oncol 1997, 8:1041-1044.
-
(1997)
Ann Oncol
, vol.8
, pp. 1041-1044
-
-
Eriksson, B.1
Renstrup, J.2
Imam, H.3
Oberg, K.4
-
67
-
-
0027215419
-
Somatostatin analogue phase 1 trials in neuroendocrine neoplasms
-
Anthony L, Johnson D, Hande K, et al. Somatostatin analogue phase 1 trials in neuroendocrine neoplasms. Acta Oncol 1993, 32:217-223.
-
(1993)
Acta Oncol
, vol.32
, pp. 217-223
-
-
Anthony, L.1
Johnson, D.2
Hande, K.3
-
68
-
-
0036111856
-
SOM230: a novel somatostatin peptidomimetic with broad somatotropin release inhibiting factor (SRIF) receptor binding and a unique antisecretory profile
-
Bruns C, Lewis I, Briner U, et al. SOM230: a novel somatostatin peptidomimetic with broad somatotropin release inhibiting factor (SRIF) receptor binding and a unique antisecretory profile. Eur J Endocrinol 2002, 146:707-716.
-
(2002)
Eur J Endocrinol
, vol.146
, pp. 707-716
-
-
Bruns, C.1
Lewis, I.2
Briner, U.3
-
69
-
-
43549111835
-
Pasireotide (SOM230): Development, mechanism of action and potential applications
-
Schmid HA Pasireotide (SOM230): Development, mechanism of action and potential applications. Mol Cell Endocrinol 2008, 14:69-74.
-
(2008)
Mol Cell Endocrinol
, vol.14
, pp. 69-74
-
-
Schmid, H.A.1
-
70
-
-
78649737406
-
-
Pasireotide LAR in patients with metastatic carcinoid tumors: Pharmacokinetics (PK) and safety results from a randomized, multicenter, phase I study. ASCO GI 2009, Abstr. 93.
-
Wolin EM, Kvols LK, Ezzat S, et al. Pasireotide LAR in patients with metastatic carcinoid tumors: Pharmacokinetics (PK) and safety results from a randomized, multicenter, phase I study. ASCO GI 2009, Abstr. 93.
-
-
-
Wolin, E.M.1
Kvols, L.K.2
Ezzat, S.3
-
71
-
-
65349180440
-
The SOM230 Carcinoid Study Group. Safety and efficacy of pasireotide (SOM230) in patients with metastatic carcinoid tumors refractory or resistant to octreotide LAR: results of a phase II study
-
Abstr. 4082., S
-
Kvols BW, Oberg K, Glusman JE, et al. The SOM230 Carcinoid Study Group. Safety and efficacy of pasireotide (SOM230) in patients with metastatic carcinoid tumors refractory or resistant to octreotide LAR: results of a phase II study. J Clin Oncol 2006, ASCO Annual Meeting Proceedings Part I 2006, 24(18S). Abstr. 4082.
-
(2006)
J Clin Oncol 2006, ASCO Annual Meeting Proceedings Part I
, vol.24
, Issue.18
-
-
Kvols, B.W.1
Oberg, K.2
Glusman, J.E.3
-
73
-
-
33845989087
-
The analysis of quantitative expression of somatostatin and dopamine receptors in gastro-entero-pancreatic tumours opens new therapeutic strategies
-
O'Toole D, Saveanu A, Couvelard A, et al. The analysis of quantitative expression of somatostatin and dopamine receptors in gastro-entero-pancreatic tumours opens new therapeutic strategies. Eur J Endocrinol 2006, 155:849-857.
-
(2006)
Eur J Endocrinol
, vol.155
, pp. 849-857
-
-
O'Toole, D.1
Saveanu, A.2
Couvelard, A.3
-
74
-
-
17944362339
-
[177Lu-DOTAO Tyr3]octreotate: comparison with [111In-DTPAo]octreotide in patients
-
Kwekkeboom DJ, Bakker WH, Kooij PP, et al. [177Lu-DOTAO Tyr3]octreotate: comparison with [111In-DTPAo]octreotide in patients. Eur J Nucl Med 2001, 28:1319-1325.
