Quantitative [123I]FP-CIT pinhole SPECT imaging predicts striatal dopamine levels, but not number of nigral neurons in different mouse models of Parkinson's disease

NeuroImage

Volumn 38, Issue 1, 2007, Pages 5-12

  Alvarez Fischer, D ^a   Blessmann, G ^a   Trosowski, C ^a   Behe M ^a   Schurrat, T ^a   Hartmann, A ^a,b   Behr, T M ^a   Oertel, W H ^a   Hoglinger G U ^a   Hoffken H ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b INSERM   (France)

Author keywords

6 OHDA; Dopamine transporter; FP CIT; MPTP; Parkinson's disease; Pinhole SPECT

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; DOPAMINE; DOPAMINE TRANSPORTER; IODINE 123; OXIDOPAMINE; RADIOLIGAND;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE BRAIN LEVEL; DOPAMINERGIC NERVE CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOLOGY; IMAGE PROCESSING; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STATISTICAL ANALYSIS; SUBSTANTIA NIGRA;

ANIMALS; CELL COUNT; DISEASE MODELS, ANIMAL; DOPAMINE; MALE; MICE; MICE, INBRED C57BL; NEURONS; PARKINSON DISEASE; RADIOPHARMACEUTICALS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SUBSTANTIA NIGRA; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TROPANES;

EID: 34548846637     PISSN: 10538119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2007.05.056     Document Type: Article

References (29)

