Defunct hematopoietic progenitor growth and heterogeneous immunological phenotypes in acquired aplastic anemia of childhood: Identification of subsets with decreased hematopoietic progenitors and increased IL15 or IL10 production

Klinische Padiatrie

Volumn 210, Issue 4, 1998, Pages 167-172

  Dirksen, U ^a,c   Asadi Moghaddam, K ^a   Fuhrer M ^b   Burdach, S ^a,c  

^a Dept of Pediat Hematol and Oncol   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 15;

ALLOGRAFT; APLASTIC ANEMIA; ARTICLE; CHILDHOOD DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; IMMUNOPATHOGENESIS; MAJOR CLINICAL STUDY; STEM CELL TRANSPLANTATION; T LYMPHOCYTE ACTIVATION;

EID: 0031877157     PISSN: 03008630     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1043874     Document Type: Article

References (32)

1. Agosti, J. M., J. D. Sprenger, L. G. Lum, R. P. Witherspoon, L. D. Fisher, R. Storb W. R. J. Henderson: Transfer of allergen-specific IgE-mediated hypersensitivity with allogeneic bone marrow transplantation. N. Engl. J. Med. 319 (1988) 1623-1628
2. Alter, B. P. N. S. Young: The bone marrow failure syndroms. In: Nathan, D. G. and F. A. Oski (Hrsg.): Hematology of infancy and childhood. Saunders, Philadelphia 1993
3. Broxmeyer, H. E., D. S. Williams, L. Lu, S. Cooper, S. L. Anderson, G. S. Beyer, R. Hoffman B. Rubin: The suppressive influences of human tumor necrosis factors on bone marrow hematopoietic progenitor cells from normal donors and patients with leukemia: synergism of tumor necrosis factor and interferon-γ. J. Immunol. 136 (1986) 4487-4495
4. Burdach, S.: Molecular regulation of hematopoietic cytokines: implication and indications for clinical use in pediatric oncology. Med. Ped. Onc. Suppl. 2 (1992) 10-17
5. Burdach, S., R. Vöhringer, D. Dilloo, K. Krauth, H. Hanenberg U. Göbel: Experimental basis of a therapy-oriented pathogenetic classification of aplastic anemia of childhood. Klin. Pädiatr. 206 (1994) 201-7
6. Carson, W. E., M. E. Ross, R. A. Baiocchi, M. J. Marien, N. Bolani, K. Grabstein M. A. Caliguri: Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-γ by natural killer cells in vitro. J. Clin. Invest. 96 (1995) 2578-2582
7. D'Andrea, A., M. Aste-Amezaga, N. M. Valiante, X. Ma, M. Kubin G. Trichineri: Interleukin 10 (IL-10) inhibits human lymphocyte interferon g production by suppressing natural killer cell stimulators factor/IL-12 synthesis in accessory cells. J. Exp. Med. 178 (1993) 1041-1048
8. Dilloo, D., R. Vöhringer, A. Josting, K. Habersang, A. Scheid S. Burdach: Bone marrow fibroblasts from children with aplastic anemia exhibit reduced Interleukin-6 production in response to cytokines and viral challenge. Pediatr. Res. 38 (1995) 716-721
9. Fleming, L. E. W. Timmeny: Aplastic anemia. J Occup Med 35 (1993) 1106
10. Frickhofen, H., J. P. Kaltwasser, H. Schrenzenmeier et al.: Treatment of aplastic anemia with antilymphocyze globulin and methylprednisolone with or without cyclosporin. N. Engl. J. Med. 324 (1991) 1297-1304
11. Frickhofen, N., J. M. Liu N. S. Young: Etiologic mechanisms of hematopoietic failure. Am. J. Pediatr. Pediatr. Hematol. Oncol. 12 (1990) 385-395
12. Gluckman, E., M. M. Horowitz, R. E. Champlin, J. M. Hows, A. Bacigulapo, J. C. Biggs, B. M. Camitta, R. P. Gale, E. C. Gordon-Smith, A. M. Marmont, T. Masaoka, N. K. C. Ramsay, A. A. Rimm, C. Rozman, K. A. Sobocinski, B. Speck M. M. Bortin: Bone marrow transplantation for severe aplastic anemia: influence of conditioning and graft versus host disease prophylaxis regiments on outcome. Blood 79 (1992) 269-275
