-
1
-
-
0037314229
-
New insights into the pathogenesis of asthma
-
Elias JA, Lee CG, Zheng T, et al. New insights into the pathogenesis of asthma. J Clin Invest 2003; 111: 291-297.
-
(2003)
J Clin Invest
, vol.111
, pp. 291-297
-
-
Elias, J.A.1
Lee, C.G.2
Zheng, T.3
-
3
-
-
0036194724
-
Mucus clearance as a primary innate defense mechanism for mammalian airways
-
Knowles MR, Boucher RC. Mucus clearance as a primary innate defense mechanism for mammalian airways. J Clin Invest 2002; 109: 571-577.
-
(2002)
J Clin Invest
, vol.109
, pp. 571-577
-
-
Knowles, M.R.1
Boucher, R.C.2
-
4
-
-
45949094270
-
Role of cilia, mucus, and airway surface liquid in mucociliary dysfunction: Lessons from mouse models
-
Mall MA. Role of cilia, mucus, and airway surface liquid in mucociliary dysfunction: lessons from mouse models. J Aerosol Med Pulm Drug Deliv 2008; 21: 13-24.
-
(2008)
J Aerosol Med Pulm Drug Deliv
, vol.21
, pp. 13-24
-
-
Mall, M.A.1
-
5
-
-
0032545213
-
Interleukin-13: Central mediator of allergic asthma
-
Wills-Karp M, Luyimbazi J, Xu X, et al. Interleukin-13: central mediator of allergic asthma. Science 1998; 282: 2258-2261.
-
(1998)
Science
, vol.282
, pp. 2258-2261
-
-
Wills-Karp, M.1
Luyimbazi, J.2
Xu, X.3
-
6
-
-
0033560126
-
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, sub-epithelial fibrosis, physiologic abnormalities, and eotaxin production
-
Zhu Z, Homer RJ, Wang Z, et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, sub-epithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 1999; 103: 779-788.
-
(1999)
J Clin Invest
, vol.103
, pp. 779-788
-
-
Zhu, Z.1
Homer, R.J.2
Wang, Z.3
-
7
-
-
0036344597
-
Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
-
Kuperman DA, Huang X, Koth LL, et al. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med 2002; 8: 885-889.
-
(2002)
Nat Med
, vol.8
, pp. 885-889
-
-
Kuperman, D.A.1
Huang, X.2
Koth, L.L.3
-
8
-
-
0036081034
-
Interleukin-13 induces a hypersecretory ion transport phenotype in human bronchial epithelial cells
-
Danahay H, Atherton H, Jones G, et al. Interleukin-13 induces a hypersecretory ion transport phenotype in human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 2002; 282: L226-L236.
-
(2002)
Am J Physiol Lung Cell Mol Physiol
, vol.282
-
-
Danahay, H.1
Atherton, H.2
Jones, G.3
-
9
-
-
0037080350
-
IL-4 is a potent modulator of ion transport in the human bronchial epithelium in vitro
-
Galietta LJ, Pagesy P, Folli C, et al. IL-4 is a potent modulator of ion transport in the human bronchial epithelium in vitro. J Immunol 2002; 168: 839-845.
-
(2002)
J Immunol
, vol.168
, pp. 839-845
-
-
Galietta, L.J.1
Pagesy, P.2
Folli, C.3
-
10
-
-
2442718786
-
+ absorption produces cystic fibrosis-like lung disease in mice
-
+ absorption produces cystic fibrosis-like lung disease in mice. Nat Med 2004; 10: 487-493.
-
(2004)
Nat Med
, vol.10
, pp. 487-493
-
-
Mall, M.1
Grubb, B.R.2
Harkema, J.R.3
-
11
-
-
0025868103
-
Demonstration that CFTR is a chloride channel by alteration of its anion selectivity
-
Anderson MP, Gregory RJ, Thompson S, et al. Demonstration that CFTR is a chloride channel by alteration of its anion selectivity. Science 1991; 253: 202-205.
-
(1991)
Science
, vol.253
, pp. 202-205
-
-
Anderson, M.P.1
Gregory, R.J.2
Thompson, S.3
-
12
-
-
54949112835
-
TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity
-
Caputo A, Caci E, Ferrera L, et al. TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity. Science 2008; 322: 590-594.