-
(2001)
Eur J Nucl Med
, vol.28
, pp. 1319-1325
-
-
Kwekkeboom, D.J.1
Bakker, W.H.2
Kooij, P.P.3
-
75
-
-
78649732936
-
Peptide receptor radionuclide therapy of gastroenteropancreatic neuroendocrine tumors
-
Felsenstein CCCP, Hannover, Germany, I. Modlin, K. Oberg (Eds.)
-
Krenning EP, Valkema R, de Herder W, et al. Peptide receptor radionuclide therapy of gastroenteropancreatic neuroendocrine tumors. A Century of Advances in Neuroendocrine Tumor Biology and Treatment 2007, 434-443. Felsenstein CCCP, Hannover, Germany. I. Modlin, K. Oberg (Eds.).
-
(2007)
A Century of Advances in Neuroendocrine Tumor Biology and Treatment
, pp. 434-443
-
-
Krenning, E.P.1
Valkema, R.2
de Herder, W.3
-
76
-
-
0034742565
-
The clinical value of [90Y-DOTA]-D-Phe1-Tyr3-octreotide (90Y-DOTATOC) in the treatment of neuroendocrine tumours: a clinical phase II study
-
Waldherr C, Pless M, Maecke HR, et al. The clinical value of [90Y-DOTA]-D-Phe1-Tyr3-octreotide (90Y-DOTATOC) in the treatment of neuroendocrine tumours: a clinical phase II study. Ann Oncol 2001, 12:941-945.
-
(2001)
Ann Oncol
, vol.12
, pp. 941-945
-
-
Waldherr, C.1
Pless, M.2
Maecke, H.R.3
-
77
-
-
10744230217
-
Receptor-mediated radionuclide therapy with 90Y-DOTATOC in association with amino acid infusion: a phase I study
-
Bodei L, Cremonesi M, Zoboli S, et al. Receptor-mediated radionuclide therapy with 90Y-DOTATOC in association with amino acid infusion: a phase I study. Eur J Nucl Med Mol Imaging 2003, 30:207-216.
-
(2003)
Eur J Nucl Med Mol Imaging
, vol.30
, pp. 207-216
-
-
Bodei, L.1
Cremonesi, M.2
Zoboli, S.3
-
78
-
-
33644616790
-
Survival and response after peptide receptor radionuclide therapy with [90Y-DOTA0, Tyr3]octreotide in patients with advanced gastroenteropancreatic neuroendocrine tumors
-
Valkema R, Pauwels S, Kvols LK, et al. Survival and response after peptide receptor radionuclide therapy with [90Y-DOTA0, Tyr3]octreotide in patients with advanced gastroenteropancreatic neuroendocrine tumors. Semin Nucl Med 2006, 36:147-156.
-
(2006)
Semin Nucl Med
, vol.36
, pp. 147-156
-
-
Valkema, R.1
Pauwels, S.2
Kvols, L.K.3
-
79
-
-
52449111580
-
Long-term evaluation of renal toxicity after peptide receptor radionuclide therapy with 90Y-DOTATOC and 177Lu-DOTATATE: the role of associated risk factors
-
Bodei L, Cremonesi M, Ferrari M, et al. Long-term evaluation of renal toxicity after peptide receptor radionuclide therapy with 90Y-DOTATOC and 177Lu-DOTATATE: the role of associated risk factors. Eur J Nucl Med Mol Imaging 2008, 35(10):1847-1856.
-
(2008)
Eur J Nucl Med Mol Imaging
, vol.35
, Issue.10
, pp. 1847-1856
-
-
Bodei, L.1
Cremonesi, M.2
Ferrari, M.3
-
80
-
-
70349481801
-
Peptide receptor therapies in neuroendocrine tumours
-
Bodei L, Ferone D, Grana C, et al. Peptide receptor therapies in neuroendocrine tumours. J Endocrinol Invest 2009, 32(4):360-369.
