A Cavalier King Charles dog with shadow chasing: Clinical recovery and normalization of the dopamine transporter binding after clomipramine treatment

Journal of Veterinary Behavior: Clinical Applications and Research

Volumn 5, Issue 6, 2010, Pages 345-349

  Vermeire, Simon ^a   Audenaert, Kurt ^b   Dobbeleir, Andre ^a,c   Vandermeulen, Eva ^a   Waelbers, Tim ^a   Peremans, Kathelijne ^a  

^a GHENT UNIVERSITY   (Belgium)

^b Faculty of Medical and Health Sciences   (Belgium)

^c Faculty of Medicine and Health Sciences   (Belgium)

Author keywords

123I FP CIT; Canine obsessive compulsive behavior; Clomipramine; Dopamine; In vivo neuro imaging; Serotonin

Indexed keywords

CANIS FAMILIARIS;

EID: 78649735496     PISSN: 15587878     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jveb.2010.07.001     Document Type: Article

References (42)

1. Alvarez-Fischer D., Blessmann G., Trosowski C., Behe M., Schurrat T., Hartmann A., Behr T., Oertel W., Hoglinger G., Hoffken H. Quantitative [(123)I]FP-CIT pinhole SPECT imaging predicts striatal dopamine levels, but not number of nigral neurons in different mouse models of Parkinson's disease. Neuroimage 2007, 38:5-12.
2. Ananth J. Clomipramine: an antiobsessive drug. Can. J. Psychiatry 1986, 31:253-258.
3. Benfield D.P., Harries C.M., Luscombe D.K. Some pharmacological aspects of desmethylclomipramine. Postgrad. Med. J. 1980, 56(Suppl 1):13-18.
4. Blier P. Norepinephrine and selective norepinephrine reuptake inhibitors in depression and mood disorders: their pivotal roles. J.Psychiatry Neurosci. 2001, 26(Suppl):S1-S2.
5. Boothe D.M. Antidepressants. Small Animal Clinical Pharmacology 2001, 500-503. WB Saunders, Philadelphia, PA. J. Maddison, S. Page, D. Church (Eds.).
6. Denys D., Van der L.G., Janssen J., De Geus F., Westenberg H.G. Low level of dopaminergic D2 receptor binding in obsessive-compulsive disorder. Biol. Psychiatry 2004, 55:1041-1045.
7. Denys D., Zohar J., Westenberg H.G. The role of dopamine in obsessive-compulsive disorder: preclinical and clinical evidence. J. Clin. Psychiatry 2004, 65(Suppl 14):11-17.
8. Di Matteo V., Di Giovanni G., Pierucci M., Esposito E. Serotonin control of central dopaminergic function: focus on in vivo microdialysis studies. Prog. Brain Res. 2008, 172:7-44.
9. Dobbeleir A., Hambye A., Vervaet A., Ham H. Quantification of Iodine-123-FP-CIT SPECT with a resolution-independent method. World J. Nucl. Med. 2005, 4:252-261.
10. Esposito E., Di Matteo V., Di Giovanni G. Serotonin-dopamine interaction: an overview. Prog. Brain Res. 2008, 172:3-6.
11. Friedlander L., Desrocher M. Neuroimaging studies of obsessive-compulsive disorder in adults and children. Clin. Psychol. Rev. 2006, 26:32-49.
12. Hesse S., Muller U., Lincke T., Barthel H., Villmann T., Angermeyer M.C., Sabri O., Stengler-Wenzke K. Serotonin and dopamine transporter imaging in patients with obsessive-compulsive disorder. Psychiatry Res. 2005, 140:63-72.
13. Hewson C.J., Luescher U.A., Parent J.M., Conlon P.D., Ball R.O. Efficacy of clomipramine in the treatment of canine compulsive disorder. J. Am. Vet. Med. Assoc. 1998, 213:1760-1766.
14. Hsu Y.Y., Serpell J.A. Development and validation of a questionnaire for measuring behavior and temperament traits in pet dogs. J. Am. Vet. Med. Assoc. 2003, 223:1293-1300.
15. Irimajiri M., Luescher A.U., Douglass G., Robertson-Plouch C., Zimmermann A., Hozak R. Randomized, controlled clinical trial of the efficacy of fluoxetine for treatment of compulsive disorders in dogs. J. Am. Vet. Med. Assoc. 2009, 235:705-709.
16. Kapur S., Remington G. Serotonin-dopamine interaction and its relevance to schizophrenia. Am. J. Psychiatry 1996, 153:466-476.
17. Kennes D., Odberg F.O., Bouquet Y., De Rycke P.H. Changes in naloxone and haloperidol effects during the development of captivity-induced jumping stereotypy in bank voles. Eur. J. Pharmacol. 1988, 153:19-24.
18. King J.N., Maurer M.P., Altmann B.O., Strehlau G.A. Pharmacokinetics of clomipramine in dogs following single-dose and repeated-dose oral administration. Am. J. Vet. Res. 2000, 61:80-85.
19. King J.N., Simpson B.S., Overall K.L., Appleby D., Pageat P., Ross C., Chaurand J., Heath S., Beata C., Weiss A., Muller G., Paris T., Bataille B., Parker J., Petit S., Wren J. Treatment of separation anxiety in dogs with clomipramine: results from a prospective, randomized, double-blind, placebo-controlled, parallel-group, multicenter clinical trial. Appl. Anim. Behav. Sci. 2000, 67:255-275.
