Electrocardiographic assessment of antianxiety medication in dogs and correlation with serum drug concentration

Journal of the American Veterinary Medical Association

Volumn 216, Issue 10, 2000, Pages 1571-1575

  Reich, Marsha R ^a   Ohad, Dan G ^a   Overall, Karen L ^a   Dunham, Arthur E ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; ANXIOLYTIC AGENT; CLOMIPRAMINE; TRICYCLIC ANTIDEPRESSANT AGENT;

ANIMAL BEHAVIOR; ARTICLE; CONTROLLED STUDY; DOG; DRUG BLOOD LEVEL; ELECTROCARDIOGRAM; HEART CONDUCTION; HEART RATE; NONHUMAN; P WAVE; QT INTERVAL;

EID: 0034658343     PISSN: 00031488     EISSN: None     Source Type: Journal    
DOI: 10.2460/javma.2000.216.1571     Document Type: Article

References (26)

1. Sigler L. Pet behavioral problems present opportunities for practitioners. Trends 1991;4:44-45.
2. Landsberg GM. The distribution of canine behavior cases at three behavior referral practices. Vet Med 1991;86:1081-1089.
3. Houpt KA, Honig SU, Reisner IR. Breaking the human-companion animal bond. J Am Vet Med Assoc 1996;208:1653-1659.
4. Patronek GJ, Glickman LT, Beck AM, et al. Risk factors for relinquishment of dogs to an animal shelter. J Am Vet Med Assoc 1996;209:572-581.
5. Miller DD, Staats SR, Partlo C, et al. Factors associated with the decision to surrender a pet to an animal shelter. J Am Vet Med Assoc 1996;209:738-742.
6. Overall KL. Canine aggression, canine elimination disorders, fears, anxieties and stereotypies, behavioral pharmacology. In: Clinical behavioral medicine for small animals. St Louis: CV Mosby Co, 1997;88-240, 293-318.
7. Simpson BS, Simpson DM. Behavioral pharmacotherapy. In: Voith VL, Borchelt PL, eds. Readings in companion animal behavior. Trenton, NJ: Veterinary Learning Systems, 1996;100-113
8. Overall KL. Pharmacologic treatments for behavioral problems. Vet Clin North Am Small Anim Pract 1997;27:637-665.
9. Clomicalm veterinary label insert. Clomicalm clinical and technical review. Greensboro, NC: Novartis Animal Health US, 1998.
10. Marshall JB, Forker AD. Cardiovascular effects of tricyclic antidepressant drugs: therapeutic usage, overdose, and management of complications. Am Heart J 1982;103:401-414.
11. Groleau G, Jotte R, Barish R. The electrocardiographic manifestations of cyclic antidepressant therapy and overdose: a review. J Emerg Med 1990;8:597-605.
12. Preskorn SH, Irwin HA. Toxicity of tricyclic antidepressants. Kinetics, mechanism, intervention: a review. J Clin Psychiatry 1982;43:151-156.
13. Jefferson JW. Cardiovascular effects and toxicity of anxiolytics and antidepressants. J Clin Psychiatry 1989;50:368-378.
14. Glassman AH, Bigger JT. Cardiovascular effects of therapeutic doses of tricyclic antidepressants. Arch Gen Psychiatry 1981;38:815-820.
15. Faravelli C, Brat A, Marchetti G, et al. Cardiac effects of clomipramine treatment. ECG and left ventricular systolic time intervals. Neuropsychobiology 1983;9:113-118.
16. Glassman AH, Roose SP, Bigger JT. The safety of tricyclic antidepressants in cardiac patients. Risk-benefit reconsidered. JAMA 1993;269:2673-2675.
17. Roose SP, Glassman AH, Dalack GW. Depression, heart disease, and tricyclic antidepressants. J Clin Psychiatry 1989;50(suppl 7):12-16.
18. Moss AJ. Measurement of the QT interval and the risk associated with QTc interval prolongation: a review. Am J Cardiol 1993;72:23B-25B.
19. Morganroth J. A symposium: QTc interval prolongation: is it beneficial or harmful? Am J Cardiol 1993;72:1B-3B.
20. Bazett HC. An analysis of the time-relations of electrocardiograms. Heart 1918;7:353-370.
21. Hamlin RL. The QT and QTc intervals: measurement and importance for the dog, in Proceedings. 16th Am Coll Vet Intern Med Forum 1998;148-149.
22. Oguchi Y, Hamlin RL. Rate of change of QT interval in response to a sudden change in the heart rate in dogs. Am J Vet Res 1994;55:1618-1623.
23. Preskorn SH. Tricyclic antidepressants: the whys and hows of therapeutic drug monitoring. J Clin Psychiatry 1989;50(suppl 7):34-42.
24. Simpson DM, Pi EH, White K. Plasma drug levels and clinical response to antidepressants. J Clin Psychiatry 1983;44:27-34.
25. Tilly LP. Right bundle branch block. Essentials of canine and feline electrocardiography interpretation and treatment. 3rd ed. Philadelphia: Lea & Febiger, 1992;78-79.
26. Bolton GR, Ettinger SJ. Right bundle branch block in the dog. J Am Vet Med Assoc 1972;160:1104-1119.