-
(2009)
J Endocrinol Invest
, vol.32
, Issue.4
, pp. 360-369
-
-
Bodei, L.1
Ferone, D.2
Grana, C.3
-
81
-
-
43749091955
-
Treatment with the radiolabeled somatostatin analog [177Lu-DOTA0, Tyr3] Octreotate: toxicity, efficacy, and survival
-
Kwekkeboom DJ, van de Herder W, Kam BL, et al. Treatment with the radiolabeled somatostatin analog [177Lu-DOTA0, Tyr3] Octreotate: toxicity, efficacy, and survival. J Clin Oncol 2008, 26:2124-2130.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2124-2130
-
-
Kwekkeboom, D.J.1
van de Herder, W.2
Kam, B.L.3
-
82
-
-
40949121019
-
Report on short-term side effects of treatments with 177Lu-octreotate in combination with capecitabine in seven patients with gastroenteropancreatic neuroendocrine tumours
-
van Essen M, Krenning EP, Kam B, et al. Report on short-term side effects of treatments with 177Lu-octreotate in combination with capecitabine in seven patients with gastroenteropancreatic neuroendocrine tumours. Eur J Nucl Med Mol Imaging 2008, 35:743-748.
-
(2008)
Eur J Nucl Med Mol Imaging
, vol.35
, pp. 743-748
-
-
van Essen, M.1
Krenning, E.P.2
Kam, B.3
-
83
-
-
74849111472
-
Peptide receptor radionuclide therapy in patients with gastroenteropancreatic neuroendocrine tumors
-
Kwekkeboom DJ, de Herder WW, van Eijck CHJ, et al. Peptide receptor radionuclide therapy in patients with gastroenteropancreatic neuroendocrine tumors. Semin Nucl Med 2010, 40:78-88.
-
(2010)
Semin Nucl Med
, vol.40
, pp. 78-88
-
-
Kwekkeboom, D.J.1
de Herder, W.W.2
van Eijck, C.H.J.3
-
84
-
-
78649720414
-
-
PRRT in entero-pancreatic NETs: a multidisciplinary approach at the European Institute of Oncology. IEO NET Study Group, ENETS 2008, poster session.
-
Bodei L, et al. PRRT in entero-pancreatic NETs: a multidisciplinary approach at the European Institute of Oncology. IEO NET Study Group, ENETS 2008, poster session.
-
-
-
Bodei, L.1
-
85
-
-
34047255081
-
The novel mTOR inhibitor RAD001 (Everolimus) induces antiproliferative effects in human pancreatic neuroendocrine tumor cells
-
Zitzmann K, De Toni EN, Brand S, et al. The novel mTOR inhibitor RAD001 (Everolimus) induces antiproliferative effects in human pancreatic neuroendocrine tumor cells. Neuroendocrinology 2007, 85:54-60.
-
(2007)
Neuroendocrinology
, vol.85
, pp. 54-60
-
-
Zitzmann, K.1
De Toni, E.N.2
Brand, S.3
-
86
-
-
71749086394
-
Expression and activation of mTOR in neuroendocrine tumors. Effects of mTOR inhibition by RAD001 upon growth, cell cycle regulation and signalling in neuroendocrine cell lines
-
S
-
Hörsch D, Tielke S, Schrader J Expression and activation of mTOR in neuroendocrine tumors. Effects of mTOR inhibition by RAD001 upon growth, cell cycle regulation and signalling in neuroendocrine cell lines. J Clin Oncol 2007, 25(18S):10570.
-
(2007)
J Clin Oncol
, vol.25
, Issue.1
, pp. 10570
-
-
Hörsch, D.1
Tielke, S.2
Schrader, J.3
-
87
-
-
0034662634
-
Insulin-like growth factor-1 is an autocrine regulator of chromogranina A secretion and growth in human neuroendocrine tumor cells
-
Von Wichert G, Jehle PM, Hoeflich A, et al. Insulin-like growth factor-1 is an autocrine regulator of chromogranina A secretion and growth in human neuroendocrine tumor cells. Cancer Res 2000, 60:4573-4581.
-
(2000)
Cancer Res
, vol.60
, pp. 4573-4581
-
-
Von Wichert, G.1
Jehle, P.M.2
Hoeflich, A.3
-
88
-
-
32944457518
-
MTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
-
O'Reilly KE, Rojo F, She QB, et al. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 2006, 66(3):1500-1508.
