Double-negative T cells are non-ALPS-specific markers of immune dysregulation found in patients with aplastic anemia

Blood

Volumn 116, Issue 23, 2010, Pages 5072-5073

  Russell, Thomas B ^a   Kurre, Peter ^b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10;

APLASTIC ANEMIA; AUTOIMMUNITY; BIOGENESIS; CELL POPULATION; CYTOPENIA; DISEASE SEVERITY; HUMAN; IMMUNE DYSREGULATION; IMMUNOPHENOTYPING; LETTER; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 78649738104     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-09-306910     Document Type: Letter

References (7)

1. Dowdell KC, Niemela JE, Price S, et al. Somatic FAS mutations are common in patients with genetically undefined autoimmune lymphoproliferative syndrome. Blood. 2009;115(25):5164-5169.
2. Bristeau-Leprince A, Mateo V, Lim A, et al. Human TCR alpha/beta+ CD4-CD8- double-negative T cells in patients with autoimmune lymphoproliferative syndrome express restricted Vbeta TCR diversity and are clonally related to CD8+ T cells. J Immunol. 2008;181(1):440-448.
3. Magerus-Chatinet A, Stolzenberg MC, Loffredo MS, et al. FAS-L, IL-10, and double-negative CD4- CD8- TCR alpha/beta+ T cells are reliable markers of autoimmune lymphoproliferative syndrome (ALPS) associated with FAS loss of function. Blood. 2009;113(13):3027-3030.
4. Dianzani U, Bragardo M, DiFranco D, et al. Deficiency of the Fas apoptosis pathway without Fas gene mutations in pediatric patients with autoimmunity/lymphoproliferation. Blood. 1997;89(8):2871-2879. (Pubitemid 27172574)
5. Dean GS, Anand A, Blofeld A, et al. Characterization of CD3+ CD4- CD8- (double negative) T cells in patients with systemic lupus erythematosus: production of IL-4. Lupus. 2002;11(8):501-507. (Pubitemid 34948069)
6. Young NS, Scheinberg P, Calado RT. Aplastic anemia. Curr Opin Hematol. 2008;15(3):162-168.
7. Dirksen U, Asadi-Moghaddam K, Fuhrer M, Burdach S. Defunct hematopoietic progenitor growth and heterogeneous immunological phenotypes in acquired aplastic anemia of childhood: identification of subsets with decreased hematopoietic progenitors and increased IL15 or IL10 production. Klin Padiatr. 1998;210(4):167-172.