1. Acton P.D., and Kung H.F. Small animal imaging with high resolution single photon emission tomography. Nucl. Med. Biol. 30 (2003) 889-895
2. Ahlskog J.E. Slowing Parkinson's disease progression: recent dopamine agonist trials. Neurology 60 (2003) 381-389
3. Andringa G., Drukarch B., Bol J.G., de Bruin K., Sorman K., Habraken J.B., and Booij J. Pinhole SPECT imaging of dopamine transporters correlates with dopamine transporter immunohistochemical analysis in the MPTP mouse model of Parkinson's disease. NeuroImage 26 (2005) 1150-1158
4. Ashkan K., Wallace B.A., Mitrofanis J., Pollo C., Brard P.Y., Fagret D., and Benabid A.L. SPECT imaging, immunohistochemical and behavioural correlations in the primate models of Parkinson's disease. Parkinsonism Relat. Disord. 13 (2007) 266-275
5. Benamer T.S., Patterson J., Grosset D.G., Booij J., de Bruin K., van Royen E., Speelman J.D., Horstink M.H., Sips H.J., Dierckx R.A., Versijpt J., Decoo D., Van Der Linden C., Hadley D.M., Doder M., Lees A.J., Costa D.C., Gacinovic S., Oertel W.H., Pogarell O., Hoeffken H., Joseph K., Tatsch K., Schwarz J., and Ries V. Accurate differentiation of parkinsonism and essential tremor using visual assessment of [123I]-FP-CIT SPECT imaging: the [123I]-FP-CIT study group. Mov. Disord. 15 (2000) 503-510
6. Barc S., Page G., Barrier L., Garreau L., Guilloteau D., Fauconneau B., and Chalon S. Relevance of different striatal markers in assessment of the MPP+-induced dopaminergic nigrostriatal injury in rat. J. Neurochem. 80 (2002) 365-374
7. Booij J., de Bruin K., Habraken J.B., and Voorn P. Imaging of dopamine transporters in rats using high-resolution pinhole single-photon emission tomography. Eur. J. Nucl. Med. Mol. Imaging 29 (2002) 1221-1224
8. Chagkutip J., Vaughan R.A., Govitrapong P., and Ebadi M. 1-Methyl-4-phenylpyridinium-induced down-regulation of dopamine transporter function correlates with a reduction in dopamine transporter cell surface expression. Biochem. Biophys. Res. Commun. 311 (2003) 49-54
9. Counihan T.J., and Penney Jr. J.B. Regional dopamine transporter gene expression in the substantia nigra from control and Parkinson's disease brains. J. Neurol. Neurosurg. Psychiatry 65 (1998) 164-169
10. Dauer W., and Przedborski S. Parkinson's disease: mechanisms and models. Neuron 39 (2003) 889-909
11. Dawson T.M., and Dawson V.L. Molecular pathways of neurodegeneration in Parkinson's disease. Science 302 (2003) 819-822
12. Eshuis S.A., Maguire R.P., Leenders K.L., Jonkman S., and Jager PL. Comparison of FP-CIT SPECT with F-DOPA PET in patients with de novo and advanced Parkinson's disease. Eur. J. Nucl. Med. Mol. Imaging 33 (2006) 200-209
13. Ferger B., Teismann P., Earl C.D., Kuschinsky K., and Oertel W.H. Salicylate protects against MPTP-induced impairments in dopaminergic neurotransmission at the striatal and nigral level in mice. Naunyn-Schmiedebergs Arch. Pharmacol. 360 (1999) 256-261
14. Franklin K.B.J., and Paxinos G. The Mouse Brain in Stereotaxic Coordinates (1997), Academic Press lim
15. Habraken J.B., de Bruin K., Shehata M., Booij J., Bennink R., van Eck Smit B.L., and Busemann Sokole E. Evaluation of high-resolution pinhole SPECT using a small rotating animal. J. Nucl. Med. 42 (2001) 1863-1869
16. Höglinger G.U., Rizk P., Muriel M.P., Duyckaerts C., Oertel W.H., Caille I., and Hirsch E.C. Dopamine depletion impairs precursor cell proliferation in Parkinson disease. Nat. Neurosci. 7 (2004) 726-735
17. Ishizu K., Yonekura M.Y., Pagani M., Magata Y., Nishizawa S., Tamaki N., Shibasaki H., and Konishi J. Ultra-high resolution SPECT system using four pinhole collimators for small animal studies. J. Nucl. Med. 36 (1995) 2282-2287
18. Li J., Jaszczak R.J., Greer K.L., Coleman R.E., Cao Z.J., and Tsui B.M. Direct cone beam SPECT reconstruction with camera tilt. Phys. Med. Biol. 38 (1993) 241-258
19. Ma K.H., Huang W.S., Chen C.H., Lin S.Z., Wey S.P., Ting G., Wang S.D., Liu H.W., and Liu J.C. Dual SPECT of dopamine system using [99mTc]TRODAT-1 and [123I]IBZM in normal and 6-OHDA-lesioned formosan rock monkeys. Nucl. Med. Biol. 29 (2002) 561-567
20. Myers R., and Hume S. Small animal PET. Eur. Neuropsychopharmacol. 12 (2002) 545-555
21. Nikolaus S., Wirrwar A., Antke C., Arkian S., Schramm N., Muller H.W., and Larisch R. Quantitation of dopamine transporter blockade by methylphenidate: first in vivo investigation using [123I]FP-CIT and a dedicated small animal SPECT. Eur. J. Nucl. Med. Mol. Imaging 32 (2005) 308-313
22. Parkinson Study Group. Dopamine transporter brain imaging to assess the effects of pramipexole vs levodopa on Parkinson disease progression. JAMA 287 (2002) 1653-1661
23. Petroske E., Meredith G.E., Callen S., Totterdell S., and Lau Y.S. Mouse model of Parkinsonism: a comparison between subacute MPTP and chronic MPTP/probenecid treatment. Neuroscience 106 (2001) 589-601
24. Ravina B., Eidelberg D., Ahlskog J.E., Albin R.L., Brooks D.J., Carbon M., Dhawan V., Feigin A., Fahn S., Guttman M., Gwinn-Hardy K., McFarland H., Innis R., Katz R.G., Kieburtz K., Kish S.J., Lange N., Langston J.W., Marek K., Morin L., Moy C., Murphy D., Oertel W.H., Oliver G., Palesch Y., Powers W., Seibyl J., Sethi K.D., Shults C.W., Sheehy P., Stoessl A.J., and Holloway R. The role of radiotracer imaging in Parkinson disease. Neurology 64 (2005) 208-215
25. Scherfler C., Donnemiller E., Schocke M., Dierkes K., Decristoforo C., Oberladstatter M., Kolbitsch C., Zschiegner F., Riccabona G., Poewe W., and Wenning G. Evaluation of striatal dopamine transporter function in rats by in vivo beta-[123I]CIT pinhole SPECT. NeuroImage 17 (2002) 128-141
26. Scherfler C., Scholz S.W., Donnemiller E., Decristoforo C., Oberladstatter M., Stefanova N., Diederen E., Virgolini I., Poewe W., and Wenning G.K. Evaluation of [123I]IBZM pinhole SPECT for the detection of striatal dopamine D2 receptor availability in rats. NeuroImage 24 (2005) 822-831
27. Snow B.J., Tooyama I., McGreer E.G., Yamada T., Calne D.B., Takahashi H., and Kimura H. Human positron emission tomography [18F]-Flourodopa studies correlate with dopamine cell counts and levels. Ann. Neurol. 34 (1993) 324-330
28. Sohlberg A., Lensu S., Jolkkonen J., Tuomisto L., Ruotsalainen U., and Kuikka J.T. Improving the quality of small animal brain pinhole SPECT imaging by Bayesian reconstruction. Eur. J. Nucl. Med. Mol. Imaging 31 (2004) 986-994
29. Uhl G.R., Walther D., Mash D., Faucheux B., and Javoy-Agid F. Dopamine transporter messenger RNA in Parkinson's disease and control substantia nigra neurons. Ann. Neurol. 35 (1994) 494-498