-
(2006)
Cancer Res
, vol.66
, Issue.3
, pp. 1500-1508
-
-
O'Reilly, K.E.1
Rojo, F.2
She, Q.B.3
-
89
-
-
0035111692
-
Somatostatin inhibits Akt phosphorylation and cell-cycle entry, but not p42/p44 mitogen-activated protein (MAP) kinase activation in normal and tumoral-pancreatic acinar cells
-
Charland S, Boucher MJ, Houde M, Rivard N Somatostatin inhibits Akt phosphorylation and cell-cycle entry, but not p42/p44 mitogen-activated protein (MAP) kinase activation in normal and tumoral-pancreatic acinar cells. Endocrinology 2001, 142:121-128.
-
(2001)
Endocrinology
, vol.142
, pp. 121-128
-
-
Charland, S.1
Boucher, M.J.2
Houde, M.3
Rivard, N.4
-
90
-
-
64549086809
-
Pituitary-independent effect of octreotide on IGF1 generation
-
Pokrajac A, Frystyk J, Flyvbjerg A, Trainer PJ Pituitary-independent effect of octreotide on IGF1 generation. Eur J Endocrinol 2009, 160:543-548.
-
(2009)
Eur J Endocrinol
, vol.160
, pp. 543-548
-
-
Pokrajac, A.1
Frystyk, J.2
Flyvbjerg, A.3
Trainer, P.J.4
-
91
-
-
52049125970
-
Efficacy of RAD001 (everolimus) and octreotide LAR in advanced low- to intermediate grade neuroendocrine tumours: results of a phase II study
-
Yao JC, Phan A, Chang DZ, et al. Efficacy of RAD001 (everolimus) and octreotide LAR in advanced low- to intermediate grade neuroendocrine tumours: results of a phase II study. J Clin Oncol 2008, 26:4311-4318.
-
(2008)
J Clin Oncol
, vol.26
, pp. 4311-4318
-
-
Yao, J.C.1
Phan, A.2
Chang, D.Z.3
-
92
-
-
73949088959
-
A phase II trial of daily oral RAD001 (everolimus) in patients with metastatic pancreatic neuroendocrine tumors (NET) after failure of cytotoxic chemotherapy
-
Yao JC, Lombard-Bohas C, Baudin E, et al. A phase II trial of daily oral RAD001 (everolimus) in patients with metastatic pancreatic neuroendocrine tumors (NET) after failure of cytotoxic chemotherapy. J Clin Oncol 2010, 28:69-76.
-
(2010)
J Clin Oncol
, vol.28
, pp. 69-76
-
-
Yao, J.C.1
Lombard-Bohas, C.2
Baudin, E.3
-
93
-
-
78649748348
-
-
Phase I/II study of everolimus (RAD001) in combination with temozolomide (TMZ) in patients (pts) with advanced pancreatic neuroendocrine tumors (NET). ASCO GI Symposium 2010; Abstr. 223.
-
Kulke M, Blaszkowsky LS, Zhu AX, et al. Phase I/II study of everolimus (RAD001) in combination with temozolomide (TMZ) in patients (pts) with advanced pancreatic neuroendocrine tumors (NET). ASCO GI Symposium 2010; Abstr. 223.
-
-
-
Kulke, M.1
Blaszkowsky, L.S.2
Zhu, A.X.3
-
94
-
-
78649746349
-
-
al. Phase I study of pasireotide (SOM230) in combination with everolimus (RAD001) in patients (pts) with advanced neuroendocrine tumors (NET). ASCO GI Symposium 2010; Abstr. 238.
-
Chan JS, Ryan DP, Fuchs C, al. Phase I study of pasireotide (SOM230) in combination with everolimus (RAD001) in patients (pts) with advanced neuroendocrine tumors (NET). ASCO GI Symposium 2010; Abstr. 238.
-
-
-
Chan, J.S.1
Ryan, D.P.2
Fuchs, C.3
-
95
-
-
78649748134
-
-
Identifier: NCT00412061.
-
Identifier: NCT00412061. http://www.clinicaltrial.gov/.
