In-situ gelling ophthalmic drug delivery system: An overview

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 2, Issue SUPPL. 4, 2010, Pages 30-34

  Rathore, K S ^a  

^a B N Girls College of Pharmacy   (India)

Author keywords

In situ gel; Ion activated in situ system; Novel ocular drug delivery system; Ph triggered in situ system; Sol to gel; Temperature evident in situ system

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; ACETAZOLAMIDE; ALGINIC ACID; CARBOPOL 940; CARTEOLOL; CHITOSAN; CIPROFLOXACIN; CLOTRIMAZOLE; COLLAGEN; DENDRIMER; ENOXACIN; GATIFLOXACIN; GELLING AGENT; GELRITE; HYALURONIC ACID; HYDROXYPROPYLMETHYLCELLULOSE; LIPOSOME; MACROGOL 400; METHYLCELLULOSE; NIOSOME; OFLOXACIN; PEFLOXACIN; PILOCARPINE; POLOXAMER; POLY(N ISOPROPYLACRYLAMIDE); POLYVINYL ALCOHOL; POVIDONE; TIMOLOL; TIMOLOL MALEATE; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; AQUEOUS SOLUTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; EYE; EYEBALL; GEL; GELATION; HUMAN; HYDROGEL; IONTOPHORESIS; NONHUMAN; PH; REVIEW; TEMPERATURE SENSITIVITY;

EID: 78649723323     PISSN: 09751491     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Review

References (37)