20. Kook P.H., Kranjc A., Dennler M., Glaus T.M. Pancreatitis associated with clomipramine administration in a dog. J. Small Anim. Pract. 2009, 50:95-98.
21. Luescher A.U. Diagnosis and management of compulsive disorders in dogs and cats. Vet. Clin. Small Anim. 2003, 33:253-267.
22. Maia T.V., Cooney R.E., Peterson B.S. The neural bases of obsessive-compulsive disorder in children and adults. Dev. Psychopathol. 2008, 20:1251-1283.
23. McTavish D., Benfield P. Clomipramine. An overview of its pharmacological properties and a review of its therapeutic use in obsessive compulsive disorder and panic disorder. Drugs 1990, 39:136-153.
24. Menzies L., Chamberlain S.R., Laird A.R., Thelen S.M., Sahakian B.J., Bullmore E.T. Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited. Neurosci. Biobehav. Rev. 2008, 32:525-549.
25. Moon-Fanelli A.A., Dodman N.H. Description and development of compulsive tail chasing in terriers and response to clomipramine treatment. J. Am. Vet. Med. Assoc. 1998, 212:1252-1257.
26. Olver J.S., O'Keefe G., Jones G.R., Burrows G.D., Tochon-Danguy H.J., Ackermann U., Scott A., Norman T. Dopamine D(1) receptor binding in the striatum of patients with obsessive-compulsive disorder. J. Affect. Disord. 2009, 114:321-326.
27. Overall K.L., Dunham A.E. Clinical features and outcome in dogs and cats with obsessive-compulsive disorder: 126 cases (1989-2000). J. Am. Vet. Med. Assoc. 2002, 221:1445-1452.
28. Peremans K., Audenaert K., Coopman F., Jacobs F., Dumont F., Slegers G., Verschooten F., van Bree H., Mertens J., Dierckx R. Regional binding index of the radiolabeled selective 5-HT2A antagonist 123I-5-I-R91150 in the normal canine brain imaged with single photon emission computed tomography. Vet. Radiol. Ultrasound. 2003, 44:344-351.
29. Pitman R.K. Animal models of compulsive behavior. Biol. Psychiatry 1989, 26:189-198.
30. Pouchelon J.L., Martel E., Champeroux P., Richard S., King J.N. Effects of clomipramine hydrochloride on heart rate and rhythm in healthy dogs. Am. J. Vet. Res. 2000, 61:960-964.
31. Rapoport J.L., Ryland D.H., Kriete M. Drug treatment of canine acral lick. An animal model of obsessive-compulsive disorder. Arch. Gen. Psychiatry 1992, 49:517-521.
32. Rapoport J.L., Wise S.P. Obsessive-compulsive disorder: evidence for basal ganglia dysfunction. Psychopharmacol. Bull. 1988, 24:380-384.
33. Rasmussen S.A., Eisen J.L. The epidemiology and differential diagnosis of obsessive compulsive disorder. J. Clin. Psychiatry 1992, 53(Suppl):4-10.
34. Reich M.R., Ohad D.G., Overall K.L., Dunham A.E. Electrocardiographic assessment of antianxiety medication in dogs and correlation with serum drug concentration. J. Am. Vet. Med. Assoc. 2000, 216:1571-1575.
35. Seksel K., Lindeman M.J. Use of clomipramine in treatment of obsessive-compulsive disorder, separation anxiety and noise phobia in dogs: a preliminary, clinical study. Aust. Vet. J. 2001, 79:252-256.
36. Stahl S. Antidepressants. Stahl's Essential Psychopharmacology 2008, 511-666. Cambridge University Press, Cambridge, United Kingdom. 3rd Ed.
37. Stein D.J. Obsessive-compulsive disorder. Lancet 2002, 360:397-405.
38. Szechtman H., Sulis W., Eilam D. Quinpirole induces compulsive checking behavior in rats: a potential animal model of obsessive-compulsive disorder (OCD). Behav. Neurosci. 1998, 112:1475-1485.
39. van der Wee N.J., Stevens H., Hardeman J.A., Mandl R.C., Denys D.A., van Megen H.J., Kahn R., Westenberg H. Enhanced dopamine transporter density in psychotropic-naive patients with obsessive-compulsive disorder shown by [123I]{beta}-CIT SPECT. Am. J. Psychiatry 2004, 161:2201-2206.
40. Vandebroek I., Odberg F.O. Effect of apomorphine on the conflict-induced jumping stereotypy in bank voles. Pharmacol. Biochem. Behav. 1997, 57:863-868.
41. Vermeire S., Audenaert K., Vandermeulen E., Waelbers T., De Spiegeleer B., Van Bree H., Peremans K. Single photon emission computed tomography (SPECT) imaging of the dopamine transporter in healthy dogs. Vet. J 2010, [Epub ahead of print].
42. Westenberg H.G., Fineberg N.A., Denys D. Neurobiology of obsessive-compulsive disorder: serotonin and beyond. CNS Spectr. 2007, 12:14-27.