Evaluation of long-lasting sensorimotor consequences following neonatal hypoxic-ischemic brain injury in rats: The neuroprotective role of MgSO 4

Neonatology

Volumn 95, Issue 1, 2008, Pages 33-40

  Pazaiti, Anastasia ^a   Soubasi, Vassiliki ^a   Spandou, Evangelia ^a   Karkavelas, George ^a   Georgiou, Thomas ^a   Karalis, Philippos ^a   Guiba Tziampiri, Olympia ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

MgSO4; Neonatal hypoxia ischemia; Sensorimotor deficit

Indexed keywords

MAGNESIUM SULFATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR CHANGE; BRAIN DAMAGE; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN TISSUE; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; FEMALE; HISTOPATHOLOGY; HYPOXIA; MALE; MOTOR COORDINATION; MUSCLE STRENGTH; NERVE CELL DIFFERENTIATION; NEUROPROTECTION; NEWBORN; NEWBORN HYPOXIA; NONHUMAN; PRIORITY JOURNAL; RAT; REFLEX; SENSORIMOTOR CORTEX; SENSORIMOTOR FUNCTION; SENSORY STIMULATION;

ANIMALS; ANIMALS, NEWBORN; BEHAVIOR, ANIMAL; BRAIN; DISEASE MODELS, ANIMAL; GAIT DISORDERS, NEUROLOGIC; HYPOXIA-ISCHEMIA, BRAIN; MAGNESIUM SULFATE; MOTOR ACTIVITY; MOVEMENT DISORDERS; MUSCLE STRENGTH; NEUROPROTECTIVE AGENTS; PROPRIOCEPTION; RATS; ROTAROD PERFORMANCE TEST;

RATTUS;

EID: 51349156580     PISSN: 16617800     EISSN: 16617819     Source Type: Journal    
DOI: 10.1159/000151753     Document Type: Article

References (36)