-
(2008)
Science
, vol.322
, pp. 590-594
-
-
Caputo, A.1
Caci, E.2
Ferrera, L.3
-
14
-
-
2642613459
-
Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma
-
Mehlhop PD, van de RM, Goldberg AB, et al. Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma. Proc Natl Acad Sci USA 1997; 94: 1344-1349.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 1344-1349
-
-
Mehlhop, P.D.1
Van De, R.M.2
Goldberg, A.B.3
-
15
-
-
0032536837
-
Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production
-
Kuperman D, Schofield B, Wills-Karp M, et al. Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production. J Exp Med 1998; 187: 939-948.
-
(1998)
J Exp Med
, vol.187
, pp. 939-948
-
-
Kuperman, D.1
Schofield, B.2
Wills-Karp, M.3
-
16
-
-
70350447528
-
Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma
-
Tachdjian R, Mathias C, Al Khatib S, et al. Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma. J Exp Med 2009; 206: 2191-2204.
-
(2009)
J Exp Med
, vol.206
, pp. 2191-2204
-
-
Tachdjian, R.1
Mathias, C.2
Al Khatib, S.3
-
17
-
-
57149104917
-
Preventive but not late amiloride therapy reduces morbidity and mortality of lung disease in βENaC-overexpressing mice
-
Zhou Z, Treis D, Schubert SC, et al. Preventive but not late amiloride therapy reduces morbidity and mortality of lung disease in βENaC- overexpressing mice. Am J Respir Crit Care Med 2008; 178: 1245-1256.
-
(2008)
Am J Respir Crit Care Med
, vol.178
, pp. 1245-1256
-
-
Zhou, Z.1
Treis, D.2
Schubert, S.C.3
-
18
-
-
0028111842
-
Anomalies in ion transport in CF mouse tracheal epithelium
-
Grubb BR, Paradiso AM, Boucher RC. Anomalies in ion transport in CF mouse tracheal epithelium. Am J Physiol 1994; 267: C293-C300.
-
(1994)
Am J Physiol
, vol.267
-
-
Grubb, B.R.1
Paradiso, A.M.2
Boucher, R.C.3
-
19
-
-
0032127980
-
+ conductance is reduced by CFTR in normal but not in cystic fibrosis airways
-
+ conductance is reduced by CFTR in normal but not in cystic fibrosis airways. J Clin Invest 1998; 102: 15-21.
-
(1998)
J Clin Invest
, vol.102
, pp. 15-21
-
-
Mall, M.1
Bleich, M.2
Greger, R.3
-
20
-
-
0036080438
-
Activation of ion secretion via proteinase-activated receptor-2 in human colon
-
Mall M, Gonska T, Thomas J, et al. Activation of ion secretion via proteinase-activated receptor-2 in human colon. Am J Physiol Gastrointest Liver Physiol 2002; 282: G200-G210.
-
(2002)
Am J Physiol Gastrointest Liver Physiol
, vol.282
-
-
Mall, M.1
Gonska, T.2
Thomas, J.3
-
21
-
-
9144240996
-
Transcript signatures in experimental asthma: Identification of STAT6-dependent and -independent pathways
-
Zimmermann N, Mishra A, King NE, et al. Transcript signatures in experimental asthma: identification of STAT6-dependent and -independent pathways. J Immunol 2004; 172: 1815-1824.
-
(2004)
J Immunol
, vol.172
, pp. 1815-1824
-
-
Zimmermann, N.1
Mishra, A.2
King, N.E.3
-
22
-
-
0033565228
-
Pulmonary epithelial sodium-channel dysfunction and excess airway liquid in pseudo-hypoaldosteronism
-
Kerem E, Bistritzer T, Hanukoglu A, et al. Pulmonary epithelial sodium-channel dysfunction and excess airway liquid in pseudo-hypoaldosteronism. N Engl J Med 1999; 341: 156-162.
-
(1999)
N Engl J Med
, vol.341
, pp. 156-162
-
-
Kerem, E.1
Bistritzer, T.2
Hanukoglu, A.3
-
23
-
-
0032433707
-
Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease
-
Matsui H, Grubb BR, Tarran R, et al. Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell 1998; 95: 1005-1015.
