Magnesium sulfate in severe perinatal asphyxia: A randomized, placebo-controlled trial

Pediatrics

Volumn 123, Issue 5, 2009, Pages

  Bhat, Mushtaq Ahmad ^a   Charoo, Bashir Ahmad ^a   Bhat, Javeed Iqbal ^a   Ahmad, Sheikh Mushtaq ^a   Ali, Syed Wajid ^a   Mufti, Masood Ul Hassan ^a  

^a SHER I KASHMIR INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Asphyxia; Magnesium sulfate; Perinatal

Indexed keywords

MAGNESIUM; MAGNESIUM SULFATE; PLACEBO; SODIUM CHLORIDE;

APGAR SCORE; ARTICLE; BRAIN DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; FEEDING BEHAVIOR; FEMALE; FETUS DISTRESS; GESTATIONAL AGE; HOSPITAL DISCHARGE; HUMAN; INFANT; LONGITUDINAL STUDY; MAGNESIUM BLOOD LEVEL; MALE; MUSCLE TONE; PERINATAL ASPHYXIA; PERINATAL PERIOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SUCKING; TERM BIRTH; TREATMENT OUTCOME;

ASPHYXIA NEONATORUM; BRAIN DISEASES; CALCIUM CHANNEL BLOCKERS; FEMALE; HUMANS; INFANT, NEWBORN; MAGNESIUM; MAGNESIUM SULFATE; MALE; NEUROLOGIC EXAMINATION; NEUROPROTECTIVE AGENTS; PROSPECTIVE STUDIES;

EID: 66049091227     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2007-3642     Document Type: Article

References (30)