1. Volpe JJ: Hypoxic-ischemic encephalopathy: biochemical and physiological aspects; in Volpe JJ (ed): Neurology of the Newborn, ed 4. Philadelphia, Saunders, 2001, pp 217-267.
2. Delivoria-Papadopoulos M, Mishra OP: Nuclear mechanisms of hypoxic cerebral injury in the newborn. Clin Perinatol 2004;31:91-105.
3. Felt BT, Schallert T, Shao J, Liu Y, Li X, Barks JDE: Early appearance of functional deficits after neonatal excitotoxic and hypoxic-ischemic injury: fragile recovery after development and role of the NMDA receptor. Dev Neurosci 2002;24:418-425.
4. Thordstein M, Bagenholm P, Thiringer K, Kjellmer I: Scavengers of free oxygen radicals in combination with magnesium ameliorate perinatal hypoxic-ischemic brain damage in the rat. Pediatr Res 1993;34:23-26.
5. 4 infusion on NMDA receptor binding characteristics during cerebral cortical hypoxiain the newborn piglet. Brain Res 1994;644:144-149.
6. Sameshima H, Ota A, Ikenoue T: Pretreatment with magnesium sulfate protects against hypoxic-ischemic brain injury but post-asphyxial treatment worsens brain damage in seven-day-old rats. Am J Obstet Gynecol 1999;180:725-730.
7. Sameshima H, Ikenoue T: Long-term magnesium sulfate treatment as protection against hypoxic-ischemic brain injury in seven-day-old rats. Am J Obstet Gynecol 2001;184:185-190.
8. Penrice J, Amess PN, Punwani S, Wylezinska M, Tyszczuk L, D'Souza P, Edwards AD, Cady EB, Wyatt JS, Reynolds EO: Magnesium sulfate after transient hypoxia-ischemia fails to prevent delayed cerebral energy failure in the newborn piglet. Pediatr Res 1997;41:443-447.
9. Galvin KA, Oorschot E: Postinjury magnesium sulfate treatment is not markedly neuroprotective for striatal medium spiny neurons after perinatal hypoxia/ischemia in the rat. Pediatr Res 1998;44:740-745.
10. Greenwood K, Cox P, Mehmet H, et al: Magnesium sulphate treatment after transient hypoxia-ischemia in the newborn piglet does not protect against cerebral damage. Pediatr Res 2000;48:346-350.
11. Alvarez-Díaz A, Hilario E, Goñi de Cerio F, Valls-i-Soler A, Alvarez-Díaz FJ: Hypoxicischemic injury in the immature brain - key vascular and cellular players. Neonatology 2007;92:227-235.
12. Hoane MR, Irish RS, Marks BB, Barth TM: Preoperative regimens of magnesium facilitate recovery of function and prevent subcortical atrophy following lesions of the rat sensorimotor cortex. Brain Res Bull 1998;45:45-51.
13. Hoane R, Barbay S, Barth TM: Large cortical 1esions produce enduring forelimb placing deficits in un-treated rats and treatment with NMDA antagonists or anti-oxidant drugs induces behavioral recovery. Brain Res Bull 2000;53:175-186.
14. Spandou E, Soubasi V, Guiba-Tziampiri O, Karkavelas G, Kaiki-Astara A, Doukas V, Papadimitriou C: Magnesium monotherapy or in combination with ketamine in perinatal hypoxic-ischemic brain damage (preliminary study). Pediatr Res 1995;38:455.
15. Rice JE, Vannucci RC, Brierley JB: The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann Neurol 1981;9:131-141.
16. Bona E, Johansson BB, Hagberg H: Sensorimotor function and neuropathology five to six weeks after hypoxia-ischemia in seven-day-old rats. Pediatr Res 1997;42:678-683.
17. Tomimatsu T, Fukuda H, Endoh M, Mu J, Watanabe N, Kohzuki M, Fuji E, Kanzaki T, Oshima K, Doi K, Kubo T, Murata Y: Effects of neonatal hypoxic-ischemic brain injury on skilled motor tasks and brainstem function in adult rats. Brain Res 2002;926:108-117.
18. Donatelle JM: Growth of the corticospinal tract and the development of placing reactions in the postnatal rat. J Comp Neurol 1997;175:207-232.
19. Bareyre FM, Saatman KE, Raghupathi R, McIntosh TK: Postinjury treatment with magnesium chloride attenuates cortical damage after traumatic brain injury in rats. J Neurotrauma 2000;17:1029-1039.
20. Heath DL, Vink R: Delayed therapy with magnesium up to 24 hours following traumatic brain injury improves motor outcome. J Neurosurg 1999;90:504-509.
21. Vink R, O'Connor CA, Nimmo AJ, Heath DL: Magnesium attenuates persistent functional deficits following diffuse traumatic brain injury in rats. Neurosci Lett 2003;336:41-44.
22. Heath DL, Vink R: Brain free magnesium concentration is predictive of motor outcome following traumatic axonal brain injury in rats. Magnes Res 1999;12:269-277.
23. Hoane MR, Raad C, Barth TM: Non-competitive NMDA antagonists and antioxidant drugs reduce striatal atrophy and facilitate recovery of function following lesions of the rat cortex. Restor Neurol Neurosci 1997;11:71-82.
24. De Ryck M, Reempts JV, Duytschaever H, Van Deuren B, Clincke G: Neocortical localization of tactile/proprioceptive limb placing reactions in the rat. Brain Res 1992;573:44-60.
25. Decker MJ, Hue GE, Caudle WM, Miller GW, Keating GL, Rye DB: Episodic neonatal hypoxia evokes executive dysfunction and regionally specific alterations in markers of dopamine signaling. Neuroscience 2003;117:417-425.
26. Grow JL, Liu YQ, Barks JDE: Can lateralizing sensorimotor deficits be identified after neonatal cerebral hypoxia-ischemia in rats? Dev Neurosci 2003;25:394-402.
27. Golan H, Huleihel M: The effect of prenatal hypoxia on brain development: short- and long-term consequences demonstrated in rodent models. Dev Sci 2006;4:338-349.
28. Spandou E, Papadopoulou Z, Soubasi V, Karkavelas G, Simeonidou C, Pazaiti A, Guiba-Tziampiri O: Erythropoietin prevents long-term sensorimotor deficits and brain injury following neonatal hypoxia-ischemia in rats. Brain Res 2005;1045:22-30.
29. Ichiba H, Yokoi T, Tamai H, Ueda T, Kim T-J, Yamano T: Neurodevelopmental outcome of infants with birth asphyxia treated with magnesium sulfate. Pediatr Int 2006;48:70-75.
30. Tyson JE, Gilstrap LG: Hope for perinatal prevention of cerebral palsy. JAMA 2003;290:2730-2732.
31. Growther CA, Hiller JE, Doyle LW, Haslam RR: Effect of magnesium sulfate given for neuroprotection before preterm birth. JAMA 2003;290:2669-2676.
32. Nishio A, Gebrewold A, Altura BT, Altura BM: Comparative vasodilator effects of magnesium salts on rat mesenteric arterioles and venules. Arch Int Pharmacodyn Thér 1989;298:139-163.
33. 4 administration after cerebral hypoxia-ischemia in newborn rats is related to the severity of brain damage. Reprod Sci 2007;14:667-677.
34. Groenendaal F, Rademaker CMA, Toet MC, et al: Effects of magnesium sulfate on amplitude-integrated continuous EEG in asphyxiated term neonates. Acta Pediatr 2002;91:1073-1077.
35. Intravenous Magnesium Efficacy in Stroke (IMAGES) Study Investigators: Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke Trial): randomized controlled trial. Lancet 2004;363:439-445.
36. Gorelick PB, Ruland S: Images and FAST-MAG: magnesium for acute ischaemic stroke. Lancet Neurol 2004;3:330.