-
-
-
-
96
-
-
78649752227
-
Phase I study of sorafenib in combination with everolimus (RAD001) in patients with advanced neuroendocrine tumors (NET)
-
Abstr. e14597
-
Chan JA, Mayer RJ, Jackson N, Malinowski P, Regan E, Kulke M Phase I study of sorafenib in combination with everolimus (RAD001) in patients with advanced neuroendocrine tumors (NET). J Clin Oncol 2010, 28(Suppl). Abstr. e14597.
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL
-
-
Chan, J.A.1
Mayer, R.J.2
Jackson, N.3
Malinowski, P.4
Regan, E.5
Kulke, M.6
-
97
-
-
78649721449
-
-
Expression of mTOR signaling pathway and effects of mTOR inhibitors on its pathway in human neuroendocrine tumors. ENETS 2010, Abst B12.
-
Iida S, Miki Y, Ono K, et al. Expression of mTOR signaling pathway and effects of mTOR inhibitors on its pathway in human neuroendocrine tumors. ENETS 2010, Abst B12.
-
-
-
Iida, S.1
Miki, Y.2
Ono, K.3
-
98
-
-
77954789459
-
Randomized run-in study of beva-cizumab (B) and everolimus (E) in low- to intermediate-grade neuroendocrine tumors (LGNETs) using perfusion CT as functional biomarker
-
[abstract 4002].
-
Yao JC, Phan AT, Fogleman D, et al. Randomized run-in study of beva-cizumab (B) and everolimus (E) in low- to intermediate-grade neuroendocrine tumors (LGNETs) using perfusion CT as functional biomarker. J Clin Oncol 2010, 28(Suppl):15s. [abstract 4002].
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL
-
-
Yao, J.C.1
Phan, A.T.2
Fogleman, D.3
-
99
-
-
12244301581
-
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet derived growth factor receptors: determination of pharmacokinetic/pharmacodynamic relationship
-
Mendel DB, Laird AD, Xin X, et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet derived growth factor receptors: determination of pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 2003, 9:327-337.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 327-337
-
-
Mendel, D.B.1
Laird, A.D.2
Xin, X.3
-
100
-
-
34548316976
-
Molecular basis for sunitinib efficacy and future clinical development
-
Faivre S, Demetri G, Sargent W, Raymond E Molecular basis for sunitinib efficacy and future clinical development. Nat Rev Drug Discov 2007, 6:734-745.
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 734-745
-
-
Faivre, S.1
Demetri, G.2
Sargent, W.3
Raymond, E.4
-
101
-
-
33644847440
-
Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patient with cancer
-
Faivre S, Delbaldo C, Vera K, et al. Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patient with cancer. J Clin Oncol 2006, 24:25-35.
-
(2006)
J Clin Oncol
, vol.24
, pp. 25-35
-
-
Faivre, S.1
Delbaldo, C.2
Vera, K.3
-
102
-
-
49149114782
-
Activity of sunitinib in patients with advanced neuroendocrine tumors
-
Kulke MH, Lenz HJ, Meropol NJ, et al. Activity of sunitinib in patients with advanced neuroendocrine tumors. J Clin Oncol 2008, 26:3403-3410.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3403-3410
-
-
Kulke, M.H.1
Lenz, H.J.2
Meropol, N.J.3
-
103
-
-
77954793635
-
Updated safety and efficacy results of the phase III trial of sunitinib (SU) versus placebo (PBO) for treatment of pancreatic neuroendocrine tumors (NET)
-
[abstract 4000]
-
Niccoli P, Raoul J, Bang Y, et al. Updated safety and efficacy results of the phase III trial of sunitinib (SU) versus placebo (PBO) for treatment of pancreatic neuroendocrine tumors (NET). J Clin Oncol 2010, 28(Suppl):15s. [abstract 4000].
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL
-
-
Niccoli, P.1
Raoul, J.2
Bang, Y.3
-
104
-
-
77954792867
-
Patient-reported outcomes (PROs) in patients (pts) with pancreatic neuroendocrine tumors (NET) receiving sunitinib (SU) in a phase III trial
-
[abstract 4003].