1. Adcock LM, Papile LA. Perinatal asphyxia. In: Cloherty JP, Eichenwald EC, Stark AR, eds. Manual of Neonatal Care. Philadelphia, PA: Lippincott Williams & Wilkins; 2008:518-528
2. Paul VK. Neonatal morbidity: report of the National Neonatal and Perinatal Database. Indian Pediatr. 1999;36(2):167-169
3. Bhat MA, Shah ZA, Makhdoomi MS, Mufti MH. Theophylline for renal functions in term neonates with perinatal asphyxia; a randomized placebo controlled trial. J Pediatr. 2006;149(2):180-184 (Pubitemid 44128549)
4. Paneth N. The causes of cerebral palsy: recent evidence. Clin Invest Med. 1993;16(2):95-102 (Pubitemid 23181199)
5. Dixon G, Badawi N, Kurinczuk JJ, et al. Early developmental outcomes after newborn encephalopathy. Pediatrics. 2002;109(1):26-33 (Pubitemid 34049423)
6. Robertson CM, Finer NN, Grace MG. School performance of survivors of neonatal encephalopathy associated with birth asphyxia at term. J Pediatr. 1989;114(5):753-760 (Pubitemid 19122969)
7. Volpe JJ. Neurology of the Newborn. Philadelphia, PA: Saunders; 2001:331-382
8. Benveniste H, Drejer J, Schousboe A, Diemer NH. Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J Neurochem. 1984;43(5):1369-1374 (Pubitemid 15205893)
9. Choi DW, Hartley DM. Calcium and glutamate induced cortical neuronal death. In: Waxman SG, eds. Molecular and Cellular Approaches to the Treatment of Neurological Disease. New York, NY: Raven Press, 1993:23-24
10. Lorek A, Takei Y, Cady EB, et al. Delayed ("secondary") cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: continuous 48-hour studies by phosphorus magnetic resonance spectroscopy. Pediatr Res. 1994;36(6):699-706 (Pubitemid 24357779)
11. Nowak L, Bregestovski P, Ascher P, Herbet A, Prochiantz A. Magnesium gates glutamate-activated channels in mouse central neurones. Nature. 1984;307(5950):462-465 (Pubitemid 14132062)
12. Henneberry RC, Novelli A, Cox JA, Lysko PG. Neurotoxicity at the N-methyl-D-aspartate receptor in energy-compromised neurons: a hypothesis for cell death in aging and disease. Ann N Y Acad Sci. 1989;568:225-233 (Pubitemid 20166540)
13. McDonald JW, Silverstein FS, Johnston MV. Magnesium reduces N-methyl-D-aspartate (NMDA)-mediated brain injury in perinatal rats. Neurosci Lett. 1990;109(1-2):234-238 (Pubitemid 20036504)
14. 4 infusion on NMDA receptor binding characteristics during cerebral cortical hypoxia in the newborn piglet. Brain Res. 1994;644(1):144-149
15. 4 administration after cerebral hypoxia-ischemia in newborn rats is related to the severity of brain damage. Reprod Sci. 2007;14(7):667-677
16. Penrice J, Amess PN, Punwani S, et al. Magnesium sulfate after transient hypoxia-ischemia fails to prevent delayed cerebral energy failure in the newborn piglet. Pediatr Res. 1997;41(3):443-447 (Pubitemid 27097917)
17. Greenwood K, Cox P, Mehmet H, et al. Magnesium sulfate treatment after transient hypoxia-ischemia in the newborn piglet does not protect against cerebral damage. Pediatr Res. 2000;48(3):346-350 (Pubitemid 30637335)
18. Schendel DE, Berg CJ, Yeargin-Allsopp M, Boyle CA, Decoufle P. Prenatal magnesium sulfate exposure and the risk for cerebral palsy or mental retardation among very low-birth-weight children aged 3 to 5 years. JAMA. 1996;276(22):1805-1810 (Pubitemid 26406229)
19. Ichiba H, Tamai H, Negishi H, et al. Randomized controlled trial of magnesium sulfate infusion for severe birth asphyxia. Pediatr Int. 2002;44(5):505-509
20. Portman RJ, Carter BS, Gaylord MS, Murphy MG, Thieme RE, Merenstein GB. Predicting neonatal morbidity after perinatal asphyxia: a scoring system. Am J Obstet Gynecol. 1990;162(1):174-182 (Pubitemid 20055445)
21. Levene M, Blennow M, Whitelaw A, Hankø E, Fellman V, Hartley R. Acute effects of two different doses of magnesium sulphate in infants with birth asphyxia. Arch Dis Child Fetal Neonatal Ed. 1995;73(3):F174-F177
22. Dubowitz LMS, Dubowitz V, Mercuri E. The Neurological Assessment of the Preterm and Full-Term Infant. London, United Kingdom: McKeith Press; 1998. Clinics in Developmental Medicine No. 148
23. Marret S, Gressens P, Gadisseux JF, Evrard P. Prevention by magnesium of excitotoxic neuronal death in the developing brain: an animal model for clinical intervention studies. Dev Med Child Neurol. 1995;37(6):473-484
24. 2+ blockade of NMDA receptors. Neurosci Lett. 1994;173(1-2):75-78 (Pubitemid 124016416)
25. Shankaran S, Laptook AR, Ehrenkranz RA, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med. 2005;353(15):1574-1584 (Pubitemid 41434636)
26. Nelson KB, Grether JK. Can magnesium sulfate reduce the risk of cerebral palsy in very low birth weight infants? Pediatrics. 1995;95(2):263-269
27. Grether JK, Hoogstrate J, Selvin S, Nelson KB. Magnesium sulfate tocolysis and risk of neonatal death. Am J Obstet Gynecol. 1998;178(1):1-6 (Pubitemid 28302785)
28. Harrison V, Fawcus S, Jordaan E. Magnesium supplementation and perinatal hypoxia: outcome of a parallel group randomised trial in pregnancy. BJOG. 2007;114(8):994-1002 (Pubitemid 47052758)
29. Natale JE, Guerguerian AM, Joseph JG, et al. Pilot study to determine the hemodynamic safety and feasibility of magnesium sulfate infusion in children with severe traumatic brain injury. Pediatr Crit Care Med. 2007;8(1):1-9 (Pubitemid 46168350)
30. Temkin NR, Anderson GD, Winn HR, et al. Magnesium sulfate for neuroprotection after traumatic brain injury: a randomised controlled trial. Lancet Neurol. 2007;6(1):29-38