13. Grabstein, K. H., J. Eisenman, K. Shanebeck, C. Rauch, S. Srinivasan, V. Fung, C. Beers, J. Richardson, M. A. Schoenborn, M. Ahdieh, L. Johnson, M. R. Alderson, J. D. Watson, D. M. Anderson J. G. Giri: Cloning of a T cell growth factor that interacts with the b chain of the interleukin-2 receptor. Science 264 (1994) 965-968
14. Kanegane, H. G. Tosato: Activation of naive and memory T cells by interleukin-15. Blood 88 (1996) 230-235
15. Kutnaki, S., R. Armitage, M. Ahdich, L. Park D. Cosman: Interleukin-15 up-regulates interleukin-2 receptor a chain but down-regulates its own high-affinity binding sites on human T and B cells. Eur. J. Immunol. 26 (1996) 1235-1239
16. Maciejewski, J. P., J. R. Hibbs, S. Anderson, P. Katevas N. S. Young: Bone marrow and peripheral blood lymphocyte phenotype in patients with bone marrow failure. Exp. Hematol. 22 (1994) 1102-1110
17. Marsh, J. C. W., J. Chang, N. G. Testa, J. M. Hows T. M. Dexter: The hematopoietic defect in aplastic anemia assessed by long-term marrow culture. Blood 76 (1990) 1748-1757
18. Marsh, J. C. W., J. Chang, N. G. Testa, J. M. Hows T. M. Dexter: In vitro assessment of marrow stem cell and stromal cell function in aplastic anemia. Br. J. Haematol. 78 (1991) 258-267
19. Munger, W., S. Quinn DeJoy, R. Jeyaseelan, L. W. Torley, K. H. Grabstein, J. Eisenmann, R. Paxton, T. Cox, M. M. Wick S. S. Kerwar: Studies evaluating the antitumor activity and toxicity of Interleukin-15, a new T cell growth factor: Comparison with Interleukin-2. Cellular Immunol. 165 (1995) 289-293
20. Nakao, S.: Interferon-γ expression and other markers as predictors of response to cyclosporine therapy for aplastic anemia. In: Raghavachar, A., H. Schrenzenmeier and N. Frickhofen (Hrsg.): Aplastic anemia: Current perspectives on the pathogenesis and treatment. 3. Blackwell-MZV, Vienna 1993
21. Nisticò, M. D. N. S. Young: Gamma-Interferon gene expression in the bone marrow of patients with aplastic anemia. Ann. Intern. Med. 120 (1994) 463-469
22. Quian, J. X., S. M. Lee, Y. Suen, E. Knoppel, C. Van de Ven M. S. Cairo: Decreased interleukin-15 from activated cord versus adult peripheral blood mononuclear cells and the effect of interleukin-15 in upregulating antitumor immune activity and cytokine production in cord blood. Blood 15 (1997) 3106-3117
23. Taga, K., H. Mostowski G. Tosato: Human interleukin-10 can directly inhibit T-cell growth. Blood 81 (1993) 2964-2971
24. Taga, K. G. Tosato: IL-10 inhibits human T cell proliferation and IL-2 production. J. Immunol. 148 (1992) 1143-1148
25. Torok-Storb, B.: Etiological mechanisms in immune-mediated aplastic anemia. Am. J. Pediatr. Hematol. 12 (1990) 396-401
26. Viale, M., A. Merli A. Bacigalupo: Analysis at the clonal level of T cell phenotype and functions in severe aplastic anemia patients. Blood 78 (1991) 1268-1274
27. Young, N.: Drugs and Chemicals as agents of bone marrow failure. In: Testa, N. and G. R. C. (Hrsg.): Hematopoiesis. Marcel Dekker, New York 1988
28. Young, N. S.: The pathogenesis and pathophysiology of aplastic anemia. Churchill-Livingston (1993) 122-159
29. Young, N. S. P. Mortimer: Viruses and bone marrow failure. Blood 63 (1993) 75-119
30. Zoumbos, N., P. Gascon, J. Dijeu N. S. Young: Interferon is a mediator of hematopoietic suppression in aplastic anemia in vitro and possibly in vivo. Proc. Natl. Acad. Sci. 82 (1985) 188-192
31. Zoumbos, N., P. Gascon, J. Djeu N. S. Young: Interferon is a mediator of hematopoietic suppression in aplastic anemia in vitro and possibly in vivo. Proc. Natl. Acad. Sci. 82 (1984) 188-192
32. Zoumbos, N. C., E. Raefsky N. S. Young: Lymphokines and hematopoiesis. Progress in hematol 14 (1986) 201-277