-
Vinik A, Bang Y, Raoul J, et al. Patient-reported outcomes (PROs) in patients (pts) with pancreatic neuroendocrine tumors (NET) receiving sunitinib (SU) in a phase III trial. J Clin Oncol 2010, 28(Suppl):15s. [abstract 4003].
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL
-
-
Vinik, A.1
Bang, Y.2
Raoul, J.3
-
105
-
-
41649114168
-
Targeting vascular endothelial growth factor in advanced carcinoid tumor: a random assignment phase II study of depot octreotide with bevacizumab and pegylated interferon alpha-2b
-
Yao JC, Phan A, Hoff PM, et al. Targeting vascular endothelial growth factor in advanced carcinoid tumor: a random assignment phase II study of depot octreotide with bevacizumab and pegylated interferon alpha-2b. J Clin Oncol 2008, 26:1316-1323.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1316-1323
-
-
Yao, J.C.1
Phan, A.2
Hoff, P.M.3
-
106
-
-
78649752666
-
-
Identifier: NCT00569127.
-
Identifier: NCT00569127. http://www.clinicaltrial.gov.
-
-
-
-
107
-
-
34250703190
-
A phase II study of temozolomide and bevacizumab in patients with advanced neuroendocrine tumors
-
SUPPL
-
Kulke MH, Stuart K, Earle CC, et al. A phase II study of temozolomide and bevacizumab in patients with advanced neuroendocrine tumors. J Clin Oncol 2006, 24(18 Suppl):4044S.
-
(2006)
J Clin Oncol
, vol.24
, Issue.18
-
-
Kulke, M.H.1
Stuart, K.2
Earle, C.C.3
-
108
-
-
77954779889
-
A phase II study of capecitabine, oxaliplatin, and bevacizumab for metastatic or unresectable neuroendocrine tumors
-
[abstract 4104]., SUPPL
-
Kunz PL, Kuo T, Zahn JM, et al. A phase II study of capecitabine, oxaliplatin, and bevacizumab for metastatic or unresectable neuroendocrine tumors. J Clin Oncol 2010, 28(Suppl):15s. [abstract 4104].
-
(2010)
J Clin Oncol
, vol.28
-
-
Kunz, P.L.1
Kuo, T.2
Zahn, J.M.3
-
109
-
-
0033809990
-
Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells
-
Perren A, Komminoth P, Saremaslani P, et al. Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells. Am J Pathol 2000, 157:1097-1103.
-
(2000)
Am J Pathol
, vol.157
, pp. 1097-1103
-
-
Perren, A.1
Komminoth, P.2
Saremaslani, P.3
-
110
-
-
34047254705
-
Rap1/B-Raf signaling is activated in neuroendocrine tumors of the digestive tract and Raf kinase inhibition constitutes a putative therapeutic target
-
Karhoff D, Sauer S, Schrader J, et al. Rap1/B-Raf signaling is activated in neuroendocrine tumors of the digestive tract and Raf kinase inhibition constitutes a putative therapeutic target. Neuroendocrinology 2007, 85:45-53.
-
(2007)
Neuroendocrinology
, vol.85
, pp. 45-53
-
-
Karhoff, D.1
Sauer, S.2
Schrader, J.3
-
111
-
-
77649190362
-
Expression of an activated mammalian target of rapamycin (mTOR) in gastroenteropancreatic neuroendocrine tumors
-
Shida T, Kishimoto T, Furuya M, et al. Expression of an activated mammalian target of rapamycin (mTOR) in gastroenteropancreatic neuroendocrine tumors. Cancer Chem Pharmacol 2010, 65:889-893.
-
(2010)
Cancer Chem Pharmacol
, vol.65
, pp. 889-893
-
-
Shida, T.1
Kishimoto, T.2
Furuya, M.3
-
112
-
-
78649738237
-
-
mTOR expression in gastrointestinal (GI) tract poorly differentiated endocrine carcinoma (PDEC). ESMO/ECCO 2009, Abstr. p-1323.
-
Catena L, Carbone A, Milione M, et al. mTOR expression in gastrointestinal (GI) tract poorly differentiated endocrine carcinoma (PDEC). ESMO/ECCO 2009, Abstr. p-1323.
-
-
-
Catena, L.1
Carbone, A.2
Milione, M.3
|