-
(1998)
Cell
, vol.95
, pp. 1005-1015
-
-
Matsui, H.1
Grubb, B.R.2
Tarran, R.3
-
24
-
-
0028343344
-
Mucociliary clearance in patients with cystic fibrosis and in normal subjects
-
Regnis JA, Robinson M, Bailey DL, et al. Mucociliary clearance in patients with cystic fibrosis and in normal subjects. Am J Respir Crit Care Med 1994; 150: 66-71.
-
(1994)
Am J Respir Crit Care Med
, vol.150
, pp. 66-71
-
-
Regnis, J.A.1
Robinson, M.2
Bailey, D.L.3
-
26
-
-
64849112204
-
In vivo uptake of inhaled particles by airway phagocytes is enhanced in patients with mild asthma compared with normal volunteers
-
Lay JC, Alexis NE, Zeman KL, et al. In vivo uptake of inhaled particles by airway phagocytes is enhanced in patients with mild asthma compared with normal volunteers. Thorax 2009; 64: 313-320.
-
(2009)
Thorax
, vol.64
, pp. 313-320
-
-
Lay, J.C.1
Alexis, N.E.2
Zeman, K.L.3
-
27
-
-
0025847373
-
Changes in mucociliary clearance during acute exacerbations of asthma
-
Messina MS, O'Riordan TG, Smaldone GC. Changes in mucociliary clearance during acute exacerbations of asthma. Am Rev Respir Dis 1991; 143: 993-997.
-
(1991)
Am Rev Respir Dis
, vol.143
, pp. 993-997
-
-
Messina, M.S.1
O'Riordan, T.G.2
Smaldone, G.C.3
-
28
-
-
67749130687
-
Ex vivo sputum analysis reveals impairment of protease-dependent mucus degradation by plasma proteins in acute asthma
-
Innes AL, Carrington SD, Thornton DJ, et al. Ex vivo sputum analysis reveals impairment of protease-dependent mucus degradation by plasma proteins in acute asthma. Am J Respir Crit Care Med 2009; 180: 203-210.
-
(2009)
Am J Respir Crit Care Med
, vol.180
, pp. 203-210
-
-
Innes, A.L.1
Carrington, S.D.2
Thornton, D.J.3
-
30
-
-
0002543851
-
The pathology of asthma, with special reference to changes in the bronchial mucosa
-
Dunnill MS. The pathology of asthma, with special reference to changes in the bronchial mucosa. J Clin Pathol 1960; 13: 27-33.
-
(1960)
J Clin Pathol
, vol.13
, pp. 27-33
-
-
Dunnill, M.S.1
-
31
-
-
67650488822
-
SPLUNC1 regulates airway surface liquid volume by protecting ENaC from proteolytic cleavage
-
Garcia-Caballero A, Rasmussen JE, Gaillard E, et al. SPLUNC1 regulates airway surface liquid volume by protecting ENaC from proteolytic cleavage. Proc Natl Acad Sci USA 2009; 106: 11412-11417.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 11412-11417
-
-
Garcia-Caballero, A.1
Rasmussen, J.E.2
Gaillard, E.3
-
32
-
-
33746593241
-
Ion and fluid transport properties of small airways in cystic fibrosis
-
Blouquit S, Regnier A, Dannhoffer L, et al. Ion and fluid transport properties of small airways in cystic fibrosis. Am J Respir Crit Care Med 2006; 174: 299-305.
-
(2006)
Am J Respir Crit Care Med
, vol.174
, pp. 299-305
-
-
Blouquit, S.1
Regnier, A.2
Dannhoffer, L.3
-
33
-
-
0034537007
-
+ absorption by extracellular nucleotides in human normal and cystic fibrosis airways
-
+ absorption by extracellular nucleotides in human normal and cystic fibrosis airways. Am J Respir Cell Mol Biol 2000; 23: 755-761.
-
(2000)
Am J Respir Cell Mol Biol
, vol.23
, pp. 755-761
-
-
Mall, M.1
Wissner, A.2
Gonska, T.3
-
34
-
-
48649096884
-
A2B adenosine receptors regulate the mucus clearance component of the lung's innate defense system
-
Rollins BM, Burn M, Coakley RD, et al. A2B adenosine receptors regulate the mucus clearance component of the lung's innate defense system. Am J Respir Cell Mol Biol 2008; 39: 190-197.
-
(2008)
Am J Respir Cell Mol Biol
, vol.39
, pp. 190-197
-
-
Rollins, B.M.1
Burn, M.2
Coakley, R.D.3
|