1. Rathore KS, Nema RK. Review on Ocular inserts. Int J PharmTech Res 2009; 1(2): 164-169.
2. Saettone MF, and Salminen L. Ocular inserts for topical delivery. Advanced drug delivery reviews 1995; 16(1): 95.
3. Rathore KS, Nema RK. Formulation and evaluation of ophthalmic films for timolol maleate. planta indica 2008; Vol.no.4: p 49-50.
4. Rathore KS, Nema RK. Glaucoma: a review. Available on-line at http://www.earticlesonline.com/Article/Glaucoma--A-Review/469815. Jan 4, 2009
5. Kaur IP, Kanwar M. Ocular preparations: the formulation approach. Drug Dev Ind Pharm 2002; 28(5):473-93.
6. Indu PK, Manjit S, Meenakshi K. Formulation and evaluation of ophthalmic preparations of acetazolamide. Int J Pharm 2000; 199: 119-127.
7. Mitan R, Gokulgandhi Jolly R, Parikh, Megha B, Dharmesh MM. A pH triggered in- situ gel forming ophthalmic drug delivery system for tropicamide. Drug Deliv Technol 2007; 5: 44-49.
8. Sultana Y, Aqil M, Ali A, Zafar S. Evaluation of carbopol-methyl cellulose based sustained-release ocular delivery system for pefloxacin mesylate using rabbit eye model. Pharm Dev Technol 2006; 11(3):313-319.
9. Srividya B, Cardoza RM, Amin PD, Sustained ophthalmic delivery of ofloxacin from a pH triggered in- situ gelling system. J Control Release 2001; 73(2-3):205-211.
10. Katarina E, Johan C, Roger, P. Rheological evaluation of poloxamer as an in- situ gel for ophthalmic use. Eur J Pharm Sci 1998; 6: 105-112.
11. El-Kamel AH, In vitro and in vivo evaluation of Pluronic F127-based ocular delivery system for timolol maleate. Int J Pharm 2002; 241(1):47-55.
12. Balasubramaniam J, Kant S, Pandit JK, In vitro and in vivo evaluation of the Gelrite gellan gum-based ocular delivery system for indomethacin. Acta Pharm 2003; 53(4):251-61.
13. Johan C, Katarina E, Roger P, Katarina, J. Rheological evaluation of gelrite in-situ gel for opthalmic use. Eur J Pharm Sci 1998; 6: 113-116.
14. Harish NM, Prabhu P, Charayu RN and Subrahmanyam, Formulation and evaluation of in-situ gel containing clotrimazole for oral candidiasis. Indian J Pharm Sci 2009, 71(4): 421-427.
15. Eaga Chandra Mohan JM, Kandukuri V, Alenki, Journal of Pharmacy Research 2009, 2(6), 1089-1094.
16. Wen Di Ma, Hui Xu, Chao Wang, Shu-Fang Nie, Wei-San Pan, Int J Pharm 2008; 350: 247-256.
17. Himanshu Gupta, Sanyog Jain, Rashi Mathur, Pushpa Mishra, Anil K Mishra, T Velpandian Drug Deliv 2007 Nov; 14 (8):507-515.
18. Cao Y, Zhang C, Shen W, Cheng Z, Yu LL, Ping Q. J Control Release. 2007; 120(3):186-194.
19. El-Kamel A, Al-Dosari H, Al-Jenoobi F. Environmentally responsive ophthalmic gel formulation of carteolol HCl. Drug Delivery. 2006; 13: 55-59.
20. Dong In Ha, Sang Bong Lee, Moo Sang Chong, and Young Moo Lee, Macromolecular Research 2006; Vol. 14, No. 1: pp 87-93.
21. Sreenivas SA, Hiremath SP and Godbole AM, Ofloxacin ocular inserts: Design, Formulation and Evaluation. Iranian Journal of Pharmacology & Therapeutics 2006;Vol. 5, No. 2: pp. 159-162.
22. Liu Z, Li J, Nie S, Liu H, Ding P, Pan W, Study of an alginate/HPMC-based in- situ gelling ophthalmic delivery system for gatifloxacin. Int J Pharm 2006; 315(1-2):12-17.
23. Liu Z, Pan W, Nie S, Zhang L, Yang X, Li J, Preparation and evaluation of sustained ophthalmic gel of enoxacin Drug Dev Ind Pharm. 2005; 31(10):969-75.
24. Aminabhavi TM, Agnihotri SA, Naidu BVK. Rheological properties and drug release characterization of pH responsive hydrogels. J Appl Polym Sci 2004; 94: 2057-2064.
25. Balasubramaniam J, Pandit JK, Ion-activated in situ gelling systems for sustained ophthalmic delivery of ciprofloxacin hydrochloride. Drug Deliv 2003; 10(3):185-191.
26. Ishibashi Tejraj, Yokoi N, Born JA, Tiffany MJ, Komuro A, Kinoshita S. Retention of reversibly thermo-gelling timolol on the human ocular surface studied by video meniscometry, Current Eye Research 2003; 27: 117-22.
27. Vadnere M, Amidon G, Lindenbaum S, Haslam JL. Int J Pharm 1984; 22: 207.
28. Zhidong L, Jiawei L, Shufang N, Hui L, Pingtian Ding, Weisan P. Study of an alginate/HPMC based in-situ gelling ophthalmic delivery system for gatifloxacin. Int J Pharm 2006; 315: 12-17.
29. Pandit D, Bharathi, A, Srinatha Ridhurkar, Singh S. Long acting ophthalmic formulation of indomethacin: Evaluation of alginate gel systems. Indian J Pharm Sci 2007; 69: 37-40.
30. Kashyap N, Vishwnath B, Sharma G. design and evaluation of biodegradable, biosensitive in situ gelling system for pulsatile delivery of insulin. Biomaterials 2007; 28: 2051-60.
31. Sautou-Miranda V, Labret F, Grand-Boyer A, Gellis C, Chopineau J. Impact of deep-freezing on the stability of 25 mg/ml vancomycin ophthalmic solutions. Int J Pharm 2002; 234: 205-207.
32. Doijad RC, Manvi FV, Malleswara Rao VSN, Prajakta, Alsae. Sustained ophthalmic delivery of gatifloxacin from in-situ gelling system. Indian J Pharm Sci 2006; 68: 814-818.
33. Draize J, Woodward G, Calvery O. Methods for the study of irritation and toxicity of substance applied topically to the skin and mucous membrane. J Pharmacol Exp Ther 1994; 82: 377-390.
34. Rathore KS, Nema RK. An Insight into Ophthalmic Drug Delivery System, IJPSDR, Apr.-June. 2009; Vol.1, Issue1: 1-5.
35. Rathore KS, Nema RK. Management of Glaucoma: a review. Int.J. PharmTech Res 2009; 1(3): 863-869.
36. Rathore KS, Nema RK, Sisodia SS, Formulation and Evaluation of Brimonidine Tartrate Ocular Films. The Pharma Review 2010; 2: p.133-139.
37. Michael H, Mostafa H, Mehdi J, Taravat G. Draize Rabbit eye test compatibility with eye irritation threshold in humans: A quantitative structural-activity relationship analysis. Toxicol Sci 2003; 76: 384-391.